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Nathan Goodyear

IOS Press - Journal Article - 0 views

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    Allopregnanolone, a produce of progesterone metabolism, shown to reduce brain injury post TBI.
Nathan Goodyear

PsychiatryOnline | The Journal of Neuropsychiatry and Clinical Neurosciences | The Neur... - 0 views

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    TBI results in hormone disruption in 25-69% of those effected.  The major cause is a pituitary/neuro-endocrine effect.  This has been described since the early 20th century.
Nathan Goodyear

Immunoexcitotoxicity as a central mechanism in chronic traumatic encephalopathy-A unify... - 0 views

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    immunoexcitotoxicity and traumatic brain injury
Nathan Goodyear

Acta Pharmacologica Sinica - The neuroprotective effects of progesterone on traumatic b... - 0 views

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    Good discussion and review of progesterone's role as neuroprotective in TBI.
Nathan Goodyear

Acute Glucocorticoid Deficiency and Diabetes Insipidus Are Common After Acute Traumatic... - 0 views

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    High rate (78%) of those post TBI have low cortisol levels due to damaged HPA axis.  Low cortisol levels post TBI are associated with an increase mortality rate and increased long-term HPA disruption.
Nathan Goodyear

High Prevalence of Chronic Pituitary and Target-Organ Hormone Abnormalities after Blast... - 0 views

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    The prevalence of post traumatic hypopituitarism post TBI sits at around 35%.  
Nathan Goodyear

High School Football and Risk of Neurodegeneration: A Community-Based Study - Mayo Clin... - 0 views

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    Study finds increased TBI in high school football players, but not an increase in neurodegenerative disease.
Nathan Goodyear

Depletion of Brain Docosahexaenoic Acid Impairs Recovery from Traumatic Brain Injury - 0 views

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    DHA plays important role in TBI risk and recovery.
Nathan Goodyear

Neuroimaging of sport concussion: persistent alterations in brain structure and functio... - 0 views

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    New study suggest brain healing lags far behind in concussion recovery.
Nathan Goodyear

Hyperbaric oxygen therapy promotes neurogenesis: where do we stand? - 0 views

  • Numerous in vivo and in vitro studies confirm that HBOT induces neurogenesis
  • HIF-1α is the principal mediator of cellular hypoxia adaptations
  • activated by hypoxia, HIF-1α causes the transcription of its regulated downstream genes, including erythropoietin (EPO) and VEGF which are known to promote neurogenesis
  • ...10 more annotations...
  • The safety of HBOT was also evaluated and it was pointed out that, if given at proper paradigms, like 1.5 ATA for 60 minutes, HBOT will not cause oxygen toxicity
  • Rockswold et al., on the other hand, found that HBOT might be potentially beneficial for severe TBI patients
  • McDonagh et al., concluded that there was insufficient evidence to establish the effectiveness of HBOT in the treatment of TBI
  • The first multicenter, randomized, double-blind, controlled trial in 2009 found that 40-hour HBOT of 24% oxygen at 1.3 ATM produced significant improvement in children's overall functioning, receptive language, social interaction, eye contact, and sensory/cognitive awareness compared to those received slightly pressurized room air
  • Another study in 2010 on 16 autism patients, adopting a similar treatment paradigm, showed no effect on a wide array of behavioral evaluations
  • To date, there is little evidence that HBOT causes malignant growth or metastasis. A history of malignancy should therefore not be considered as a contraindication for HBOT
  • HBOT enhances the production of reactive oxygen species (ROS) and causes oxidative stress in body tissues
  • Excessive accumulation of oxidative stress may contribute to neurodegenerative processes and cell death in the brain, as seen in diseases like Alzheimer's disease (AD) and Parkinson's disease (PD)
  • Hormesis
  • process that results in a functional improvement of cellular stress resistance, survival, and longevity in response to sub-lethal levels of stress
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    great review of hbot, brain injury, neuroplasticity and neurogenesis.
Nathan Goodyear

Omega-3 fatty acid supplementation and reduction... [J Neurosurg. 2011] - PubMed - NCBI - 0 views

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    Animal model shows that n-3 intake reduced axonal injury after injury insult.  This implies a use in n-3 intake even after an insult has occured. This implies a role for n-3 in neuroplasticity.
wheelchairindia9

Weight Cuff - 0 views

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    Tynor Weight Cuff Tynor Weight cuffs are used to exercise ailing joints to build strength and aid recovery. Tynor Weight Cuff is flexible and cushion, so it does not injure. Recommended for use to improve muscle tone, muscle mass, strength and stamina. Tynor Weight Cuff Features Offers 1 kg resistance when wrapped around Weight is wrapped in comfortable and soft fabric Used to build muscles, flexibility or to lose weight Can be secured easily around to prevent injuries or accidents Cuff is safe to be used during everyday activities as well Tynor Weight Cuff Measurements Sizes Available: 1/2 Kg / 1Kg / 2 Kg
Nathan Goodyear

Ketogenic Diet - Nutrition and Traumatic Brain Injury - NCBI Bookshelf - 0 views

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    good review of the impact of ketones on TBI.  The authors conclude that precursors to ketones may be the right approach to treatment.  This would be MCT's and ketones.
Nathan Goodyear

Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-indu... - 0 views

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    Omega 3 supplementation found to blunt microglial TBI inflammation. 
Nathan Goodyear

Hyperbaric oxygen therapy for traumatic brain injury - 0 views

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    great review article on the positive effects of hbot in TBI
Nathan Goodyear

Prevalence of chronic hypopituitarism after blast concussion -- Wilkinson et al. 27 (1)... - 1 views

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    One of the first studies to look at PCS found that 42% of soldiers produced abnormally low hormone production following TBI one year after the injury.  This study highlights the potential pituitary dysfunction that can result from TBI.
wheelchairindia9

Chest Binder - 0 views

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    Tynor Chest Binder Chest Binder is applied to the thoracic region to compress and bind the rib cage and provide splinting to the sternum while allowing sufficient flexibility for comfortable breathing. Anatomic chest pad. Controlled compression. Optimum chest splinting. Soft feel. Tynor Chest Binder Features 50 mm thick PUF pad hold and binds the fractured sternum without compromising on patient comfort. Strong elastic band gives good grip and helps in equidistribution of pressure. Reduces post operative pain and discomfiture. Facilitates phlegm expulsion after cardio thoracic surgery. Tynor Chest Binder Measurements Measure circumference around the chest.
Nathan Goodyear

Neuroprotective Effects of Cannabidiol but Not Δ9-Tetrahydrocannabinol in Rat... - 0 views

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    CBD protects agains neural injury.
Nathan Goodyear

Chronic Traumatic Encephalopathy: Chronic Degenerative Disease - 0 views

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    Good discussion on chronic traumatic encephalopathy. CTE is a condition found in the military and sports related head trauma. This is usually the result of low, repetitive impact injuries to the brain. Though, genetic susceptibility is discussed as well.
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