post-traumatic hypopituitarism is found in 40% of those with TBI. The severity does correlate with the increased likelihood of developing PTHP. Isolated deficiencies have been found in PTHP.
The majority of people with PTHP after TBI remain undiagnosed. The current thought, is that 25% of those with TBI have at least one pituitary hormone deficiency. It does not have to be total pituitary failure. Deficiencies can be isolated.
One of the first studies to look at PCS found that 42% of soldiers produced abnormally low hormone production following TBI one year after the injury. This study highlights the potential pituitary dysfunction that can result from TBI.