Now, this is in a rat TBI model; but progesterone was shown to reduce the inflammatory response post TBI. Particularily, through NF-kappa B inhibition.
The majority of people with PTHP after TBI remain undiagnosed. The current thought, is that 25% of those with TBI have at least one pituitary hormone deficiency. It does not have to be total pituitary failure. Deficiencies can be isolated.
Abstract on listed here: but bioidentical progesterone and allopregnanolone (product of progesterone metabolism) shown to reduce inflammation after TBI. This inflammation is what results in much of the post-TBI complications.
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progesterone shown to decrease NF-KappaB and other inflammatory signaling after TBI in rat model. Part of the role of progesterone is as an anti-inflammatory.
short term fasting and ketosis provides neuroprotection and preserves mitochondria in animal TBI study. This study found preventative effects of the ketones.
allopregnanolone increases human neural stem cells. Not only does allopregnanolone reduce inflammation, it plays a role in neurogenesis and thus recovery.
progesterone shown to have neuroprotective and healing properties in the CNS. This has implications in Stroke, and possibly even excitotoxic disease such as Parkinson's, Alzhemier's...