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Nathan Goodyear

Dietary Strategy to Repair Plasma Membrane After Brain Trauma - 0 views

nnr.sagepub.com/...75.full

BDNF curcumin DHA TBI concussion brain injury traumatic brain injury

shared by Nathan Goodyear on 30 Aug 15 - No Cached
  • strategies directed to preserve phospholipids in the plasma membrane such as the use of dietary docosahexaenoic acid (C22:6n-3; DHA)5 can have beneficial effects for post-TBI recovery
  • DHA is the most abundant polyunsaturated fatty acid (PUFA) in the brain
  • Curcumin provided in the diet before TBI can reduce oxidative damage and counteract TBI-related cognitive dysfunction.
  • ...8 more annotations...
  • Our previous study indicated that n-3 fatty acids supplemented in the diet counteracted learning disability after TBI
  • There was a significant group effect on BDNF (F 4,25 = 5.229, P < .01 by ANOVA), and FPI reduced BDNF levels (50% of CTL, P < .01; Figure 1C), which was counteracted by DHA supplementation (90% of CTL, P < .05; Figure 1C). Curcumin also counteracted this reduction of BDNF
  • The combination of curcumin and DHA had a trend of greater effects in BDNF (117% of CTL; Figure 1C) compared with DHA or curcumin alone.
  • curcumin contributed to enhance the action of DHA, protecting against cognitive impairment, and these effects were associated with elevations in the BDNF receptor signaling
  • Our current results show that curcumin contributes to enhance the effects of DHA on TBI by promoting phosphorylation of the BDNF receptor TrkB in the hippocampus.
  • previous evidence indicates that curcumin10 and DHA5 counteract TBI-related learning disability by involving BDNF
  • The effects of the DHA diet and curcumin on cognitive enhancement were consistent with enhanced elevations in BDNF receptor signaling
  • effects of DHA and curcumin up to 2 weeks after TBI because this is the most critical period for the course of injury recovery because the brain is metabolically dysfunctional during this time
  • Nathan Goodyear on 30 Aug 15
     
    study that finds curcumin + DHA increased cognitive improvement after TBI within 2 weeks.  Good discussion of the proposed mechanism--increased BDNF.
Nathan Goodyear

Therapeutic effects of progesterone and its metabolites in traumatic brain injury may i... - 0 views

www.ncbi.nlm.nih.gov/...PMC3680782

progesterone non-genomic signaling head progesterone metabolites TBI brain injury trauma allopregnanolone traumatic brain injury

shared by Nathan Goodyear on 17 Mar 14 - No Cached
  • Nathan Goodyear on 17 Mar 14
     
    Progesterone and its metabolite allopregnanolone show promise in protecting the brain in TBI.
Nathan Goodyear

Accumulation of Dietary Docosahexaenoic Acid in the Brain Attenuates Acute Immune Respo... - 0 views

stroke.ahajournals.org/...2903.abstract

Omega-3 EFA DHA stroke inflammation brain injury head trauma

shared by Nathan Goodyear on 17 Nov 11 - No Cached
  • Nathan Goodyear on 17 Nov 11
     
    DHA shown to protect against post stroke inflammation and injury.  This has implications on any head injury.
Nathan Goodyear

"Unanswered Questions from the Vaccine Injury Compensation Program: A R" by Mary Hollan... - 0 views

digitalcommons.pace.edu/...6

vaccine autism spectrum disorders ASD

shared by Nathan Goodyear on 10 May 11 - No Cached
  • Nathan Goodyear on 10 May 11
     
    Unanswered Questions from the Vaccine Injury Compensation Program: A Review of Compensated Cases of Vaccine-Induced Brain Injury
Nathan Goodyear

Head-injury profoundly affects gut microbiota homeostasis: results of a pilot study - S... - 0 views

www.sciencedirect.com/...S0899900717301387

TBI traumatic brain injury head injury gut gut bacteria gut flora gut health gut microbiome gut microbiota gut-brain

shared by Nathan Goodyear on 13 Jul 17 - No Cached
  • Nathan Goodyear on 13 Jul 17
     
    New study finds that head injury alters gut bacteria.  This destroys the isolated systems thinking of traditional medicine.  This is the gut-grain connection, but in REVERSE.
Nathan Goodyear

Dietary Supplementation With the Omega-3 Fatty Acid Docosahe... : Neurosurgery - 0 views

journals.lww.com/...with_the_omega_3_fatty.31.aspx

brain injury brain TBI traumatic brain injury DHA

shared by Nathan Goodyear on 31 Aug 15 - No Cached
  • Nathan Goodyear on 31 Aug 15
     
    Animal study finds pre-emptive DHA at 40 mg/kg reduced injury response during medically induced TBI.  Not only can DHA be used with TBI, but this study suggests it can be used in a prevention mode.
Nathan Goodyear

Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) - Nutrition and Traumatic Br... - 0 views

www.ncbi.nlm.nih.gov/...NBK209320

TBI traumatic brain injury brain injury omega 3 omega-3 DHA EPA fish oil brain

shared by Nathan Goodyear on 31 Aug 15 - No Cached
  • Nathan Goodyear on 31 Aug 15
     
    Evidence does support that n-3 reduces inflammation; yet limited evidence exists to provide direct evidence that n-3 protects against TBI.
Nathan Goodyear

Docosahexaenoic Acid Reduces ER Stress and Abnormal Protein Accumulation and Improves N... - 0 views

www.jneurosci.org/...3743.short

TBI traumatic brain injury brain injury DHA omega 3 omega-3 brain

shared by Nathan Goodyear on 31 Aug 15 - No Cached
  • Nathan Goodyear on 31 Aug 15
     
    Animal study finds DHA aids recovery from TBI.
Nathan Goodyear

Hypopituitarism after traumatic brain injury. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15879352

traumatic brain injury post traumatic hypopituitarism PTHP TBI brain low Testosterone hormones brain injury

shared by Nathan Goodyear on 21 Jan 16 - No Cached
  • Nathan Goodyear on 21 Jan 16
     
    TBI results in isolated or complete pituitary failure (PTHP) in up to 40% of those with TBI.  
Nathan Goodyear

Targeting Dopamine in Acute Traumatic Brain Injury - 0 views

www.ncbi.nlm.nih.gov/...PMC3269831

TBI traumatic brain injury dopamine brain brain injury concussion PCS post concussion syndrome

shared by Nathan Goodyear on 21 Feb 16 - No Cached
  • Nathan Goodyear on 21 Feb 16
     
    great read on the current understanding of dopamine in TBI--essentially an excitotoxic story.
Nathan Goodyear

Vitamin E Protects Against Oxidative Damage and Learning Disability After Mild Traumati... - 0 views

www.ncbi.nlm.nih.gov/...PMC2824788

vitamin E traumatic brain injury TBI brain injury brain

shared by Nathan Goodyear on 21 Feb 16 - No Cached
  • Nathan Goodyear on 21 Feb 16
     
    Animal study: vitamin E protects against mild TBI
Nathan Goodyear

Time-level relationship for lipid peroxidation and the protective effect of alpha-tocop... - 0 views

www.ncbi.nlm.nih.gov/...9696087

vitamin E TBI traumatic brain injury brain injury brain

shared by Nathan Goodyear on 21 Feb 16 - No Cached
  • Nathan Goodyear on 21 Feb 16
     
    Animal study: vitamin E (alpha tocopherol only therapy) protected against lipid oxidation in mild and severe TBI.
Nathan Goodyear

Interleukin-10 mediates the neuroprotection of hyperbaric oxygen therapy against trauma... - 0 views

www.ncbi.nlm.nih.gov/...24291771

hyperbaric hyperbaric therapy brain TBI traumatic brain injury IL-10

shared by Nathan Goodyear on 17 May 17 - No Cached
  • Nathan Goodyear on 17 May 17
     
    abstract of animal study finds that hyperbaric therapy provides neuroprotection via increase in IL-10; improved blood-brain barrier, improved tight junctions were about of the benefit found.
Nathan Goodyear

Dietary Curcumin Supplementation Counteracts Reduction in Levels of Molecules Involved ... - 0 views

www.ncbi.nlm.nih.gov/...PMC2805661

curcumin TBI traumatic brain injury mitochondria tumeric

shared by Nathan Goodyear on 03 Nov 13 - No Cached
  • Nathan Goodyear on 03 Nov 13
     
    TBI leaves the mitochondria of the brain compromised.  The result is a compromise in the ability to produce energy leaving the brain limited in its ability to heal and or handle additional insults.  This animal study found curcumin able to provide preservation of the energy pathways post TBI.  This has implications on any neuro-insult, not just TBI
Nathan Goodyear

Hypopituitarism after traumatic brain injury - 0 views

www.eje-online.org/...679.full

post-traumatic hypopituitarism PTHP TBI traumatic brain injury brain trauma neurology pituitary hypothalamus hormone hormones injury

shared by Nathan Goodyear on 09 Jul 12 - No Cached
  • PTHP is observed in about 40% of patients with a history of TBI
  • Nathan Goodyear on 09 Jul 12
     
    post-traumatic hypopituitarism is found in 40% of those with TBI.  The severity does correlate with the increased likelihood of developing PTHP.  Isolated deficiencies have been found in PTHP.
Nathan Goodyear

Emory WHSC :: Press Releases - 0 views

whsc.emory.edu/press_releases2.cfm

progesterone bioidentical hormones BHRT natural brain injury TBI

shared by Nathan Goodyear on 18 Jan 12 - No Cached
  • Nathan Goodyear on 18 Jan 12
     
    progesterone shown to have promise as a treatment in those with traumatic brain injury
Nathan Goodyear

Progesterone for acute traumatic ... [Cochrane Database Syst Rev. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21249708

progesterone BHRT bioidentical TBI hormone hormones brain injury natural

shared by Nathan Goodyear on 18 Jan 12 - No Cached
  • Nathan Goodyear on 18 Jan 12
     
    significant improvement found in 3 studies that looked at progesterone in people with acute traumatic brain injuries. 
Nathan Goodyear

Improved outcomes from the administration of proge... [Crit Care. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18447940

progesterone TBI brain trauma injury bioidentical hormone hormones natural BHRT

shared by Nathan Goodyear on 19 Jan 12 - No Cached
  • Nathan Goodyear on 19 Jan 12
     
    progesterone shown to be neuroprotective in individuals with traumatic brain injuries.  In addition to improved neurologic function, there was a decreased mortality rate in the progesterone treated group compared to placebo.
Nathan Goodyear

Speech dysfunction due to trazodone-fluoxetine combination in traumatic brain injury, B... - 0 views

informahealthcare.com/...026990597123593

trazodone zoloft fluoxetine traumatic brain injury

shared by Nathan Goodyear on 03 Jan 12 - No Cached
  • Nathan Goodyear on 03 Jan 12
     
    common insomnia cocktail has powerful side effects
Nathan Goodyear

Improved outcomes from the administrati - PubMed Mobile - 0 views

www.ncbi.nlm.nih.gov/...18447940

bioidentical hormone hormones progesterone TBI traumatic brain injury

shared by Nathan Goodyear on 29 Jan 12 - No Cached
  • Nathan Goodyear on 29 Jan 12
     
    bioidentical progesterone shown to improve outcomes for up to 6 months in those with traumatic brain injuries (TBI).  That is decreased mortality and less cognitive deficits
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