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Nathan Goodyear

Clinical and Pathological Roles of Ro/SSA Autoantibody System - 0 views

www.hindawi.com/...606195

Anti-SSA antibodies Anti-Ro Lupus Sjogren's syndrome autoimmune disease

shared by Nathan Goodyear on 12 Aug 13 - No Cached
  • Nathan Goodyear on 12 Aug 13
     
    Clinical use of anti-SSA antibodies.  Most commonly linked with Lupus and Sjogren's syndrome.  
Nathan Goodyear

Assessment of thyroid function during ... [Clin Endocrinol (Oxf). 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19094075

Hashimoto's thyroiditis hypothyroid hypothyroidism autoimmune disease thyroid hormone hormones inflammation

shared by Nathan Goodyear on 28 Aug 13 - No Cached
  • Nathan Goodyear on 28 Aug 13
     
    Hashimoto's Thyroiditis can show variability in thyroid function.
Nathan Goodyear

Racial and age-related differences in incid... [Am J Clin Pathol. 1994] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8209854

Hashimoto's thyroiditis hypothyroid hypothyroidism thyroid autoimmune disease inflammation hormone hormones

shared by Nathan Goodyear on 28 Aug 13 - No Cached
  • Nathan Goodyear on 28 Aug 13
     
    Hashimoto's thyroiditis is more common in white females.
Nathan Goodyear

Clonal relationship between Hashimoto thyroidi... [J Clin Pathol. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18006670

thyroid cancer Hashimoto's thyroiditis autoimmune disease inflammation hormone hormones

shared by Nathan Goodyear on 28 Aug 13 - No Cached
  • Nathan Goodyear on 28 Aug 13
     
    this study proposes link between Hashimoto's thyroiditis and thyroid lymphoma.
Nathan Goodyear

Thyroidectomy for Hashimoto's thyroiditis: complicat... [Thyroid. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18631001

Hashimoto's thyroiditis autoimmune disease inflammation thyroid cancer hormone hormones

shared by Nathan Goodyear on 28 Aug 13 - No Cached
  • Nathan Goodyear on 28 Aug 13
     
    Thyroid cancer increased in those with Hashimoto's thyroiditis.  
Nathan Goodyear

INCREASED INCIDENCE OF WELL-DIFFERENTIATED THYROID CANCER ASSOCIATED WITH HASHIMOTO'S T... - 0 views

www.ncbi.nlm.nih.gov/...PMC2430882

Hashimoto's thyroiditis thyroid cancer hormone hormones autoimmune disease inflammation

shared by Nathan Goodyear on 28 Aug 13 - No Cached
  • Nathan Goodyear on 28 Aug 13
     
    Strong link between Hashimoto's thyroiditis and thyroid cancer.  Risk increased 3 fold.
Nathan Goodyear

Mechanisms dependent on tryptophan catabolism regulate immune responses in pr... - 0 views

www.ncbi.nlm.nih.gov/...PMC1809473

Sjogren sjögren syndrome autoimmune disease Tryptophan metabolism IDO disordered

shared by Nathan Goodyear on 30 Oct 13 - No Cached
  • Nathan Goodyear on 30 Oct 13
     
    Disordered Tryptophan metabolism is a useful biomarker for those with Sjogren's syndrome.  This study found an increased degradation of Tryptophan and increased IDO activity that correlated with increased severity of Sjogren's syndrome.
Nathan Goodyear

JCI - Myasthenia gravis: past, present, and future - 0 views

www.jci.org/29894

myasthenia gravis autoimmune disease myasthenia gravis

shared by Nathan Goodyear on 03 Apr 14 - No Cached
  • Nathan Goodyear on 03 Apr 14
     
    Good underlying discussion of the pathogenesis of myasthenia gravis.
Nathan Goodyear

ftp://www.bf.lu.lv/grozs/MolekularasBiologijas/Imunol%20II/Publik%C4%81cijas%20semin%C4... - 0 views

www.bf.lu.lv/...ent%20regulation%20of%20AI.pdf

gut flora gut microbiome gut microbiota gut Testosterone hormone hormones autoimmune disease

shared by Nathan Goodyear on 30 Apr 15 - No Cached
  • Nathan Goodyear on 30 Apr 15
     
    full article to previous abstract:  fecal transplant from male mice to female mice resulted in an increase in Testosterone production in the female mice revealing a link between the gut microbial population, diversity and Testosterone production.
Nathan Goodyear

Human papillomavirus vaccine and systemic lup... [Clin Rheumatol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23624585

HPV vaccine vaccination Lupus autoimmune disease.

shared by Nathan Goodyear on 11 Nov 13 - No Cached
  • Nathan Goodyear on 11 Nov 13
     
    6 cases presented in women that developed Lupus following HPV vaccination.
Nathan Goodyear

Association between endogenous sex steroid hormones and inflammatory biomarkers in US men - 0 views

www.ncbi.nlm.nih.gov/...PMC3812341

low Testosterone Estrogen Estradiol low T Testosterone hormone hormones CRP inflammation SHBG WBC men male

shared by Nathan Goodyear on 28 Apr 15 - No Cached
  • modest statistically significant inverse associations for total and calculated free testosterone, and modest positive associations for total and calculated free estradiol with CRP concentration
  • Estradiol concentrations were also weakly positively associated with WBC count
  • SHBG was weakly inversely associated with WBC
  • ...21 more annotations...
  • An association between testosterone and WBC count was not observed
  • These findings are consistent with the hypothesis that in men higher androgen concentration is anti-inflammatory, and higher estrogen concentration is pro-inflammatory.
  • the probability of elevated CRP concentrations (≥ 3 mg/L) decreased with higher total and calculated free testosterone concentrations, while the probability increased with higher total and calculated free estradiol concentrations
  • there is ample evidence supporting the immunosuppressive effect of androgens
  • The incidence of autoimmune diseases is higher in androgen-deficient men
  • Studies have shown that the induction of hypogonadism in older men is followed by a significant increase in IL-6 concentrations (Khosla et al. 2002), a potent stimulator of inflammation, and that activation of the androgen receptor exerts a direct anti-inflammatory effect
  • It has been suggested that the mechanisms for the immunosuppressive effect of androgens could be either a direct effect on the expression of inflammatory genes (Bellido et al. 1995; Asirvatham et al. 2006), or an indirect effect through inhibition of nuclear factor-kB activation
  • Estradiol is the major biologically active estrogen, and about 80% is formed in adult men from the aromatization of testosterone primarily in the adipose tissue
  • estrogen can stimulate the transcription factor C/EBP-β, which is involved in CRP transcription
  • Most prior cross-sectional studies have observed inverse associations between androgen concentrations and inflammatory biomarkers
  • A recent study in Chinese men showed that lower concentrations of total and calculated free testosterone were associated with higher CRP concentration
  • Data from the Boston Area Community Health Survey also reported inverse associations between testosterone and CRP concentrations
  • Total testosterone was inversely associated with WBC count (Tang et al. 2007; Schneider et al. 2009; Brand et al. 2012), but calculated free testosterone was not associated with WBC
  • The first trial found a decrease in CRP, interleukin-1β (IL-1β), and tumor necrosis factor-α (TNFα) but no changes in IL-6 and IL-10 concentrations between the active treatment and placebo arms
  • the majority of studies in the literature have not observed statistically significant associations between estradiol and inflammatory biomarkers in men, although several of them observed point estimates in the positive direction
  • total testosterone and estradiol compete for binding to SHBG, and seem to have opposite effects on the concentration of inflammatory biomarkers
  • A small randomized controlled trial of estrogen replacement therapy in prostate cancer patients showed an increase in CRP in the active treatment group versus the comparator group
  • Obese men are known to have lower androgen concentrations compared to their normal-weight counterparts
  • The strongest suggestion of an interaction was the inverse association between androstanediol glucuronide and CRP concentrations in obese participants, while the association was positive in the non-obese
  • A recent Chinese cross-sectional study observed stronger inverse associations between total testosterone and CRP concentrations in individuals with a BMI of 27.5 kg/m2 or greater
  • our results suggest that total and calculated free testosterone are modestly inversely associated with CRP concentrations, and that total and calculated free estradiol are modestly positively associated with CRP and WBC
  • Nathan Goodyear on 28 Apr 15
     
    Study results suggest that higher Testosterone and lower Estrogen levels provide anti-inflammatory effects in men.  The inflammatory biomarker assessed here was CRP.  Low total and calculated free Testosterone was associated with an increase in CRP.  In contrast, total and free Estrogen was associated with an increase in CRP.  Estradiol increased WBC count and SHBG was inversely related to WBC count in this study.
Nathan Goodyear

Selenium and human health : The Lancet - 0 views

www.thelancet.com/...abstract

Selenium health

shared by Nathan Goodyear on 10 Nov 14 - No Cached
  • Low selenium status has been associated with increased risk of mortality, poor immune function, and cognitive decline
  • Higher selenium status or selenium supplementation has antiviral effects, is essential for successful male and female reproduction, and reduces the risk of autoimmune thyroid disease.
  • Prospective studies have generally shown some benefit of higher selenium status on the risk of prostate, lung, colorectal, and bladder cancers, but findings from trials have been mixed, which probably emphasises the fact that supplementation will confer benefit only if intake of a nutrient is inadequate
  • Nathan Goodyear on 10 Nov 14
     
    Selenium is a "U" shaped curve.  Abstract only available here.
Nathan Goodyear

Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multi... - 0 views

www.ncbi.nlm.nih.gov/...PMC5809128

cancer anal cancer nivolumab immunotherapy

shared by Nathan Goodyear on 13 Jul 18 - No Cached
  • Patients received a median of six doses of nivolumab
  • four of the first 12 patients had partial responses
  • Nine (24% [95% CI 15–33]) of 37 patients achieved a response (seven partial responses and two complete responses
  • ...16 more annotations...
  • no treatment-related deaths
  • the most common adverse events were anaemia (26 [70%]), fatigue (25 [68%]), and rash
  • hypothyroidism
  • hypothyroidism
  • nivolumab-related autoimmune hypothyroidism, which resolved after a short course of corticosteroids
  • No grade 3 or 4 adverse events occurred
  • Nivolumab resulted in objective responses in 24% of patients with metastatic SCCA
  • Historically, doublet chemotherapy with cisplatin and fluorouracil has been the most common treatment for patients with metastatic SCCA
  • our results suggest that immune checkpoint blockade agents might extend overall survival beyond currently available therapies, especially if provided early in the disease treatment course
  • the dose of nivolumab we used differs from the 2016 recommendation of a fixed 240 mg every 2 weeks
  • 25% of patients develop distant metastases
  • most patients with localised SCCA are cured by chemoradiation
  • More than 90% of cases of SCCA are linked to prior infection with human papillomavirus (HPV)
  • Within tumour cells, HPV oncoproteins are immunogenic and can trigger an anti-tumour host immune response by recruitment of tumour-infiltrating lymphocytes
  • Tumour cells express PD-L1 and, on binding its inhibitory receptor PD-1 on the surface of T cells, downregulate T-cell activation and thwart the local anti-tumour immune response
  • Nivolumab is a humanised monoclonal antibody against PD-1 that disrupts this interaction, enabling T-cell cytotoxicity. It has activity as a monotherapy in advanced solid cancers, such as head and neck cancer, melanoma, non-small-cell lung cancer, and renal cell carcinoma
  • Nathan Goodyear on 13 Jul 18
     
    study finds nivolumab helpful in some patients with surgically unresectable or metastatic anal cancer.  The dose used was 3 mg/kg every 2 weeks. 
Nathan Goodyear

High-dose vitamin C therapy for inclusion body myositis. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11411094

vitamin C IV vitamin C myositis autoimmune disease intravenous vitamin C inflammation

shared by Nathan Goodyear on 17 Aug 17 - No Cached
  • Nathan Goodyear on 17 Aug 17
     
    study finds "high dose" IV vitamin C benefited 3 of 5 patients in short 4 week study.  The "high dose" was not high dose at all, so that fact that a low dose of IV vitamin C will benefit dermatomysotis in over 50% of the patients in this very small study points to the question, what if actually high dose vitamin C is used.
Nathan Goodyear

http://orthomolecular.org/library/jom/1987/pdf/1987-v02n02-p083.pdf - 0 views

orthomolecular.org/...1987-v02n02-p083.pdf

cancer germanium autoimmune disease NK cells immune system

shared by Nathan Goodyear on 30 May 18 - No Cached
  • Nathan Goodyear on 30 May 18
     
    Great review on the evidence behind Germanium.
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