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Nathan Goodyear

Potential Therapeutic Effects of Curcumin, the Anti-inflammatory Agent, Against Neurode... - 0 views

www.ncbi.nlm.nih.gov/...PMC2637808

curcumin inflammation disease turmeric natural cardiovascular disease CVD autoimmune disease myeloperoxidase Diabetes IBD inflammatory bowel disease

shared by Nathan Goodyear on 15 Oct 13 - No Cached
  • The starting dose was 500 mg/day and if no toxicity was noted, the dose was then escalated to another level in the order of 1,000, 2,000, 4,000, 8,000, and 12,000 mg/day. There was no treatment-related toxicity up to 8 g/day but the bulky volume of the drug was unacceptable to the patients beyond 8 g/day.
  • The serum concentration of curcumin usually peaked at 1 to 2 hours after oral intake of curcumin and gradually declined within 12 hours
  • Nathan Goodyear on 15 Oct 13
     
    Great article on the benefits of curcumin in therapy for inflammation and disease.
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Nathan Goodyear

Low-dose Interleukin-2 in the Treatment of Autoimmune Disease | touchONCOLOGY - 0 views

www.touchoncology.com/...2-treatment-autoimmune-disease

cancer autoimmune disease Tregs Treg cells Treg immune system disease IL-2

shared by Nathan Goodyear on 04 Apr 18 - No Cached
Amol kashikar liked it
  • affect approximately 5 to 8 % of the US population
  • the incidence and prevalence of autoimmune diseases are rising
  • Type 1 diabetes (T1D), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and inflammatory bowel disease (IBD) account for the majority of the patients with autoimmune diseases
  • ...9 more annotations...
  • Autoimmune diseases are characterized by a breakdown of mechanisms that allow the immune system to distinguish between self and nonself and maintain immunologic self-tolerance
  • Tregs, which are important in the maintenance of peripheral immune tolerance.
  • Several subtypes of Tregs exist, the most well studied being CD4+ cells that express high-level CD25 and the transcription factor forkhead box P3 (FOXP3)
  • Treg deficiency or dysfunction is associated with autoimmune disease
  • In clinical studies, decreased levels of circulating CD25+CD4+ T cells have been reported in patients with autoimmune disease
  • These data have led to the hypothesis that augmentation of Tregs may be a useful therapeutic strategy in autoimmune disease
  • Treg augmentation has resulted in clinical improvements in numerous animal models of autoimmune diseases
  • the administration of in vitro expanded CD4+CD25highCD127-Tregs has been found to be safe and may help to preserve β-cell function in children with T1D
  • ability of IL-2 to augment the numbers and function of CD4+ Tregs.
  • Nathan Goodyear on 04 Apr 18
     
    Great article.  Immune dysfunction plays role in autoimmune disease and cancer.  Treg cells sit at the center of autoimmunity.  This artice highlights the different uses: low dose IL2 therapy to augment Tregs and reduce autoinflammation and high dose IL2 to augment Treg cells in the fight against cancer.
Nathan Goodyear

Intestinal Lymphocyte Populations in Children with Regressive Autism: Evidence for Exte... - 0 views

mercola.fileburst.com/....lymphocytes%20in%20autism.pdf

ASD autism IBD inflammation gut intestine

shared by Nathan Goodyear on 29 Jan 12 - No Cached
  • Nathan Goodyear on 29 Jan 12
     
    inflammatory changes in the intestines of children with regression autism found that is different from others with inflammatory bowel diseases.
Nathan Goodyear

Clinical significance of colonic fermenta... [Am J Gastroenterol. 1990] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...2220719

n-butyrate inflammation inflammatory bowel disease IBD ulcerative colitis Chron's cancer

shared by Nathan Goodyear on 09 Sep 11 - No Cached
  • Nathan Goodyear on 09 Sep 11
     
    low n-butyrate implicated in inflammatory bowel conditions
Nathan Goodyear

Nutritional protective mechanisms against gut inflammation - 0 views

www.jnutbio.com/...fulltext

nutritional gut inflammation PPAR-gamma IBD inflammatory bowel disease

shared by Nathan Goodyear on 07 Jun 13 - No Cached
  • Nathan Goodyear on 07 Jun 13
     
    Nice review of inflammation originating from the gut.  This article nicely points out the pathway involving PPAR gamma and its anti-inflammatory effects in gut inflammatory conditions such as IBD. This article also specifically discusses natural compounds that activate PPAR gamma and thus reduce inflammation.  Good deep biochemical discussion of how natural therapies reduce inflammation.  
Nathan Goodyear

Antioxidant effects of herbal therapies used by patients with inflammatory bowel diseas... - 0 views

onlinelibrary.wiley.com/...full

IBD inflammatory bowel disease slippery elm inflammation gut GI

shared by Nathan Goodyear on 20 Feb 17 - No Cached
  • Nathan Goodyear on 20 Feb 17
     
    slipper elm as well as other herbs found to reduce inflammation in IBD.
Nathan Goodyear

Acetyl-11-keto-beta-boswellic acid, a constituent of a herbal medicine from Boswellia s... - 0 views

www.ncbi.nlm.nih.gov/...11355324

boswellia inflammation IBD ulcerative colitis UC colitis Frankincense

shared by Nathan Goodyear on 20 Feb 17 - No Cached
  • Nathan Goodyear on 20 Feb 17
     
    animal study finds Boswellia reduces inflammation in Inflammatory Bowel Disease.
Nathan Goodyear

American Journal of Gastroenterology - Abstract of article: Diagnostic Precision of Fec... - 0 views

www.nature.com/...ajg2007150a.html

IBD IBS inflammation gut GI Calprotectin colorectal cancer cancer inflammatory bowel disease

shared by Nathan Goodyear on 21 May 14 - No Cached
  • Nathan Goodyear on 21 May 14
     
    Fecal calprotectin is found to be a much better screening test for IBD than colorectal cancer.  Though, fecal Calprotectin levels were found to be elevated in colorectal cancer compared to controls, the sensitivity and specificity was low.  In contrast, a fecal Calprotectin > 100 mg/g, in this study, was found to be specific and sensitive for IBD and excluding IBS.
Nathan Goodyear

Induction of clinical response and remission of inflammatory bowel disease by use of he... - 0 views

www.ncbi.nlm.nih.gov/...PMC3769914

UC ulcerative colitis IBD inflammatory bowel disease Aloe aloe vera natural medicine boswellia

shared by Nathan Goodyear on 25 Jan 16 - No Cached
  • Nathan Goodyear on 25 Jan 16
     
    Study of natural therapies against UC are limited, but this review found statistical benefit in patients with IBD.  No induction of remission was seen.
Nathan Goodyear

Fecal calprotectin is a surrogate marker f... [Inflamm Bowel Dis. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22344983

Calprotectin IBD inflammation inflammatory bowel disease

shared by Nathan Goodyear on 06 Jan 14 - No Cached
  • Nathan Goodyear on 06 Jan 14
     
    Calprotectin useful as biomarker to follow remission/active IBD disease.  
Nathan Goodyear

Calprotectin is a stronger predictive marker of relapse in ulcerative colitis than in C... - 0 views

gut.bmj.com/...364.abstract

Calprotectin IBD inflammatory bowel disease inflammation GI gut ulcerative colitis

shared by Nathan Goodyear on 21 May 14 - No Cached
  • Nathan Goodyear on 21 May 14
     
    Fecal Calprotectin found to be useful as monitor for Ulcerative colitis relapse.  This was found more specific for UC than Crohn's disease.  There was a 14 fold higher relapse risk in those with levels > 150.
Nathan Goodyear

Role of commensal and probiotic bacteria in human health: a focus on inflammatory bowel... - 0 views

microbialcellfactories.biomedcentral.com/...1475-2859-12-71

probiotic gut flora gut microbiome gut microbiota gut commensal bacteria disease

shared by Nathan Goodyear on 12 Jan 16 - No Cached
  • Nathan Goodyear on 12 Jan 16
     
    to be read review on commensal bacteria and metabolic disease link
Nathan Goodyear

Role of fecal calprotectin as a biomarker ... [Inflamm Bowel Dis. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16775498

calprotectin inflammation IBD inflammatory bowel disease

shared by Nathan Goodyear on 06 Jan 14 - No Cached
  • Nathan Goodyear on 06 Jan 14
     
    Calprotectin useful marker in assessment of colonic inflammation.
Nathan Goodyear

Herbal Medicine in the Treatment of Ulcerative Colitis - 0 views

www.ncbi.nlm.nih.gov/...PMC3271691

ulcerative colitis herbs natural gut health disease IBD inflammatory bowel disease

shared by Nathan Goodyear on 01 Jun 15 - No Cached
  • Nathan Goodyear on 01 Jun 15
     
    nice literature review of natural therapies for the treatment of UC.
Nathan Goodyear

Questions and answers on the role of faecal calprotectin as a biological marker in infl... - 0 views

www.sciencedirect.com/...S1590865808001916

Calprotectin inflammation IBD colorectal cancer infection disease

shared by Nathan Goodyear on 21 May 14 - No Cached
  • Nathan Goodyear on 21 May 14
     
    Calprotectin is a useful biomarker in IBD.  Colorectal cancer and GI infection can also increase fecal Calprotectin. 
Nathan Goodyear

Microbial Cell Factories | Full text | Role of commensal and probiotic bacteria in huma... - 0 views

www.microbialcellfactories.com/...71

dysbiosis probiotic gut health

shared by Nathan Goodyear on 05 May 15 - No Cached
  • The most frequently found species are Gram-positive bacteria
  • Nathan Goodyear on 05 May 15
     
    good review of dysbiosis, commensal bacteria and gut health.
Nathan Goodyear

Curcumin inhibits VEGF-mediated angiogenesis in hu... [Gut. 2008] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...18596194

curcumin Cancer Inflammatory Bowel Disease

shared by Nathan Goodyear on 29 Mar 11 - No Cached
  • Moreover, curcumin inhibits microvascular endothelial cell angiogenesis through inhibition of COX-2 expression and PGE(2) production, suggesting that this natural product possesses antiangiogenic properties, which warrants further investigation as adjuvant treatment of IBD and cancer.
  • Nathan Goodyear on 29 Mar 11
     
    Curcumin reduces inflammation in IBD and Cancer
Nathan Goodyear

The use of fecal calprotectin and la... [Acta Gastroenterol Belg. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24261027

calprotectin lactoferrin inflammation IBD IBS inflammatory bowel disease

shared by Nathan Goodyear on 06 Jan 14 - No Cached
  • Nathan Goodyear on 06 Jan 14
     
    Useful biomarkers: calprotectin and lactoferrin used to follow GI inflammation.  Calprotectin is useful to follow inactive/active IBD.  It also has been show to predict recurrence and can aid in differentiation between IBD and IBS.  Lactoferrin appears to be a biomarker more useful in GI inflammation.
Nathan Goodyear

Fecal Calprotectin: Validation as a Noninvasive Measure of B... : Journal of Pediatric ... - 0 views

journals.lww.com/...dation_as_a_Noninvasive.3.aspx

Calprotectin children IBD inflammatory bowel disease

shared by Nathan Goodyear on 21 May 14 - No Cached
  • Nathan Goodyear on 21 May 14
     
    fecal Calprotectin validated in the measure of IBD in children.
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