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Nathan Goodyear

The role of gut microbiota in the gut-brain axis: current challenges and perspectives. ... - 0 views

www.researchgate.net/...nt_challenges_and_perspectives

gut brain microbiota dysbiosis gut-brain axis

shared by Nathan Goodyear on 17 Feb 14 - No Cached
  • Nathan Goodyear on 17 Feb 14
     
    Great discussion of the gut brain connection.
Nathan Goodyear

Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant die... - 0 views

www.cmaj.ca/385

gut flora dysbiosis microbiota Cesarean delivery C_S breast feeding children pediatrics infants

shared by Nathan Goodyear on 17 Feb 14 - No Cached
  • Nathan Goodyear on 17 Feb 14
     
    Cesarean delivery and lack of breast feeding significantly alter gut flora.  This has potential significant metabolic consequences--diabetes, asthma, obesity...The urge to deliver at convenient times may lay the foundation for our metabolic crisis in the US.
Nathan Goodyear

Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms - 0 views

physrev.physiology.org/...1235.long

Kisspeptin HPA GNRH hormones reproduction hormone regulation

shared by Nathan Goodyear on 17 Feb 14 - No Cached
  • Nathan Goodyear on 17 Feb 14
     
    good, detailed discussion of HPAG signaling with a focus on the role of Kisspeptin--a GNRH secretagogue.
Nathan Goodyear

Metabolic influences on neuroendocrine regulation of reproduction - 0 views

www.ncbi.nlm.nih.gov/...PMC3898855

metabolism metabolic regulation reproduction Leptin Ghrelin Insulin Kisspeptin GNRH

shared by Nathan Goodyear on 17 Feb 14 - No Cached
  • Energy storage occurs mainly at the level of white adipose tissue, where adipocytes secrete the anorexigenic adipokine leptin
  • humans and laboratory animals with leptin or insulin deficiency or resistance and/or increased ghrelin levels exhibit delayed or absent puberty and frequently display hypogonadotropic hypogonadism, which prevents fertility
  • Ghrelin suppresses pulsatile gonadotropin-releasing hormone (GnRH) release [14,15], thus serving as a signal to suppress reproduction in times of famine
  • ...4 more annotations...
  • Neuropeptides derived from POMC/CART neurons exert a potent anorectic action, thus decreasing food intake and body weight
  • AgRP and NPY have the opposite (orexigenic) effect, inducing food intake.
  • GnRH neurons have been shown to express insulin receptor mRNA and protein [27] and are activated by insulin
  • Kisspeptins (encoded by KISS1) have been identified in the last decade as the most potent secretagogues of GnRH release.
  • Nathan Goodyear on 17 Feb 14
     
    Good, although brief, discussion of the interaction between metabolism and hormones.  Kisspeptin is a GNRH secreatagogue "upstream".   Insulin, Leptin, and Gherlin can inhibit GNRH through resistance and low levels.  Probably a U shaped graph of optimal activity.
Nathan Goodyear

On Estrogen, Cholesterol Metabolism, and Breast Cancer - NEJM - 1 views

www.nejm.org/...NEJMcibr1315176

cholesterol metabolite metabolism breast cancer estrogen receptor ER 27-hydroxycholesterol

shared by Nathan Goodyear on 17 Feb 14 - No Cached
  • Nathan Goodyear on 17 Feb 14
     
    Cholesterol metabolite linked to increased breast cancer risk through estrogen receptor signaling.  The metabolite is 27-hydorxycholesterol.
Nathan Goodyear

ERα/E2 signaling suppresses the expressi... [Mol Cell Endocrinol. 2012] - Pub... - 0 views

www.ncbi.nlm.nih.gov/...22683664

ER alpha ER-alpha Estradiol Nur77 low T Testosterone

shared by Nathan Goodyear on 15 Feb 14 - No Cached
  • Nathan Goodyear on 15 Feb 14
     
    Another support point for Estrogen as a cause of low Testosterone.  This animal study points to signaling of Estradiol through ER alpha.  This study found high expression of ER alpha and subsequent signaling by E2 decreased cAMP and Nur77 transcription factor.  Nur77 increases steroid synthesis.  This was confirmed with ER alpha knockout mice.
Nathan Goodyear

Long-term effect of ciprofloxacin on tes... [Int J Fertil Steril. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24520454

Testosterone cipro ciprofloxacin antibiotics infertility Leydig cells gonadotropins

shared by Nathan Goodyear on 15 Feb 14 - No Cached
  • Nathan Goodyear on 15 Feb 14
     
    mouse study finds that long-term cipro can lead to biochemical disruption of the testicles resulting in infertility, effected sperm counts, and decreased Testosterone.
Nathan Goodyear

The Effect of Oral Feeding of Tribulus t... [Int J Fertil Steril. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24520465

Tribulus Tribulus terrestris low T Testosterone opiates opiate addiction

shared by Nathan Goodyear on 15 Feb 14 - No Cached
  • Nathan Goodyear on 15 Feb 14
     
    Tribulus found to increase sex hormone production in opiate addicted male rats.  Opiates are known causes of low T in men.
Nathan Goodyear

Predictive parameters of accelerated muscle loss in... [Am J Med. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24524994

muscle Total Testosterone free T type II diabetes type II DM parathyroid PTH

shared by Nathan Goodyear on 15 Feb 14 - No Cached
  • Nathan Goodyear on 15 Feb 14
     
    Study looked at muscle loss in older men and found that low activity, type II diabetes, low Total Testosterone and low free Testosterone, and increased PTH are associated with an increased muscle loss 
Nathan Goodyear

PLOS ONE: Effect of Marine-Derived n-3 Polyunsaturated Fatty Acids on C-React... - 0 views

www.plosone.org/...10.1371%2Fjournal.pone.0088103

inflammation omega 3 omega-3 n-3 CRP IL-6 TNF-alpha

shared by Nathan Goodyear on 14 Feb 14 - No Cached
  • Nathan Goodyear on 14 Feb 14
     
    meta-analysis finds that omega-3 fatty acids decrease CRP, IL-6, and TNF-alpha.
Nathan Goodyear

Twenty five year follow-up for breast cancer incidence and mortality of the Canadian Na... - 0 views

www.bmj.com/bmj.g366

mammograms mammogram breast cancer

shared by Nathan Goodyear on 12 Feb 14 - No Cached
  • Nathan Goodyear on 12 Feb 14
     
    Study that followed breast screening for 25 years with mammograms finds that no decrease in mortality from regular mammograms.
Nathan Goodyear

Is administrating branched-chain amino acid-enriched nutrition achieved symptom-free in... - 0 views

www.ncbi.nlm.nih.gov/...PMC3882488

BCAA branched chain amino acids NH3 metabolism muscle glutamine glutamate glutamic acid liver cirrhosis disease nutrition

shared by Nathan Goodyear on 10 Feb 14 - No Cached
  • Nathan Goodyear on 10 Feb 14
     
    BCAA improve NH3 metabolism.  This is via muscle metabolism as reported in other studies.  This study highlighted the differences in BCAA supplementation.  One caveat is that high glutamine is the result from glutamate and this can increase hepatic encephalopathy.
Nathan Goodyear

Branched-chain amino acids and muscle ammoni... [Metab Brain Dis. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23315357

NH3 muscle brain urea cycle metabolism BCAA branched chain amino acids liver cirrhosis disease

shared by Nathan Goodyear on 10 Feb 14 - No Cached
  • BCAA metabolism may improve muscle net ammonia removal by supplying carbon skeletons for formation of alfa-ketoglutarate that combines with two ammonia molecules to become glutamine
  • Nathan Goodyear on 10 Feb 14
     
    Muscle becomes the primary mode of NH3 metabolism in liver cirrhosis.  The authors here propose that it is via an increase in muscle mass rather than specifically lowering NH3.  In fact, there is an early increase in NH3 production.
Nathan Goodyear

Effects of oral branched-chain amino acids o... [Nutr Clin Pract. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23945292

BCAA branched chain amino acids liver disease cirrhosis hepatic encephalopathy mild

shared by Nathan Goodyear on 10 Feb 14 - No Cached
  • Nathan Goodyear on 10 Feb 14
     
    BCAA aid NH3 metabolism in the muscle in those with liver cirrhosis.  This specifically can aid hepatic encephalopathy and mild hepatic encephalopathy.
Nathan Goodyear

Branched-chain amino acids increase arterial blood ammonia in spite of enhanced intrins... - 0 views

ajpgi.physiology.org/...G269

BCAA branched chain amino acids NH3 ammonia liver disease cirrhosis alpha-ketoglutarate

shared by Nathan Goodyear on 10 Feb 14 - No Cached
  • Nathan Goodyear on 10 Feb 14
     
    Good review of the effects of BCAA on ammonia metabolism.  BCAA increase intramuscular NH3 production through the production of alpha-ketoglutarate.
Nathan Goodyear

Branched-chain amino acids and ammonia metabolism in liver disease: Therapeutic implica... - 0 views

www.sciencedirect.com/...S0899900713000907

BCAA branched chain amino acids glutamate glutamic acid glutamine alpha-ketoglutarate NH3 ammonia liver disease cirrhosis

shared by Nathan Goodyear on 10 Feb 14 - No Cached
  • Nathan Goodyear on 10 Feb 14
     
    BCAA are low in patients with liver cirrhosis due to increased glutamate production from glutamine.  The addition of BCAA in these patients is not without side effects--increased NH3 production.  The addition of alpha ketoglutarate should alleviate this risk.
Nathan Goodyear

http://www.integratedhealthclinic.com/assets/byCancerType/Pancreatic/4-LDN%20and%20IV%2... - 0 views

www.integratedhealthclinic.com/...IV%20Alpha%20Lipoic%20Acid.pdf

alpha lipoic acid ALA cancer pancreatic LDN low dose naltrexone selenium milk thistle silymarin IV intravenous

shared by Nathan Goodyear on 10 Feb 14 - No Cached
  • Nathan Goodyear on 10 Feb 14
     
    Author describes the long-term survival of a man with metastatic pancreatic cancer using IV alpha lipoic acid, low dose naltrexone, diet, and oral triple therapy of milk thistle, ALA, and selenium.  The safety profile is very good as compared to traditional therapy for metastatic pancreatic cancer.
Nathan Goodyear

α-Lipoic Acid Induced Elevated S-adenosylhomocysteine and Depleted S-adenosyl... - 0 views

www.ncbi.nlm.nih.gov/...PMC2782850

IV alpha lipoic acid intravenous ALA cysteine SAMe liver disease cirrhosis

shared by Nathan Goodyear on 10 Feb 14 - No Cached
  • Nathan Goodyear on 10 Feb 14
     
    IV alpha lipoic acid does decrease liver cysteine and SAMe levels.
Nathan Goodyear

http://lipoic.dreamhosters.com/berkson/1999-Berkson-Med-Klin.pdf - 0 views

lipoic.dreamhosters.com/...1999-Berkson-Med-Klin.pdf

alpha lipoic acid milk thistle silymarin selenium hepatitis liver disease damage

shared by Nathan Goodyear on 10 Feb 14 - No Cached
  • Nathan Goodyear on 10 Feb 14
     
    Triple antioxidant therapy in the treatment of Hepatitis C.
Nathan Goodyear

Vitamin D Deficiency and Liver Disease - 0 views

www.ncbi.nlm.nih.gov/...PMC2950664

vitamin D vitamin d liver disease deficiency

shared by Nathan Goodyear on 10 Feb 14 - No Cached
  • Nathan Goodyear on 10 Feb 14
     
    Those with liver disease will have lower vitamin D levels.
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