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Nathan Goodyear

ERα/E2 signaling suppresses the expressi... [Mol Cell Endocrinol. 2012] - Pub... - 0 views

www.ncbi.nlm.nih.gov/...22683664

ER alpha ER-alpha Estradiol Nur77 low T Testosterone

shared by Nathan Goodyear on 15 Feb 14 - No Cached
  • Nathan Goodyear on 15 Feb 14
     
    Another support point for Estrogen as a cause of low Testosterone.  This animal study points to signaling of Estradiol through ER alpha.  This study found high expression of ER alpha and subsequent signaling by E2 decreased cAMP and Nur77 transcription factor.  Nur77 increases steroid synthesis.  This was confirmed with ER alpha knockout mice.
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