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Nathan Goodyear

BMC Microbiology | Full text | The Firmicutes / Bacteroidetes ratio of the human microb... - 0 views

  • The microbiota of the large intestine plays an important role in host metabolism and maintenance of host health
  • Our results defining a standard adult profile, together with previous reports, showed that C. leptum, C. coccoides, Bacteroides and Bifidobacterium represent the four dominant groups of the adult fecal microbiota
  • Sub-dominant groups are Lactobacilli Enterobacteriaceae, Desulfovibrio, Sporomusa, Atopobium as well as other bacterial groups including Clostridium clusters XI, XIVb, and XVIII
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  • In infant fecal microbiota, we observed Bifidobacterium as the dominant group
  • this observation is strongly related to diet, being enhanced by breast feeding
  • Significant higher numbers of Bifidobacterium were observed in infants versus adults and seniors
  • the gastrointestinal tract is first colonized by facultative anaerobes, such as E. coli
  • Strict anaerobes, such as Clostridium, colonize at later stages, as can be seen by the relatively low levels of C. leptum and C. coccoides in infants
  • diet change must be considered among the primary causes for such a shift of microbiota between infants and adults.
  • In the case of elderly subjects, our qPCR results indicated a significant increase in the counts of E. coli when compared to adults. This data is consistent with other publications indicating that elderly subjects harbor a different E. coli microbiota profile compared to younger adults
  • a number of authors reported a reduction in the numbers and diversity of many protective commensal anaerobes, such as Bacteroides and Bifidobacteria
  • The Firmicutes to Bacteroidetes ratio was already shown to be of significant relevance in signaling human gut microbiota status
  • Our measurements of the Firmicutes/Bacteroidetes ratio in adults obtained by our species-specific qPCR are in agreement with those obtained by Ley et al
  • Compared with young adults, the elderly have a different digestive physiology, characterized at a physiological level by a reduction in transit and of digestive secretions
  • The Firmicutes/Bacteroidetes ratio undergoes an increase from birth to adulthood and is further altered with advanced age
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    Good discussion of the gut microbiome.  Age effects the gut bacteria balance.  The Firmicutes/Bacteroidetes ratio increases from young, to young adult, to the elderly in this study.  Is this simply a reflection of aging or is the a biomarker that can be changed through diet and targeted probiotics?
Nathan Goodyear

Epigenetic correlates of neonatal contact in humans | Development and Psychopathology |... - 0 views

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    physical contact with infants effects changes in genetic expression--epigenetics.  In this study, methylation patters were altered in the evaluation of 4 genes by "maternal contact" with infants 4-5 years later indicating a lasting and possible life-long effect of genetic expression from a mother's hug.
Nathan Goodyear

Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant die... - 0 views

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    Cesarean delivery and lack of breast feeding significantly alter gut flora.  This has potential significant metabolic consequences--diabetes, asthma, obesity...The urge to deliver at convenient times may lay the foundation for our metabolic crisis in the US.
Nathan Goodyear

Neonatal abstinence syndrome and associated health care... [JAMA. 2012] - PubMed - NCBI - 0 views

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    Very disturbing trend.  Study finds that opioid addicted infants are on a dramatic risk in the US.  This study looked at Neionatal abstinence syndrome from 2000 to 2009.  This follows the significant increase in maternal opioid prescription use.  We physicians must do better.  Patients must demand better.  This study just focused on hospital costs directly associated with the Neonatal period.  No cost estimates are evaluated for long-term care.
wheelchairindia9

Chair For Cerebral Palsy Child - 0 views

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    Cerebral palsy (CP) is a group of conditions caused by medical abnormalities in the development of a fetus or the early life of a child. These lead to damage or delayed development in the brain. The disorder is permanent and, though it does not worsen with age, the level of functionality of a person with cerebral palsy varies widely: in some cases, effects may be very minor, while in others, movement is impaired to the extent that a wheelchair is required. Common complications associated with CP vary by the type of CP disorder but can include vision problems, seizures, learning disabilities, and issues speaking, writing, and performing other tasks. Cerebral palsy causes problems with muscle tone, movement, balance and/or coordination. Symptoms and effects range from mild to severe. In some infants, problems are evident soon after birth. In others, diagnosis comes in later infancy or toddlerhood. Cerebral Palsy Wheelchair Description: The model designed for cerebral palsy child only. Ultra light weight aluminium alloy frame. Seat Width 38 cms (15"). Net Weight: 18.5 kgs. Epoxy powder coated frame. Detachable arm rest & foot rest provided. Elevated and swinging foot rest. Elevated foot rest provided to elevate leg angle. Height adjustable and detachable head rest. Hydraulic reclining high back for a comfortable posture. Hydraulic adjustable seat angle. Detachable back and seat pad. Extra cushion upholstery provided to under arm, head & calg Foldable. Lever and paddle brakes provided. Safety belt provided. Maintenance free rear solid wheels. Cloth look like water proof upholstery. Anti wheels for better safety and stability. Extra cushion upholstery provided to under arm, head & leg Folding action. Lever and paddle brakes provided. Safety belt provided. Maintenance free rear solid wheels. Cerebral Palsy Wheelchair Recline system: Recline system provides kids with the most comfortable resting environment. It also allows stretching abdomin
Nathan Goodyear

Effects of maternal docosahexaenoic acid intake on visual function and neurodevelopment... - 0 views

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    DHA supplementation in mother increased DHA phosopholipid levels in infant; though no change in neurodevelopment was noted
Nathan Goodyear

Development of the infant intestinal microbiome: A bird's eye view of a complex process... - 0 views

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    Only abstract available here, but disease begins with altered infant gut microbiome
wheelchairindia

Pediatric Wheelchair - 0 views

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    The body size differences are paralleled by maturational changes. The smaller body of an infant or neonate is substantially different physiologically from that of an adult. Congenital defects, genetic variance, and developmental issues are of greater concern to pediatricians than they often are to adult physicians. A major difference between pediatrics and adult medicine is that children are minors and, in most jurisdictions, cannot make decisions for themselves. The issues of guardianship, privacy, legal responsibility and informed consent must always be considered in every pediatric procedure. In a sense, pediatricians often have to treat the parents and sometimes, the family, rather than just the child. Adolescents are in their own legal class, having rights to their own health care decisions in certain circumstances. In basic terms, pediatricians take care of all of the children's needs from emotional support to medical support. Wheelchair india as Pediatric Wheelchair Manufacturers and Pediatric Wheelchair supplier sale at low cost - price, We Sale online Pediatric Powered Wheelchair and Pediatric Electric Wheelchair at wholesale prices...
Nathan Goodyear

Theoretical causes of autism - 0 views

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    This article discusses the many potential causes of the increasing autism epidemic. One listed is the toxic pregnant/infant environment and the immunoexcitotoxic impact.
Nathan Goodyear

Vitamin D and autism: Clinical review. [Res Dev Disabil. 2012] - PubMed - NCBI - 1 views

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    Vitamin D deficiency may play a role in autism.  Though this may seem logical, through NF-KappaB inhibition, the mode of protection may be more in pregnancy.  I believe that the in-utero environment is setting up our children for increased ASD rates.  Then add in the manner in which we treat our children as infants with massive vaccinations.
Nathan Goodyear

Chronic Testosterone Replacement Exerts Cardioprotection against Cardiac Ischemia-Reper... - 0 views

  • In this study, the cardioprotective effects of testosterone in testosterone-deprived rats heart with I/R injury were demonstrated
  • Prior to I/R injury, testosterone replacement provided cardioprotective effects in testosterone-deprived rats as indicated by (1) improved cardiac functions by markedly preserved %EF and %FS, and (2) attenuated cardiac sympathovagal imbalance by a markedly decreased LF/HF ratio
  • Testosterone replacement exerts cardioprotective effects by improving left ventricular function and cardiac sympathovagal balance impaired by testosterone deprivation in ORX rats
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  • During the I/R period, testosterone replacement in ORX rats exerted the beneficial effects as indicated by (1) improved left ventricular pressure; (2) markedly decreased infarct size; (3) reduced fatal cardiac arrhythmias by increased time to 1st VT/VF onset and reduced arrhythmia scores; and (4) attenuated cardiac mitochondrial dysfunction caused by I/R injury by reducing ROS production, cardiac mitochondrial swelling and mitochondria membrane depolarization.
  • Chronic testosterone replacement also ameliorates left ventricular dysfunction, and reduces the infarct size and cardiac arrhythmias impaired by I/R injury under testosterone-deprived conditions
  • The mechanisms responsible for these beneficial effects of testosterone could be due to its ability to attenuate cardiac mitochondrial dysfunction and cardiomyocyte apoptosis
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    animal study finds that Testosterone therapy is cardioprotective in a preventative mode and with myocardial injury.  Normalization of Testosterone in these animals with low T reduced infant injury size and improved heart function.  
Nathan Goodyear

Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Dis... - 0 views

  • The gut microbiota participates in the body’s metabolism by affecting energy balance, glucose metabolism, and low-grade inflammation associated with obesity and related metabolic disorders
  • Firmicutes and Bacteroidetes represent the two largest phyla in the human and mouse microbiota and a shift in the ratio of these phyla has been associated with many disease conditions, including obesity
  • In obese humans, there is decreased abundance of Bacteroidetes compared to lean individuals
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  • weight loss in obese individuals results in an increase in the abundance of Bacteroidetes
  • there is conflicting evidence on the composition of the obese microbiota phenotype with regards to Bacteroidetes and Firmicutes ratios
  • Bifidobacteria spp. from the phyla Actinobacteria, has been shown to be depleted in both obese mice and human subjects
  • While it is not yet clear which specific microbes are inducing or preventing obesity, evidence suggests that the microbiota is a factor.
  • targeted manipulation of the microbiota results in divergent metabolic outcomes depending on the composition of the diet
  • The microbiota has been linked to insulin resistance or type 2 diabetes (T2D) via metabolic syndrome and indeed the microbiota of individuals with T2D is also characterized by an increased Bacteroidetes/Firmicutes ratio, as well as an increase in Bacillus and Lactobacillus spp
  • It was also observed that the ratio of Bacteriodes-Prevotella to C. coccoides-E. rectale positively correlated with glucose levels but did not correlate with body mass index [80]. This suggests that the microbiota may influence T2D in conjunction with or independently of obesity
  • In humans, high-fat Western-style diets fed to individuals over one month can induce a 71% increase in plasma levels of endotoxins, suggesting that endotoxemia may develop in individuals with GI barrier dyfunction connected to dysbiosis
  • LPS increases macrophage infiltration essential for systemic inflammation preceding insulin resistance, LPS alone does not impair glucose metabolism
  • early treatment of dysbiosis may slow down or prevent the epidemic of metabolic diseases and hence the corresponding lethal cardiovascular consequences
  • increased Firmicutes and decreased Bacteroidetes, which is the microbial profile found in lean phenotypes, along with an increase in Bifidobacteria spp. and Lactobacillus spp
  • mouse and rat models of T1D have been shown to have microbiota marked by decreased diversity and decreased Lactobacillus spp., as well as a decrease in the Firmicutes/Bacteroidetes ratio
  • microbial antigens through the innate immune system are involved in T1D progression
  • The microbiota appears to be essential in maintaining the Th17/Treg cell balance in intestinal tissues, mesenteric and pancreatic lymph nodes, and in developing insulitis, although progression to overt diabetes has not been shown to be controlled by the microbiota
  • There is evidence that dietary and microbial antigens independently influence T1D
  • Lactobacillus johnsonii N6.2 protects BB-rats from T1D by mediating intestinal barrier function and inflammation [101,102] and a combination probiotic VSL#3 has been shown to attenuate insulitis and diabetes in NOD mice
  • breast fed infants have higher levels of Bifidobacteria spp. while formula fed infants have higher levels of Bacteroides spp., as well as increased Clostridium coccoides and Lactobacillus spp
  • the composition of the gut microbiota strongly correlates with diet
  • In mice fed a diet high in fat, there are many key gut population changes, such as the absence of gut barrier-protecting Bifidobacteria spp
  • diet has a dominating role in shaping gut microbiota and changing key populations may transform healthy gut microbiota into a disease-inducing entity
  • “Western” diet, which is high in sugar and fat, causes dysbiosis which affects both host GI tract metabolism and immune homeostasis
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    Nice discussion of how diet, induces gut bacterial change, that leads to metabolic endotoxemia and disease.
wheelchairindia9

Cp Child Wheelchair - 0 views

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    young children have a different set of needs than adults. Aesthetically, devices designed for kids are often sleek and colorful, and functionally, they are typically lightweight and adjustable. As any parent knows, young people don't stay the same size for long and since a wheelchair is a major purchase -- don't want a simple growth spurt to render it useless. Wheelchair category offers models that feature seat width and depth adjustability, elevating legrests, and other versatile features. As a weight-bearing activity is critical to proper physical and mental function-which is why children with cerebral palsy, who may sit for stretches in a wheelchair and typically are unable to stand on their own, can benefit greatly from pediatric standers as part of a comprehensive pediatric rehabilitation program. Pediatric standers are offered in passive, active and mobile formats: Passive standers stay in one place and feature a support surface, active standers allow reciprocal movement of the extremities while in a standing position, and mobile standers enable users to self-propel. Cerebral Palsy Wheelchair: Cerebral Palsy Wheelchair Description: The model designed for cerebral palsy child only. Ultra light weight aluminium alloy frame. Seat Width 38 cms (15"). Net Weight: 18.5 kgs. Epoxy powder coated frame. Detachable arm rest & foot rest provided. Elevated and swinging foot rest. Elevated foot rest provided to elevate leg angle. Height adjustable and detachable head rest. Hydraulic reclining high back for a comfortable posture. Hydraulic adjustable seat angle. Detachable back and seat pad. Extra cushion upholstery provided to under arm, head & calg Foldable. Lever and paddle brakes provided. Safety belt provided. Maintenance free rear solid wheels. Cloth look like water proof upholstery. Anti wheels for better safety and stability. Extra cushion upholstery provided to under arm, head & leg. Folding action. Lever and paddle brakes provide
Nathan Goodyear

Reduced seroconversion to measles in infants given... [Lancet. 1995] - PubMed result - 0 views

  • vitamin A may limit replication of vaccine-strain measles vaccine
  • These results suggest that simultaneous high- dose vitamin A may thwart seroconversion to live measles vaccine in infants with maternal antibodies.
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    Vitamin A limits replication of measles virus
Nathan Goodyear

Distinct composition of gut microbiota during pregnancy in overweight and normal-weight... - 0 views

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    the gut bacterial balance in overweight women is distinctly different than normal weight women during pregnancy.  We know that bacterial balance in the infants plays a pivotal role in obesity risk.  Maybe, probiotic and gut health in the pregnant mother is the starting point to preventing obesity risk in children
Nathan Goodyear

Delivery mode shapes the acquisition and structure of the initial microbiota across mul... - 0 views

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    Study finds infants born vaginally have gut flora similar to mother's vaginal flora--Lactobacillus, Prevotella, or Sneathia species.  In contrast, those born via C/S have gut flora similar to that on the skin surface--staphylococcus, corynebacterium...
Nathan Goodyear

Microbial programming of health and disease starts during fetal life - Koleva - 2015 - ... - 0 views

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    Only abstract available.  Authors propose, which is supported by other evidence, that the gut microbiome of the infant begins while in utero.
spineneuro

Children With Brain Tumors Will Benefit From Targeted Treatment - 0 views

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    List of top brain tumor surgeons India, accomplished a large-scale examination of 241 infants from around the world identified with glioma brain tumors - working with colleagues at the list of top 10 hospitals for brain tumor surgery India.
Nathan Goodyear

ANTENATAL MAGNESIUM SULFATE FOR THE PREVENTION OF CEREBRAL PALSY IN PRETERM INFANTS <34... - 0 views

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    IV magnesium shown to reduce risk of cerebral palsy in meta-analysis.
Nathan Goodyear

Non-Celiac Gluten Sensitivity | Molina-Infante | OmniaScience Monographs - 0 views

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    Only abstract available here.  Non-celiac gluten sensitivity review.  NCGS is an innate immune response rather than a humoral or autoimmune response.
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