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Nathan Goodyear

Selenium in reproductive health - 0 views

www.ajog.org/...abstract

selenium pregnancy PIH PPROM PTL pre-eclampsia women glutathione detoxification

shared by Nathan Goodyear on 27 Jan 12 - No Cached
  • Nathan Goodyear on 27 Jan 12
     
    Many studies have been published on Selenium deficiency and decreased reproduction and pregnancy complications.  This study provides a nice review of Selenium and reproduction.  This is a just the abstract and will post the full article when it become available
Nathan Goodyear

Bisphenol A and Reproduction, January 5, 2011, Friedrich 305 (1): 28 - JAMA - 0 views

jama.ama-assn.org/...28.2.short

BPA plastics toxins reproduction men male infertility

shared by Nathan Goodyear on 30 Jun 11 - No Cached
  • Nathan Goodyear on 30 Jun 11
     
    BPA from plastics known to cause reproductive problems in humans, now shown to cause sterility, suggesting mode of action
Nathan Goodyear

NK Cells Expressing a Progesterone Receptor Are Susceptible to Progesterone-Induced Apo... - 0 views

www.jimmunol.org/...5746.full

progesterone PR receptors NK cell reproduction infertility immunity

shared by Nathan Goodyear on 14 May 12 - No Cached
  • Nathan Goodyear on 14 May 12
     
    NK cells have progesterone receptors.  This has important immunologic and reproductive impact.
Nathan Goodyear

Metabolic influences on neuroendocrine regulation of reproduction - 0 views

www.ncbi.nlm.nih.gov/...PMC3898855

metabolism metabolic regulation reproduction Leptin Ghrelin Insulin Kisspeptin GNRH

shared by Nathan Goodyear on 17 Feb 14 - No Cached
  • Energy storage occurs mainly at the level of white adipose tissue, where adipocytes secrete the anorexigenic adipokine leptin
  • humans and laboratory animals with leptin or insulin deficiency or resistance and/or increased ghrelin levels exhibit delayed or absent puberty and frequently display hypogonadotropic hypogonadism, which prevents fertility
  • Ghrelin suppresses pulsatile gonadotropin-releasing hormone (GnRH) release [14,15], thus serving as a signal to suppress reproduction in times of famine
  • ...4 more annotations...
  • GnRH neurons have been shown to express insulin receptor mRNA and protein [27] and are activated by insulin
  • AgRP and NPY have the opposite (orexigenic) effect, inducing food intake.
  • Neuropeptides derived from POMC/CART neurons exert a potent anorectic action, thus decreasing food intake and body weight
  • Kisspeptins (encoded by KISS1) have been identified in the last decade as the most potent secretagogues of GnRH release.
  • Nathan Goodyear on 17 Feb 14
     
    Good, although brief, discussion of the interaction between metabolism and hormones.  Kisspeptin is a GNRH secreatagogue "upstream".   Insulin, Leptin, and Gherlin can inhibit GNRH through resistance and low levels.  Probably a U shaped graph of optimal activity.
Nathan Goodyear

Reproductive and developmental effects of p... [Crit Rev Toxicol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24903855

phthalates xenoestrogens xenoestrogen male hormone hormones

shared by Nathan Goodyear on 16 Jun 14 - No Cached
  • Nathan Goodyear on 16 Jun 14
     
    phthalates are xenoestrogens that is toxic to male reproductive health.
Nathan Goodyear

The impact of male overweight on semen quality and outcome of assisted reproduction Tho... - 0 views

www.ajandrology.com/article.asp

infertility BMI sperm count sperm concentration sperm motility

shared by Nathan Goodyear on 23 Sep 14 - No Cached
  • Nathan Goodyear on 23 Sep 14
     
    Abstract only. Study in men seeking reproductive assistance found that increasing BMI had no negative impact on sperm concentration, sperm count, motility and seminal volume. 
Nathan Goodyear

http://www.fertstert.org/article/S0015-0282(16)62744-9/pdf - 0 views

www.fertstert.org/...pdf

male fertility male reproduction contraception vasectomy

shared by Nathan Goodyear on 04 Aug 17 - No Cached
  • Nathan Goodyear on 04 Aug 17
     
    good review of male reproductive physiology.  
Nathan Goodyear

Vitamin D and assisted reproductive treatment outcome: a systematic review and meta-ana... - 0 views

academic.oup.com/...4582928

vitamin d infertility reproduction fertility

shared by Nathan Goodyear on 22 Nov 17 - No Cached
  • Nathan Goodyear on 22 Nov 17
     
    New meta-analysis suggests vitamin D is key to fertility rates in ART.  At Seasons Wellness, we have long advocated vitamin D in fertility treatment.
harshitatyagi

Is it moral/ethical to use assisted reproductive technologies (ART) such as in-vitro fe... - 0 views

www.quora.com/...Geetanjali-Kapoor-31

Infertility Treatment Fertility Treatment IVF Treatment Assisted Reproductive Technology

shared by harshitatyagi on 09 Nov 22 - No Cached
  • harshitatyagi on 09 Nov 22
     
    Yes, it is completely fine to opt In-vitro fertilization when suffering from infertility, It is the most popular method accepted all around the globe, and only due to this treatment method many couples have been able to become parents.
Nathan Goodyear

Environmental anti-androgens and male reproductive health: focus on phthalates and test... - 0 views

www.reproduction-online.org/...305.long

environmental male health low T xenoestrogens phthalates testicular dysgenesis syndrome

shared by Nathan Goodyear on 11 Mar 13 - No Cached
  • Nathan Goodyear on 11 Mar 13
     
    good review of the effect of environmental xenoestrogens and low T in men.
Nathan Goodyear

http://archives.esf.org/fileadmin/Public_documents/Publications/SPB40_MaleReproductiveH... - 0 views

archives.esf.org/...B40_MaleReproductiveHealth.pdf

men male hormones fertility sperm male fertility male reproduction male reproductive health

shared by Nathan Goodyear on 09 Feb 17 - No Cached
  • Nathan Goodyear on 09 Feb 17
     
    good analysis of the declining sperm issue in men worldwide.
Nathan Goodyear

Duration of intralipid's suppressive eff... [Am J Reprod Immunol. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18782287

intralipid therapy natural killer cells NK infertility reproduction reproductive failure

shared by Nathan Goodyear on 16 Apr 12 - No Cached
  • Nathan Goodyear on 16 Apr 12
     
    Intralipid therapy effect in treating natural killer cell overactivity in those women that have immune mediated recurrent pregnancy loss.
Nathan Goodyear

Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms - 0 views

physrev.physiology.org/...1235.long

Kisspeptin HPA GNRH hormones reproduction hormone regulation

shared by Nathan Goodyear on 17 Feb 14 - No Cached
  • Nathan Goodyear on 17 Feb 14
     
    good, detailed discussion of HPAG signaling with a focus on the role of Kisspeptin--a GNRH secretagogue.
Nathan Goodyear

Effects of Organochlorine Compounds on Menstrual Cycles - DERT - 0 views

www.niehs.nih.gov/...menses.cfm

DDT environmental toxins endocrine disruptors menstrual cycles

shared by Nathan Goodyear on 08 Sep 11 - No Cached
  • Nathan Goodyear on 08 Sep 11
     
    DDT effects female reproduction and development
fnfdoc

Causes And Symptoms Of PCOS | Your Health Our Priority - 0 views

www.fnfdoc.com/...causes-symptoms-pcos

PCOD PCOS Polycystic Ovary Syndrome

shared by fnfdoc on 07 May 18 - No Cached
  • fnfdoc on 07 May 18
     
    PCOS is a disease of the female reproductive system that is characterized by hairiness, infrequent or heavy periods, skin disorders and infertility. Its symptoms and causes need immediate medical care as it can be deadly.
fnfdoc

Home Remedies For PCOS | Your Health Our Priority - 0 views

www.fnfdoc.com/...home-remedies-pcos

Home Remedies For PCOS

shared by fnfdoc on 09 May 18 - No Cached
  • fnfdoc on 09 May 18
     
    PCOS is a serious disease of the female reproductive tract identified by male pattern baldness, hirsutism, sleep apnea and infertility. Unfortunately, there is no cure for it. However, some home remedies can help ease the symptoms.
Nathan Goodyear

Ibuprofen alters human testicular physiology to produce a state of compensated hypogona... - 0 views

www.pnas.org/...1715035115.full

ibuprofen Testosterone epigenetics hormones low Testosterone low T

shared by Nathan Goodyear on 09 Jan 18 - No Cached
  • The levels of LH in the ibuprofen group had increased by 23% after 14 d of administration
  • This increase was even more pronounced at 44 d, at 33%
  • We found an 18% decrease (P = 0.056) in the ibuprofen group compared with the placebo group after 14 d (Fig. 1A) and a 23% decrease (P = 0.02) after 44 d (Fig. 1C). Taken together, these in vivo data suggest that ibuprofen induced a state of compensated hypogonadism during the trial, which occurred as early as 14 d and was maintained until the end of the trial at 44 d
  • ...27 more annotations...
  • We first investigated testosterone production after 24 and 48 h of ibuprofen exposure to assess its effects on Leydig cell steroidogenesis. Inhibition of testosterone levels was significant and dose-dependent (β = −0.405, P = 0.01 at 24 h and β = −0.664, P < 0.0001 at 48 h) (Fig. 2A) and was augmented over time
  • The AMH data show that the hypogonadism affected not only Leydig cells but also Sertoli cells and also occurred as early as 14 d of administration
  • Sertoli cell activity showed that AMH levels decreased significantly with ibuprofen administration, by 9% (P = 0.02) after 14 d (Fig. 1B) and by 7% (P = 0.05) after 44 d compared with the placebo group
  • Examination of the effect of ibuprofen exposure on both the ∆4 and ∆5 steroid pathways (Fig. 2B) showed that it generally inhibited all steroids from pregnenolone down to testosterone and 17β-estradiol; the production of each steroid measured decreased at doses of 10−5–10−4 M. Under control conditions, production of androstenediol and dehydroepiandrosterone (DHEA) was below the limit of detection except in one experiment with DHEA
  • Measuring the mRNA expression of genes involved in steroidogenesis in vitro showed that ibuprofen had a profound inhibitory effect on the expression of these genes (Fig. 3 B–D), consistent with that seen above in our ex vivo organ model. Taken together, these data examining effects on the endocrine cells confirm that ibuprofen-induced changes in the transcriptional machinery were the likely reason for the inhibition of steroidogenesis.
  • Suppression of gene expression concerned the initial conversion of cholesterol to the final testosterone synthesis. Hence, expression of genes involved in cholesterol transport to the Leydig cell mitochondria was impaired
  • A previous study reported androsterone levels decreased by 63% among men receiving 400 mg of ibuprofen every 6 h for 4 wk
  • We next examined the gene expression involved in testicular steroidogenesis ex vivo and found that levels of expression of every gene that we studied except CYP19A1 decreased after exposure for 48 h compared with controls
  • the changes in gene expression indicate that the transcriptional machinery behind the endocrine action of Leydig cells was most likely impaired by ibuprofen exposure.
  • Together, these data show that ibuprofen also directly impairs Sertoli cell function ex vivo by inhibiting transcription
  • ibuprofen use in men led to (i) elevation of LH; (ii) a decreased testosterone/LH ratio and, to a lesser degree, a decreased inhibin B/FSH ratio; and (iii) a reduction in the levels of the Sertoli cell hormone AMH
  • The decrease in the free testosterone/LH ratio resulted primarily from the increased LH levels, revealing that testicular responsiveness to gonadotropins likely declined during the ibuprofen exposure. Our data from the ex vivo experiments support this notion, indicating that the observed elevation in LH resulted from ibuprofen’s direct antiandrogenic action
  • AMH levels were consistently suppressed by ibuprofen both in vivo and ex vivo, indicating that this hormone is uncoupled from gonadotropins in adult men. The ibuprofen suppression of AMH further demonstrated that the analgesic targeted not only the Leydig cells but also the Sertoli cells, a feature encountered not only in the human adult testis but also in the fetal testis
  • ibuprofen displayed broad transcription-repression abilities involving steroidogenesis, peptide hormones, and prostaglandin synthesis
  • a chemical compound, through its effects on the signaling compounds, can result in changes in the testis at gene level, resulting in perturbations at higher physiological levels in the adult human
  • The analgesics acetaminophen/paracetamol and ibuprofen have previously been shown to inhibit the postexercise response in muscles by repressing transcription
  • Previous ex vivo studies on adult testis have indeed pointed to an antiandrogenicity, only on Leydig cells, of phthalates (41), aspirin, indomethacin (42), and bisphenol A (BPA) and its analogs
  • ibuprofen’s effects were not restricted to Leydig and Sertoli cells, as data showed that the expression of genes in peritubular cells was also affected
  • short-term exposure
  • In the clinical setting, compromised Leydig cell function resulting in increased insensitivity to LH is defined as compensated hypogonadism (4), an entity associated with all-cause mortality
  • compensated hypogonadic men present with an increased likelihood of reproductive, cognitive, and physical symptoms
  • an inverse relationship was recently reported between endurance exercise training and male sexual libido
  • AMH concentrations are lower in seminal plasma from patients with azoospermia than from men with normal sperm levels
  • inhibin B is a key clinical marker of reproductive health (32). The function of AMH, also secreted by Sertoli cells, and its regulation through FSH remain unclear in men
  • the striking dual effect of ibuprofen observed here on both Leydig and Sertoli cells makes this NSAID the chemical compound, of all the chemical classes considered, with the broadest endocrine-disturbing properties identified so far in men.
  • after administration of 600 mg of ibuprofen to healthy volunteers
  • 14 d or at the last day of administration at 44 d
  • Nathan Goodyear on 09 Jan 18
     
    ibuprofen alters genetic expression that results in decreased Testosterone production.
harshitatyagi

Can Endometriosis Spread To Other Organs? - 0 views

sco.lt/96WdzU

endometriosis endometriosis treatment endmetriosis symptoms endometriosis diagnosis

shared by harshitatyagi on 23 Nov 22 - No Cached
  • harshitatyagi on 23 Nov 22
     
    Endometriosis is known as one of the complications of women's reproductive parts. Also, research says that it affects primarily 10% of women starting their adolescence. Still, many believe that it is not as harmful an illness as it sounds, without having any idea that it is...
harshitatyagi

Get All The Answers for Queries Regarding Ovulation - Crysta IVF - 0 views

www.launchora.com/...for-queries-regarding-ovulatio

Ovulation Ovulation Symptoms Ovulation Signs Ovulation Calender Ovulation Tracker Ovulation Calculator Ovulation Days Ovulation cycle What happen during Ovulation Ovulation period for pregnancy

shared by harshitatyagi on 17 Oct 22 - No Cached
  • harshitatyagi on 17 Oct 22
     
    Ovulation is when a female's body releases an egg from the ovary so that sperm can fertilize it to complete the reproduction process effectively. Hence, in this article, we will cover all the essential details regarding ovulation, its signs and symptoms, and how long it lasts.
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