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Nathan Goodyear

https://endo.confex.com/endo/2014endo/webprogram/Paper11377.html - 0 views

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    from CHAMP study: low serum Testosterone, free Testosterone, Estradiol and Estrone associated with functional decline in elderly men via muscle weakness.
Nathan Goodyear

Green tea could reduce pancreatic cancer risk: Study explains how -- ScienceDaily - 0 views

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    Study proposes mechanism by which Green tea protects against Pancreatic cancer.
Nathan Goodyear

Cadmium - a metallohormone? - 0 views

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    Great review article on the endocrine disrupting role of Cadmium.  Cadmium binds to the ER-alpha inducing an estrogen signal.  Cadmium also binds to the androgen receptor as well.  This study proposes a similar activation of ER-alpha and AR by Cadmium.
Nathan Goodyear

New aspects of cadmium as endocrine disruptor. [Environ Sci. 2006] - PubMed - NCBI - 0 views

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    Cadmium is an endocrine disruptor: binds to estrogen receptors and the androgen receptor. 
Nathan Goodyear

Effects of maternal dietary exposure to cadmium during pregnancy on mammary cancer risk... - 0 views

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    Animal study finds that Cadmium is estrogenic.  This study found that not only was Cadmium an endocrine disruptor for the pregnant animals, but was also estrogenic in the mammary glands of the offspring.
Nathan Goodyear

Association between Lead and Cadmium and Reproductive Hormones in Peripubertal U.S. Girls - 0 views

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    Study finds higher Pb levels in young girls is associated with delayed puberty onset.  This occurs through an inverse relationship with inhibin B and follicular development.  This relationship was also found with Cadmium.  Both of these heavy metals are toxic to the ovaries.
Nathan Goodyear

https://endo.confex.com/endo/2014endo/webprogram/Paper14285.html - 0 views

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    Statin use found to be associated with cognitive decline.  The authors defined use as long-term, though 2 years of use was found to be associated with decline.   interestingly, metabolic syndrome was not found to be associated with cognitive decline.
Nathan Goodyear

Muscle Mass Index As a Predictor of Longevity in Older Adults - The American Journal of... - 0 views

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    Higher muscle mass associated with lower mortality in older adults.  so many focus on cardio and forget about resistance training.
Nathan Goodyear

Duration of gluten exposure in adult coeliac disease does not correlate with the risk f... - 0 views

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    Studies have shown increased risk of autoimmune disease with gluten exposure early in life in those with Celiac disease.  This study found no increase risk with gluten exposure later in life.
Nathan Goodyear

Review: The Impacts of Circulating 25-Hydroxyvitamin D Levels on Cancer Patient Outcome... - 0 views

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    meta-analysis, so take it for what it is worth; but higher vitamin D levels at the time of diagnosis were associate with better outcomes in those with cancer.  The improved outcomes included cancer mortality, disease-free survival, and overall survival.
Nathan Goodyear

Androgens are bronchoactive drugs that act by relaxing airway smooth muscle and prevent... - 0 views

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    Androgens relax smooth muscles of airways in men with asthma.  The metabolite 5beta-DHT was the most potent in this action.  This has implications in men with low T and asthma.  
Nathan Goodyear

Androgen Deprivation Therapy and the Re-em... [Oncol Hematol Rev. 2014] - PubMed - NCBI - 0 views

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    Sometimes I think medicine has lost its mind.  Or at least, it is not thinking things through.  To give IV estrogen to decrease Testosteorne in men with prostate cancer is devoid of the pathophysiology of prostate cancer and cardiovascular disease in men.  Elevated Estradiol in men increases CRP, IL-1beta, and TNF-alpha to name a few cytokines.  The proported purpose of the IV estrogen is to prevent the cardiovascular complications associated with ADT.  Yet, elevated aromatase activity and low T in men are both shown to be associated with increased CVD in men.
Nathan Goodyear

Estrogen Receptor Signaling and Its Relationship to Cytokines in Systemic Lupus Erythem... - 0 views

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    Nice review of the literature of Estrogens, estrogen receptors and their effect on cytokine production and Lupus.
Nathan Goodyear

The impact of vitamin D in breast cancer: genomics, pathways, metabolism - 0 views

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    Good review of data on vitamin D, Vitamin D receptors and cancer risk.  Studies have shown that low Vitamin D levels are associated with increased cancer risk and that higher vitamin D levels are associated with reduced cancer risk.  The ability to fully map out vitamin Ds role in the physiology is probably difficult due to the heterogeneity of cancer development and physiology.
Nathan Goodyear

Progesterone induces the growth and infiltrat... [Biomed Res Int. 2014] - PubMed - NCBI - 0 views

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    Progesterone shown to stimulate growth and migration of astrocytes in the brain.  The has both implications in cancer, such as in astrocytomas, but also in TBI.  The study also found that the Progesterone antagonist RU486 inhibited this effect.  A more thorough evaluation would have included the pregnane metabolites.
Nathan Goodyear

The prevalence of prediabetes in population of Polish men with late-onset hypogonadism,... - 0 views

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    Study of late onset of low T in polish men found a significantly increased prevalence of glucose metabolism dysregulation when compared to normal T control group.  In the low T group, Total Testosterone and Free Testosterone levels were decreased. 
Nathan Goodyear

Marked Testosterone Deficiency-Related Symptoms Ma... [J Sex Med. 2014] - PubMed - NCBI - 0 views

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    The more severe the symptoms, the more the increased risk of CVD in men with low T.
Nathan Goodyear

Healthy Lifestyle Change and Subclinical Atherosclerosis in Young Adults - 0 views

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    For so many, lifestyles are seen as unobtainable and of limited benefit.  This study proves otherwise.  This study found that lifestyle changes made in middd-life were associated with a decrease in cardiovascular disease.  Equally important, many were found to be able to implement said lifestyle changes--this flies in the face of what a lot of physicians believe.
Nathan Goodyear

Long-term effects of the rhaponti... [J Steroid Biochem Mol Biol. 2012] - PubMed - NCBI - 0 views

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    No long-term negative effects seen with Err 731 supplementation.  Particularily, the authors were looking for endometrial stimulation.  But, previous studies had shown a dominant ER-beta affinity, which would not favor endometrial stimulation.
Nathan Goodyear

Subtype-specific activation of estrogen recept... [Phytomedicine. 2007] - PubMed - NCBI - 0 views

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    Study finds that Err 731, extract of Siberian Rhubarb, strong affinity for ER-beta and weak activity for ER-alpha in bone, though none found present in endometrial cells.  This is the second study to provide evidence of molecular mechanism of action through ER-beta receptors.
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