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Ketone bodies have been shown to benefit the mitochondria in the brains of those with Alzheimer's disease.  This ketosis can be achieved through low carb/protein, high fat diet.

loss of methylation plays a role in the development of autoimmune disease states.

low DHEA associated with increased cardiovascular disease risk.  This was presented at the Endocrine Society 94th Annual meeting.

oxidative stress and Parkinson's disease

Glutathione restoration should be an important role in people with Parkinson's Disease

glutathione depletion plays early, active role in the development of Parkinson's disease

chronic inflammation appears to be the major player in aging and age-related chronic diseases

study shows increased activity and exercise delays onset of chronic disease.   Inactivity and obesity decreased the age of 

good read on an alternate hypothesis of the pathophysiology of MS. THe author proposes that MS is an inflammatory induced dysfunction of lipid metabolism. This is in contrast to the current held dogma that MS is an autoimmune disease.

nice review of how thyroid disease effects cardiac function. Notice the author of this paper describes "thy- roxine (T4) which is a prohormone and tri-iodothyronine (T3) which acts as the final mediator".

elevated homocysteine and low folic acid levels associated with increased risk of Alzheimer's disease and dementia.

Testosterone therapy, injected intracoronary, resulted in vasodilation and improved blood flow in men with CAD.

How the gut contributes to inflammation and disease: through TLR.

IV glutathione shown to slow profession of Parkinson's Disease.  IV was given at doses of 600 mg IV twice daily for 30 days.

good review of understanding of how poor glucose control, oxidative stress result in AGE and Alzheimer's disease.

NAC shown to improve secondary measures of cognitive function in small study in those with Alzheimer's disease. NAC proves to be a reliable means to reduce free radical induced advanced glycation end productions and resultant inflammation. Also was shown to be well tolerated.

This study finds that AGE, advanced glycation end products, play a significant role in free radical generation and neurodegenerative disease. Quote: "... pharmacologoical approaches which break the vicious cycle of oxidative stress and neurodegeneration offer new opportunities for the treatment of AD. These approaches include AGE- inhibitors, antioxidants, and anti-inflammatory substances which prevent radical production." They focus on the pharmacological, how about the natural first?

Use of Vitamin C and Vitamin E associated with a 78% reduced prevalence of Alzheimer's disease.

This study found an inverse association between elevated 8-hydroxy-2-deoxyguanosine and low antioxidants in individuals with Alzheimer's disease.

individuals with the lowest LDL associated with a 350% increase rate of Parkinson's disease.