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Nathan Goodyear

Effects of thyroxine as compared with thyroxine pl... [N Engl J Med. 1999] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...9971866

T3 T4 hypothyroidism armour thyroid USP

shared by Nathan Goodyear on 19 Nov 10 - No Cached
  • n patients with hypothyroidism, partial substitution of triiodothyronine for thyroxine may improve mood and neuropsychological function;
  • Nathan Goodyear on 19 Nov 10
     
    Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism.
Nathan Goodyear

Franken-Thyroxine Making Your Thyroid Condition Worse? | GreenMedInfo | Blog entry | Na... - 0 views

www.greenmedinfo.com/...g-your-thyroid-condition-worse

thyroid synthroid bioidentical Thyroxine hormone

shared by Nathan Goodyear on 01 Aug 11 - No Cached
  • Nathan Goodyear on 01 Aug 11
     
    synthroid is not biodentical Thyroxine (thyroid) hormone
Nathan Goodyear

Effects of Thyroxine as Compared with Thyroxine plus Triiodothyronine in Patients with ... - 0 views

www.nejm.org/...NEJM199902113400603

Armour T4 T3 synthroid hypothyroidism hypothyroid thyroid

shared by Nathan Goodyear on 01 Aug 11 - No Cached
  • Nathan Goodyear on 01 Aug 11
     
    Armour Thyroid (T4 and T3 combined) provides better symptom control when compared to synthroid alone (T4)
Nathan Goodyear

Thyroid Hormone Replacement Therapy in Primary Hypothyroidism: A Randomized Trial Compa... - 0 views

www.annals.org/412

hypothyroid hypoth hormone thyroid replacement

shared by Nathan Goodyear on 20 Dec 10 - No Cached
  • Nathan Goodyear on 20 Dec 10
     
    study shows end points, designed in study, showed no change with combined thyroid therapy; but patients preferred combined therapy.
Nathan Goodyear

Impaired Peripheral Conversion of Thyroxine to Trhodothyronine - Annual Review of Medic... - 0 views

www.annualreviews.org/...annurev.me.28.020177.000421

hypothyroid hypothyroidism thyroxine t4 reverse t3

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Nathan Goodyear on 08 Mar 11
     
    peripheral conversion of t4 to reverse t3
Nathan Goodyear

Higher Free Thyroxine Levels Predict Increased Incidence of Dementia in Older Men: The ... - 0 views

jcem.endojournals.org/...E2230.abstract

thyroid free free T3 free T4 reverse T3 dementia

shared by Nathan Goodyear on 06 Dec 12 - No Cached
  • Nathan Goodyear on 06 Dec 12
     
    what a silly study!  They look at free T4, the weakest thyroid hormone and found high levels to be associated with dementia.  However, they failed to assess free T3, the most biologically active, and reverse T3, inactive.  This study was like they intentionally blinded themselves of the body's physiology to study dementia.  This is the problem with a lot of research today: they have forgotten their foundation. Many older adults struggle with poor free T4 to free T3 conversion and high reverse T3 conversion.  So, without knowing what these clients were doing in these pathways makes their conclusion obsolete.
Nathan Goodyear

Abnormal serum thyroid hormones concentration... [Pak J Biol Sci. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21874823

thyroid hormones TBG thyroxin-binding globulins

shared by Nathan Goodyear on 09 May 12 - No Cached
  • Nathan Goodyear on 09 May 12
     
    95-99% of thyroid hormones are protein bound and inactive.
Nathan Goodyear

thyroid disease and the heart - 0 views

www.ncbi.nlm.nih.gov/...v084p00455.pdf

thyroid disease heart T3 T4 thyroxine try-idodothyronine

shared by Nathan Goodyear on 31 Jan 12 - No Cached
  • Nathan Goodyear on 31 Jan 12
     
    nice review of how thyroid disease effects cardiac function. Notice the author of this paper describes "thy- roxine (T4) which is a prohormone and tri-iodothyronine (T3) which acts as the final mediator".
Nathan Goodyear

Low-T3 Syndrome - 0 views

circ.ahajournals.org/...708.long

T3 low T3 cardiac heart disease CVD cardiovascular thyroid hormone hormones hypothyroid hypothyroidism

shared by Nathan Goodyear on 03 Jul 12 - No Cached
  • More than 80% of the biologically active hormone triiodothyronine (T3) derives from peripheral conversion of prohormone thyroxine (T4) secreted by the thyroid gland
  • Low thyroid hormone concentrations, in particular low serum T3 concentrations, are a common finding in patients with nonthyroidal illnesses, including cardiac disorders
  • a direct relationship between low circulating levels of T3 and adverse prognosis of cardiac patients
  • ...4 more annotations...
  • The present study clearly shows the existence of a strong association between the reduction of biologically active T3 and mortality in a large population of cardiac hospitalized patients
  • highly significant increase in the incidence of cardiac and cumulative deaths in patients with low T3 compared with patients with normal T3 levels
  • the relevance of the low T3 state as a strong, independent predictor of mortality in cardiac patients
  • low T3 concentrations are a strong independent predictive marker of poor prognosis in cardiac patients
  • Nathan Goodyear on 03 Jul 12
     
    low T3 associated with poor prognosis in cardiac patients.   Poor prognosis = death.  T3 is important in cardiac remodeling, which is inherently important with cardiac disease.
Nathan Goodyear

L-Thyroxine therapy in subclinical hypothyroidism.... [Ann Intern Med. 1984] - PubMed r... - 0 views

www.ncbi.nlm.nih.gov/...6428290

Hypothyroid hypothyroidism therapy

shared by Nathan Goodyear on 19 Nov 10 - No Cached
  • Nathan Goodyear on 19 Nov 10
     
    Treatment in subclinical hypothyroidism provides statistical benefits to patient symptoms
Nathan Goodyear

Peripheral autoregulation of thyroxine to triiodot... [Horm Metab Res Suppl. 1984] - Pu... - 0 views

www.ncbi.nlm.nih.gov/...6595193

Thyroid T4 T3 hormone hormones 5' deiodinase

shared by Nathan Goodyear on 19 Nov 10 - No Cached
  • Nathan Goodyear on 19 Nov 10
     
    Thyroid T4 to T3 conversion
Nathan Goodyear

Levothyroxine therapy and serum free thyroxine and... [J Endocrinol Invest. 2002] - Pub... - 0 views

www.ncbi.nlm.nih.gov/...11929079

hypothyroid hypothyroidism T4 synthroid levothyroxine T3

shared by Nathan Goodyear on 20 Dec 10 - No Cached
  • Nathan Goodyear on 20 Dec 10
     
    T4 therapy (synthroid) alone does not increase serum free T3 concentrations in many patients
Nathan Goodyear

Elevated Serum Thyrotropin in Thyroxine-Treated Patients with Hypothyroidism Given Sert... - 0 views

www.nejm.org/...NEJM199710023371415

zoloft SSRI hypothyroid hypothyroidism

shared by Nathan Goodyear on 20 Dec 10 - No Cached
  • Nathan Goodyear on 20 Dec 10
     
    zoloft lowers thyroid function
Nathan Goodyear

Only the combined treatment with thyroxine and triiodothyronine ensures euthyroidism in... - 0 views

endo.endojournals.org/...2490

hypothyroid hypothyroidism T4 T3

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Combined replacement therapy with T4 and T3 (in proportions similar to those secreted by the normal rat thyroid) completely restored euthyroidism in thyroidectomized rats at much lower doses of T4 than those needed to normalize T3 in most tissues when T4 alone was used
  • Nathan Goodyear on 08 Mar 11
     
    combined T4/T3 therapy the best approach in hypothyroidism
Nathan Goodyear

Kent Holtorf: Long Term Weight Loss - More Than Will Power? - 0 views

www.huffingtonpost.com/...-weight-loss---m_b_192933.html

leptin reverse T3 weight loss

shared by Nathan Goodyear on 09 Mar 11 - No Cached
  • which is a major reason for the regaining of lost weight with dieting as well being the mechanism behind stress induced weight gain (it is not due to increased cortisol).
  • f greater than 10, it demonstrates there is a degree of leptin resistance contributing to an inability to lose weight
  • that it is difficult to lose weight with leptin resistance. High carbohydrate diets and in particular high-fructose corn syrup is shown to significantly increase leptin resistance and is a likely mechanism that high fructose corn syrup is associated with obesity
  • ...9 more annotations...
  • inactive thyroid hormone called thyroxine
  • it is problem inside the cell that the inactive T4 is not converted to T3 but rather to a mirror image of T3 called reverse T3. The reverse T3 has the opposite effect of T3, blocking the effects of T3 and lowering rather than increasing metabolism.
  • Studies are showing that stress and dieting (especially yo-yo dieting) can set this hormone into action as well as chronic illness such as diabetes, chronic fatigue syndrome and fibromyalgia.
  • As soon as the body senses a reduction in calories, the production of reverse T3 is stimulated to lower metabolism
  • With chronic dieting or stress, the body often stays in this "starvation mode" with elevated levels of reverse T3 and decreased levels of T3, which is a major reason for the regaining of lost weight with dieting as well being the mechanism behind stress induced weight gain (it is not due to increased cortisol).
  • which is a major reason for the regaining of lost weight with dieting as well being the mechanism behind stress induced weight gain (it is not due to increased cortisol).
  • which is a major reason for the regaining of lost weight with dieting as well being the mechanism behind stress induced weight gain (it is not due to increased cortisol).
  • Studies are showing that such standard testing will miss 80% of thyroid dysfunction
  • ree T3/reverse T3 ratio
  • Nathan Goodyear on 09 Mar 11
     
    Fantastic review by Dr. Holtorf on reverse T3, leptin, and weight loss
Nathan Goodyear

Extrathyroidal Conversion of Thyroxine to 3,3',5'-Triiodothyronine (Reverse-T3)and to 3... - 0 views

jcem.endojournals.org/...733

reverse T3 free T4 hypothyroid hypothyroidism extrathyroidal conversion

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Nathan Goodyear on 08 Mar 11
     
    reverse T3 comes from peripheral conversion from free T4
Nathan Goodyear

A Radioimmunoassay for 3,3',5'-L-Triiodothyronine (Reverse T3): Assessment of Thyroid G... - 0 views

jcem.endojournals.org/...660

reverse T3 estrogen pregnancy hypothyroid hypothyroidism

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Both pregnancy and estrogen administration were associated with increases in serum reverse T3 concentrations presumably because of their ability to augment thyroxine binding globulin synthesis.
  • Nathan Goodyear on 08 Mar 11
     
    oral estrogen supplementation increase reverse T3 and lowers metabolism and leads to weight gain
Nathan Goodyear

Diagnosing Growth Hormone Deficiency in Adults - 0 views

www.hindawi.com/...972617

HGH GH human growth hormone growth hormone IGF-1

shared by Nathan Goodyear on 04 Nov 14 - No Cached
  • it is clear that serum IGF-1 and or IGFBP-3 can be normal in patients with undisputed GHD
  • Various investigators have reported normal IGF-1 values in 37–70% of GH deficient adults
  • The co-administration of arginine and GHRH (the combined test) is a powerful stimulus for GH production and has gained increasing acceptance as a useful method of diagnosing GHD [34]. This test has been advocated as a suitable alternative to ITT
  • ...12 more annotations...
  • The glucagon stimulation test (GST) is a reliable, safe alternative to the ITT in the diagnosis of GHD
  • An intravenous infusion of arginine (0.5 g/kg body weight) together with an intravenous bolus of GHRH (1 mcg/kg body weight) is administered [30]. Serum samples for GH are then obtained every 15–30 minutes for two hours.
  • Obesity, particularly marked obesity, is associated with blunted GH secretion in response to provocative stimuli
  • It has also been suggested that that even mildly increased BMI (25–30 kg/m2) can result in diminished stimulated GH production in 13% of healthy subjects
  • Corneli et al. have defined BMI-specific cut-off points for diagnosing adult-onset GHD using GHRH + arginine—11.5 ng/mL for those with BMI < 25 kg/m2, 8.0 ng/mL for BMI 25–30 kg/m2, 4.2 ng/mL for those with BMI > 30 kg/m2
  • GH levels are higher during the luteal phase in comparison with the follicular phase of the cycle
  • Oral, in contrast to transdermal oestrogen, lowers IGF-1 levels and is associated with increased GH levels
  • Adequate pituitary replacement with thyroxine and hydrocortisone are needed for optimal GH production
  • one cannot rely on a low IGF-1 to diagnose GHD in women taking oral oestrogen preparations.
  • Numerous GH secretagogues are available with the insulin tolerance test being the gold standard and the glucagon stimulation test or the GHRH + arginine as acceptable alternatives
  • ain et al. found the GST to be at least as good as the ITT in provoking GH secretion
  • the GST is safe, with almost no contraindications, it causes nausea and sometimes vomiting in 15–20% of subjects
  • Nathan Goodyear on 04 Nov 14
     
    Nice, more recent analysis, of HGH testing.
Nathan Goodyear

Hashimoto's Thyroiditis, Risk of Coronary Heart Disease, and l-Thyroxine Treatment: A N... - 0 views

press.endocrine.org/...jc.2014-2990

Hashimoto's thyroiditis hypothyroidism hypothyroid thyroid heart disease coronary heart disease disease

shared by Nathan Goodyear on 28 Jan 15 - No Cached
  • Nathan Goodyear on 28 Jan 15
     
    Hashimoto's hypothyroidism is associated with a 44% increase in Heart disease in women under the age o 49.  A non-significant change was seen in men.  This study found that T4 therapy reduced this risk.  A better study would have been if T4 was compared to T4 + T3.
Nathan Goodyear

Lipoprotein(a) as a cardiovascular risk factor: current status - 0 views

eurheartj.oxfordjournals.org/...2844.full

cardiovascular risk disease lipoprotein a Lp(a) LDL lipoprotein(a) niacin

shared by Nathan Goodyear on 06 Aug 14 - No Cached
  • Lipoprotein(a) is a plasma lipoprotein consisting of a cholesterol-rich LDL particle with one molecule of apolipoprotein B100 and an additional protein, apolipoprotein(a)
  • Elevated Lp(a) levels can potentially increase the risk of CVD (i) via prothrombotic/anti-fibrinolytic effects as apolipoprotein(a) possesses structural homology with plasminogen and plasmin but has no fibrinolytic activity and (ii) via accelerated atherogenesis as a result of intimal deposition of Lp(a) cholesterol, or both
  • evidence suggests that apolipoprotein(a) adducts extracellularly and covalently to apolipoprotein B100-containing lipoproteins, predominantly LDL
  • ...2 more annotations...
  • Lp(a) is relatively refractory to both lifestyle and drug intervention.
  • Other agents reported to decrease Lp(a) to a minor degree (<10%) include aspirin, l-carnitine, ascorbic acid combined with l-lysine, calcium antagonists, angiotensin-converting enzyme inhibitors, androgens, oestrogen, and its replacements (e.g. tibolone), anti-estrogens (e.g. tamoxifen), and thyroxine replacement in hypothyroid subjects
  • Nathan Goodyear on 06 Aug 14
     
    full article on the previously posted abstract on Lp(a).  
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