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A Novel Estradiol/Estrogen Receptor α-dependent Transcriptional Mechanism Con... - 0 views

www.jbc.org/...18825.long Estradiol ER alpha prolactin ER-alpha Breast Cancer
shared by Nathan Goodyear on 19 Aug 19 - No Cached
  • Nathan Goodyear on 19 Aug 19
     
    Estradiol increases prolactin receptor transcription through their ER-alpha receptor.
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A Randomised, Double Blind, Placebo-Controlled Pilot Study of Oral Artesunate Therapy f... - 0 views

www.sciencedirect.com/...S2352396414000346 tumor markers CEA cancer artesuante
shared by Nathan Goodyear on 30 Apr 20 - No Cached
  • Nathan Goodyear on 30 Apr 20
     
    Artesunate has anti-cancer effects.
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The effect of plant sterols on serum triglyceride concentrations is dependent on baseli... - 0 views

www.ncbi.nlm.nih.gov/...PMC3549411 plant sterols triglycerides
shared by Nathan Goodyear on 10 Mar 17 - No Cached
  • Nathan Goodyear on 10 Mar 17
     
    plant sterols lower triglycerides.
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Hyperbaric oxygen therapy promotes neurogenesis: where do we stand? - 0 views

www.ncbi.nlm.nih.gov/...PMC3231808 hbot hyperbaric therapy hyperbaric brain TBI stroke neurogenesis neuorplasticity
shared by Nathan Goodyear on 18 May 17 - No Cached
  • Numerous in vivo and in vitro studies confirm that HBOT induces neurogenesis
  • HIF-1α is the principal mediator of cellular hypoxia adaptations
  • activated by hypoxia, HIF-1α causes the transcription of its regulated downstream genes, including erythropoietin (EPO) and VEGF which are known to promote neurogenesis
  • ...10 more annotations...
  • The safety of HBOT was also evaluated and it was pointed out that, if given at proper paradigms, like 1.5 ATA for 60 minutes, HBOT will not cause oxygen toxicity
  • Rockswold et al., on the other hand, found that HBOT might be potentially beneficial for severe TBI patients
  • McDonagh et al., concluded that there was insufficient evidence to establish the effectiveness of HBOT in the treatment of TBI
  • The first multicenter, randomized, double-blind, controlled trial in 2009 found that 40-hour HBOT of 24% oxygen at 1.3 ATM produced significant improvement in children's overall functioning, receptive language, social interaction, eye contact, and sensory/cognitive awareness compared to those received slightly pressurized room air
  • Another study in 2010 on 16 autism patients, adopting a similar treatment paradigm, showed no effect on a wide array of behavioral evaluations
  • To date, there is little evidence that HBOT causes malignant growth or metastasis. A history of malignancy should therefore not be considered as a contraindication for HBOT
  • HBOT enhances the production of reactive oxygen species (ROS) and causes oxidative stress in body tissues
  • Excessive accumulation of oxidative stress may contribute to neurodegenerative processes and cell death in the brain, as seen in diseases like Alzheimer's disease (AD) and Parkinson's disease (PD)
  • Hormesis
  • process that results in a functional improvement of cellular stress resistance, survival, and longevity in response to sub-lethal levels of stress
  • Nathan Goodyear on 18 May 17
     
    great review of hbot, brain injury, neuroplasticity and neurogenesis.
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Hyperbaric treatment for children with autism: a multicenter, randomized, double-blind,... - 0 views

bmcpediatr.biomedcentral.com/...1471-2431-9-21 hyperbaric hyperbaric therapy brain autism
shared by Nathan Goodyear on 17 May 17 - No Cached
  • Nathan Goodyear on 17 May 17
     
    study finds hyperbaric therapy improves children with autism.
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Randomized placebo-controlled trial of testosterone replacement in men with mild Leydig... - 0 views

www.ncbi.nlm.nih.gov/...11589674 Testosterone testosterone therapy low T low Testosterone libido
shared by Nathan Goodyear on 10 Jun 17 - No Cached
  • Nathan Goodyear on 10 Jun 17
     
    The authors conclusion here is all wrong.  The men with low T had improvement in energy and LDL, but no improvement in mood and sexual function.
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Long-Term Immunomodulatory Effects of a Mediterranean Diet in Adults at High ... - 0 views

jn.nutrition.org/...1684.short mediterranean mediterranean diet heart health heart nutrition cardiovascular disease inflammation hsCRP CRP TNF-alpha
shared by Nathan Goodyear on 01 Jun 17 - No Cached
  • Nathan Goodyear on 01 Jun 17
     
    Mediterranean diet found to reduce hsCRP, IL-6, TNF-alpha, and MCP in high-risk adults out to 5 years!  This study compared the Mediterranean diet to a low fat diet.
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In vivo transcriptomic profile after a Mediterranean diet in high-cardiovascular risk p... - 0 views

ajcn.nutrition.org/...845.short Mediterranean diet nutrition heart failure heart heart health cardiovascular disease hypertension extra virgin olive oil cardiovascular
shared by Nathan Goodyear on 01 Jun 17 - No Cached
  • Nathan Goodyear on 01 Jun 17
     
    Diet is a language that interacts with out DNA.  Study finds that Mediterranean diet + extra virgin olive oil alters genetic expression to reduce cardiovascular risk.
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Frontiers | Prevalence of Non-responders for Glucose Control Markers after 10 Weeks of ... - 0 views

journal.frontiersin.org/...full insulin resistance exercise HITT high intensity intermittent training
shared by Nathan Goodyear on 22 Aug 17 - No Cached
  • Nathan Goodyear on 22 Aug 17
     
    Exercise is key to healthy lifestyle: High Intensity Interval Training for Insulin resistance found to improve waist circumference, systolic bp, and HOMA-IR; Increased non-responders for insulin and glucose in those with mild IR versus severe IR.
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The Risk of Fluoroquinolone-induced Tendinopathy and Tendon Rupture - 0 views

www.ncbi.nlm.nih.gov/...PMC2921747 flouroquinolones ciprofloxacin levoquin tendinitis tendinopathy Tendon rupture
shared by Nathan Goodyear on 02 Aug 17 - No Cached
  • Achilles tendinitis or rupture is among the most serious side effects associated with FQ use
  • The large body of data provided by clinical reports, histopathological examination, and experimental studies provides cogent evidence supporting a direct link between FQ use and tendonitis/tendon rupture
  • Risk factors associated with FQ-induced tendon disorders include age greater than 60 years, corticosteroid therapy, renal failure, diabetes mellitus, and a history of musculoskeletal disorders
  • ...17 more annotations...
  • The average age of FQ-induced tendinopathy is 64 years, with a male-to-female ratio of 2:1, and a 27-percent incidence of bilateral involvement
  • Although more than 95 percent of cases of tendinitis/rupture secondary to FQ involve the Achilles tendon, other reported sites of tendon involvement include the quadriceps, peroneus brevis, and rotator cuff
  • FQs demonstrate a 3.8-fold greater risk for development of Achilles tendinitis/rupture
  • a large population-based case control analysis, patients treated with FQs exhibited a substantially increased risk of developing tendon disorders overall (1.7-fold), tendon rupture (1.3-fold), and ATR (4.1-fold)
  • patients taking FQs with concurrent exposure to corticosteroids were found to experience a compounding effect on the risk of tendon rupture, specifically a 46-fold greater predisposition
  • Some authors have recommended that patients with a history of Achilles tendinitis and advanced age should not be prescribed FQ antibiotics
  • Approximately 50 percent of patients will recover within 30 days, with 25 percent of patients having symptoms persistent for longer than two months
  • Approximately 85 percent of patients present in less than one month
  • The exact pathophysiology of FQ-induced tendinopathy remains elusive
  • it is possible that FQs have a direct cytotoxic effect on enzymes found in mammalian musculoskeletal tissue
  • It has been theorized that FQs disproportionately affect human tendons that have a limited capacity for repair, such as in older patients or structural compromise (i.e., pre-existing tendinopathy or trauma)
  • histopathological findings are similar to those observed in overuse conditions in athletes
  • Treatment with a FQ should be discontinued and physical therapy initiated
  • treatment should include rest and decreasing the physical load on the tendon.
  • The mean latency period between the start of FQ treatment and occurrence of tendinopathy has been reported to be a few hours to months, with a median onset of 6 days
  • Because rupture can occur even late in the course of treatment or after discontinuation of FQ use, patients receiving a FQ should be counseled to seek medical attention immediately if symptoms, such as redness, pain, swelling, and stiffness, develop
  • FQs should be used cautiously in patients with risk factors associated with tendinitis, such as advanced age, history of tendon rupture, corticosteroid use, and/or acute or chronic renal dysfunction
  • Nathan Goodyear on 02 Aug 17
     
    Great review of the link between flouroquinolones and Tendinitis and Tendon rupture.  Yes, there is a direct link.
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Frontiers | Microbiome-Derived Lipopolysaccharide Enriched in the Perinuclear Region of... - 0 views

journal.frontiersin.org/...full LPS lipopolysaccharides Alzheimer's disease brain inflammation
shared by Nathan Goodyear on 23 Sep 17 - No Cached
  • lipopolysaccharides (LPS), either alone or in combination, have indicated that when compared, bacterial LPSs exhibit the strongest induction of pro-inflammatory signaling in human neuronal–glial cells in primary coculture of any single inducer, and different LPS extracts from different gastrointestinal (GI)-tract resident Gram-negative bacteria appeared to have different pro-inflammatory potential
  • powerful inducer of the NF-κB
  • In both neocortex and hippocampus, LPS has been detected to range from a ~7- to ~21-fold increase abundance in AD brain
  • ...15 more annotations...
  • Major Gram-negative bacilli of the human GI-tract, such as the abundant B. fragilis and Escherichia coli (E. coli), are capable of discharging a remarkably complex assortment of pro-inflammatory neurotoxins
  • (i) bacterial amyloids (10, 21); (ii) endotoxins and exotoxins (5, 12); (iii) LPS (12, 18); and (iv) small non-coding RNAs (sncRNAs)
  • integral components of the outer leaflet of the outer membrane of Gram-negative bacteria, LPS
  • LPS, the major molecular component of the outer membrane of Gram-negative bacteria normally serves as a physical barrier providing the bacteria protection from its surroundings
  • LPS is also recognized by the immune system as a marker for the detection of bacterial pathogen invasion and responsible for the development of inflammatory response is perhaps the most potent stimulator and trigger of inflammation known
  • AD-affected brains have remarkably large loads of bacterial-derived toxins compared to controls. The transfer of noxious, pro-inflammatory molecules from the GI-tract microbiome to the CNS may be increasingly important during the course of aging when both the GI-tract and blood–brain barriers become significantly more permeable
  • first evidence of a perinuclear association of LPS with AD brain cell nuclei
  • LPS-mediated stimulation of chronic inflammation, beta-amyloid accumulation, and episodic memory decline in murine models of AD (39, 40) and a biophysical association of LPS with amyloid deposits and blood vessels in human AD patients
  • Strong adherence of LPS to the nuclear periphery has recently been shown to inhibit nuclear maturation and function that may impair or block export of mRNA signals from brain cell nuclei, a highly active organelle with extremely high rates of transcription, mRNA processing, and export into the cytoplasm
  • LPS may be further injurious to the nuclear membrane just as LPS contributes to cerebrovascular endothelial cell membrane injury
  • high intake of dietary fiber is a strong inhibitor of B. fragilis abundance and proliferation in the intact human GI-tract and as such is a potent inhibitor of the neurotoxic B. fragilis-derived amyloids, LPS, enterotoxins, and sncRNAs.
  • GI-tract microbiome-derived LPS may be an important initiator and/or significant contributor to inflammatory degeneration in the AD CNS
  • LPS has been recently localized to the same anatomical regions involved in AD-type neuropathology
  • a known pro-inflammatory transcription factor complex that triggers the expression of pathogenic pathways involved in neurodegenerative inflammation
  • pro-inflammatory amyloids, endo- and exotoxins, LPSs, and sncRNAs but also serve as potent sources of membrane-disrupting agents
  • Nathan Goodyear on 23 Sep 17
     
    LPS links gut to inflammation in Alzheimer's disease
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Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle: Cell Metabolism - 0 views

www.cell.com/...S1550-4131(12)00005-8 exercise methylation epigenetics muscle
shared by Nathan Goodyear on 03 Oct 17 - No Cached
  • our results provide evidence to suggest that acute exercise induces gene-specific DNA hypomethylation in human skeletal muscle
  • Our results suggest that DNA methylation is a component of the exercise-induced effect on expression of these genes.
  • Caffeine exposure decreased promoter methylation of Pgc-1α, Tfam, Mef2a, Cs, and Pdk4
  • ...4 more annotations...
  • the effect of exercise on DNA methylation in human skeletal muscle and provide evidence that acute exercise alters promoter methylation of exercise-responsive genes in a dose-dependent manner
  • DNA methylation was unaltered 48 hr after a 3-week exercise training program, whereas RNA expression of PGC-1α and TFAM promoters was elevated (data not shown), further suggesting that DNA hypomethylation is a transient mechanism involved in mRNA synthesis
  • Our findings that ionomycin, AICAR, or ROS production increased mRNA expression without altering promoter methylation may support the notion that DNA methylation does not exclusively control exercise-induced gene expression
  • acute exercise leads to transient changes in DNA methylation in adult skeletal muscle
  • Nathan Goodyear on 03 Oct 17
     
    Small study finds acute exercise is associated with epigenetic alteration of muscle through methylation.  This study found a hypomethylation of the genes PGC-1alpha, PDK4, and PPAR-delta with a respondent increase in expression.  The methylation activity was in the promoter region of these genes.
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Effects of Quercetin on Adiponectin-Mediated Insulin Sensitivity in Polycystic Ovary Sy... - 0 views

www.ncbi.nlm.nih.gov/...27824398 Quercetin inflammation insulin insulin resistance adiponectin PCOS polycystic ovary syndrome obesity hormones
shared by Nathan Goodyear on 10 Dec 17 - No Cached
  • Nathan Goodyear on 10 Dec 17
     
    Quercetin found to increase adiponectin levels within women with PCOS with insulin resistance. Adiponectin has been shown to be inversly associated with insulin and insulin resistance.  
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Endothelium and control of vascular function. State of the Art lecture. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...2661425 vitamin C NO nitric oxide blood pressure CV cardiovascular disease hypertension endothelium
shared by Nathan Goodyear on 20 Dec 17 - No Cached
  • Nathan Goodyear on 20 Dec 17
     
    vitamin C, absorbed via the endothelium, increases NO.  This will have a positive effect in lowering the blood pressure.
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Effect of Distinct Lifestyle Interventions on Mobilization of Fat Storage Pools: The CE... - 0 views

circ.ahajournals.org/...CIRCULATIONAHA.117.030501 Mediterranean diet diet nutrition lifestyle obesity lifestyle intervention weight loss
shared by Nathan Goodyear on 19 Dec 17 - No Cached
  • Nathan Goodyear on 19 Dec 17
     
    low carb mediterranean nutrition out performs low fat diet; but both are not served by following weight number.  MRI shows that fat mobilization of the superior low carb mediterranean nutrition plan is not adequately reflected in weight measurement. 
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Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras | Nature Communi... - 0 views

www.nature.com/...s41467-017-01019-z cancer glucose sugar nutrition genetics vitamin C RAS
shared by Nathan Goodyear on 20 Oct 17 - No Cached
  • glucose deprivation triggers apoptosis47 and vitamin C treatment kills RAS-oncogene expressing tumor cells, but not wild-type RAS containing cells, by inhibition of GAPDH
  • Nathan Goodyear on 20 Oct 17
     
    New study out of the UK supports the role of glucose in cancer growth and aggressiveness.  This research found that high influx of glucose into the glycolysis pathway upregulated the RAS oncogene via accumulation of the Fructose 1,6 bisphosphonate through the enzyme phosphofructokinase..
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Substantial contribution of extrinsic risk factors to cancer development - 0 views

www.ncbi.nlm.nih.gov/...PMC4836858 cancer lifestyle
shared by Nathan Goodyear on 03 Jan 18 - No Cached
  • Here we provide evidence that intrinsic risk factors contribute only modestly (<10~30%) to cancer development
  • we conclude that cancer risk is heavily influenced by extrinsic factors. These results carry immense consequences for strategizing cancer prevention
  • cancers are proposed to originate from the malignant transformation of normal tissue progenitor and stem cells
  • ...14 more annotations...
  • “Intrinsic processes” include those that result in mutations due to random errors in DNA replication whereas “extrinsic factors” are environmental factors that affect mutagenesis rates (such as UV radiation, ionizing radiation, and carcinogens
  • intrinsic factors do not play a major causal role.
  • intrinsic cancer risk should be determined by the cancer incidence for those cancers with the least risk in the entire group controlling for total stem cell divisions
  • if one or more cancers would feature a much higher cancer incidence, for example, lung cancer among smokers vs. non-smokers, then this most likely reflects additional (and probably extrinsic) risk factors (smoking in this case)
  • Particularly, for breast and prostate cancers, it has long been observed that large international geographical variations exist in their incidences (5-fold for breast cancer, 25-fold for prostate cancer)14, and immigrants moving from countries with lower cancer incidence to countries with higher cancer rates soon acquire the higher risk of their new country
  • Colorectal cancer is another high-incidence cancer that is widely considered to be an environmental disease17, with an estimated 75% or more colorectal cancer risk attributable to diet
  • melanoma, its risk ascribed to sun exposure is around 65–86%
  • non-melanoma basal and squamous skin cancers, ~90% is attributable to UV
  • 75% of esophageal cancer, or head and neck cancer are caused by tobacco and alcohol
  • HPV may cause ~90% cases in cervical cancer23, ~90% cases in anal cancer24, and ~70% in oropharyngeal cancer
  • HBV and HCV may account for ~80% cases of hepatocellular carcinoma
  • H pylori may be responsible for 65–80% of gastric cancer
  • While a few cancers have relatively large proportions of intrinsic mutations (>50%), the majority of cancers have large proportions of extrinsic mutations, for example, ~100% for Myeloma, Lung and Thyroid cancers and ~80–90% for Bladder, Colorectal and Uterine cancers, indicating substantial contributions of carcinogen exposures in the development of most cancers
  • onsistent estimate of contribution of extrinsic factors of >70–90% in most common cancer types. This concordance lends significant credibility to the overall conclusion on the role of extrinsic factors in cancer development
  • Nathan Goodyear on 03 Jan 18
     
    Really great read.  Cancer is a majority lifestyle disease.
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Integrating Thyroid Hormone Signaling in Hypothalamic Control of Metabolism: Crosstalk ... - 0 views

www.ncbi.nlm.nih.gov/...PMC6073315 thyroid thyroid receptors crosstalk thyroid hormone receptors
shared by Nathan Goodyear on 30 May 21 - No Cached
  • Nathan Goodyear on 30 May 21
     
    To be read
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