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Nathan Goodyear

Regulation of mitochondrial biogenesis by thyroid hormone - 0 views

ep.physoc.org/...121.full.pdf+html

T3 mitochondria thyroid hormone receptors TRH thyroid hormone response elements TRE hormone thyroid

shared by Nathan Goodyear on 29 Jun 13 - No Cached
  • Nathan Goodyear on 29 Jun 13
     
    Study describes the T3 effect on mitochondrial biogenesis.  T3 interacts with receptors involved with mitochondrial biogenesis in 3 ways: thyroid hormone receptors (TR), thyroid hormone receptor elements (TRE), and a combination of the two.
Nathan Goodyear

Thyroid Hormone Receptor Agonists Reduce Serum Cholesterol Independent of the LDL Receptor - 0 views

endo.endojournals.org/...6136.abstract

LDL cholesterol T3 thyroid hormone hormones receptor receptors

shared by Nathan Goodyear on 28 Nov 12 - No Cached
  • Nathan Goodyear on 28 Nov 12
     
    New study shows that T3 and thyroid hormone agonists reduce LDL.  This is independent that LDL receptors.  Previously, it was thought that T3 increased LDL receptor expression.  But, this study shows that T3 lowers LDL independent of the LDL receptors.  
Nathan Goodyear

Thyroid hormone receptors and resistance to thyroid hormone disorders - 0 views

www.ncbi.nlm.nih.gov/...PMC4578869

receptors" "thyroid hormone thyroid receptors

shared by Nathan Goodyear on 07 Nov 18 - No Cached
  • Nathan Goodyear on 07 Nov 18
     
    Great review on thyroid hormone receptors alpha and beta, which are nuclear receptors.
Nathan Goodyear

Thyroid Hormone Action Is Disrupted by Bisphenol A as an Antagonist - 0 views

jcem.endojournals.org/...5185.abstract

BPA Bisphenol A T3 thyroid hormone thyroid hormone environmental toxins

shared by Nathan Goodyear on 02 Apr 13 - No Cached
  • Nathan Goodyear on 02 Apr 13
     
    Bisphenol A (BPA) shown to interfere with the T3 and thyroid hormone receptor interaction.  This study even showed that BPA inhibited thyroid receptor transcription.
Nathan Goodyear

Minireview: Thyroid Hormone Transporters: The Knowns and the Unknowns: Molecular Endocr... - 0 views

press.endocrine.org/...me.2010-0095

thyroid hormone receptors hormones

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • the majority of TRs is located in the nucleus
  • Nathan Goodyear on 24 Sep 14
     
    thyroid hormone transportation.  The majority of the thyroid hormone receptors are in the nucleus of the cell.
Nathan Goodyear

An Adult Female With Resistance to Thyroid Hormone Mediated by Defective Thyr... - 0 views

jcem.endojournals.org/...4254.abstract

thyroid hormone receptor resistance

shared by Nathan Goodyear on 14 Nov 13 - No Cached
  • Nathan Goodyear on 14 Nov 13
     
    case study of 6 year old with thyroid hormone resistance as a mechanism of disrupted thyroid metabolism
Nathan Goodyear

JCI - Thyroid hormone resistance syndrome. Inhibition of normal receptor function by mu... - 0 views

www.jci.org/115225

thyroid hormone resistance thyroid hormone resistance syndrome

shared by Nathan Goodyear on 02 Apr 13 - No Cached
  • Nathan Goodyear on 02 Apr 13
     
    Thyroid hormone resistance is not a new term.  This study goes back to 1991.
Nathan Goodyear

Sex Hormone-Binding Globulin in the Diagnosis of Peripheral Tissue Resistance to Thyroi... - 0 views

jcem.endojournals.org/...740.abstract

hypothyroid thyroid thyroid disease T3 T4 SHBG hormone resistance hormones

shared by Nathan Goodyear on 10 Dec 12 - No Cached
  • Nathan Goodyear on 10 Dec 12
     
    T3, and T4 for that matter, increases SHBG.  This would be a novel method to determine thyroid hormone receptor insensitivity or resistance.
Nathan Goodyear

Resistance to thyroid hormone due to defective thyroid receptor alpha - 0 views

www.ncbi.nlm.nih.gov/...PMC4559105

thyroid hormone resistance thyroid hormones

shared by Nathan Goodyear on 27 Apr 16 - No Cached
  • Nathan Goodyear on 27 Apr 16
     
    Thyroid hormone resistance.
Nathan Goodyear

Integrating Thyroid Hormone Signaling in Hypothalamic Control of Metabolism: Crosstalk ... - 0 views

www.ncbi.nlm.nih.gov/...PMC6073315

thyroid thyroid receptors crosstalk thyroid hormone receptors

shared by Nathan Goodyear on 30 May 21 - No Cached
  • Nathan Goodyear on 30 May 21
     
    To be read
Nathan Goodyear

Specific 3,3′,5′-Triiodothyronine (Reverse T3) Binding Sites on Rat Liver Pla... - 0 views

informahealthcare.com/...10799898309041848

reverse T3 rT3 3 3' 5'-Triiodothyronine thyroid hormone hormones receptor

shared by Nathan Goodyear on 12 Feb 15 - No Cached
  • Nathan Goodyear on 12 Feb 15
     
    rat model finds T4 and rT3 receptors at plasma membrane.  T3 was found to bind with lower affinity than rT3 and T4 at the same receptor binding site.
Nathan Goodyear

Estradiol-induced proliferation of papillary and follicular thyroid cancer ce... - 0 views

www.spandidos-publications.com/...1067

thyroid papillary follicular cancer estrogen estradiol hormone hormones ER alpha ER-alpha ER beta ER-beta PR receptors progesterone

shared by Nathan Goodyear on 25 Nov 13 - No Cached
  • Nathan Goodyear on 25 Nov 13
     
    Estradiol increased thyroid papillary and follicular cancer cells via both ER alpha and ER beta in this study.  What is also interesting is that estradiol did not increase PR expression.
Nathan Goodyear

Arquivos Brasileiros de Endocrinologia & Metabologia - Influence of estradiol and triio... - 0 views

www.scielo.br/scielo.php

T3 triiodothyronine cancer ER ER alpha ER-alpha estrogen thyroid hormone hormones receptors Estradiol E2

shared by Nathan Goodyear on 13 Aug 14 - No Cached
  • Nathan Goodyear on 13 Aug 14
     
    Study finds T3 effects on ER-alpha is likely a non-genomic pathway.  This study found a down regulation of ER-alpha in tumor cell lines by T3.
Nathan Goodyear

Crosstalk between Integrin αvβ3 and Estrogen Receptor-α Is Involved in Thyroi... - 0 views

www.ncbi.nlm.nih.gov/...PMC3222665

ER alpha thyroid hormones thyroid integrin αvβ3 cancer ER-alpha lung cancer

shared by Nathan Goodyear on 13 Apr 21 - No Cached
  • Nathan Goodyear on 13 Apr 21
     
    Integrin αvβ3 cross talk with ER-alpha + lung cancer
Nathan Goodyear

Thyroid Hormone Causes Mitogen-Activated Protein Kinase-Dependent Phosphorylation of th... - 0 views

academic.oup.com/...2500000

estrogen breast cancer T3 thyroid hormones T4 ER alpha ER-alpha thyroid estradiol

shared by Nathan Goodyear on 30 Jan 21 - No Cached
  • Nathan Goodyear on 30 Jan 21
     
    Now, here is a kicker...T4 induces ER-alpha activation/signaling similar to estrogen.
Nathan Goodyear

PLOS ONE: Overexpression of the Mitochondrial T3 Receptor Induces Skeletal Muscle Atrop... - 0 views

www.plosone.org/...journal.pone.0005631

muscle aging T3 thyroid hormone hormones

shared by Nathan Goodyear on 29 Jun 13 - No Cached
  • Nathan Goodyear on 29 Jun 13
     
    Overexpression of T3 receptors can contribute to muscle loss with aging.  
Nathan Goodyear

PLOS ONE: Overexpression of the Mitochondrial T3 Receptor p43 Induces a Shift in Skelet... - 0 views

www.plosone.org/...journal.pone.0002501

mitochondria T3 thyroid hormone hormones muscle PPAR-gamma PPAR PGC1-alpha

shared by Nathan Goodyear on 29 Jun 13 - No Cached
  • Nathan Goodyear on 29 Jun 13
     
    T3 induces beneficial oxidative changes in muscles through its interaction with mitochondrial receptors.  PGC-1alpha and PPAR-gamma were involved in this process.  The important point here is that T3 is increasing oxidative function of muscle through interaction with mitochondria.
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