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Nathan Goodyear

Desiccated Thyroid Extract Compared With Levothyroxine in the Treatment of Hypothyroidi... - 0 views

press.endocrine.org/...jc.2012-4107

hypothyroid hypothyroidism thyroid T4 T3 hormones metabolism

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Our study has shown DTE therapy caused modest weight loss, and nearly half (48.6%) of the study patients expressed preference for DTE over l-T4
  • our study showed significantly higher TSH in the DTE-treated group, which suggests that the improvement observed in the DTE-treated group is not mediated through the changes in TSH levels
  • Nathan Goodyear on 24 Sep 14
     
    Study finds desiccated thyroid (armour thyroid) was associated with great weight loss, mood improvement than T4 alone.  Desiccated thyroid was preferred by patients in the study.  Conversion rate was 100 mcg T4 to 88 mg desiccated thyroid.
Nathan Goodyear

Minireview: Cracking the Metabolic Code for Thyroid Hormone Signaling - 0 views

www.ncbi.nlm.nih.gov/...PMC3159779

thyroid hormone hormones reverse T3 free T3 rT3 T4 metabolism

shared by Nathan Goodyear on 16 Aug 14 - No Cached
  • Nathan Goodyear on 16 Aug 14
     
    Here is a great review of thyroid hormone metabolism published in the very relevant journal Endocrinology.  The review describes the peripheral metabolism of the pro hormone T4 and the peripheral metabolism to free T3 and/or reverse T3 and the associated metabolic implications.  Why don't more endocrinologists read?This is an animal study.
Nathan Goodyear

An Adult Female With Resistance to Thyroid Hormone Mediated by Defective Thyr... - 0 views

jcem.endojournals.org/...4254.abstract

thyroid hormone receptor resistance

shared by Nathan Goodyear on 14 Nov 13 - No Cached
  • Nathan Goodyear on 14 Nov 13
     
    case study of 6 year old with thyroid hormone resistance as a mechanism of disrupted thyroid metabolism
Nathan Goodyear

Acute myocardial infarction and thyroid function: New pathophysiological and therapeuti... - 0 views

informahealthcare.com/...07853890.2011.573501

thyroid hormone hormones T3 heart attack heart health myocardial infarction MI

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    Thyroid hormone plays significant role in cardiac remodeling after acute myocardial infarction.  Thyroid hormone, particularly T3 as the vast majority of T3 is produced in heart tissue via D1 enzymatic activity, improves cardiac contractility, reduces systemic vascular resistance, reduces cardiac work load, decreases blood pressure, improves cardiac metabolism, and thus improves outcomes post MI.
Nathan Goodyear

Cracking the Code for Thyroid Hormone Signaling - 0 views

www.ncbi.nlm.nih.gov/...PMC3715916

thyroid hormone hormones T3 T4 rT3 reverse T3

shared by Nathan Goodyear on 16 Aug 14 - No Cached
  • Nathan Goodyear on 16 Aug 14
     
    nice review of thyroid physiology.  Good discussion of peripheral thyroid metabolism.
Nathan Goodyear

Thyroid Replacement Therapy and Heart Failure - 0 views

circ.ahajournals.org/...385.full

thyroid T3 hormone hormones cardiovascular disease heart health failure CHF MI myocardial infarction heart attack heart disease

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • A good biomarker of intracardiac TH signaling would be helpful but has not been identified. In the absence of such a marker, a rational, cautious therapeutic approach might be to restore and maintain over time biochemical euthyroidism as documented by normal circulating levels of TSH, FT4, and FT3.
  • a low-T3 state resulting from altered peripheral TH metabolism secondary to caloric restriction is associated with impaired cardiac contractility
  • Low-T3 syndrome is the central finding and defines the illness in a variety of acute and chronic severe nonthyroidal illnesses with cardiac origin, including MI, HF, and surgically treated cardiac disease.1 Low circulating levels of T3 in the absence of primary thyroid hypofunction have been found in 20% to 30% of patients with dilated cardiomyopathy.
  • ...1 more annotation...
  • FT3 levels were inversely correlated to coronary artery disease
  • Nathan Goodyear on 24 Sep 14
     
    Great review of the current understanding of thyroid hormone metabolism in cardiac tissue.  Low T3 and increased rT3 (via increased D3 activity) is CLEARLY associated with poor cardiac performance and post MI and CHF is associated with poor outcomes.  T3 is critical in cardiac remodeling and recovery post MI.  T3 is actually a vasodilatory in the coronary arteries.   Why a endocrinologist would call rT3 useless only points to their ignorance of the literature.
Nathan Goodyear

Small Differences in Thyroid Function May Be Important for Body Mass Index and the Occu... - 0 views

press.endocrine.org/...jc.2004-2225

Thyroid hypothyroid hypothyroidism hormone hormones BMI metabolism obesity weight

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    Even small movements of thyroid function within the "reference rage of normal" is associated with significant metabolic, BMI, and weight effects.
Nathan Goodyear

Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling: Endocri... - 0 views

press.endocrine.org/...er.2008-0019

thyroid deiodinase T3 T4 hormone hormones

shared by Nathan Goodyear on 24 Nov 14 - No Cached
  • From a broad perspective, this paradigm can be seen as an example of how hormones are activated or inactivated in a controlled fashion in specific extraglandular tissues, in an analogous role to 5α-reductase and P450 aromatase in sex steroid metabolism and to 11β-hydroxysteroid dehydrogenase in glucocorticoid metabolism.
  • Nathan Goodyear on 24 Nov 14
     
    better source for previous post on thyroid metabolism and deiodinase.
Nathan Goodyear

Metabolic Effects of Liothyronine Therapy in Hypothyroidism: A Randomized, Double-Blind... - 0 views

jcem.endojournals.org/...3466.abstract

T3 T4 hypothyroid hypothyroidism functional armour thyroid cholesterol LDL weight-loss overweight obesity metabolic effects therapy

shared by Nathan Goodyear on 08 Dec 11 - No Cached
  • Nathan Goodyear on 08 Dec 11
     
    T3 shown increase weight loss, lower LDL, decrease apolipoprotein B, decrease T cholesterol versus T4.  This flies in the face of conventional medical dogma, that T 4 (synthroid, levothyroxine) is the only route of thyroid replacement.  In fact, this suppports the use of armour thyroid, a T4/T3 combination.
Nathan Goodyear

Effects of Hypo- and Hyperthyroidism on Noradrenergic Activity and Glycerol Concentrati... - 0 views

press.endocrine.org/...jc.2003-030576

thyroid hormone adipose tissue adipose fat obesity metabolism noradrenaline norepinephrine

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    Thyroid hormone increased localized norepinephrine production and liposlys resulting in decreases SQ adipose tissue compared to hypothyroid.  This study showed a localized effect of adipose tissue by thyroid hormone. 
Nathan Goodyear

Peripheral metabolism of thyroid hormones: a revie... [Altern Med Rev. 2000] - PubMed r... - 0 views

www.ncbi.nlm.nih.gov/...10956378

hypothyroidism hypothyroid T4 T3

shared by Nathan Goodyear on 20 Dec 10 - No Cached
  • The common feature of these disorders is a low level of circulating T3, with generally normal to slightly elevated blood T4 levels and either normal or slightly suppressed TSH levels. This pattern of altered thyroid hormone levels is generally agreed to be a result of impairment in extra-thyroidal peripheral metabolism
  • Nathan Goodyear on 20 Dec 10
     
    thyroid replacement is not just about T4 (synthroid); but about T3, which is 5.4 x more potent
Nathan Goodyear

Metabolic Effects of Liothyronine Therapy in Hypothyroidism: A Randomized, Double-Blind... - 0 views

press.endocrine.org/...jc.2011-1329

T4 T3 hypothyroid hypothyroidism thyroid lipids weight loss metabolism cholesterol hormones

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • tissue euthyroidism is the net result of multiple steps including conversion of the prohormone T4 into its active metabolite T3, which is ultimately responsible for signaling at the end-organ target level
  • The circulating and intracellular pools of T3 of treated hypothyroid patients (i.e. devoid of endogenous TH production) depend entirely on the conversion of exogenous l-T4 into T3
  • TH is the major regulator of basal metabolic rate
  • ...8 more annotations...
  • The substitution of l-T3 for l-T4 caused a significant weight loss
  • The substitution of l-T3 for l-T4 caused a significant reduction in lipid parameters
  • TH action is increased in the liver, and the SHBG increase supports this hypothesis
  • The changes in serum lipid metabolism parameters are similar to the effects observed with drugs approved for the treatment of dyslipidemia
  • This differential response appears to be limited to the lipid metabolism and SHBG, whereas no differences in indices of insulin resistance were detected. This is remarkable because hyperthyroid states are associated with an increase in hepatic gluconeogenesis (37), and overt thyrotoxicosis is a known cause of secondary diabetes.
  • Despite the increase in serum T3, the l-T3 treatment did not cause major changes in cardiovascular or musculoskeletal function, as indicated by the echocardiographic and maximal exercise tolerance tests and DXA studies.
  • Similarly, no significant differences were observed in blood pressure, heart rate, or endothelial vascular function
  • In conclusion, the results of this pharmacology, proof-of-concept study indicate that replacement therapy of hypothyroidism with l-T3, compared with l-T4 causes weight loss and favorable changes in the lipid profile without appreciable side effects
  • Nathan Goodyear on 24 Sep 14
     
    Crossover study finds T3 versus T4 results in more weight loss, improved lipid management and increased SHBG without any adverse cardiovascular effects.   The T3 was dosed 3 x daily due to its short half life compared to T4.
Nathan Goodyear

Combination Treatment with T4 and T3: Toward Personalized Replacement Therapy in Hypoth... - 0 views

press.endocrine.org/...jc.2011-3399

hypothyroid hypothyroidism T4 T3 thyroid metabolism hormones

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    reference review suggests improved results with combined T4/T3 treatment for hypothyroid patients.  Also, a good review of thyroid metabolism.  Patients prefer the combination therapy versus T4 alone indicating improved symptoms with combined therapy.
Nathan Goodyear

Thyroid function and thyroid hormone metabol... [Klin Wochenschr. 1981] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...7241955

hypothyroid hypothyroidism TSH T3 syndrome low aging thyroid hormone

shared by Nathan Goodyear on 07 Feb 12 - No Cached
  • Nathan Goodyear on 07 Feb 12
     
    This study doesn't find evidence of low t3-syndrome, but suggests the impairment of TSH secretion (low TSH)is the first potential sign of thyroid dysfunction.
Nathan Goodyear

Influence of Thyroid Hormone on Progesterone Transformation in Man - 0 views

jcem.endojournals.org/...831.abstract

thyroid hormone progesterone man hormones

shared by Nathan Goodyear on 03 Jun 13 - No Cached
  • Nathan Goodyear on 03 Jun 13
     
    hormones effect each other.  In this study, thyroid found to effect progesterone metabolism in men.
Nathan Goodyear

A randomized, open-label, crossover study ... [Menopause. 2007 Nov-Dec] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17507833

BHRT HRT estrogen oral transdermal therapy treatment hormones TBG thyroid liver metabolism

shared by Nathan Goodyear on 16 Nov 11 - No Cached
  • Nathan Goodyear on 16 Nov 11
     
    oral estrogen is a bad choice as it relates to BHRT or HRT for that matter.  Compared to transdermal estrogen, oral estrogen through increasing TBG and slowed liver metabolism results in decreased thyroid hormone production.  
Nathan Goodyear

http://www.altmedrev.com/publications/5/4/306.pdf - 0 views

www.altmedrev.com/...306.pdf

thyroid hormones hormone metabolism

shared by Nathan Goodyear on 23 Feb 14 - No Cached
  • Nathan Goodyear on 23 Feb 14
     
    A good review of peripheral metabolism of thyroid hormones
Nathan Goodyear

Serum TSH, T4, and Thyroid Antibodies in the United States Population (1988 to 1994): N... - 0 views

press.endocrine.org/...jcem.87.2.8182

hypothyroid hypothyroidism thyroid TSH hormones

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    This article finds the mean TSH level in the "healthy" population to be 1.5.  Calls into question any level above that with symptoms of hypothyroid.  Full, adequate thyroid including free T3 and rT3 must be done.
Nathan Goodyear

Treatment of Resistance to Thyroid Hormone--Primum Non Nocere -- Weiss and Refetoff 84 ... - 0 views

jcem.endojournals.org/...401

thyroid hormone hormones resistance

shared by Nathan Goodyear on 19 Nov 10 - No Cached
  • Nathan Goodyear on 19 Nov 10
     
    Thyroid Hormone resistance
Nathan Goodyear

Thyroid Function Is Intrinsically Linked to Insulin Sensitivity and Endotheli... - 0 views

jcem.endojournals.org/...3337

thyroid function IR insulin resistance vascular disease

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • Nathan Goodyear on 01 Feb 11
     
    thyroid, insulin, and vascular function all linked; no linear thinking here
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