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Nathan Goodyear

Ketone bodies as a therapeutic for Alzheim... [Neurotherapeutics. 2008] - PubMed - NCBI - 0 views

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    Ketone bodies have been shown to benefit the mitochondria in the brains of those with Alzheimer's disease.  This ketosis can be achieved through low carb/protein, high fat diet.
Nathan Goodyear

DNA methylation and autoimmune disease. [Clin Immunol. 2003] - PubMed - NCBI - 0 views

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    loss of methylation plays a role in the development of autoimmune disease states.
Nathan Goodyear

Low Steroid Levels Linked to Increased Risk of Cardiovascular Disease - 0 views

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    low DHEA associated with increased cardiovascular disease risk.  This was presented at the Endocrine Society 94th Annual meeting.
Nathan Goodyear

Redox imbalance in Parkinson's disease. [Biochim Biophys Acta. 2008] - PubMed - NCBI - 0 views

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    oxidative stress and Parkinson's disease
Nathan Goodyear

Glutathione, iron and Parkinson's disease. [Biochem Pharmacol. 2002] - PubMed - NCBI - 0 views

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    Glutathione restoration should be an important role in people with Parkinson's Disease
Nathan Goodyear

Glutathione-a review on its role and significance in Parkinson's disease - 0 views

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    glutathione depletion plays early, active role in the development of Parkinson's disease
Nathan Goodyear

Molecular inflammation: Underpinnings of aging and age-related diseases 10.1016/j.arr.2008.07.002 : Ageing Research Reviews | ScienceDirect.com - 0 views

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    chronic inflammation appears to be the major player in aging and age-related chronic diseases
Nathan Goodyear

Access : The role of exercise and PGC1|[alpha]| in inflammation and chronic disease : Nature - 0 views

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    study shows increased activity and exercise delays onset of chronic disease.   Inactivity and obesity decreased the age of 
Nathan Goodyear

Multiple Sclerosis is not a Disease of the Immune System - 0 views

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    good read on an alternate hypothesis of the pathophysiology of MS. THe author proposes that MS is an inflammatory induced dysfunction of lipid metabolism. This is in contrast to the current held dogma that MS is an autoimmune disease.
Nathan Goodyear

thyroid disease and the heart - 0 views

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    nice review of how thyroid disease effects cardiac function. Notice the author of this paper describes "thy- roxine (T4) which is a prohormone and tri-iodothyronine (T3) which acts as the final mediator".
Nathan Goodyear

Homocysteine and folate as risk factors for dementia and Alzheimer disease - 0 views

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    elevated homocysteine and low folic acid levels associated with increased risk of Alzheimer's disease and dementia.
Nathan Goodyear

Effects of Testosterone on Coronary Vasomotor Regulation in Men With Coronary Heart Disease - 0 views

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    Testosterone therapy, injected intracoronary, resulted in vasodilation and improved blood flow in men with CAD.
Nathan Goodyear

TLR Signaling in the Gut in Health and Disease - 0 views

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    How the gut contributes to inflammation and disease: through TLR.
Nathan Goodyear

Reduced intravenous glutathione in the treatment of early parkinson's disease 10.1016/S0278-5846(96)00103-0 : Progress in Neuro-Psychopharmacology and Biological Psychiatry | ScienceDirect.com - 0 views

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    IV glutathione shown to slow profession of Parkinson's Disease.  IV was given at doses of 600 mg IV twice daily for 30 days.
Nathan Goodyear

Alzheimer's disease--synergistic effects of ... [J Neural Transm. 1998] - PubMed - NCBI - 0 views

  • AGEs are protein modifications that contribute to the formation of the histopathological and biochemical hallmarks of AD: amyloid plaques, neurofibrillary tangles and activated microglia
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    good review of understanding of how poor glucose control, oxidative stress result in AGE and Alzheimer's disease.
Nathan Goodyear

Controlled trial of N-acetylcysteine for patients with probable Alzheimer's disease - 0 views

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    NAC shown to improve secondary measures of cognitive function in small study in those with Alzheimer's disease. NAC proves to be a reliable means to reduce free radical induced advanced glycation end productions and resultant inflammation. Also was shown to be well tolerated.
Nathan Goodyear

Investigations on oxidativ... [Eur Arch Psychiatry Clin Neurosci. 1999] - PubMed - NCBI - 0 views

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    This study finds that AGE, advanced glycation end products, play a significant role in free radical generation and neurodegenerative disease. Quote: "... pharmacologoical approaches which break the vicious cycle of oxidative stress and neurodegeneration offer new opportunities for the treatment of AD. These approaches include AGE- inhibitors, antioxidants, and anti-inflammatory substances which prevent radical production." They focus on the pharmacological, how about the natural first?
Nathan Goodyear

JAMA Network | Archives of Neurology | Reduced Risk of Alzheimer Disease in Users of Antioxidant Vitamin SupplementsThe Cache County Study - 0 views

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    Use of Vitamin C and Vitamin E associated with a 78% reduced prevalence of Alzheimer's disease.
Nathan Goodyear

Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer Disease - 0 views

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    This study found an inverse association between elevated 8-hydroxy-2-deoxyguanosine and low antioxidants in individuals with Alzheimer's disease.
Nathan Goodyear

Low LDL cholesterol and increased risk of Parkins... [Mov Disord. 2008] - PubMed - NCBI - 0 views

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    individuals with the lowest LDL associated with a 350% increase rate of Parkinson's disease.
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