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Nathan Goodyear

Oral contraceptive use and saliva diurnal pattern of metabolic ster... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25592051

oral contraceptives Testosterone DHEA cortisol contraception hormones

shared by Nathan Goodyear on 29 Jan 15 - No Cached
  • Nathan Goodyear on 29 Jan 15
     
    Oral contraceptives shown to reduce Testosterone and DHEA in women, but no effect on cortisol was seen.
Nathan Goodyear

The effect of marjoram (Origanum majorana) tea on the hormonal prof... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25662759

PCOS herbs natural marjoram DHEA insulin

shared by Nathan Goodyear on 23 Feb 15 - No Cached
  • Nathan Goodyear on 23 Feb 15
     
    small study finds marjoram daily intake reduced DHEA and insulin and improved insulin sensitivity (when compared to placebo group) in women with PCOS.  This study too is ahead of print and only abstract is available.
Nathan Goodyear

A relationship in adrenal androgen levels between mothers and their children from a dioxin-exposed region in Vietnam - ScienceDirect - 0 views

www.sciencedirect.com/...S0048969717316911

EDC endocrine disrupting chemicals hormones endocrine disruptors agent orange DHEA androstenedione

shared by Nathan Goodyear on 04 Oct 17 - No Cached
  • Nathan Goodyear on 04 Oct 17
     
    Endocrine Disrupting Chemicals from 1970 still disrupting hormones today.  Three fold increase in DHEA in 3 year old children via saliva and androstenedione in mothers compared to controls.
Nathan Goodyear

Thieme E-Journals - Hormone and Metabolic Research / Abstract - 0 views

www.thieme-connect.com/...DOI

selenium pregnancy hormones infertility fertility DHEA hirsutism CRP MDA malondialdehyde inflammation PCOS polycystic ovary syndrome

shared by Nathan Goodyear on 11 Dec 17 - No Cached
  • Nathan Goodyear on 11 Dec 17
     
    Short study found that Selenium improved pregnancy rate compared to placebo, reduced DHEA, hirsutism, CRP and MDA
Nathan Goodyear

Postmenopausal breast cancer risk in r... [Cancer Causes Control. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...14575357

breast cancer cancer estrone estradiol testosterone hormone hormones

shared by Nathan Goodyear on 12 Jun 13 - No Cached
  • Nathan Goodyear on 12 Jun 13
     
    Breast cancer associated with high levels of estrone, estradiol, testosterone, and less with androstenedione and DHEAS.  Those individuals being doped by physicians (a whole lot) are increasing their risk of many health diseases, including breast cancer.
Nathan Goodyear

Androgen insufficiency in women: diagnostic and therapeutic implications - 0 views

humupd.oxfordjournals.org/...421.full

SHBG androgen testosterone androgens DHT women insufficiency deficiency

shared by Nathan Goodyear on 12 Jun 13 - No Cached
  • SHBG has a differing binding affinity for sex steroids in the following order; DHT > testosterone > androstenedione > estradiol > estrone
  • SHBG also weakly binds DHEA, but not DHEAS
  • Nathan Goodyear on 12 Jun 13
     
    Good discuss of androgen deficiency in women.  Also, good discussion of SHBG.  
Nathan Goodyear

Increased estrogen formation and estrogen to androgen ratio in the synovial fluid of patients with rheumatoid arthritis. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...14719200

RA rheumatoid arthritis estrogen Testosterone inflammation

shared by Nathan Goodyear on 09 May 16 - No Cached
  • Nathan Goodyear on 09 May 16
     
    high estrogen to Testosterone levels in synovial fluid in those with RA.  The authors here propose that DHEA can stimulate inflammation through aromatase activity.
Nathan Goodyear

Serum vitamin D and sex hormones levels in men and women: The Multi-Ethnic Study of Atherosclerosis (MESA). - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...28041602

vitamin d hormones Testosterone estradiol SHBG

shared by Nathan Goodyear on 09 Jan 17 - No Cached
  • Nathan Goodyear on 09 Jan 17
     
    cross sectional study finds low vitamin D associated with a decrease in SHBG and an increase in free Testosterone;  a decrease in estradiol and an increase in DHEA was seen in women.  No association with total Testosterone was found.  There are studies that show a direct decrease in testicular Testosterone production in men with low vitamin D and decrease in AR function.
Nathan Goodyear

Endogenous Sex Hormone Changes in Postmenopausal Women in the Diabetes Prevention Program - 0 views

www.ncbi.nlm.nih.gov/...PMC3410266

hormone hormones therapy diabetes metformin

shared by Nathan Goodyear on 20 Aug 13 - No Cached
  • Nathan Goodyear on 20 Aug 13
     
    I find this study a good example of the distortion in medical science.  This study looked at lifestyle changes as its effect on hormones and glucose regulation.  This study found a decrease in estrogen, decrease in DHEA, and an increase in SHBG.  However, they included metformin therapy in the lifestyle arm of the study.  What about metformin is "lifestyle"?
Nathan Goodyear

Endogenous Levels of Circulating Androgens and Risk of Crohn's Disease and Ulcerative Colitis Among Women: A Nested Case-Control Study from the Nur... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25844961

Testosterone hormone hormones IBD Crohn's disease ulcerative colitis women disease

shared by Nathan Goodyear on 29 Apr 15 - No Cached
  • Nathan Goodyear on 29 Apr 15
     
    serum Testosterone levels increasing in the normal range were found to be associated with a reduced risk of Crohn's disease in women.   No such relationship was found with ulcerative colitis, with DHEA, or with SHBG.
Nathan Goodyear

Statin Therapy Worsens Insulin Sensitivity in Women With Polycystic Ovary Syndrome (PCOS): A Prospective, Randomized, Double-Blind, Placebo-Controlled Study - 0 views

jcem.endojournals.org/...jc.2013-2674.abstract

statin insulin sensitivity resistance PCOS diabetes polycystic ovarian syndrome

shared by Nathan Goodyear on 28 Oct 13 - No Cached
  • Nathan Goodyear on 28 Oct 13
     
    statin therapy worsens insulin sensitivity in women with PCOS.  Statin therapy in this study did lower CRP, LDL and triglycerides.  Of note, DHEA decreased. This should be no surprise as statins are HMG-CoA reductase inhibitors which reduces hormone synthesis from cholesterol.
Nathan Goodyear

BioMed Central | Full text | Low salivary testosterone levels in patients with breast cancer - 0 views

www.biomedcentral.com/...547

saliva testing salivary DHEAS hormone tesosterone hormones evaluation BHRT

shared by Nathan Goodyear on 16 Nov 10 - No Cached
  • Nathan Goodyear on 16 Nov 10
     
    saliva testing used in breast cancer study
Nathan Goodyear

Dehydroepiandrosterone in systemic lupus erythemat... [Arthritis Rheum. 1995] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...8849355

dehydroepiandrosterone SLE Lupus

shared by Nathan Goodyear on 05 Jan 11 - No Cached
  • Nathan Goodyear on 05 Jan 11
     
    DHEA aids in SLE treatment for mild/moderat SLE
Nathan Goodyear

An open study of dehydroepiandrosterone in systemi... [Arthritis Rheum. 1994] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...7945493

dehydroepiandrosterone Lupus SLE

shared by Nathan Goodyear on 05 Jan 11 - No Cached
  • Nathan Goodyear on 05 Jan 11
     
    DHEA improves SLE symptom score and reduces Corticosteroid requirments
Nathan Goodyear

Dehydroepiandrosterone suppresses interleukin 10 synthesis in women with systemic lupus erythematosus - 0 views

www.ncbi.nlm.nih.gov/...PMC1754850

dehydroepiandrosterone interleukin Lupus

shared by Nathan Goodyear on 05 Jan 11 - No Cached
  • Nathan Goodyear on 05 Jan 11
     
    DHEA lowers Lupus Flares in CHinese women
Nathan Goodyear

Re: Plasma Sex Steroid Hormone Levels and Risk of Breast Cancer in Postmenopausal Women - J. Natl. Cancer Inst. - 0 views

jnci.oxfordjournals.org/...380.full

hormones breast cancer SHBG

shared by Nathan Goodyear on 28 Jan 11 - No Cached
  • Nathan Goodyear on 28 Jan 11
     
    non-SHBG bound serum estradiol, testosterone and DHEA reveal increase breast cancer risk; other studies show saliva testing equal to serum non-bound SHBG hormones
Nathan Goodyear

Effect of resistance exercise on muscle steroidogenesis | Journal of Applied Physiology - 0 views

jap.physiology.org/...1754

resistance resistance training training exercise Testosterone male female hormone hormones muscle

shared by Nathan Goodyear on 03 Sep 14 - No Cached
  • skeletal muscle cell cultures incubated with DHEA produced testosterone in a DHEA dose-dependent manner
  • Muscle joins a growing list of tissues found to be capable of steroidogenesis
  • testosterone appears to have a role in the maintenance of muscle mass in women, although the importance of this role has not yet been fully established.
  • ...7 more annotations...
  • Circulating testosterone concentrations are generally elevated following a bout of resistance exercise in men (24, 31, 46, 52), whereas findings for the effect of resistance exercise on circulating testosterone in women are equivocal, with increases (10, 42) and no changes observed (22, 31)
  • swimming (51) and treadmill running (2) can significantly increase muscle testosterone concentrations in male and female rats
  • This upregulation of muscle testosterone in rats appears, at least in part, to be due to an increase in 3β-HSD and 17β-HSD type 1 expression
  • The primary finding in this study was that muscle steroidogenesis (i.e., testosterone production) in highly resistance-trained humans was not affected by an acute bout of heavy resistance exercise
  • A secondary finding was that the apparent molecular mass of 17β-HSD type 3 was increased following a single bout of heavy resistance exercise.
  • No differences were found for muscle testosterone or steroidogenic enzyme (17β-HSD type 3 and 3β-HSD types 1 and 2) concentrations between sexes or in response to resistance exercise
  • In conclusion, heavy resistance exercise did not induce changes in muscle steroidogenesis as measured by muscle concentrations of testosterone, 3β-HSD types 1 and 2, and 17β-HSD type 3 in highly resistance-trained young men and women.
  • Nathan Goodyear on 03 Sep 14
     
    Resistance exercise did not increase muscle concentrations of Testosterone in men or women.  The individuals in this study were actively training.  These were not sedentary individuals.
Nathan Goodyear

Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism - 0 views

www.pnas.org/...1715035115.full

ibuprofen Testosterone epigenetics hormones low Testosterone low T

shared by Nathan Goodyear on 09 Jan 18 - No Cached
  • The levels of LH in the ibuprofen group had increased by 23% after 14 d of administration
  • This increase was even more pronounced at 44 d, at 33%
  • We found an 18% decrease (P = 0.056) in the ibuprofen group compared with the placebo group after 14 d (Fig. 1A) and a 23% decrease (P = 0.02) after 44 d (Fig. 1C). Taken together, these in vivo data suggest that ibuprofen induced a state of compensated hypogonadism during the trial, which occurred as early as 14 d and was maintained until the end of the trial at 44 d
  • ...27 more annotations...
  • We first investigated testosterone production after 24 and 48 h of ibuprofen exposure to assess its effects on Leydig cell steroidogenesis. Inhibition of testosterone levels was significant and dose-dependent (β = −0.405, P = 0.01 at 24 h and β = −0.664, P < 0.0001 at 48 h) (Fig. 2A) and was augmented over time
  • The AMH data show that the hypogonadism affected not only Leydig cells but also Sertoli cells and also occurred as early as 14 d of administration
  • Sertoli cell activity showed that AMH levels decreased significantly with ibuprofen administration, by 9% (P = 0.02) after 14 d (Fig. 1B) and by 7% (P = 0.05) after 44 d compared with the placebo group
  • Examination of the effect of ibuprofen exposure on both the ∆4 and ∆5 steroid pathways (Fig. 2B) showed that it generally inhibited all steroids from pregnenolone down to testosterone and 17β-estradiol; the production of each steroid measured decreased at doses of 10−5–10−4 M. Under control conditions, production of androstenediol and dehydroepiandrosterone (DHEA) was below the limit of detection except in one experiment with DHEA
  • Measuring the mRNA expression of genes involved in steroidogenesis in vitro showed that ibuprofen had a profound inhibitory effect on the expression of these genes (Fig. 3 B–D), consistent with that seen above in our ex vivo organ model. Taken together, these data examining effects on the endocrine cells confirm that ibuprofen-induced changes in the transcriptional machinery were the likely reason for the inhibition of steroidogenesis.
  • Suppression of gene expression concerned the initial conversion of cholesterol to the final testosterone synthesis. Hence, expression of genes involved in cholesterol transport to the Leydig cell mitochondria was impaired
  • A previous study reported androsterone levels decreased by 63% among men receiving 400 mg of ibuprofen every 6 h for 4 wk
  • We next examined the gene expression involved in testicular steroidogenesis ex vivo and found that levels of expression of every gene that we studied except CYP19A1 decreased after exposure for 48 h compared with controls
  • the changes in gene expression indicate that the transcriptional machinery behind the endocrine action of Leydig cells was most likely impaired by ibuprofen exposure.
  • Together, these data show that ibuprofen also directly impairs Sertoli cell function ex vivo by inhibiting transcription
  • ibuprofen use in men led to (i) elevation of LH; (ii) a decreased testosterone/LH ratio and, to a lesser degree, a decreased inhibin B/FSH ratio; and (iii) a reduction in the levels of the Sertoli cell hormone AMH
  • The decrease in the free testosterone/LH ratio resulted primarily from the increased LH levels, revealing that testicular responsiveness to gonadotropins likely declined during the ibuprofen exposure. Our data from the ex vivo experiments support this notion, indicating that the observed elevation in LH resulted from ibuprofen’s direct antiandrogenic action
  • AMH levels were consistently suppressed by ibuprofen both in vivo and ex vivo, indicating that this hormone is uncoupled from gonadotropins in adult men. The ibuprofen suppression of AMH further demonstrated that the analgesic targeted not only the Leydig cells but also the Sertoli cells, a feature encountered not only in the human adult testis but also in the fetal testis
  • ibuprofen displayed broad transcription-repression abilities involving steroidogenesis, peptide hormones, and prostaglandin synthesis
  • a chemical compound, through its effects on the signaling compounds, can result in changes in the testis at gene level, resulting in perturbations at higher physiological levels in the adult human
  • The analgesics acetaminophen/paracetamol and ibuprofen have previously been shown to inhibit the postexercise response in muscles by repressing transcription
  • Previous ex vivo studies on adult testis have indeed pointed to an antiandrogenicity, only on Leydig cells, of phthalates (41), aspirin, indomethacin (42), and bisphenol A (BPA) and its analogs
  • ibuprofen’s effects were not restricted to Leydig and Sertoli cells, as data showed that the expression of genes in peritubular cells was also affected
  • short-term exposure
  • In the clinical setting, compromised Leydig cell function resulting in increased insensitivity to LH is defined as compensated hypogonadism (4), an entity associated with all-cause mortality
  • compensated hypogonadic men present with an increased likelihood of reproductive, cognitive, and physical symptoms
  • an inverse relationship was recently reported between endurance exercise training and male sexual libido
  • AMH concentrations are lower in seminal plasma from patients with azoospermia than from men with normal sperm levels
  • inhibin B is a key clinical marker of reproductive health (32). The function of AMH, also secreted by Sertoli cells, and its regulation through FSH remain unclear in men
  • the striking dual effect of ibuprofen observed here on both Leydig and Sertoli cells makes this NSAID the chemical compound, of all the chemical classes considered, with the broadest endocrine-disturbing properties identified so far in men.
  • after administration of 600 mg of ibuprofen to healthy volunteers
  • 14 d or at the last day of administration at 44 d
  • Nathan Goodyear on 09 Jan 18
     
    ibuprofen alters genetic expression that results in decreased Testosterone production.
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