Vitamin D is an important immunomodulator. Vitamin D shown to have benefit in Th1 and Th2 mediated disease states. Asthma and COPD benefit and other Th1 mediated diseases, such as MS, type 1 Diabetes, RA...
Good article on the immunomodulation effect of vitamin D. The importance of vitamin D goes back to pregnancy. Vitamin D deficiencies during pregnancy inhibit appropriate invariant Natrual killer cells, which play important regulatory effect in autoimmune disease. Even with restoration of vitamin D levels with replacement, the full positive effects of vitamin D are not seen due to limited iNKT potential.
Incredible review to the evidence of action of artemisinin and its metabolites in cancer: apoptotic, arrest of cell growth, anti-inflammatory, immunomodulation...
Estradiol in mice predisposed to Lupus have increased inflammation and characteristics of Lupus. In contrast, Estradiol in those without predisposition, do not. Clearly this is an inflammatory signaling problem. Studies have shown an Interferon gamma signaling deficit in those with Lupus.
Testosterone decreases the above inflammation signaling.
ECHO-7 virus strain, Picornaviridae family, Enterovirus genus, Enteric Cytopathic Human Orphan (ECHO) type 7, group IV, positive-sense single-stranded RNA virus
a few side effects were reported, for example subfebrile temperature (37.5°C for a couple of days), pain in the tumour area, sleepiness and diarrhoea
In this retrospective study, however, there was no record of any untoward side effect from Rigvir treatment or its discontinuation
Early observations of tumour regressions after virus infections have been published starting from the late 19th century
The present results show that in substage IB, IIA, IIB and IIC melanoma patients, Rigvir administration after surgery significantly (P<0.05) prolongs survival compared with patients who were managed according to current published guidelines
no value higher than grade 2 was recorded in Rigvir-treated patients. This is in contrast to most other cancer therapies, where grades 3 and 4 are frequently observed
Administration of virus induces the formation of neutralising antibodies that might potentially influence the efficiency of Rigvir
In 94 healthy adult participants tested, the titres were found to be low (1 : 20 to 1 : 62) 39,40. When tested in 155 adult cancer patients who had not been treated with Rigvir, neutralising antibodies against ECHO-7 were detected in ∼50% of the patients
the presence of ECHO-7 antibodies was shown to increase with age in children and level off to a plateau of around 75% in adults
Rigvir is an immunomodulator that affects both the humoral, antibody-mediated, and the cellular immune systems
neutralising antibodies do not affect efficacy when local or regional administration is used
it reduces the viability of melanoma, as well as pulmonary, gastric, pancreatic, bone, and breast cancer cell cultures
It is oncolytic in melanoma and rectum cancer patients
shown to improve the 5-year survival in rectum cancer patients
RIGVIR shown to improve survival against standard therapy in stage IB, IIA, IIB, and IIC in malignant melanoma patients in retrospective study. Side effects are minimal. Neutralizing antibodies are an area to watch that likely effects individual outcome beyond that of the type of cancer
Awesome read on the immune system and cancer. Specifically, the acid/base environment in the local cancer bed and its effects on the immune system and therapies.