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Nathan Goodyear

A Review of the Role of Wnt in Cancer Immunomodulation - 0 views

www.mdpi.com/...htm

Wnt TME tumor microenvironment cancer

shared by Nathan Goodyear on 23 Aug 19 - No Cached
  • Nathan Goodyear on 23 Aug 19
     
    Wnt provides immunomodulation to suppress the immune response in the TME.
Nathan Goodyear

Effects of vitamin D on immune disorders with special regard to asthma, COPD and autoim... - 0 views

www.expert-reviews.com/...ers.12.57

vitamin d vitamin autoimmune diseases asthma COPD

shared by Nathan Goodyear on 12 Aug 13 - No Cached
  • Nathan Goodyear on 12 Aug 13
     
    Vitamin D is an important immunomodulator.  Vitamin D shown to have benefit in Th1 and Th2 mediated disease states. Asthma and COPD benefit and other Th1 mediated diseases, such as MS, type 1 Diabetes, RA...
Nathan Goodyear

Symposium 3: Vitamin D and immune function: from pregnancy to adolescence - 0 views

www.ncbi.nlm.nih.gov/...PMC3733090

vitamin d vitamin immune function Natural killer cells invariant NKT iNKT pregnancy

shared by Nathan Goodyear on 12 Aug 13 - No Cached
  • Nathan Goodyear on 12 Aug 13
     
    Good article on the immunomodulation effect of vitamin D.  The importance of vitamin D goes back to pregnancy.   Vitamin D deficiencies during pregnancy inhibit appropriate invariant Natrual killer cells, which play important regulatory effect in autoimmune disease.  Even with restoration of vitamin D levels with replacement, the full positive effects of vitamin D are not seen due to limited iNKT potential.
Nathan Goodyear

Immunomodulatory effects of Vitamin D in multiple sclerosis - 0 views

brain.oxfordjournals.org/...1146.long

Vitamin D MS multiple Sclerosis multiple sclerosis Th17 T reg T-reg

shared by Nathan Goodyear on 12 Aug 13 - No Cached
  • Nathan Goodyear on 12 Aug 13
     
    Vitamin D has an important immunomodulating role in MS.  Vitamin D increases Treg cells and decreases IL-6, but more importantly IL-17.
Nathan Goodyear

Vitamin D-mediated immune regulation in multipl... [J Neurol Sci. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21723567

vitamin D vitamin D MS multiple sclerosis T reg T-reg

shared by Nathan Goodyear on 12 Aug 13 - No Cached
  • Nathan Goodyear on 12 Aug 13
     
    Vitamin D's immunomodulating role is an important tool in those with MS. Particularily, it increases T reg cells.
Nathan Goodyear

Artemisinin and its derivatives in cancer therapy: status of progress, mechanism of act... - 0 views

link.springer.com/...10.1007%2Fs00280-017-3251-7

artemisinin artesunate cancer

shared by Nathan Goodyear on 14 May 19 - No Cached
  • Nathan Goodyear on 14 May 19
     
    Incredible review to the evidence of action of artemisinin and its metabolites in cancer: apoptotic, arrest of cell growth, anti-inflammatory, immunomodulation...
Nathan Goodyear

Methionine enkephalin (MENK) improved the functions of bone marrow-derived dendritic ce... - 0 views

www.ncbi.nlm.nih.gov/...PMC3579904

cancer MET-enkephalin MET-5

shared by Nathan Goodyear on 15 Aug 21 - No Cached
  • Nathan Goodyear on 15 Aug 21
     
    MET-enkephalin acts as an immunomodulator via dendritic cell and CD8 activity
Nathan Goodyear

Sex hormones as immunomodulators in heal... [Int Immunopharmacol. 2001] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11407317

Lupus SLE inflammation Sex hormones hormone Estradiol Testosterone

shared by Nathan Goodyear on 31 Jul 13 - No Cached
  • Nathan Goodyear on 31 Jul 13
     
    Estradiol in mice predisposed to Lupus have increased inflammation and characteristics of Lupus.  In contrast, Estradiol in those without predisposition, do not.  Clearly this is an inflammatory signaling problem.  Studies have shown an Interferon gamma signaling deficit in those with Lupus.  Testosterone decreases the above inflammation signaling.
Nathan Goodyear

Adapted ECHO-7 virus Rigvir immunotherapy (oncolytic virotherapy) prolongs survival in ... - 0 views

www.ncbi.nlm.nih.gov/...PMC4560272

RIGVIR cancer oncolytic therapy immunotherapy cancer immunotherapy

shared by Nathan Goodyear on 16 Oct 18 - No Cached
  • Rigvir is a 2 ml frozen solution
  • ECHO-7 virus strain, Picornaviridae family, Enterovirus genus, Enteric Cytopathic Human Orphan (ECHO) type 7, group IV, positive-sense single-stranded RNA virus
  • a few side effects were reported, for example subfebrile temperature (37.5°C for a couple of days), pain in the tumour area, sleepiness and diarrhoea
  • ...12 more annotations...
  • In this retrospective study, however, there was no record of any untoward side effect from Rigvir treatment or its discontinuation
  • Early observations of tumour regressions after virus infections have been published starting from the late 19th century
  • The present results show that in substage IB, IIA, IIB and IIC melanoma patients, Rigvir administration after surgery significantly (P<0.05) prolongs survival compared with patients who were managed according to current published guidelines
  • no value higher than grade 2 was recorded in Rigvir-treated patients. This is in contrast to most other cancer therapies, where grades 3 and 4 are frequently observed
  • Administration of virus induces the formation of neutralising antibodies that might potentially influence the efficiency of Rigvir
  • In 94 healthy adult participants tested, the titres were found to be low (1 : 20 to 1 : 62) 39,40. When tested in 155 adult cancer patients who had not been treated with Rigvir, neutralising antibodies against ECHO-7 were detected in ∼50% of the patients
  • the presence of ECHO-7 antibodies was shown to increase with age in children and level off to a plateau of around 75% in adults
  • Rigvir is an immunomodulator that affects both the humoral, antibody-mediated, and the cellular immune systems
  • neutralising antibodies do not affect efficacy when local or regional administration is used
  • it reduces the viability of melanoma, as well as pulmonary, gastric, pancreatic, bone, and breast cancer cell cultures
  • It is oncolytic in melanoma and rectum cancer patients
  • shown to improve the 5-year survival in rectum cancer patients
  • Nathan Goodyear on 16 Oct 18
     
    RIGVIR shown to improve survival against standard therapy in stage IB, IIA, IIB, and IIC in malignant melanoma patients in retrospective study. Side effects are minimal. Neutralizing antibodies are an area to watch that likely effects individual outcome beyond that of the type of cancer
Nathan Goodyear

ScienceDirect - 0 views

www.sciencedirect.com/...S1044579X17300366

Cancer immunotherapy immune system acid alkaline immunomodulation

shared by Nathan Goodyear on 16 Nov 18 - No Cached
  • Nathan Goodyear on 16 Nov 18
     
    Awesome read on the immune system and cancer. Specifically, the acid/base environment in the local cancer bed and its effects on the immune system and therapies.
Nathan Goodyear

Increasing the Effectiveness of Intravenous Vitamin C as an Anticancer Agent - ISOM - 0 views

www.isom.ca/...tamin-c-as-an-anticancer-agent

vitamin C "IV vitamin C" ozone cancer immunotherapy

shared by Nathan Goodyear on 16 May 17 - No Cached
  • Nathan Goodyear on 16 May 17
     
    Good review of ways to increase the anti-cancer efficacy of IV vitamin C.
Nathan Goodyear

Vitamin D and the immunomodulation of rotator cuff injury - 0 views

www.ncbi.nlm.nih.gov/...PMC4913983

vitamin d sports injury sports medicine sports athletes inflammation

shared by Nathan Goodyear on 19 Oct 16 - No Cached
  • Nathan Goodyear on 19 Oct 16
     
    vitamin D important in healing sports injuries.
Nathan Goodyear

Cancer acidity: An ultimate frontier of tumor immune escape and a novel target of immun... - 0 views

www.sciencedirect.com/...S1044579X17300366

TME cancer tumor microenvironment acid tumor cancer acidic pH

shared by Nathan Goodyear on 19 Apr 20 - No Cached
  • Nathan Goodyear on 19 Apr 20
     
    Acidic pH in TME favors cancer growth and spread immunologically.
Nathan Goodyear

Dichloroacetate improves immune dysfunction caused by tumor-secreted lactic acid and in... - 0 views

pubmed.ncbi.nlm.nih.gov/23420584

tumor microenvironment TME immunosuppression cancer immunomodulation DCA lactic acid

shared by Nathan Goodyear on 13 Mar 21 - No Cached
  • Nathan Goodyear on 13 Mar 21
     
    The title tells all: Dichloroacetate improves immune dysfunction caused by tumor-secreted lactic acid and increases antitumor immunoreactivity
Nathan Goodyear

A Randomized Phase II Preoperative Study of Autophagy Inhibition With High-Dose Hydroxy... - 0 views

www.ncbi.nlm.nih.gov/...PMC8086597

immunomodulation hydroxychloroquine pancreatic cancer autophagy inhibitor

shared by Nathan Goodyear on 03 May 21 - No Cached
  • Nathan Goodyear on 03 May 21
     
    Preoperative hydroxychloroquine shows benefit as autophagy inhibitor in conjunction with surgery and chemotherapy
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