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Nathan Goodyear

The Ketogenic Diet and Sport: A Possible Marriage? : Exercise and Sport Sciences Reviews - 0 views

journals.lww.com/..._and_Sport___A_Possible.8.aspx

nutrition diet ketogenic ketogenic diet sports athletes exercise sports medicine

shared by Nathan Goodyear on 16 Nov 16 - No Cached
  • It is important to note that, although the blood level of glucose drops, it still remains at a physiological level (23), which is maintained through gluconeogenesis involving glucogenic amino acids and also glycerol released from triglycerides
  • “physiological ketosis” where KB levels may rise to 7 to 8 mmol L-1 (but without any pH change). In “pathological diabetic ketoacidosis,” on the other hand, ketonemia can exceed 20 mmol L-1 and also cause lowering of blood pH
  • in the initial phase of KD, about 16% of glucose comes from glycerol (released from triglyceride hydrolysis) and the bulk (60–65 g) from proteins via gluconeogenesis (proteins may be of either dietary or endogenous origin
  • ...5 more annotations...
  • the protein supply consumed during a KD “preserves,” as demonstrated, lean body mass
  • The importance of glycerol as a glucose source increases progressively during ketosis; in fact, glycerol passes from supplying 16% of total glucose to an average of 60% after many days (>7 d) of complete fasting (from 38% in lean individual to 79% in the obese).
  • The possible reasons for the effectiveness of KD for weight loss may be listed as follows, in order of evidence, strongest first: Figure 3Image Tools 1. Appetite reduction: protein satiety, effects on appetite-related hormones such as ghrelin, and possibly a sort of direct appetite-blocking effect of KB 2. Reduced lipogenesis and increased fat oxidation 3. A reduction in respiratory quotient may indicate a greater metabolic efficiency in fat oxidation 4. A thermic effect of proteins and increased energy usage by gluconeogenesis
  • all data regarding biochemical and molecular mechanisms suggest that it is very difficult to increase muscle mass during a KD; use of which really should be limited to the few days immediately before competition in bodybuilding.
  • a long-term KD can interfere with some muscle hypertrophy mechanisms and this could be counterproductive if the aim of the athlete is to gain muscle mass
  • Nathan Goodyear on 16 Nov 16
     
    Great read on the ketogenic  and its application to sports/training...
Nathan Goodyear

Association of handgrip strength to cardiovascular mortality in pre-diabetic and diabetic patients: A subanalysis of the ORIGIN trial (PDF Download Available) - 0 views

www.researchgate.net/...ubanalysis_of_the_ORIGIN_trial

strength muscle hand-grip strength hand-grip strength test mortality diabetes CVD cardiovascular disease autoimmune inflammation

shared by Nathan Goodyear on 21 Jun 16 - No Cached
  • Nathan Goodyear on 21 Jun 16
     
    Handgrip strength test is found to be associated inversely with mortality and cardiovascular events in men and women with diabetes and glucose dysregulation.  Strength is more predictive of morality in men versus women, but this study finds predictive value for both.
Nathan Goodyear

The origins of age-related proinflammatory state - 0 views

bloodjournal.hematologylibrary.org/...2294.full

inflammation aging cytokines immune system adipocytokines

shared by Nathan Goodyear on 25 Apr 12 - No Cached
  • Nathan Goodyear on 25 Apr 12
     
    aging found to be associated with a rise in inflammatory markers.  This leads to the theory that age-related diseases are in part due to chronic inflammation
Nathan Goodyear

The Androgen Derivative 5α-Androstane-3β,17β-Diol Inhibits Prostate Cancer Cell Migration Through Activation of the Estrogen Receptor β Subtype - 0 views

cancerres.aacrjournals.org/...5445.full

prostate cancer 3-beta androstanediol DHT metabolite E-cadherin ER beta ER-beta male hormone hormones men

shared by Nathan Goodyear on 27 Jan 14 - No Cached
  • In the early stages, prostate cancer growth is dependent on circulating androgens
    • Nathan Goodyear
      Nathan Goodyear on 27 Jan 14
       
      This is in contrast to studies that show poor prognosis with Lower T at time of diagnosis of prostate cancer
  • 5α-reductase not only provides a potent amplification of the androgenic signal ( 4– 6), but it also prevents estrogen formation by subtracting testosterone from the action of aromatase ( 7, 8), thus blocking activation of the estrogen receptor subtypes (ERα and ERβ; refs. 9, 10)
  • ERβ is the prevailing subtype ( 11), and a growing body of evidence points to the protective role of this receptor in prostate cancer
  • ...3 more annotations...
  • It has been shown that the transformation of the dihydrotestosterone to 5α-androstane-3α,17β-diol (3α-diol) and 5α-androstane-3β,17β-diol (3β-Adiol), generates two metabolites unable to bind the androgen receptor, but possessing a very high affinity for the estrogen receptors
  • the effects of testosterone may result from the balance between the androgenic and the estrogenic molecules originating from its catabolism.
  • Recent data have been published postulating a direct estrogenic role of the 3β-hydroxylated derivatives of dihydrotestosterone in the prostate development and homeostasis
  • Nathan Goodyear on 27 Jan 14
     
    Here is the full article.
Nathan Goodyear

Transdermal testosterone replacement therapy in men - 0 views

www.ncbi.nlm.nih.gov/...PMC3891651

Testosterone replacement transdermal low T male hormone hormones

shared by Nathan Goodyear on 05 Feb 14 - No Cached
  • a recent study has suggested that it may sometimes be inaccurate because of abnormal fluctuation of other circulating androgens
    • Nathan Goodyear
      Nathan Goodyear on 05 Feb 14
       
      The authors are referencing the increase in the suggestions to use other testing techniques i.e. saliva.
  • Testosterone therapy can inhibit hepcidin transcription and is associated with increased iron incorporation into red blood cells and increased erythropoietin concentrations
  • Transdermal TRT has a more favorable adverse effect profile when compared to buccal testosterone formulations
  • ...13 more annotations...
  • Approximately 0.3% of testosterone is converted into estradiol by aromatase (CYP19A1)
  • the recommendation for injectable testosterone esters is to check the serum concentration midway between injections
  • it is recommended for serum testosterone to be evaluated 3 to 12 hours after application of the transdermal patch
  • testosterone concentrations should be checked 2–3 months after initiation of therapy and after adjusting the dose
  • a study from 1989 utilizing testosterone transdermally containing 5, 10, or 15 mg of testosterone showed that peak concentrations of testosterone were achieved 3 to 8 hours after scrotal application in hypogonadal men
  • It is used for many medications and has the advantage of high bioavailability, absence of hepatic first pass metabolism, increased therapeutic efficacy, and steadiness of plasma concentrations of the drug
  • evaluate serum testosterone at the end of the dosing interval for testosterone pellets
  • increased amount of fat leads to increased extragonadal aromatase activity, resulting in increased concentrations of estradiol. High circulating concentrations of estradiol down regulate the HPG axis and decrease the amount of circulating testosterone
  • Up to 80% of plasma estradiol originates from aromatization of testosterone and less than 20% of estradiol in the circulation is secreted by the testes
  • A PSA concentration, digital rectal examination, and hematocrit should be performed at baseline and at 3 months, 6 months, then yearly after TRT is initiated.
  • measure serum testosterone any time after the patient has been on treatment with gel for at least 1 week
  • If the hematocrit rises above 54%, treatment should be discontinued
  • elderly men having higher estradiol serum concentrations than postmenopausal women
Nathan Goodyear

Scopus preview - Scopus - Document details - 0 views

www.scopus.com/...display.url

mercury Hg superoxide disumutase NAC N-acetylcysteine

shared by Nathan Goodyear on 10 Oct 13 - No Cached
  • Nathan Goodyear on 10 Oct 13
     
    Mercury decreases levels of superoxide dismutase in the lungs of rats exposed.  This study found NAC found to be protective.
Nathan Goodyear

Scopus - Document details - 0 views

www.scopus.com/...display.url

cancer immune system NK cells NK natural killer cells innate

shared by Nathan Goodyear on 15 Jun 14 - No Cached
  • Nathan Goodyear on 15 Jun 14
     
    Stress decreases the innate immune response.  This is critical in the battle against cancer.  Specifically, low NK activity is found in stress individuals with cancer.
Nathan Goodyear

Scopus preview - Scopus - Document details - 0 views

www.scopus.com/...display.url

BDNF brain derived neurotrophic factor neuroplasticity

shared by Nathan Goodyear on 03 Nov 13 - No Cached
  • Nathan Goodyear on 03 Nov 13
     
    BDNF promotes neurogenesis
Nathan Goodyear

Scopus - Document details - 0 views

www.scopus.com/...display.url

high protein amino acid diet insulin resistance

shared by Nathan Goodyear on 21 Oct 13 - No Cached
  • Nathan Goodyear on 21 Oct 13
     
    Overnutrition through high protein intake associated with liver and skeletal muscle insulin resistance.
Nathan Goodyear

Scopus - Document details - 0 views

www.scopus.com/...display.url

amino acids high protein diet insulin resistance

shared by Nathan Goodyear on 21 Oct 13 - No Cached
  • Nathan Goodyear on 21 Oct 13
     
    Amino acids contribute to skeletal muscle insulin resistance.  A marked glycogen synthesis decrease (64%) was found in this study.
Nathan Goodyear

Scopus - Document details - 0 views

www.scopus.com/...display.url

high protein diet Diabetes insulin resistance

shared by Nathan Goodyear on 22 Oct 13 - No Cached
  • Nathan Goodyear on 22 Oct 13
     
    High protein intake associated with increased type II Diabetes.  Many take in too much protein and actually need to increase fat and fiber rich carbs.
Nathan Goodyear

Guidelines have done more harm than good. [Blood Purif. 2008] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...18182801

medical practice medicine guidelines standard of care

shared by Nathan Goodyear on 12 May 11 - No Cached
  • Guidelines certainly do not encourage clinicians to consider and treat each patient as an individual
  • This all but guarantees many guidelines are obsolete by the time they are published
  • unlikely to stimulate original research
  • ...2 more annotations...
  • reated by a process that is artificial, laborious and cumbersome
  • uidelines are produced with industry support and recommendations often have a major impact on sales of industry products
  • Nathan Goodyear on 12 May 11
     
    Medical guidelines likely do more harm than good
Nathan Goodyear

NMJ Original Research: Reproducibility and Reliability of Two Food Allergy Testing Methods - Natural Medicine Journal: The Official Journal of the American Association of Naturopathic Physicians - 0 views

www.naturalmedicinejournal.com/article_content.asp

ALCAT

shared by Nathan Goodyear on 02 May 11 - No Cached
  • Nathan Goodyear on 02 May 11
     
    ALCAT shown to be reproducible and reliable
Nathan Goodyear

Thyroid Replacement Therapy and Heart Failure - 0 views

circ.ahajournals.org/...385.full

thyroid T3 hormone hormones cardiovascular disease heart health failure CHF MI myocardial infarction heart attack heart disease

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • A good biomarker of intracardiac TH signaling would be helpful but has not been identified. In the absence of such a marker, a rational, cautious therapeutic approach might be to restore and maintain over time biochemical euthyroidism as documented by normal circulating levels of TSH, FT4, and FT3.
  • a low-T3 state resulting from altered peripheral TH metabolism secondary to caloric restriction is associated with impaired cardiac contractility
  • Low-T3 syndrome is the central finding and defines the illness in a variety of acute and chronic severe nonthyroidal illnesses with cardiac origin, including MI, HF, and surgically treated cardiac disease.1 Low circulating levels of T3 in the absence of primary thyroid hypofunction have been found in 20% to 30% of patients with dilated cardiomyopathy.
  • ...1 more annotation...
  • FT3 levels were inversely correlated to coronary artery disease
  • Nathan Goodyear on 24 Sep 14
     
    Great review of the current understanding of thyroid hormone metabolism in cardiac tissue.  Low T3 and increased rT3 (via increased D3 activity) is CLEARLY associated with poor cardiac performance and post MI and CHF is associated with poor outcomes.  T3 is critical in cardiac remodeling and recovery post MI.  T3 is actually a vasodilatory in the coronary arteries.   Why a endocrinologist would call rT3 useless only points to their ignorance of the literature.
star yu

Qué es causa patogenesia de la hipertensión nefropatía - 0 views

www.hospitalrenal.com/...558.html

nefropatía hipertensiva.

shared by star yu on 14 Feb 15 - No Cached
  • star yu on 14 Feb 15
     
    Departamento de nefropatía hipertensiva original hipertensión causa benigno arterias pequeñas nefroesclerosis.(se llama hipertensiva renal arteriosclerosis) y maligno nefroesclerosis arteriolar malignoYacompañado de las manifestaciones clínicas adecuadas de la enfermedad Normalmente hay muchos años historia enfermedad de la hipertensión.El daño de tubular más temprano que glomerular.La noche orina aumenta.La función de concentración de la orina solta,la orino cambia menos,hay menos proteinuria,hay hematuria y tubo en bajo de espejo,normalmente hay otras enfermedad de órgano blanco.
star yu

El Paciente de Nefropatía Diabética con la Creatinina 7.2 Puede Evitar la Diálisis - 0 views

www.enfermedad-renal.com/...2718.html

diálisis creatinina el tratamiento La nefropatía diabética

shared by star yu on 08 Dec 15 - No Cached
  • star yu on 08 Dec 15
     
    Es sabido por todos que la nefropatía diabética es causada por largos términos de la diabetes, así como paciente de nefropatía diabètica con tan alto nivel de creatinina ,si quieres evitar la diálisis ,debe controlar bien su enfermedad original ,los siguientes son todos que le recomiendo los tratamientos efectivos.
star yu

Una Muchacha con el Trasplante Renal Falló Encuentra una Salida - 0 views

www.hospitalrenal.com/...1088.html

Micro-Medicina China osmoterapiala diálisisel trasplante renal

shared by star yu on 15 Dec 15 - No Cached
  • star yu on 15 Dec 15
     
    Una muchacha con el trasplante renal falló encuentra su cambio de consulta externa . Nombre: Takun Género: Femenino Edad: 19 Estado Civil: Soltero Nacionalidad: Mauricio Tipo de original de Enfermedades: Síndrome nefrótico Historia médica: Hace 17 años, se le diagnosticó como el paciete de síndrome nefrótico .
star yu

La Nefropatía Diabética con la Creatinina 6.5 Cómo Curarla - 0 views

www.hospitalrenal.com/...1056.html

Micro-Medicina China osmoterapiala nefropatía diabéticala creatininael tratamiento

shared by star yu on 03 Dec 15 - No Cached
  • star yu on 03 Dec 15
     
    Como todos sabemos la nefropatía diabética es causada por largas penas de diabetes. Así que si usted quiere controlar bien esta enfermedad, se debe controlar bien la enfermedad original. En base a este punto, usted debe tomar un tratamien Como todos sabemos la nefropatía diabética es causada por largas penas de diabetes .
Nathan Goodyear

Effect of the oncolytic ECHO-7 virus Rigvir® on the viability of cell lines of human origin in vitro - 0 views

www.ncbi.nlm.nih.gov/...PMC5868171

RIGVIR cancer immunotherapy immunotherapy cancer

shared by Nathan Goodyear on 19 Oct 18 - No Cached
  • Nathan Goodyear on 19 Oct 18
     
    In vitro studies confirm reduced viability of melanoma, rhabdomyoscarcoma, gastric adenocarcinoma, lun carcinoma, and pancreas adenocarcinoma cells with the use of the oncolytic RIGVIR virus
Nathan Goodyear

Ki-67 is a prognostic parameter in breast cancer patients: results of a large population-based cohort of a cancer registry - 0 views

www.ncbi.nlm.nih.gov/...PMC3669503

ki-67 cancer breast cancer

shared by Nathan Goodyear on 06 Sep 18 - No Cached
  • A wide range of techniques is available to assess tumor cell proliferation such as calculating mitotic figures in stained tissue segments, flow cytometric analysis to determine the proportion of cells being in the S phase of the cell cycle, examination of thymidine-labeling index, proliferating cell nuclear antigen (PCNA), or cyclins E and D
  • Ki-67 is a nuclear protein being associated with cellular proliferation and was originally identified by Gerdes et al.
  • Ki-67 nuclear antigen is expressed in certain phases of the cell cycle namely S, G1, G2, and M phases, but is nonexisting in G0
  • ...11 more annotations...
  • Ki-67 is also expressed at low levels (<3 % of cells) in ER-negative cells, but not in ER-positive cells
  • A meta-analysis involving 12,155 patients demonstrated that the Ki-67 positivity confers a higher risk of recurrence and a worse survival rate in patients with early breast cancer.
  • high levels of Ki-67 are associated with worse prognoses
  • Ki-67 was associated with worse survival rates
  • associated with proliferation
  • higher tumor stages and higher nodal status were associated with higher Ki-67 quartiles indicating that the more aggressive the tumor is the higher is the percentage of cells positively stained for Ki-67
  • Previous studies were able to demonstrate that a prognostic model, the IHC 4 score, using ER, PR, HER2, and Ki-67 provides similar prognostic information to that in the 21-gene Genomic Health recurrence score
  • ER status has been largely identified as being inversely correlated with Ki-67, with the higher rates of ER positivity shown in the lowest proliferating tumors
  • high levels of Ki-67 are associated with HER2/-neu positivity according to former studies
  • higher values of Ki-67-labeling index were associated with adverse prognostic factors
  • Ki-67-labeling index was associated with larger tumors, higher tumor grade, peritumoral vascular invasion, and HER-2 positivity
  • Nathan Goodyear on 06 Sep 18
     
     Increased disease free survival and overall survival in people with breast cancer with ki-67 <15%
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