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https://www.thefastleanpro.us/ - 0 views

www.thefastleanpro.us

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shared by fitspresso on 27 Sep 23 - No Cached
  • fitspresso on 27 Sep 23
     
    Fast Lean Pro™ (official) | weight lose Formula thefastleanpro.us · by Fast Lean Pro Fast Lean Pro Only $49/Bottle Limited Time Offer! Fast Lean Pro Special Deal + Special 51% Discount Save $300 + 180 Days Money Back Guarantee FastLeanPro The #1 Solution To natural metabolism booster helps you lose weight quickly without starving yourself. Fast Lean Pro is a natural powder supplement for weight loss that has recently been developed by Japanese scientists. Regular Price: $99/per bottle Only for: $49/per bottle What Is Fast Lean Pro? Fast Lean Pro is a powdered dietary powdery supplement designed to aid in weight loss. It contains a unique combination of ingredients that are believed to activate the body's "fasting switch" to optimize results. This product focuses not only on weight loss but also on promoting cellular rejuvenation, fasting, and a healthy metabolism. The concept behind Fast Lean Pro is that incorporating fasting into one's lifestyle can lead to positive outcomes irrespective of individual food choices and eating habits. To comprehend the mechanism of the Fast Lean Pro process, it is necessary to delve into its specific details. One of the few weight loss pills on the market that contains Fibersol is Fast Lean Pro. This safe, specialized fiber adds bulk to its weight when combined with water, curbing your appetite before it throws off your meal plan. If you're trying to lose weight or curb your appetite, Fast Lean Pro can help. Supporting substances such as niacin and chromium contribute to this. The body can further benefit from these nutrients, such as through improved metabolic regulation. Fast lean Pro is non-GMO, vegan friendly, and contains no artificial ingredients or stimulants. Fast Lean Pro is a weight loss product that promotes the body's natural self-feeding process. The body naturally removes old, damaged cells through a process known as autophagy to encourage cell regeneration and repair. Recent studies by a group
Nathan Goodyear

Metabolite profiles and the risk of developing diabetes : Nature Medicine : Nature Publ... - 0 views

www.nature.com/...nm.2307.html

diabetes metabolism branch chain overload hypothesis branched chain amino acids amino acids protein isoleucine leucine valine tyrosine phenylalanine

shared by Nathan Goodyear on 21 Oct 13 - No Cached
  • Nathan Goodyear on 21 Oct 13
     
    High amino acid intake associated with 5 fold higher risk of Diabetes.  The risk required 3 out of 5 amino acids isoleucine, leucine, valine, tyrosine, and phenylalanine.
Nathan Goodyear

Branched Chain Amino Acid Supplementation for Patients with Cirrhosis | Clinical Correl... - 0 views

www.clinicalcorrelations.org/?p=3544

BCCA branched chain amino acids liver cirrhosis hepatitis amino acids

shared by Nathan Goodyear on 05 Oct 15 - No Cached
  • low level of BCAAs in patients with cirrhosis is hypothesized to be one of multiple factors responsible for development of hepatic encephalopathy
  • supplementation of BCAAs is thought to facilitate ammonia detoxification by supporting synthesis of glutamine, one of the non-branched chain amino acids, in skeletal muscle and in the brain as well as diminishing the influx of AAAs across the blood-brain barrier
  • oral BCAA supplementation is more useful in chronic encephalopathic patients than is parenteral BCAA supplementation in patients with acute encephalopathy
  • ...35 more annotations...
  • malnutrition progressing to cachexia is another common manifestation of cirrhosis
  • Malnutrition can be mitigated with BCAA supplementation
  • Studies show that administration of amino acid formulas enriched with BCAAs can reduce protein loss, support protein synthesis, and improve nutritional status of patients with chronic liver disease
  • Leucine has been shown to be the most effective of the BCAAs because it acts via multiple pathways to stimulate protein synthesis
  • BCAAs metabolites inhibit proteolysis
  • Patients with cirrhosis have both insulin deficiency and insulin resistance
  • BCAAs (particularly leucine) help to reverse the catabolic, hyperglucagonemic state of cirrhosis both by stimulating insulin release from the pancreatic β cells and by decreasing insulin resistance allowing for better glucose utilization
  • Coadministration of BCAAs and glucose has been found to be particularly useful
  • BCAA supplementation improves protein-energy malnutrition by improving utilization of glucose, thereby diminishing the drive for proteolysis, inhibiting protein breakdown, and stimulating protein synthesis
  • Cirrhotic patients have impaired immune defense, characterized by defective phagocytic activity and impaired intracellular killing activity
  • another effect of BCAA supplementation is improvement of phagocytic function of neutrophils and possibly improvement in natural killer T (NKT) cell lymphocyte activity
  • BCAA supplementation may reduce the risk of infection in patients with advanced cirrhosis not only through improvement in protein-energy malnutrition but also by directly improving the function of the immune cells themselves
  • BCAA administration has also been shown to have a positive effect on liver regeneration
  • A proposed mechanism for improved liver regeneration is the stimulatory effect of BCAAs (particularly leucine) on the secretion of hepatocyte growth factor by hepatic stellate cells
  • BCAAs activate rapamycin signaling pathways which promotes albumin synthesis in the liver as well as protein and glycogen synthesis in muscle tissue
  • Chemical improvement with BCAA treatment is demonstrated by recovery of serum albumin and lowering of serum bilirubin levels
  • long-term oral BCAA supplementation was useful in staving off malnutrition and improving survival by preventing end-stage fatal complications of cirrhosis such as hepatic failure and gastrointestinal bleeding
  • The incidence of death by any cause, development of liver cancer, rupture of esophageal varices, or progression to hepatic failure was decreased in the group that received BCAA supplementation
  • Patients receiving BCAA supplementation also have a lower average hospital admission rate, better nutritional status, and better liver function tests
  • patients taking BCAA supplementation report improved quality of life
  • BCAAs have been shown to mitigate hepatic encephalopathy, cachexia, and infection rates, complications associated with the progression of hepatic cirrhosis
  • BCAAs make up 20-25% of the protein content of most foods
  • Highest levels are found in casein whey protein of dairy products and vegetables, such as corn and mushrooms. Other sources include egg albumin, beans, peanuts and brown rice bran
  • In addition to BCAAs from diet, oral supplements of BCAAs can be used
  • Oral supplementation tends to provide a better hepatic supply of BCAAs for patients able to tolerate PO nutrition as compared with IV supplementation, especially when treating symptoms of hepatic encephalopathy
  • Coadministration of BCAAs with carnitine and zinc has also been shown to increase ammonia metabolism further reducing the encephalopathic symptoms
  • Cirrhotic patients benefit from eating frequent, small meals that prevent long fasts which place the patient in a catabolic state
  • the best time for BCAA supplementation is at bedtime to improve the catabolic state during starvation in early morning fasting
  • A late night nutritional snack reduces symptoms of weakness and fatigability, lowers postprandial hyperglycemia, increases skeletal muscle mass,[25] improves nitrogen balance, and increases serum albumin levels.[26] Nocturnal BCAAs even improve serum albumin in cirrhotic patients who show no improvement with daytime BCAAs
  • Protein-energy malnutrition (PEM), with low serum albumin and low muscle mass, occurs in 65-90% of cases of advanced cirrhosis
  • hyperglucagonemia results in a catabolic state eventually producing anorexia and cachexia
  • BCAAs are further depleted from the circulation due to increased uptake by skeletal muscles that use the BCAAs in the synthesis of glutamine, which is produced in order to clear the ammonia that is not cleared by the failing liver
  • patients with chronic liver disease, particularly cirrhosis, routinely have decreased BCAAs and increased aromatic amino acids (AAAs) in their circulation
  • Maintaining a higher serum albumin in patients with cirrhosis is associated with decreased mortality and improved quality of life
  • the serum BCAA concentration is strongly correlated with the serum albumin level
  • Nathan Goodyear on 05 Oct 15
     
    great review of cirrhosis and BCCA supplementation.
Nathan Goodyear

Branched-chain amino acid metabolism in cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC5732628

branched chain amino acids cancer BCAA

shared by Nathan Goodyear on 15 Mar 19 - No Cached
hoangkimchi liked it
  • Nathan Goodyear on 15 Mar 19
     
    Branched-chain amino acids play role in cancer. Sugar is not the only player and glutamine is not the only amino acid involved.
Nathan Goodyear

Update on branched-chain amino acid supplementation in liver... : Current Opinion in Ga... - 0 views

journals.lww.com/...nched_chain_amino_acid.12.aspx

branched chain amino acids liver cirrhosis hepatitis amino acids protein BCCA

shared by Nathan Goodyear on 05 Oct 15 - No Cached
  • Nathan Goodyear on 05 Oct 15
     
    Branched chain amino acids for those with liver cirrhosis.  This is deficiency is due to the hyperglucoganemia that results from the catabolic metabolism.  It is interesting that peripheral metabolism also sets up.  
Nathan Goodyear

Frontiers | Branched-Chain Amino Acid Ingestion Stimulates Muscle Myofibrillar Protein ... - 1 views

journal.frontiersin.org/...full

BCAA amino acids resistance training exercise recovery exercise muscle

shared by Nathan Goodyear on 18 Jul 17 - No Cached
  • BCAAs exhibit the capacity to stimulate myofibrillar-MPS, however a full complement of EAA could be necessary to stimulate a maximal response of myofibrillar-MPS following resistance exercise
  • This information potentially has important nutritional implications for selecting amino acid supplements to facilitate skeletal muscle hypertrophy in response to resistance exercise training and the maintenance of muscle mass during aging, unloading, or disease
  • results from the present study suggest that ingesting BCAAs alone, without the other EAA, provides limited substrate for protein synthesis in exercised muscles
  • ...3 more annotations...
  • the overall response of MPS is not maximized. Instead, the limited availability of EAA likely explains the qualitative difference in magnitude of the MPS response to ingestion of BCAAs alone and ingestion of similar amounts of BCAAs as part of intact whey protein
  • decreased EAA concentrations following leucine ingestion
  • these data support the notion that EAA availability is the rate-limiting factor for stimulating a maximal MPS response to resistance exercise with BCAA ingestion
  • Nathan Goodyear on 18 Jul 17
     
    Complete amino acid supplementation exceeds muscle building capacity (myofibrillar-MPS) over BCAA alone.
Nathan Goodyear

Amino Acid Intake Is Inversely Associated with Arterial Stiffness and Central Blood Pre... - 0 views

jn.nutrition.org/...jn.115.214700.abstract

amino acids protein cardiovascular cardiovascular disease health atherosclerosis

shared by Nathan Goodyear on 01 Aug 16 - No Cached
  • Nathan Goodyear on 01 Aug 16
     
    Select amino acids found to be cardioprotective.
Nathan Goodyear

The effects of amino acid supplementation on horm... [Metabolism. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16483870

training athlete athletic training muscle performance amino acid supplementation total testosterone testosterone

shared by Nathan Goodyear on 26 Jun 12 - No Cached
  • Nathan Goodyear on 26 Jun 12
     
    amino acid supplementation shown to maintain total testosterone  levels in resistance training overreaching compared to placebo.  This study was small and only lasted 4 weeks.
Nathan Goodyear

The effects of amino acid supplementatio... [J Strength Cond Res. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12741860

amino acids supplementation muscular performance training strength muscle

shared by Nathan Goodyear on 26 Jun 12 - No Cached
  • Nathan Goodyear on 26 Jun 12
     
    amino acid supplementation improves muscular performance in resistance training.
Nathan Goodyear

Neuron - Activation of Central Orexin/Hypocretin Neurons by Dietary Amino Acids - 0 views

www.cell.com/...S0896627311007823

amino acids fatigue afternoon sugar orexin_hpocretin cells

shared by Nathan Goodyear on 01 Dec 11 - No Cached
  • Nathan Goodyear on 01 Dec 11
     
    non-essential amino acids are beneficial in preventing those afternoon energy slumps.  Sugar with its resultant insulin spike would make this worse.
Nathan Goodyear

Maternal amino acid supplementation for intrauterine growth restriction - 0 views

www.ncbi.nlm.nih.gov/...PMC3181118

amino acids pregnancy

shared by Nathan Goodyear on 07 Mar 12 - No Cached
  • Nathan Goodyear on 07 Mar 12
     
    amino acid supplementation shown to have mixed results during pregnancy.
Nathan Goodyear

Maternal amino acid supplementation ... [Front Biosci (Schol Ed). 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21196387

amino acid pregnancy

shared by Nathan Goodyear on 07 Mar 12 - No Cached
  • Nathan Goodyear on 07 Mar 12
     
    Amino acid supplementation and pregnancy.
Nathan Goodyear

Cambridge Journals Online - British Journal of Nutrition - Abstract - Post-exercise whe... - 0 views

journals.cambridge.org/...displayAbstract

Whey protein exercise recovery amino acids muscle nutrition

shared by Nathan Goodyear on 17 Sep 13 - No Cached
  • Nathan Goodyear on 17 Sep 13
     
    Whey protein hydrolysate shown to be superior to amino acids in recovery phase of exercise.  
Nathan Goodyear

Evaluation of the antiobesity effects of an amino ... [J Int Med Res. 2010 May-Jun] - P... - 0 views

www.ncbi.nlm.nih.gov/...20819421

weight loss fat L-Arginine overweight obesity exercise CLA

shared by Nathan Goodyear on 09 Jul 11 - No Cached
  • four amino acids (lysine, proline, alanine and arginine)
  • with or without conjugated linoleic acid to healthy overweight humans before and after exercising
  • When compared with the placebo group, several indicators, such as waist and hip circumferences, were found to have significantly decreased in the test supplement groups compared with the placebo
  • ...1 more annotation...
  • These results suggest that ingestion of these supplements might enhance the fat-burning effects of exercise.
  • Nathan Goodyear on 09 Jul 11
     
    certain amino acids pre and post exercise help to preserve muscle mass.  This has profound implications on fat loss and maintenance of fat loss long term
Nathan Goodyear

The Role of Post-Exercise Nutrient Administration on Muscle Protein Synthesis and Glyco... - 0 views

www.ncbi.nlm.nih.gov/...PMC3761704

exercise athlete athletes recovery exercise recovery training protein carbohydrates glycogen muscle

shared by Nathan Goodyear on 10 Feb 16 - No Cached
  • Whey protein was superior to that of casein in upregulating protein synthesis
  • ability to digest more rapidly than casein protein
  • Free form amino acid ingestion acts similarly to whey by displaying a rapid and strong increase in aminoacidemia
  • ...11 more annotations...
  • it appears that protein synthesis rapidly increases for up to two hours after amino acid administration
  • The intervention of dietary protein or amino acid supplementation in conjunction with resistance training has proven to effectively increase protein synthesis rates
  • 291% increase in protein synthesis following the exercise bout, while protein degradation remained unchanged from baseline quantities
  • it has been established that post-exercise EAA supplementation stimulates protein synthesis, in conjunction with a positive protein balance, comparable to that of intravenous infusion of amino acids
  • Casein and whey protein ingestion yielded similar values of net positive protein balance, and thus an overall increase in protein synthesis
  • A later analysis revealed that soy protein increased protein synthesis in rats similar to that of whey after a treadmill exercise protocol
  • A human trial, however, concluded that milk proteins (caseins and whey) in comparison to soy promoted greater muscle protein accretion when they were ingested after regular resistance training
  • Whey hydrolysate ingested after a resistance exercise bout acutely stimulated mixed muscle protein synthesis 31% greater than soy
  • adequate amount of protein (20 g) is ingested (Tipton et al., 2009) immediately before or after a resistance exercise bout
  • The rapid phase lasts approximately 30-60 minutes and does not require the presence of insulin
  • slow phase, which can last up to several hours if carbohydrate availability is high and insulin levels remain elevated
  • Nathan Goodyear on 10 Feb 16
     
    Good review of recovery supplement strategy.
Nathan Goodyear

metabolic correction for attention deficit/hyperactivity disorder: A biochemical-physio... - 0 views

functionalfoodscenter.net/...63028864.pdf

ADHD diet children pediatrics minerals vitamins essential fatty acids amino acids

shared by Nathan Goodyear on 13 Feb 13 - No Cached
  • Nathan Goodyear on 13 Feb 13
     
    This study of 116 patients diagnosed with ADHD, found that 80% could achieve improvement or "ameliorate" ADHD symptoms with supplementation with minerals, vitamins, amino acids, and essential fatty acids. I too have seen this in my practice. Maybe ADD/ADHD is simply a gut/dietary problem manifested in the brains of our children. That we treat with powerful drugs, that simply can be treated with dietary change
Nathan Goodyear

Use of amino acids as growth hormone-relea... [Nutrition. 2002 Jul-Aug] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12093449

GH growth hormone HGH arginine lysine ornithine nutrition

shared by Nathan Goodyear on 30 Jun 14 - No Cached
  • Nathan Goodyear on 30 Jun 14
     
    Study finds that amino acid supplementation does not increase GH release.
Nathan Goodyear

Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1 - 0 views

www.sciencedirect.com/...S1550413106001586

insulin resistance high protein diet dietary amino acid

shared by Nathan Goodyear on 21 Oct 13 - No Cached
  • Nathan Goodyear on 21 Oct 13
     
    High amino acid intake, in this case infusion, results in overnutrition and insulin resistance.  
Nathan Goodyear

Overactivation of S6 Kinase 1 as a Cause of Human Insulin Resistance During Increased A... - 0 views

diabetes.diabetesjournals.org/...2674

high protein diet dietary insulin resistance

shared by Nathan Goodyear on 21 Oct 13 - No Cached
  • Nathan Goodyear on 21 Oct 13
     
    High protein intake can lead to insulin resistance.  Glucose regulation by insulin and skeletal muscle removal of glucose is disrupted by high amino acid intake through disruption of secondary insulin signaling.
Nathan Goodyear

Scopus - Document details - 0 views

www.scopus.com/...display.url

amino acids high protein diet insulin resistance

shared by Nathan Goodyear on 21 Oct 13 - No Cached
  • Nathan Goodyear on 21 Oct 13
     
    Amino acids contribute to skeletal muscle insulin resistance.  A marked glycogen synthesis decrease (64%) was found in this study.
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