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Contents contributed and discussions participated by Nathan Goodyear

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Nathan Goodyear

Low Testosterone Level and Risk of Alzheimer's Disease in the Elderly Men: a Systematic... - 0 views

www.ncbi.nlm.nih.gov/...26154489

low T low Testosterone alzheimer's disease Testosterone men hormones hormone

shared by Nathan Goodyear on 21 Jul 15 - No Cached
  • Nathan Goodyear on 21 Jul 15
     
    Just abstract available here; low Testosterone in meta-analysis found to be associated with increased Alzheimer's disease risk in elderly men.
Nathan Goodyear

Effect of Opioids on Testosterone Levels: Cross-Sectional Study using NHANES. - PubMed ... - 0 views

www.ncbi.nlm.nih.gov/...26177122

low T low Testosterone opiates opioids Testosterone men hormone hormones

shared by Nathan Goodyear on 21 Jul 15 - No Cached
  • Nathan Goodyear on 21 Jul 15
     
    opiate use increases odds of low Testosterone; however, this is just one piece. 
Nathan Goodyear

Severe Starvation-Induced Hepatocyte Autophagy as a Cause of Acute Liver Injury in Anor... - 0 views

www.hindawi.com/...749169

liver enzymes anorexia malnutrition nutrition

shared by Nathan Goodyear on 20 Jul 15 - No Cached
  • Nathan Goodyear on 20 Jul 15
     
    extreme malnutrition as in anorexia is found to be associated with increased liver enzymes.
Nathan Goodyear

Prevalence and Predictors of Abnormal Liver Enzymes in Young Women with Anorexia Nervosa - 0 views

www.ncbi.nlm.nih.gov/...PMC2561189

anorexia liver enzymes malnutrition women nutrition

shared by Nathan Goodyear on 20 Jul 15 - No Cached
  • Nathan Goodyear on 20 Jul 15
     
    liver enzymes inversely associated with body fat in women with anorexia.
Nathan Goodyear

Catechol estrogen metabolites and conjugates in different regions of the prostate of No... - 1 views

carcin.oxfordjournals.org/...329.long

estrogen metabolites prostate cancer COMT GSH estrogen 4-hydroxyestradiol

shared by Nathan Goodyear on 17 Jul 15 - No Cached
  • Nathan Goodyear on 17 Jul 15
     
    loss of ability to handle estrogen quinone metabolites is due to decreased detoxification capacity i.e.COMT, GSH...is associated with prostate carcinogenesis in rats.
Nathan Goodyear

A PERSPECTIVE ON THE ROLE OF ESTROGEN IN HORMONE-INDUCED PROSTATE CARCINOGENESIS - 0 views

www.ncbi.nlm.nih.gov/...PMC3921257

prostate cancer estrogen aromatase men hormones

shared by Nathan Goodyear on 17 Jul 15 - No Cached
  • Nathan Goodyear on 17 Jul 15
     
    review article points to the concept that it is not Testosterone, but Estrogen that is involved with carcinogenesis of the prostate.
Nathan Goodyear

Associations of the Fecal Microbiome With Urinary Estrogens and Estrogen Metabolites in... - 0 views

press.endocrine.org/...jc.2014-2222

estrogen metabolites gut flora gut microbiome gut microbiota hormones cancer breast cancer microbiome estrogen

shared by Nathan Goodyear on 16 Jul 15 - No Cached
  • Nathan Goodyear on 16 Jul 15
     
    Post-menopause women with increased gut microbiome diversity found to be associated with increased urinary excretion of estrogen metabolites compared to parent estrogens.  This relationship has been shown to be associated with a reduced breast cancer risk.
Nathan Goodyear

http://joe.endocrinology-journals.org/content/167/2/281.full.pdf - 0 views

joe.endocrinology-journals.org/...281.full.pdf

estrogen metabolites 4-hydroxyestrone cancer estrogen hormones 2-hydroxyestrone 2-OH-estrone 4-OH-estrone

shared by Nathan Goodyear on 16 Jul 15 - No Cached
  • Nathan Goodyear on 16 Jul 15
     
    good discussion of the estrogen metabolites and increased estrogenic activity; including cancer risk.  Particular attention is given to the 4-hydroxyestrone metabolite.
Nathan Goodyear

Estrogen Metabolism and Risk of Breast Cancer in Postmenopausal Women - 0 views

jnci.oxfordjournals.org/...326.full

estrogen metabolism cancer breast cancer estrogen metabolites

shared by Nathan Goodyear on 16 Jul 15 - No Cached
  • Nathan Goodyear on 16 Jul 15
     
    Get article on estrogen metabolism/metabolites and their effects on the risk of breast cancer in post menopause women.  This article brings to light new information: 2:16alpha estrone ratio is not a great predicted of risk, 2-OH and 4-OH metabolites can form quinone intermediates...
Nathan Goodyear

New Frontiers in Androgen Biosynthesis and Metabolism - 0 views

www.ncbi.nlm.nih.gov/...PMC3206266

androgen androgens metabolites prostate cancer hormones

shared by Nathan Goodyear on 15 Jul 15 - No Cached
  • Nathan Goodyear on 15 Jul 15
     
    great article on androgen metabolism in the diseased prostate.
Nathan Goodyear

Roles for the Backdoor Pathway of Androgen Metabolism in Prostate Cancer Response to Ca... - 0 views

www.ncbi.nlm.nih.gov/...PMC4062952

DHT androgen androgens 3 alpha-androstanediol prostate cancer male hormones

shared by Nathan Goodyear on 15 Jul 15 - No Cached
  • Nathan Goodyear on 15 Jul 15
     
    "back door" DHT production from 3 alpha-androstanediol following ADT.
Nathan Goodyear

British Journal of Cancer - Androgen metabolism in prostate cancer: from molecular mech... - 0 views

www.nature.com/...bjc2014268a.html

androgens metabolites hormones hormone Testosterone DHT 3 alpha-androstanediol 3 beta androstanediol cancer

shared by Nathan Goodyear on 15 Jul 15 - No Cached
  • Nathan Goodyear on 15 Jul 15
     
    androgen metabolites and prostate cancer promotion.
Nathan Goodyear

The Androgen 5α-Dihydrotestosterone and Its Metabolite 5α-Androstan-3β, 17β-D... - 0 views

www.jneurosci.org/...1448.full

DHT 3 beta androstanediol androgens Hypothalamus HPA hormones stress

shared by Nathan Goodyear on 15 Jul 15 - No Cached
  • Sex steroid hormones are primarily responsible for sex difference in adult HPA function; androgens inhibit whereas estrogens enhance HPA axis activation after a stressor
  • the PVN contains relatively high levels of AR (Bingaman et al., 1994; Zhou et al., 1994) and ERβ (Alves et al., 1998; Hrabovszky et al., 1998; Somponpun and Sladek, 2003) but is essentially devoid of ERα
  • the nonaromatizable androgen DHT and the nonselective ER ligand E2 influence HPA reactivity by acting on neurons within or surrounding the PVN
  • ...9 more annotations...
  • inhibitory action of DHT is detectable at both the level of hormone secretion as well as PVN c-fos mRNA expression
  • the inhibition can be mimicked by the DHT metabolite 3β-diol and by the subtype selective ERβ agonist DPN
  • E2 acts to enhance HPA reactivity
  • the ability of the ER antagonist tamoxifen, but not the AR antagonist flutamide, to block the inhibitory actions of DHT, speaks to the intracellular mechanism by which this inhibitory signal might be transduced.
    • Nathan Goodyear
      Nathan Goodyear on 15 Jul 15
       
      that is because the interaction with the DHT metabolite is not with the AR, but with the ER-beta.
  • the DHT metabolite 3β-diol and the ERβ-subtype-selective agonist DPN suppressed ACTH, corticosterone, and c-fos mRNA responses to restraint stress in a manner similar to DHT
  • metabolism of DHT to 3β-diol and subsequent binding to ERβ can be inhibitory to HPA reactivity, and this is one possible mechanism for the action of DHT.
  • Our data also suggest that E2 enhances the reactivity of the HPA axis to stress by acting on or near neurons of the PVN
  • the actions of E2 appear to be through an ERα-dependent mechanism
  • these studies suggest that ERβ, within the male hypothalamus, acts to inhibit the HPA axis and that the inhibitory effects of DHT may be, at least in part, via its intracellular conversion to 3β-diol and subsequent binding to ERβ
  • Nathan Goodyear on 15 Jul 15
     
    DHT metabolites: particularly 3beta-androstanediol inhibit HPA axis through ER-beta.
Nathan Goodyear

Combined Diet and Physical Activity Promotion Programs to Prevent Type 2 Diabetes Among... - 0 views

annals.org/article.aspx

lifestyle diet nutrition exercise diabetes

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  • Nathan Goodyear on 15 Jul 15
     
    Meta analysis does find that diet and exercise (lifestyle changes) do reduce risk of diabetes.
Nathan Goodyear

Chronic maternal stress inhibits the capacity to up-regulate placental 11beta-hydroxyst... - 0 views

www.ncbi.nlm.nih.gov/...16135661

11beta-HSD2 stress cortisol glucocorticoids

shared by Nathan Goodyear on 14 Jul 15 - No Cached
  • Nathan Goodyear on 14 Jul 15
     
    acute stress is associated with increased 11beta-HSD2 in pregnant rat model.
Nathan Goodyear

11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression o... - 0 views

www.ncbi.nlm.nih.gov/...PMC2212859

11-betaHSD1 11-betaHSD metabolic syndrome atherosclerosis

shared by Nathan Goodyear on 14 Jul 15 - No Cached
  • Nathan Goodyear on 14 Jul 15
     
    inhibition of 11beta-HSD1 improves metabolic syndrome and atherosclerosis.  This suggests that metabolic syndrome is associated with increase 11beta-HSD1 expression/activity.  Animal study
Nathan Goodyear

Progesterone receptor modulates ER[agr] action in breast cancer : Nature : Nature Publi... - 0 views

www.nature.com/...nature14583.html

Progesterone breast cancer ER alpha ER-alpha cancer PR-C

shared by Nathan Goodyear on 14 Jul 15 - No Cached
  • Nathan Goodyear on 14 Jul 15
     
    Abstract only available here.  Progesterone and Progesterone receptor key to regulating ER alpha and slowing breast cancer growth.
Nathan Goodyear

Effects of astaxanthin on oxidative stress in overweight and obese adults. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21480416

oxidative stress astaxanthin malondialdehyde superoxide disumutase isoprostane

shared by Nathan Goodyear on 14 Jul 15 - No Cached
  • Nathan Goodyear on 14 Jul 15
     
    short study found that astaxanthin at 5 and 20 mg was associated with a reduction in oxidative stress biomarkers.
Nathan Goodyear

Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight su... - 0 views

www.ncbi.nlm.nih.gov/...21964877

astaxanthin MDA malondialdehyde oxidative stress SOD superoxide disumutase oxidized LDL LDL LDL cholesterol CVD

shared by Nathan Goodyear on 14 Jul 15 - No Cached
  • Nathan Goodyear on 14 Jul 15
     
    Astaxanthin at 20 mg found to reduce oxidized LDL and other oxidative stress biomarkers as assessed by Malondialdehydy, SOD, Isoprostane, and TAC.  The dose was 20 mg for 12 weeks. This higher dose was associated with minimal side effects--red stools.
Nathan Goodyear

Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in ... - 0 views

www.ncbi.nlm.nih.gov/...22828460

astaxanthin TBARS oxidative stress exercise soccer SOD antioxidant antioxidants

shared by Nathan Goodyear on 14 Jul 15 - No Cached
  • Postexercise CK and AST levels were significantly lower in Asx group compared to P group (P<0.05)
  • Nathan Goodyear on 14 Jul 15
     
    study finds soccer training is associated with increased oxidative stress as measured by TBARS, SOD, superoxide anion and other oxidative stress load biomarkers.  Astaxanthin was associated with less oxidative stress.
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