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Nathan Goodyear

Nutrigenomics of extra-virgin olive oil: A review - Piroddi - 2016 - BioFactors - Wiley... - 0 views

onlinelibrary.wiley.com/...full

olive oil nutrigenomics epigenetics nutrition CVD cardiovascular disease

shared by Nathan Goodyear on 05 Dec 17 - No Cached
  • Nathan Goodyear on 05 Dec 17
     
    Great review on the nutrigenomics of Olive oil.
Nathan Goodyear

Epigenetic changes in blood leukocytes following an omega-3 fatty acid supplementation - 0 views

www.ncbi.nlm.nih.gov/...PMC5405524

epigenetics nutrigenomics omega 3 omega-3 diet nutrition methylation fats EPA DHA

shared by Nathan Goodyear on 15 Sep 17 - No Cached
  • Nathan Goodyear on 15 Sep 17
     
    Epigenetic and really nutrigenomics: 6 week study of 3 gram omega 3 intake induced methylation changes.  Get that?  Only 6 weeks of omega 3 intake induces a change in genetic expression.
Nathan Goodyear

Nutrigenomic basis of beneficial effects of... [Mol Cell Biochem. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18636317

chromium insulin resistance type II DM diabetes

shared by Nathan Goodyear on 31 Aug 12 - No Cached
  • Nathan Goodyear on 31 Aug 12
     
    Chromium improves insulin resistance.
Nathan Goodyear

The role of nutrition related genes and nutrigenetics in understanding the pathogenesis... - 0 views

www.sciencedirect.com/...S2213879X16000183

nutrition diet epigenetics nutrigenomics cancer genes DNA

shared by Nathan Goodyear on 07 Feb 18 - No Cached
mamdouh_hfz liked it
  • Nathan Goodyear on 07 Feb 18
     
    good review article on nutrition, epigenetics, and cancer
Nathan Goodyear

Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi - 0 views

www.ncbi.nlm.nih.gov/...PMC5374554

epigenetics nutrition Genome nutrigenomics

shared by Nathan Goodyear on 11 Dec 17 - No Cached
  • Plant miRNA miR168a was found to present in the sera of mammals including human and regulate human gene LDLRAP1
  • plant miRNAs can present within human circulating system through dietary intake and regulate human gene expression emerged. Broccoli sourced miR159 was found in human sera and proved to inhibit breast cancer growth through targeting the gene TCF7
  • This miRNA, with same 6mer and 7mer-A1 target seed sequence as hsa-miR-4259 and hsa-miR-4715-5p, was predicted to target human JAK-STAT signaling pathway gene SPRY4 and transcription regulation genes through miRTar
  • ...1 more annotation...
  • plant miRNAs present in human circulating system were proven to be able to target human genes
  • Nathan Goodyear on 11 Dec 17
     
    Plant microRNA found in human serum.  Previous studies have shown that these plant microRNA's can interact with the human genome.
Nathan Goodyear

Cross-kingdom inhibition of breast cancer growth by plant miR159 - 0 views

www.ncbi.nlm.nih.gov/...PMC4746606

cancer epigenetics nutrigenomics nutrition diet

shared by Nathan Goodyear on 11 Dec 17 - No Cached
  • MicroRNAs (miRNAs), a major family of small RNAs, are ∼23 nt-long single strands of RNA that bind to mRNA transcripts to inhibit their translation
  • A recent study by Zhang et al. reported that plant-derived miRNAs can be found in human serum.
  • The group demonstrates that the plant miRNA miR168 may be taken up through dietary intake to inhibit the expression of its target low-density lipoprotein receptor 1 in the liver21, providing the first evidence that miRNA in food may influence gene expression in mammalian organs.
  • ...6 more annotations...
  • A more recent finding by the same group shows that a plant miRNA from honeysuckle is able to inhibit Influenza A replication22, indicating that plant miRNAs may be useful for treating human diseases.
  • We found that plant miR159 could be detected in human sera and its levels were inversely correlated with BC incidence and progression.
  • We further identified TCF7 as a mammalian target for miR159 and showed the anti-proliferative function of miR159 in BC cells using in vitro and in vivo models, demonstrating for the first time that a plant miRNA is able to influence BC cell growth.
  • certain dietary miRNAs from plants and other species may serve as highly affordable and powerful means of treatment with minimal inconvenience to patients.
  • miR159 which (using a synthetic mimic) targets TCF7 to inhibit the proliferation of cells whose growth is dependent on TCF7 such as the BC cells MDA-MB-231
  • our study using a BC model clearly indicates the anti-tumor effect of orally administered synthetic miR159 in its naturally existing form with the plant-specific 2'-O-methylation, suggesting the feasibility of using synthetic forms of plant miRNAs as dietary supplements in the treatment of human cancers, including those outside of the GI track
  • Nathan Goodyear on 11 Dec 17
     
    Plant microRNA found to exist in human serum from gut absorption to then alter genetic expression in in-vitro and in vivo studies.
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