Hormone therapy and Alzheimer disease dementia: Ne... [Neurology. 2012] - PubMed - NCBI - 0 views
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Nathan Goodyear on 01 Nov 12study finds that HRT given as women transition through menopause has benefiical effect in people with Alzheimer's. However, when given years later, after menopause, no benefit is found. In fact, rates increased. Several flaws with this study. First, they used synthetic hormones, particularily progestins. Second, there seems to be no thought that the interpretation of the signal has changed. For example, we know that when men have low T, their estrogen receptor status changes from ER beta to ER alpha, which is more proinflammatory. Third, use bioidentical hormones and compare these to synthetic hormones.