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Finally, something that lowers the risk associated with synthetic progestins. Progestins are progesterone pretenders that increase breast cancer. Apigenin, a component of bioflavonoid, was shown to inhibit growth and intact cause cell death.

Study compared bioidentical progesterone (micronized progesterone) to a synthetic progestin in the inhibition of endometrial hyperplasia progression.  The study found that the synthetic progestin worked best, but they both inhibited progression of the endometrial hyperplasia when followed out to 3 months therapy.

Progestin is not a good synthetic progesterone anyways; but this study shows that progestin in obese women in the form of contraception, increases the risk of type II DM.

The estrogenic activity of synthetic progestins used in oral contraceptives.

medroxyprogesterone acetate, synthetic progestin, shown to increase inflammation signaling in human breast cancer cells.  This is a proposed mechamism by which growth stimulation occurs with prover and breast cancer.  

I look forward to the published results of this study as this abstract references the WHI as the "same entry" criteria.  I imagine the HRT would be the same too, but will wait to see.  There is a serious problem with proper reporting of synthetic estrogens as bioidentical estrogens and synthetic progestins as bioidentical progesterone;  Also, what is the dosage. Most individuals are massively overdosed.  This study was said to be a "landmark".  Could just be don't use synthetic hormones: which is what the WHI said.

Estrogenic potential of progestins in oral contraceptives to stimulate human breast cancer cell proliferation.

medroxyprogsterone acetate (synthetic progestin) increase vascular function in postmenopausal women

synthetic progestins promote estrogen alpha Receptor activity: increased growth potential

synthetic progestin (MPA) off sets beneficial estrogen heart benefits

bioidentical progesterone lowers breast cancer risk; synthetic progestins increase breast cancer risk

Yale study finds estrogen therapy in improves health in women ages 50-59.  The problems with hormone therapy is synthetics and overdosing.  The problem with the WHI was they used medroxy progesterone acetate--a synthetic progestin.   That is not progesterone.  This study estimated that 91,000 + died due to the uneducated view that estrogen HRT is dangerous.  What is dangerous is leaving the HRT and BHRT recommendations to those with conflicts of interest and a lack of knowledge of the science.

Study finds that estradiol combined with synthetic progestin increased CRP.  No surprise.

synthetic progestins stimulate breast cancer

synthetic progestins increase breast cancer risk

study finds that HRT given as women transition through menopause has benefiical effect in people with Alzheimer's.  However, when given years later, after menopause, no benefit is found.  In fact, rates increased.  Several flaws with this study.  First, they used synthetic hormones, particularily progestins.  Second, there seems to be no thought that the interpretation of the signal  has changed.  For example, we know that when men have low T, their estrogen receptor status changes from ER beta to ER alpha, which is more proinflammatory.  Third, use bioidentical hormones and compare these to synthetic hormones.

study of 80,377 postmenopausal women found no increase/decrease in breast cancer in women on estradiol and progesterone (RR 1.0).  However, estradiol and provera (synthetic progestin) found a 69% increased breast cancer risk (RR 1.69).

No surprise that progesterone and the synthetic progestin medroxyprogesterone acetate (MPA) have different effects on the vascular endothelium. MPA inhibits NO production, whereas Progesterone maintains NO production.  MPA promoted platelet adhesion whereas Progesterone did not--significant implication in plaque formation.

Estradiol has been shown to have positive health effects on vascular endothelium.  The synthetic progestin, medroxyprogesterone acetate, negates this.  

watch out!  bioidentical progesterone provides improved symptom control versus synthetic progestin MPA