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pharmacybiz

Avacta Halts Sale Of Covid-19 Rapid Antigen LFT - 0 views

www.pharmacy.biz/t-to-boost-omicron-sensitivity

Avacta pharmacy-business Do-lateral-flow-tests-detect-omicron rapid-antigen-LFT-AffiDX Rapid-antigen-test Can-lateral-flow-tests-detect-omicron

shared by pharmacybiz on 11 Jan 22 - No Cached
  • pharmacybiz on 11 Jan 22
     
    Britain's biotech firm Avacta Group on Monday (January 10) announced halting sales of its Covid-19 rapid antigen lateral flow test AffiDX to replace antibodies in the device and increase its ability to diagnose the Omicron variant. The company stated that AffiDX is capable of detecting Omicron when the virus is present in high numbers in samples, but the sensitivity of the test reduces at lower viral loads. The performance of all rapid antigen tests came under scanner in wake of a large number of mutations in the Omicron variant. AffiDX contains both a proprietary Affimer reagent and a commercially available antibody. The Affimer reagent detects the Omicron variant with the same sensitivity as the Delta variant, and performance of the antibody is paired with the Affimer reagent in the test. This has been affected by the additional Omicron mutations, the firm said. Alastair Smith, chief executive of Avacta Group, said: "Our determination to only provide high quality, high performance diagnostic tests has led us to the correct decision to pause all marketing of the AffiDX® lateral flow antigen test. We have, of course, been unable to market the product in the UK since October 2021, as the product continues to await approval under the new CTDA regulatory process.
Nathan Goodyear

Communication between genomic and non-genomic signaling events coordinate steroid hormo... - 0 views

www.ncbi.nlm.nih.gov/...PMC5864526

genomic signaling cancer hormones non-genomic signaling

shared by Nathan Goodyear on 10 Apr 21 - No Cached
  • steroid hormones typically interact with their cognate receptor in the cytoplasm for AR, glucocorticoid receptor (GR) and PR, but may also bind receptor in the nucleus as appears to often be the case for ERα and ERβ
  • This ligand binding results in a conformational change in the cytoplasmic NRs that leads to the dissociation of HSPs, translocation of the ligand-bound receptor to the nucleus
  • In the nucleus, the ligand-bound receptor dimerizes and then binds to DNA at specific HREs to regulate gene transcription
  • ...25 more annotations...
  • some steroid hormone-induced nuclear events can occur in minutes
  • the genomic effects of steroid hormones take longer, with changes in gene expression occurring on the timescale of hours
  • Classical steroid hormone signaling occurs when hormone binds nuclear receptors (NR) in the cytoplasm, setting off a chain of genomic events that results in, among other changes, dimerization and translocation to the nucleus where the ligand-bound receptor forms a complex with coregulators to modulate gene transcription through direct interactions with a hormone response element (HRE)
  • NRs have been found at the plasma membrane of cells, where they can propagate signal transduction often through kinase pathways
  • Membrane-localized ER, PR and AR have been reported to modulate the activity of MAPK/ERK, phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), nitric oxide (NO), PKC, calcium flux and increase inositol triphosphate (IP3) levels to promote cell processes including autophagy, proliferation, apoptosis, survival, differentiation, and vasodilation
  • ERα36, a 36kDa truncated form of ERα that lacks the transcriptional activation domains of the full-length protein. Membrane-localized ERα36 can activate pathways including protein kinase C (PKC) and/or mitogen activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) to promote the progression of various cancers
  • G protein-coupled receptor 30 (GPR30), also referred to as G protein-coupled estrogen receptor (GPER), is a membrane-localized receptor that has been observed to respond to estrogen to activate rapid signaling
  • hormone-responsive G protein coupled receptor is Zip9, which androgens can activate
  • GPRC6A is another G protein-coupled membrane receptor that is responsive to androgen
  • androgen-mediated non-genomic signaling through this GPCR can modulate male fertility, hormone secretion and prostate cancer progression
  • non-NR proteins located at the cell surface can bind to steroid hormones and respond by eliciting rapid signaling events
  • Estrogens have been shown to induce rapid (i.e. seconds) calcium flux via membrane-localized ER (mER)
  • ER-calcium dynamics lead to activation of kinase pathways such as MAPK/ERK which can result in cellular effects like migration and proliferation
  • 17β-estradiol (E2) has been reported to promote angiogenesis through the activation of GPER
  • Membrane NRs may also mediate rapid signaling through crosstalk with growth factor receptors (GFR)
  • A similar crosstalk occurs between the receptor tyrosine kinase insulin-related growth factor-1 receptor (IGF-IR) and ERα. Not only does IGF-IR activate ERα, but inhibition of IGF-IR downregulates estrogen-mediated ERα activity, suggesting that IGF-IR is essential for maximal ERα signaling
    • Nathan Goodyear
      Nathan Goodyear on 10 Apr 21
       
      This is a bombshell that shatters the current right brain approach to ER. It completely shatters the concept of eat sugar, whatever you want, with cancer treatment in ER+ or hormonally responsive cancer!
  • Further, ER activates IGF-IR pathways including MAPK
  • GPER is involved in the transactivation of the EGFR independent of classical ER
  • tight interconnection between genomic and non-genomic effects of NRs.
  • non-genomic pathways can also lead to genomic effects
  • androgen-bound AR associates with the kinase Src at the plasma membrane, activating Src which then leads to a signaling cascade through MAPK/ERK
  • However, Src can also increase the expression of AR target genes by the ligand-independent transactivation of AR
  • extranuclear steroid hormone actions can potentially reprogram nuclear NR events
  • estrogen modulated the expression of several genes including endothelial nitric oxide synthase (eNOS) via rapid signaling pathways
  • epigenetic changes can then mediate genomic events in uterine tissue and breast cancer cells
Nathan Goodyear

Colonization-Induced Host-Gut Microbial Metabolic Interaction - 0 views

mbio.asm.org/...e00271-10.full

gut flora gut microbiome gut microbiota CYP450 metabolism

shared by Nathan Goodyear on 06 May 15 - No Cached
  • he gut microbiota enhances the host’s metabolic capacity for processing nutrients and drugs and modulate the activities of multiple pathways in a variety of organ systems.
  • Acquisition of the gut microbiota was associated with rapid increase in body weight (4%) over the first 5 days of colonization
  • The colonization process stimulated glycogenesis in the liver prior to triggering increases in hepatic triglyceride synthesis
  • ...11 more annotations...
  • modifications of hepatic Cyp8b1 expression and the subsequent alteration of bile acid metabolites
  • Expression and activity of major drug-metabolizing enzymes (Cyp3a11 and Cyp2c29) were also significantly stimulated
  • The gut microbiota (GM) exhibits a relatively low level of diversity compared to those of most soil ecosystems and in humans it is comprised of usually no more than nine phyla of microorganisms, of which only two are dominant: the Firmicutes and the Bacteroidetes
  • colonization of a germfree gut was rapid and remarkably stable, establishing within only a week after first exposure
  • a study conducted on germfree rats by Nicholls et al. showed that 3 weeks were necessary to obtain a stabilization and “normalization”
  • the microbiota status affects the systemic metabolism of the host, modulating the metabolic fingerprint of topographically remote organs such as the liver and the kidney
  • Gut colonization induces a rapid weight gain associated with stimulation of hepatic glycogenesis and triglyceride synthesis
  • Gut colonization alters bile acid metabolite profiles via modulation of hepatic Cyp8b1 expression
  • Bile acids are well-known contributors to glucose and lipid metabolism in the liver
  • GM is known to alter bile metabolism
  • GM is also known to exert a strong influence on the metabolism of xenobiotics
  • Nathan Goodyear on 06 May 15
     
    The effects of gut microbiome are not confined to the gut.  They alter bile acid metabolism and thus lipid/glucose metabolism.  They alter CYP450 activity.  They effect metabolism.  They effect the metabolism, and thus effects, of other drugs. 
Nathan Goodyear

Effects of Self-Selected Mass Loss on Performance and Mood i... : The Journal of Streng... - 0 views

journals.lww.com/...ss_Loss_on_Performance.18.aspx

wrestlers rapid weight loss

shared by Nathan Goodyear on 23 May 11 - No Cached
  • Nathan Goodyear on 23 May 11
     
    rapid weight loss in wrestlers pre-event causes increased mood effects and confusion
Syed Amjad Ali

E-Templates - A new approach in Rapid E-Learning Course Development - 0 views

www.elearningserv.com/...-e-learning-course-development

Etemplates in india list of top elearning templates models e-templates for training courses

shared by Syed Amjad Ali on 24 Oct 14 - No Cached
  • Syed Amjad Ali on 24 Oct 14
     
    Advanced eLearning Authoring Tools have made eLearning Development Easy The rapid and extensive advances in technology have brought on incredible innovation in all fields of human interest. The impact of the same can be seen in the e-learning space, and these days, this specialized segment is breaking new ground continuously.
kunalkumar03

Get rid of the Stretch Marks | Best Stretch Marks Removal Laser Treatment - Pixigenus -... - 1 views

youtu.be/W7nUffxg5Rk

hormones hormone cancer Testosterone inflammation Men disease Male obesity low

shared by kunalkumar03 on 01 Feb 19 - No Cached
  • kunalkumar03 on 01 Feb 19
     
    Stretch marks are formed deep within the dermis layer and happen due to rapid stretching, this causes damage to the skin's connecting tissues. To get rid of these stretch marks we are introducing to you our latest laser treatment i.e. PIXIGENUS. It is a unique technology to eliminate stretchmarks from various parts of the body. Watch the full video to know more. Stretch marks are caused because of rapid stretching of the skin that results into scars and discoloration of the skin. There are many reasons which can lead to stretch marks such as rapid weight reduction, quick weight gain, excessive exercise, steroids, pregnancy, hormonal changes, puberty etc. Millions of women have stretch marks, but this fact does little to lessen the embarrassment that most women feel at the appearance of these unattractive striations on their skin. Stretch marks, also known as striae, are a form of scarring on the skin with an off-color hue. Over time they may reduce, but will not disappear completely. Tearing of the dermis results into stretch marks.
hadiyasafdar

10 Things I wish I'd known before Breast Augmentation - 0 views

dubaicosmeticsurgeryclinics.blogspot.com/...sh-id-known-before-breast.html

#invisible scar breast augmentation #breast Dubai #scar #scarless

shared by hadiyasafdar on 12 Jan 17 - No Cached
  • hadiyasafdar on 12 Jan 17
     
    Breast augmentation procedure is designed to enhance the size and fullness of the breasts, usually with breast implants. If you are unhappy with the appearance of your breasts because they are smaller in size or they have lost their volume or shape due to pregnancy or rapid weight fluctuations, you might consider a breast augmentation to get the breasts of your desire.
Nathan Goodyear

Bisphenol A Promotes Human Prostate Stem-Progenitor Cell Self-Renewal and Increases In ... - 0 views

www.ncbi.nlm.nih.gov/...PMC3929731

BPA bisphenol A cancer prostate cancer prostate xenoestrogens

shared by Nathan Goodyear on 20 Apr 16 - No Cached
  • these findings show that estrogen stimulates human prostate epithelial stem cell self-renewal and progenitor cell amplification (prostasphere size), with the greatest effects observed at lower E2 doses.
  • Similar to E2, BPA increased prostasphere number and size with significant and maximal effects observed at 10 nM BPA
  • Taken together, these results provide strong evidence that, similar to E2, BPA increases stem cell self-renewal and progenitor amplification in normal human prostate epithelial cells
  • ...13 more annotations...
  • these findings provide further support that E2 and BPA maintain the stem-like state within the normal prostate epithelial cell population
  • Our previous findings demonstrated that normal prostate stem-progenitor cells within the prostaspheres expressed ERα and ERβ, implicating them as direct targets for E2 and BPA action
  • p-Akt and p-Erk, well established downstream targets of membrane-associated ERs
  • BPA and E2 had equimolar capacity for activation of these rapid signaling pathways in human prostaspheres, thus identifying a dynamic and robust signaling pathway initiated by low-dose BPA exposure in prostate stem-progenitor cells.
  • these findings indicate that both rapid membrane-initiated estrogen action and genomic ER signaling pathways are operative in human prostate progenitor cells.
  • these results document the fact that levels of bioactive BPA in the present study are similar to levels found in human umbilical cord blood and newborns in the general population
  • the present findings identify for the first time that in vivo exposure of the human prostate epithelium to low doses of BPA significantly increases the susceptibility of the human prostate epithelium to hormonal carcinogenesis.
  • The current study provides clear evidence that, similar to E2, normal human prostate stem and progenitor cells are direct targets for BPA action
  • Both hormones increased stem-like cell numbers in primary prostate epithelial cultures in a dose-dependent manner and augmented the number and size of 3-D cultured prostaspheres, markers of stem cell self-renewal and progenitor cell proliferation, respectively
  • signaling pathways engaged by estrogens through these separate receptors are multiple and complex, including both membrane-initiated signaling and genomic activation via ER transcriptional activity
  • Estrogen action is mediated by ERα and ERβ
  • the current results indicate that developmental exposure to BPA, at doses routinely found in humans, significantly increases the cancer risk in human prostate epithelium in response to elevated estrogen levels in an androgen-supported milieu. Because relative estrogen levels rise in aging men, we suggest that humans may be susceptible to BPA-driven prostate disease in a manner similar to that in the rodent models.
  • We propose that early-life perturbations in estrogen signaling including inappropriate exposure to BPA have the potential to amplify and modify the stem-progenitor cell populations within the human prostate gland and, in so doing, alter the normal homeostatic mechanisms that maintain a growth neutral state throughout life
  • Nathan Goodyear on 20 Apr 16
     
    Bisphenol A exposure in utero found to increase prostate cancer risk later in life.  This exposure occurred at typical life exposure levels as found in umbilical cord blood sampling,  This occurred through stem cell self-renewal and progenitor amplification
Nathan Goodyear

Determination of salivary cortisol b... [Scand J Clin Lab Invest. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19396659

saliva salivary testing test cortisol hormone hormones mass spectrometry MS

shared by Nathan Goodyear on 10 Jul 12 - No Cached
  • Nathan Goodyear on 10 Jul 12
     
    saliva testing of cortisol via mass spectrometry is said to be "rapid, sensitive, and simple to perform..."
Nathan Goodyear

Effects of estrogen on memory funct... [Psychoneuroendocrinology. 1992] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...1484915

estrogen memory women surgical menopause hormones postmenopause

shared by Nathan Goodyear on 10 Mar 14 - No Cached
  • Nathan Goodyear on 10 Mar 14
     
    estrogen therapy in surgical menopause preserves memory.  Rapid decline in estrogen levels post surgical menopause is associated with cognitive/memory decline.  Versus placebo, estrogen therapy preserved memory function.
Nathan Goodyear

ESTROGEN SIGNALING AND NEUROPROTECTION IN CEREBRAL ISCHEMIA - 0 views

www.ncbi.nlm.nih.gov/...PMC3324183

estrogen estradiol cerebral ischemia neuordegeneration brain protection ROS oxidative stress

shared by Nathan Goodyear on 10 Mar 14 - No Cached
  • Nathan Goodyear on 10 Mar 14
     
    estradiol plays an important role in neuropreservation following cerebral ischemia.  The mechanism is through ER alpha stimulation.  The result is a reduction of ROS and oxidative stress.  This occurs through the classic intranuclear and the rapid membrane receptors as well.
Nathan Goodyear

SpringerLink - Article - 0 views

www.antidepressantsfacts.com/09-25-zoloft-SSRI-toxicity.htm

SSRI depression

shared by Nathan Goodyear on 25 May 11 - No Cached
  • Nathan Goodyear on 25 May 11
     
    SSRI increase serotonin levels rapidly after initiation of therapy; to rapid to explain the therapeutic latency associated with re-uptake inhibition only
Willow O'Donnell

Refurbished Baxter Sigma Spectrum Infusion IV Pump | willowmed | Tumblr - 0 views

willowmed.tumblr.com/...ation-software-to-help-prevent

Purchase IV pumps Purchase infusion pumps Sell you infusion pumps

shared by Willow O'Donnell on 24 Nov 14 - No Cached
  • Willow O'Donnell on 24 Nov 14
     
    The Baxter SIGMA Spectrum Infusion System is redefining smart technology with Second Generation software to help prevent pump-related medication errors. The SIGMA Spectrum Infusion System provides multiple error prevention systems along with bi-directional wireless communication and comprehensive log analysis software to create CQI reports. SIGMA Spectrum pump provides rapid, intuitive work-flow using a bright, easy to read color display and on-board digital help screens. SIGMA Spectrum pump also provides economic value by utilizing Baxter's standard IV administration sets.
Nathan Goodyear

Intravenous Fluid Use in Athletes - 0 views

www.ncbi.nlm.nih.gov/...PMC3435915

IV nutrition intravenous fluids exercise sports medicine sports athlete athletes

shared by Nathan Goodyear on 13 Jan 15 - No Cached
  • The current data suggest that IV rehydration is faster than oral
  • There may be physiological benefits of decreased heart rate and norepinephrine in athletes rehydrated via IV route
  • Muscle damage during exercise in the heat was assessed by myoglobin and creatine kinase
  • ...4 more annotations...
  • Postexercise blood 1 hour and 24 hours showed no differences in circulating myoglobin or creatine kinase
  • IV administration of fluids can rapidly replace plasma volume
  • The rapid increase in plasma volume is transient, and no measureable difference between IV and oral prehydration exists after 15 minutes of exercise
  • The use of IV fluid may be beneficial for a subset of fluid sensitive athletes
  • Nathan Goodyear on 13 Jan 15
     
    IV nutrition pre-event, intra-event, and post-event for recovery.
Willow O'Donnell

Refurbished Baxter Sigma Spectrum Infusion IV Pump - 0 views

www.tribesmart.com/...r553235

Infusion IV Pump Purchase infusion pumps

shared by Willow O'Donnell on 27 Nov 14 - No Cached
  • Willow O'Donnell on 27 Nov 14
     
    The Baxter SIGMA Spectrum Infusion System is redefining smart technology with Second Generation software to help prevent pump-related medication errors. The SIGMA Spectrum Infusion System provides multiple error prevention systems along with bi-directional wireless communication and comprehensive log analysis software to create CQI reports. SIGMA Spectrum pump provides rapid, intuitive work-flow using a bright, easy to read color display and on-board digital help screens.
Nathan Goodyear

The Role of Post-Exercise Nutrient Administration on Muscle Protein Synthesis and Glyco... - 0 views

www.ncbi.nlm.nih.gov/...PMC3761704

exercise athlete athletes recovery exercise recovery training protein carbohydrates glycogen muscle

shared by Nathan Goodyear on 10 Feb 16 - No Cached
  • Whey protein was superior to that of casein in upregulating protein synthesis
  • ability to digest more rapidly than casein protein
  • Free form amino acid ingestion acts similarly to whey by displaying a rapid and strong increase in aminoacidemia
  • ...11 more annotations...
  • it appears that protein synthesis rapidly increases for up to two hours after amino acid administration
  • The intervention of dietary protein or amino acid supplementation in conjunction with resistance training has proven to effectively increase protein synthesis rates
  • 291% increase in protein synthesis following the exercise bout, while protein degradation remained unchanged from baseline quantities
  • it has been established that post-exercise EAA supplementation stimulates protein synthesis, in conjunction with a positive protein balance, comparable to that of intravenous infusion of amino acids
  • Casein and whey protein ingestion yielded similar values of net positive protein balance, and thus an overall increase in protein synthesis
  • A later analysis revealed that soy protein increased protein synthesis in rats similar to that of whey after a treadmill exercise protocol
  • A human trial, however, concluded that milk proteins (caseins and whey) in comparison to soy promoted greater muscle protein accretion when they were ingested after regular resistance training
  • Whey hydrolysate ingested after a resistance exercise bout acutely stimulated mixed muscle protein synthesis 31% greater than soy
  • adequate amount of protein (20 g) is ingested (Tipton et al., 2009) immediately before or after a resistance exercise bout
  • The rapid phase lasts approximately 30-60 minutes and does not require the presence of insulin
  • slow phase, which can last up to several hours if carbohydrate availability is high and insulin levels remain elevated
  • Nathan Goodyear on 10 Feb 16
     
    Good review of recovery supplement strategy.
spineneuro

French to India Medical Travel: Sentez-vous mieux avec des soins fiables disp... - 0 views

frenchtoindiamedicaltravel.blogspot.com/...le-care-best-neurosurgeon.html

Meilleur neurochirurgien du Fortis Hospital Delhi Dr Sandeep Vaishya Dr Sandeep Vaishya Meilleur neurochirurgien Gamma Knife en Inde Radiochirurgie au couteau gamma Hôpitaux à bas prix pour la chirurgie radio-gamma Knife

shared by spineneuro on 17 Nov 21 - No Cached
  • spineneuro on 17 Nov 21
     
    Aujourd'hui, le meilleur neurochirurgien de l'hôpital Fortis de Delhi, le Dr Sandeep Vaishya, est le premier fournisseur national de procédures au couteau gamma aux personnes du monde entier. Pour une réponse rapide aux requêtes Adresse e-mail : dr.sandeepvaishya@neurospinehospital.com N° de téléphone : +91-9325887033
spineneuro

Best Interventional Neuroradiologist in India Offering Rapid Diagnostic Coupled with Lo... - 0 views

www.101pressrelease.com/tic-coupled-with-local-therapy

Brain Tumor Surgery in India Top Hospitals for Brain Tumor India Dr. Vipul Gupta India Best Interventional Neurologist in Delhi India Dr. Vipul Gupta Contact Number

shared by spineneuro on 19 Oct 21 - No Cached
  • spineneuro on 19 Oct 21
     
    The best hospital for brain tumor surgery in India is designing a brand new, fast molecular diagnostic and sustained launch healing that could be deployed at some stage in brain surgery to treat gliomas and prevent their return. For Appointment Email: dr.vipulgupta@neurospinehospital.com Phone No.: +91-9325887033
indiacardiacsurg

French Health Trip To India: Un chirurgien cardiaque pour enfants en Inde cré... - 0 views

french-health-trip-2-india.blogspot.com/...ld-heart-surgeon-in-india.html

chirurgien cardiaque pour enfants en Inde cardiaque enfants en Inde

shared by indiacardiacsurg on 08 Dec 21 - No Cached
  • indiacardiacsurg on 08 Dec 21
     
    De plus, le chirurgien cardiaque pour enfants en Inde offre un taux de réussite de 99,6% car il est effectué à l'aide de la technologie la plus avancée, à la hauteur de ce que possèdent même les pays les plus évolués du monde. Obtenez une réponse rapide aux requêtes, appelez-nous simplement au +91-9370586696 ou par e-mail : enquiry@indiacardiacsurgerysite.com
spineneuro

French to India Medical Travel: Revenez à une vie de qualité avec les chirurg... - 0 views

frenchtoindiamedicaltravel.blogspot.com/...s-cervical-spine-surgeons.html

Les chirurgiens indiens du rachis cervical cervical chirurgiens du rachis cervical

shared by spineneuro on 09 Dec 21 - No Cached
  • spineneuro on 09 Dec 21
     
    Les chirurgiens indiens du rachis cervical ont une expérience et des compétences reconnues dans le monde entier pour la chirurgie de la laminoplastie cervicale. Des patients du monde entier viennent en Inde en raison de l'intérêt thérapeutique des 10 meilleurs chirurgiens de la colonne cervicale en Inde ou en raison de l'offre médicale plus élevée des chirurgiens de la colonne cervicale indiens qui pratiquent ces chirurgies aux taux les plus modérés. Cliquez ici pour un rendez-vous rapide ou appelez le +91-98604-32255 ou envoyez un courriel à enquiry@spineandneurosurgeryhospitalindia.com
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