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Nathan Goodyear

Low-dose Interleukin-2 in the Treatment of Autoimmune Disease | touchONCOLOGY - 0 views

www.touchoncology.com/...2-treatment-autoimmune-disease

cancer autoimmune disease Tregs Treg cells Treg immune system disease IL-2

shared by Nathan Goodyear on 04 Apr 18 - No Cached
Amol kashikar liked it
  • affect approximately 5 to 8 % of the US population
  • the incidence and prevalence of autoimmune diseases are rising
  • Type 1 diabetes (T1D), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and inflammatory bowel disease (IBD) account for the majority of the patients with autoimmune diseases
  • ...9 more annotations...
  • Autoimmune diseases are characterized by a breakdown of mechanisms that allow the immune system to distinguish between self and nonself and maintain immunologic self-tolerance
  • Tregs, which are important in the maintenance of peripheral immune tolerance.
  • Several subtypes of Tregs exist, the most well studied being CD4+ cells that express high-level CD25 and the transcription factor forkhead box P3 (FOXP3)
  • Treg deficiency or dysfunction is associated with autoimmune disease
  • In clinical studies, decreased levels of circulating CD25+CD4+ T cells have been reported in patients with autoimmune disease
  • These data have led to the hypothesis that augmentation of Tregs may be a useful therapeutic strategy in autoimmune disease
  • Treg augmentation has resulted in clinical improvements in numerous animal models of autoimmune diseases
  • the administration of in vitro expanded CD4+CD25highCD127-Tregs has been found to be safe and may help to preserve β-cell function in children with T1D
  • ability of IL-2 to augment the numbers and function of CD4+ Tregs.
  • Nathan Goodyear on 04 Apr 18
     
    Great article.  Immune dysfunction plays role in autoimmune disease and cancer.  Treg cells sit at the center of autoimmunity.  This artice highlights the different uses: low dose IL2 therapy to augment Tregs and reduce autoinflammation and high dose IL2 to augment Treg cells in the fight against cancer.
hadiyasafdar

10 Things I wish I'd known before Breast Augmentation - 0 views

dubaicosmeticsurgeryclinics.blogspot.com/...sh-id-known-before-breast.html

#invisible scar breast augmentation #breast Dubai #scar #scarless

shared by hadiyasafdar on 12 Jan 17 - No Cached
  • hadiyasafdar on 12 Jan 17
     
    Breast augmentation procedure is designed to enhance the size and fullness of the breasts, usually with breast implants. If you are unhappy with the appearance of your breasts because they are smaller in size or they have lost their volume or shape due to pregnancy or rapid weight fluctuations, you might consider a breast augmentation to get the breasts of your desire.
hadiyasafdar

Injection Buttock Augmentation with Implants vs. Fat Injections - 0 views

medium.com/...-vs-fat-injections-a8ae61f5ca0

#buttockliftDubai #buttocklifttreatmentdubai #fatinjectiondubai #fattransferdubai #fatinjectiontreatmentdubai

shared by hadiyasafdar on 27 Jan 17 - No Cached
  • hadiyasafdar on 27 Jan 17
     
    The demand of buttock augmentation is increasing massively with the advancements in cosmetic sector. Many women who have small buttocks in comparison to their body type and frame or ones who wish to have well contoured and fuller buttocks are considering buttock augmentation. Your buttocks may have lost shape and volume over the years
hadiyasafdar

Is it true that Breast augmentation can cause cancer? My Experience - 0 views

dubaicosmeticsurgeryclinics.blogspot.com/...t-breast-augmentation-can.html

ScarBreastAugmentation invisiblescarbreastaugmentation surgicalscarrevision scalessbreastaugmentation breastaugmentation

shared by hadiyasafdar on 18 Jan 17 - No Cached
  • hadiyasafdar on 18 Jan 17
     
    There are many speculations associated with breast implants; they go as big as cancer and as little as scar breast augmentation. I will share with you my true experience and share my true thoughts.
Nathan Goodyear

[Antitumor effect in mice of an organic germanium compound (Ge-132) when different admi... - 0 views

www.ncbi.nlm.nih.gov/...4073929

germanium NK cells immune system cancer

shared by Nathan Goodyear on 30 May 18 - No Cached
  • Nathan Goodyear on 30 May 18
     
    IV germanium augments NK activity in mouse blood providing anti-tumor activity.  Different activity found with po and intra-peritoneal injection--augmentation of cytotoxic macrophages.  Prolongation of life was not found in the IV arm.
spineneuro

Dr. Vidyadhara S India Introduces ClarifEye Augmented Reality Spine Surgical Navigation - 0 views

www.briefingwire.com/...lity-spine-surgical-navigation

Dr. Vidyadhara S Best Spine Surgeon Manipal Bangalore dr vidyadhara s reviews Manipal hospital

shared by spineneuro on 10 Feb 22 - No Cached
  • spineneuro on 10 Feb 22
     
    "Augmented reality surgical navigation facilitates us to place pedicle screws in positions wherein we simply couldn't or would not do in any other case," said Dr. Vidyadhara S India. Contact Details Dr. Vidyadhara S. Best Spine Surgeon Manipal Bangalore
Nathan Goodyear

Metabolic management of glioblastoma multiforme using standard therapy together with a ... - 0 views

www.ncbi.nlm.nih.gov/...PMC2874558

ketogenic ketogenic diet cancer ketones ketone bodies

shared by Nathan Goodyear on 17 Nov 16 - No Cached
  • Nathan Goodyear on 17 Nov 16
     
    case study highlights the use of a calorie restricted, ketogenic diet to augment glioblastoma multiforme.  In incomplete resection, at 2 months no brain tumor was visualized via PET and MRI.
Nathan Goodyear

Natural Killer Cells in Pregnancy and Recurrent Pregnancy Loss: Endocrine and Immunolog... - 0 views

edrv.endojournals.org/...44.full

natural killer cells pregnancy loss recurrent immune system miscarriage NK

shared by Nathan Goodyear on 15 Apr 12 - No Cached
  • NK cells have been the cells most extensively studied, primarily because they constitute the predominant leukocyte population present in the endometrium at the time of implantation and in early pregnancy
  • parental chromosomal abnormalities, uterine anatomic anomalies, endometrial infections, endocrine etiologies (luteal phase defect, thyroid dysfunction, uncontrolled diabetes mellitus), antiphospholipid syndrome, inherited thrombophilias, and alloimmune causes
  • estrogen
  • ...28 more annotations...
  • progesterone
  • prolactin
  • In summary, in vivo animal experiments have shown an inhibitory role of estrogen on peripheral NK cell lytic activity, which is partly due to suppression of NK cell output by the bone marrow and partly due to suppression of individual NK cell cytotoxicity. However, in vitro studies so far have failed to show conclusively a direct effect of estrogen on NK cells.
  • At the progesterone concentrations believed to be present in the uterus [up to 10−5 m at the maternal-fetal interface (35)], studies consistently show inhibition of lymphocyte proliferation (33) and inhibition of NK cytolytic activity in vitro
  • The exact role of prolactin in NK cell regulation is unknown.
  • The overall effects of estrogen on NK cells are likely multifactorial, therefore, and depend on the type of cell affected as well as the kind of ER expressed by that cell.
  • It is known that progesterone can directly affect T cell differentiation in vitro, suppressing development of the Th1 pathway and enhancing differentiation along the Th2 pathway (44)
  • Th1 cells predominantly produce interferon-γ (IFN-γ), IL-2, and TNF-β and are involved in cell-mediated immunity. Th2 cells produce IL-4, IL-5, IL-6, IL-10, and IL-13 and stimulate humoral immunity
  • Furthermore, in response to progesterone, γδ T cells produce progesterone-induced blocking factor (PIBF) (54
  • A defining characteristic of NK cells is their ability to lyse target cells without prior sensitization and without restriction by HLA antigens.
  • NK cell function is mainly regulated by IL-2 and IFN-γ
  • IL-2 causes both NK cell proliferation and enhanced cytotoxicity. IFN-γ augments NK cytolytic activity, but does not cause NK proliferation. The two cytokines act synergistically to augment NK cytotoxicity (6).
  • The largest leukocyte population in the endometrium consists of NK cells named large granulated lymphocytes
  • there is a significant increase in the number of uNK cells throughout the secretory phase, which peaks in early pregnancy when uNK cells comprise about 75% of uterine leukocytes (62)
  • Second, uNK cell phenotype changes during the normal menstrual cycle and early pregnancy (68)
  • general proinflammatory effect of estrogen, causing an influx of macrophages and neutrophils, which is antagonized by progesterone through its receptor (70, 71).
  • The mechanism of such a progesterone-induced local immunosuppression is unclear.
  • progesterone plays an important role in proliferation and differentiation of uNK cells (32).
  • Through promotion of a uterine Th2 environment, progesterone could indirectly affect uNK cell function
  • The mechanism of this increase in uNK cell numbers has been addressed in both human and mouse models, and is likely the result of: 1) recruitment of peripheral NK cells to the uterus, and 2) proliferation of existing uNK cells
  • prolactin system plays an important role in implantation and the maintenance of pregnancy
  • the exact pathways of hormonal regulation of NK cells remain to be delineated.
  • The exact function of uNK cells has not yet been unequivocally determined
  • uNK cells express a different cytokine profile, compared with resting peripheral NK cells. mRNAs for granulocyte CSF, M-CSF, GM-CSF, TNF-α, IFN-γ, TGF-β, and leukemia inhibitory factor (LIF) have been found in decidual CD56+ cells
  • Their increased numbers in early pregnancy, their hormonal dependence, and their close proximity to the infiltrating trophoblast all suggest that they play an important role in the regulation of the maternal immune response to the fetal allograft and the control of trophoblast growth and invasion during human pregnancy
  • role of uNK cell-derived cytokines on trophoblast growth and differentiation (114, 115, 116, 117).
  • Th1 immunity to trophoblast is associated with RPL, whereas Th2 immunity is associated with a successful pregnancy
  • RPL is associated with Th1 immunity, for which NK cells are partly responsible.
  • Nathan Goodyear on 15 Apr 12
     
    dysregulated immune system plays role in recurrent miscarriage.  Specifically, this article discusses natural killer cells (NK).
Nathan Goodyear

Limited effects of dietary curcumin on Th-1 driven colitis in IL-10 deficient mice sugg... - 0 views

www.ncbi.nlm.nih.gov/...PMC2584828

curcumin IL-10 NF-kappaB inflammation IBD ulcerative colitis Crohn's disease

shared by Nathan Goodyear on 17 Jan 12 - No Cached
  • Nathan Goodyear on 17 Jan 12
     
    curcumin shown to inhibit NF-kappaB through a IL-10 dependent pathway.  IL-10 is required and curcumin appears to augment the inhibition of NF-kappaB
Nathan Goodyear

Curcumin works synergistically with paclitaxel to inhibit breast cancer in a mouse mode... - 0 views

www.greenmedinfo.com/...ibit-breast-cancer-mouse-model

curcumin NF-KappaB inflammation breast cancer CA

shared by Nathan Goodyear on 19 Jan 12 - No Cached
  • Nathan Goodyear on 19 Jan 12
     
    curcumin shown to augment paclitaxel in breast cancer treatment.  Specifically, NF-kappaB inhibition resulted in reduction in tumor size, decreased tumor cell proliferation, increased apoptosis, and decreased MM-9.
Nathan Goodyear

http://prhsj.rcm.upr.edu/index.php/prhsj/article/viewFile/911/629 - 0 views

prhsj.rcm.upr.edu/...629

IV vitamin C alpha lipoic acid ALA cancer intravenous

shared by Nathan Goodyear on 18 Mar 14 - No Cached
  • Nathan Goodyear on 18 Mar 14
     
    Quick review of the mechanism of action by IV vitamin C in cancer.  Alpha lipoic acid augments the apoptotic effects of IV vitamin C.
Nathan Goodyear

Exercise and the brain: something to chew on - 0 views

www.ncbi.nlm.nih.gov/...PMC2680508

exercise brain neurogenesis neurplasticity

shared by Nathan Goodyear on 03 Nov 13 - No Cached
  • Nathan Goodyear on 03 Nov 13
     
    The absolute best way to promote neurogenesis is through exercise.  This is through an increase in BDNF.  There are ways to augment this: curcumin, n-3, nutrition...  The concept that the brain doesn't heal is out the window.
Nathan Goodyear

The ROS-induced cytotoxicity of ascorbate is attenuated by hypoxia and HIF-1alpha in th... - 0 views

onlinelibrary.wiley.com/...full

vitamin C IV IV vitamin C hypoxia HIF-1alpha HBO hyperbaric oxygen hyperbaric cancer

shared by Nathan Goodyear on 13 Nov 14 - No Cached
  • Nathan Goodyear on 13 Nov 14
     
    vitamin C effects decreased by hypoxia which increases HIF-1alpha.  The authors propose oxygen therapy, hyperbaric, to improve and augment the cytotoxic effects of vitamin C.
Nathan Goodyear

The Addition of Beta-hydroxy-beta-methylbutyrate and Isomaltulose to Whey Protein Impro... - 0 views

www.tandfonline.com/...07315724.2014.938790

whey protein resistance training exercise exercise recovery

shared by Nathan Goodyear on 20 Oct 15 - No Cached
  • Nathan Goodyear on 20 Oct 15
     
    Whey protein is beneficial as supplementation for resistance training recovery. This study found the addition of a leucine metabolite, beta-hydroxy-beta-methylbutyrate, and the carbohydrate Isomaltulose before, during, and after high intensity exercise further augmented recovery.
Nathan Goodyear

Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC ... - 0 views

onlinelibrary.wiley.com/...ijc.25499

DCA dichloroacetate dichloracetic acid chemotherapy cancer

shared by Nathan Goodyear on 08 Nov 18 - No Cached
  • Nathan Goodyear on 08 Nov 18
     
    DCA works in synergy, augments, effects of anti-mitochondrial chemo agents cisplatin and topetecan
Nathan Goodyear

[Artesunate combined with vinorelbine plus cisplatin in treatment of advanced non-small... - 0 views

www.ncbi.nlm.nih.gov/...18241646

Artesunate cancer NSCLC "non-small cell lung cancer"

shared by Nathan Goodyear on 11 Dec 18 - No Cached
  • Nathan Goodyear on 11 Dec 18
     
    Artesunate augments cisplatin and navelbine.
Nathan Goodyear

Artesunate enhances the therapeutic response of glioma cells to temozolomide by inhibit... - 0 views

www.ncbi.nlm.nih.gov/...PMC5341871

Cancer artesunate temodar glioblastoma glioblastoma multiforme

shared by Nathan Goodyear on 19 Dec 18 - No Cached
  • Nathan Goodyear on 19 Dec 18
     
    Artesunate augments Temodar in animal model of glioblastoma.
Nathan Goodyear

Effect of Neoadjuvant Chemotherapy Plus Regional Hyperthermia on Long-term Outcomes Amo... - 0 views

jamanetwork.com/...2672386

hyperthermic therapy hyperthermia cancer chemotherapy

shared by Nathan Goodyear on 30 Aug 18 - No Cached
  • Heat exposure (40 °C to 43 °C) of cancer cells in preclinical studies, and hyperthermia regionally applied to patients in early randomized clinical studies, have shown synergistic activity with ionizing radiation and chemotherapy
  • For the combination of hyperthermia with chemotherapy, the study group at Munich7 was the first to demonstrate the safety and efficacy of regional hyperthermia (RHT) in patients with high-risk sarcoma.
  • Nathan Goodyear on 30 Aug 18
     
    hyperthermia therapy augments chemo therapy.
Nathan Goodyear

Ifosfamide plus etoposide combined with regional hyperthermia in patients with locally ... - 0 views

ascopubs.org/...JCO.1990.8.11.1818

hyperthermia hyperthermic therapy cancer chemotherapy

shared by Nathan Goodyear on 30 Aug 18 - No Cached
  • Nathan Goodyear on 30 Aug 18
     
    Hyperthermic therapy augments chemotherapy for some with advanced sarcomas.  Systemic temperature at 37.4 C in this study.
Nathan Goodyear

Effects of Angiotensin, Vasopressin and Aldosterone on Proliferation of MCF-7 Cells and... - 0 views

ar.iiarjournals.org/...1843.full

cancer breast cancer renin angiotensin system aldosterone

shared by Nathan Goodyear on 10 Sep 18 - No Cached
  • The renin-angiotensin system (RAS) has been associated with local tumor growth, inflammation, angiogenesis and facilitation of metastasis
  • Aldosterone and vasopressin did not alter cellular growth (Figure 1) and did not alter doxorubicin sensitivity
  • angiotensin increased the growth of MCF-7 cells
  • ...2 more annotations...
  • losartan
  • evidence that breast cancer chemotherapy can be influenced by anti-hypertensive treatment
  • Nathan Goodyear on 10 Sep 18
     
    upregulated RAS associated with stimulated breast cancer growth.  Anti-hypertensive therapy not only can it impact the cancer growth potential but also can augment chemotherapy.
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