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Nathan Goodyear

Short term vitamin D exposure alters methylation status of term placental villi - Placenta - 0 views

www.placentajournal.org/...pdf

epigenetics vitamin d pregnancy placenta methylation

shared by Nathan Goodyear on 10 Nov 17 - No Cached
  • Nathan Goodyear on 10 Nov 17
     
    Vitamin D alters genetic expression of the placenta during pregnancy through methylation of CpG islands to effect transcription and increased expression and decreased expression of genes.
Nathan Goodyear

Acute changes in 5-HT metabolism after S-adeno... [Gen Pharmacol. 1989] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...2473938

SAMe methylation depression serotonin

shared by Nathan Goodyear on 26 Jun 12 - No Cached
  • Nathan Goodyear on 26 Jun 12
     
    SAMe increased hippocampal serotonin levels by 300% in rat brain model.  Methylation is known to play a major role in serotonin, dopamine, and norepinephrine.
Nathan Goodyear

Specific Contribution of Methionine and Choline in Nutritional Nonalcoholic Steatohepat... - 0 views

www.ncbi.nlm.nih.gov/...PMC2881778

SAMe methylation GSH glutathione NASH nonalcoholic steatohepatitis NAFLD non-alcoholic fatty liver

shared by Nathan Goodyear on 26 Jun 12 - No Cached
  • Nathan Goodyear on 26 Jun 12
     
    review of SAMe, methylation, and Glutathione in the development of Nonalcoholic Steatohepatitis (NASH).  This would serve as a potential treatment for those with NAFLD.
Nathan Goodyear

The role of S-adenosyl methionine in preventing FOLFOX-induced liver toxicity: a retros... - 0 views

informahealthcare.com/...14740338.2011.562888

SAMe methylation cancer CBS cystathionine Beta-synthase glutathione GSH chemotherapy

shared by Nathan Goodyear on 27 Jun 12 - No Cached
  • Nathan Goodyear on 27 Jun 12
     
    SAMe shown to lower liver toxicity in chemotherapy treatment.  SAMe could be a powerful chemotherapeutic adjuvant.  This makes since, because cancer is known to be a hypomethylated state.  Low methyl donors will reduce CBS activity and thus lower glutathione.  This will result in increased oxidative stress and inflammation in the liver.  SAMe will open the CBS activity up and increase glutathione production.
Nathan Goodyear

S-Adenosylmethionine Inhibits the Growth of Cancer Cells by Reversing the Hypomethylati... - 0 views

www.ncbi.nlm.nih.gov/...PMC2999854

SAMe methylation oncogenes colon cancer cancer

shared by Nathan Goodyear on 27 Jun 12 - No Cached
  • Nathan Goodyear on 27 Jun 12
     
    SAMe shown to resolve the hypomethylation status of oncogenes. This allows increased genetic expression.  By improving methylation with SAMe, we can reduce oncogenic expression and thus be a useful cancer therapy adjunct.
Nathan Goodyear

CpG hypermethylation of the promoter region inactivates the estrogen receptor... - 0 views

onlinelibrary.wiley.com/...full

prostate cancer ER beta ER-beta estrogen methylation BPH benign prostatic hypertrophy

shared by Nathan Goodyear on 21 Jan 14 - No Cached
  • Nathan Goodyear on 21 Jan 14
     
    ER beta expression that is lost in prostate carcinogenesis occurs via methylation at the ER beta gene promoter sites 19CpG.  What is really interesting is that ER beta expression was present in all of the samples with BPH, but was absent in 83% of the prostate cancer samples.
Nathan Goodyear

The dietary phase 2 protein inducer sulforaph... [Am J Hypertens. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22052072

methylation sulforphane broccoli nutrition diet

shared by Nathan Goodyear on 09 Sep 13 - No Cached
  • Nathan Goodyear on 09 Sep 13
     
    Granted, an animal study, sulforphane from broccoli reduces blood pressure through methylation.
Nathan Goodyear

http://www.epa.gov/teach/chem_summ/mercury_org_summary.pdf - 0 views

www.epa.gov/...mercury_org_summary.pdf

Mercury Organic methyl ethyl methylMercury Hg ethylMercury EPA heavy metals toxicity

shared by Nathan Goodyear on 17 Feb 14 - No Cached
  • Nathan Goodyear on 17 Feb 14
     
    EPA paper on Organic Mercury: methyl and ethyl mercury.
Nathan Goodyear

Urinary Estrogens and Estrogen Metabolites and Subsequent Risk of Breast Cancer among P... - 0 views

cancerres.aacrjournals.org/...696.full

estrogen metabolites estrogen metabolism ER estrogen receptors ROS hormones cancer breast cancer

shared by Nathan Goodyear on 07 Oct 15 - No Cached
  • both 2- and 4-catechol estrogen metabolites bind to the ER with affinities comparable with estradiol, 4-catechol estrogen metabolites have lower dissociation rates than estradiol and an enhanced ability to upregulate ER-dependent processes
  • 2-catechol estrogen metabolites act as either weak mitogens (39) or weak inhibitors of cell proliferation
  • While 16α-hydroxyestrone binds to the ER with lower affinity than estradiol, it binds covalently (41) and leads to a constitutively activated ER
  • ...15 more annotations...
  • 4-hydroxyestradiol and 16α-hydroxyestrone increasing proliferation and decreasing apoptosis in a manner similar to estradiol; however, these effects were achieved only at concentrations 10-fold higher than estradiol (39). In contrast, 2-hydroxyestradiol did not have substantial proliferative or antiapoptotic effects
  • In our study, the associations with both 2-hydroxyestrone and 16α-hydroxyestrone were nonsignificantly inverse and we did not observe a consistent trend or significant associations between the 2-hydroxyestrone:16α-hydroxyestrone ratio and breast cancer risk
  • Ratios of the 3 hydroxylation pathways were not significantly associated with risk although the 2:16-pathway and 4:16-pathway ratios were suggestively inversely associated
  • a significant inverse association with the ratio of parent estrogens to estrogen metabolites
  • several potentially estrogenic and genotoxic mechanisms
  • Estrogen metabolites also can be genotoxic
  • Catechol estrogens can be oxidized into quinones and induce DNA damage directly through the formation of DNA adducts, or indirectly via redox cycling and generation of reactive oxygen species
  • the oxidized forms of the catechol estrogens differ in their ability to damage DNA through adducts, with oxidized 2-catechols forming stable and reversible DNA adducts and oxidized 4-catechols forming unstable adducts, which lead to depurination and mutations
  • 2- and 4-catechols have been shown to produce reactive oxygen species and induce oxidative DNA damage
  • act independently from the ER
  • 16α-Hydroxyestrone also may be genotoxic
  • While the catechol estrogens have estrogenic and genotoxic potential, the methylated catechol estrogens, which are catechol estrogens with one hydroxyl group methylated, have been hypothesized to lower the risk of breast cancer
  • The suggested mechanisms are indirect, by decreasing circulating levels of catechol estrogens and thereby the opportunity for catechols to exert genotoxic or proliferative effects, or direct, by inhibiting tumor growth and inducing apoptosis
  • the balance between phase I (oxidation) and phase II (methylation) metabolism of estrogen may be important in hormonally related cancer development.
  • Despite the estrogenic and genotoxic potential of many of the estrogen metabolites, we only observed a significantly increased breast cancer risk with one estrogen metabolite, 17-epiestriol, which has particularly strong estrogenic activity and binds to both ERα and ERβ with an affinity comparable with estradiol
  • Nathan Goodyear on 07 Oct 15
     
    review of estrogen metabolites and breast cancer risk in premenopausal women.
Nathan Goodyear

Urinary estrogens and estrogen metabolites and subsequent risk of breast cancer among p... - 0 views

www.ncbi.nlm.nih.gov/...PMC3271178

estrogen metabolites estrogen metabolites cancer hormones

shared by Nathan Goodyear on 04 Oct 15 - No Cached
  • While the catechol estrogens have estrogenic and genotoxic potential, the methylated catechol estrogens, which are catechol estrogens with one hydroxyl group methylated, have been hypothesized to lower risk of breast cancer.
  • Despite the estrogenic and genotoxic potential of many of the EM, we only observed a significantly increased breast cancer risk with one EM, 17-epiestriol, which has particularly strong estrogenic activity and binds to both ERα and ERβ with an affinity comparable to estradiol
  • We did not observe reduced risk for higher concentrations of 2-pathway EM relative to 16-pathway EM, nor did we observe a consistent benefit of higher concentrations of methylated catechol EM compared with catechol EM.
  • ...4 more annotations...
  • EM also can be genotoxic, but the individual EM vary in their ability to induce DNA damage
  • Catechol estrogens can be oxidized into quinones and induce DNA damage directly through the formation of DNA adducts, or indirectly via redox cycling and generation of reactive oxygen species
  • the oxidized forms of the catechol estrogens differ in their ability to damage DNA through adducts, with oxidized 2-catechols forming stable and reversible DNA adducts and oxidized 4-catechols forming unstable adducts, which lead to depurination and mutations
  • 2- and 4-catechols have been shown to produce reactive oxygen species and induce oxidative DNA damage (46). These catechols also induce neoplastic transformation in ER-cells, and thus act independently from the ER
  • Nathan Goodyear on 04 Oct 15
     
    Estrogen metabolites.
Nathan Goodyear

Neuron - Epigenetic Status of Gdnf in the Ventral Striatum Determines Susceptibility an... - 0 views

www.cell.com/...S0896627310010718

stress depression methylation glial cell-derived neurotrophic factor Gdnf

shared by Nathan Goodyear on 10 Oct 11 - No Cached
  • Nathan Goodyear on 10 Oct 11
     
    How you respond to stress is a reflection of your genetics and environment.  The bodies ability to express genes, such as the glial cell-derived neurotrophic factor, impacts an individual's expression in the face of stress.  You have a genetic predisposition, but with poor methylation you end up with more depression in the presence of stress
Nathan Goodyear

How environmental and genetic factors combine to c... [Neurotoxicology. 2008] - PubMed ... - 0 views

www.ncbi.nlm.nih.gov/...18031821

autism spectrum disorders ASD

shared by Nathan Goodyear on 05 Jul 11 - No Cached
  • Genetic polymorphisms adversely affecting sulfur metabolism, methylation, detoxification, dopamine signaling and the formation of neuronal networks occur more frequently in autistic subjects.
  • a "redox/methylation hypothesis of autism" is described, in which oxidative stress, initiated by environment factors in genetically vulnerable individuals, leads to impaired methylation and neurological deficits secondary to reductions in the capacity for synchronizing neural networks.
  • Nathan Goodyear on 05 Jul 11
     
    proposed hypothesis of autism
Nathan Goodyear

Epigenetic changes in blood leukocytes following an omega-3 fatty acid supplementation - 0 views

www.ncbi.nlm.nih.gov/...PMC5405524

epigenetics nutrigenomics omega 3 omega-3 diet nutrition methylation fats EPA DHA

shared by Nathan Goodyear on 15 Sep 17 - No Cached
  • Nathan Goodyear on 15 Sep 17
     
    Epigenetic and really nutrigenomics: 6 week study of 3 gram omega 3 intake induced methylation changes.  Get that?  Only 6 weeks of omega 3 intake induces a change in genetic expression.
Nathan Goodyear

Dietary selenium's protective effects against methylmercury toxicity. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20561558

selenium mercury fish methyl mercury diet nutrition heavy metals

shared by Nathan Goodyear on 14 Sep 17 - No Cached
  • Nathan Goodyear on 14 Sep 17
     
    Selenium versus methyl mercury content of fish renders the argument of mercury content of fish as a concern, but in a few fish.
Nathan Goodyear

Erratum to: DNA methylation age of human tissues and cell types | Genome Biology | Full... - 0 views

genomebiology.biomedcentral.com/...s13059-015-0649-6

aging methylation

shared by Nathan Goodyear on 30 Sep 16 - No Cached
  • Nathan Goodyear on 30 Sep 16
     
    correction of his Hovarth's prior publication in 2013.
Nathan Goodyear

DNA methylation in cancer: too much, but also too little - 0 views

www.nature.com/...1205651a.html

cancer methylation hypermethylation hypomethylation

shared by Nathan Goodyear on 30 Jun 16 - No Cached
  • Nathan Goodyear on 30 Jun 16
     
    hypermethylation and hypomethylation shown to play roles in carcinogenesis.
Nathan Goodyear

S-adenosylmethionine in alcoholic liver cirrhosis:... [J Hepatol. 1999] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10406187

SAMe NAFLD GSH glutathione liver cirrhosis cirrhosis liver

shared by Nathan Goodyear on 27 Jun 12 - No Cached
  • Nathan Goodyear on 27 Jun 12
     
    SAMe, at doses of 1200 mg, shown to decrease mortality rate and prolong transplantation in those with cirrhosis.  Very likely, these individuals, if tested, had low SAMe and methyl donors as well as depleted glutathione. This is a set up for low phosphotidyl choline/ethanolamine levels resulting in fat accumulation.
Nathan Goodyear

S-adenosylmethionine reduces the progress of... [Neurobiol Aging. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22221883

SAMe Alzheimer's disease Alzheimer's aging

shared by Nathan Goodyear on 27 Jun 12 - No Cached
  • Nathan Goodyear on 27 Jun 12
     
    SAMe helps to correct disordered homocysteine metabolism due to B- vitamin deficiency found in Alzheimer's disease.  SAMe show to reduce amyloid production, improve memory, decrease Tau, and reduced plaque formation.  Now, this was in a mice model, but SAMe as a methyl donor can benefit clients with dementia with minimal side effects.
Nathan Goodyear

Vitamin Intervention for Stroke Prevention Trial - 0 views

stroke.ahajournals.org/...2404.full

homocysteine vitamin B12 folic acid VISP stroke prevention vitamins

shared by Nathan Goodyear on 25 Jul 12 - No Cached
  • Nathan Goodyear on 25 Jul 12
     
    Vitamin B12, methyl cobalamin, is very important in lowering homocysteine levels through methionine synthase.  The VISP trial did not show efficacy in the intention to treat analysis.  However, analysis of the efficacy reveals that many clients had too low of vitamin B12 levels due to malabsorption and vitamin B12 levels should have been higher in the VISP intention to treat.
Nathan Goodyear

Neurobehavioural effects of developmental toxicity : The Lancet Neurology - 0 views

www.thelancet.com/...abstract

flourine toxins environmental brain neurology ADD ADHD autism ASD pediatrics children

shared by Nathan Goodyear on 11 Mar 14 - No Cached
  • Nathan Goodyear on 11 Mar 14
     
    new study out of the Lancet labels Flouride as neurotoxicant, along with lead, methyl mercury, PCBs, arsenic, toluene and others.   This is not a political issue and needs to be reviewed scientifically.  These toxicants impair neurodevelopment and may be one reason for the rapidly rising conditions associated: i.e. ADD, ADHD, autism...
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