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Nathan Goodyear

Epigenetic Gene Promoter Methylation at Birth Is Associated With Child's Later Adiposity - 0 views

diabetes.diabetesjournals.org/...db10-0979.abstract

obesity pregnancy overweight epigenetics

shared by Nathan Goodyear on 19 Apr 11 - No Cached
  • a substantial component of metabolic disease risk has a prenatal developmental basis
  • Nathan Goodyear on 19 Apr 11
     
    Mother's diet effects the obesity risk of her child
Nathan Goodyear

1210_article_14 - 0 views

jpp.krakow.pl/...14_article.html

neurotoxic thimerosal vaccinations

shared by Nathan Goodyear on 03 Apr 11 - No Cached
  • These modulatory effects - which most likely involve binding with functional thiol residues - are interwoven with neurotoxic actions of both mercurials.
  • THIM is metabolized in the body to ethyl mercury (EtHg) and subsequently to inorganic mercury forms, which accumulate in tissues of vital organs, including the brain (22). Information about neurochemical and neurotoxic effects of THIM is still limited, but the existing data indicate that in pharmacodynamics and toxicity THIM/EtHg does not differ significantly from methyl mercury (MeHg), which has been studied more extensively, although these compounds differ somewhat in pharmacokinetics (8).
  • Several studies documented that the neurotoxic effects of mercurials involve glutamate-mediated excitotoxicty, due to their ability to inhibit uptake of glutamate in astrocytes, resulting in an increase of the extracellular level of this excitatory amino acid
  • Nathan Goodyear on 03 Apr 11
     
    neurotoxic effects of thimerosal
Nathan Goodyear

Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in... - 0 views

www.ajcn.org/...1611.abstract

glutathione autism oxidative stress

shared by Nathan Goodyear on 28 Jun 11 - No Cached
  • Nathan Goodyear on 28 Jun 11
     
    glutathione beneficial in autism
Nathan Goodyear

Understanding and determining the etiology of auti... [Cell Mol Neurobiol. 2010] - PubM... - 0 views

www.ncbi.nlm.nih.gov/...19774457

autism ASD detoxification

shared by Nathan Goodyear on 05 Jul 11 - No Cached
  • Worldwide, the rate of autism has been steadily rising.
  • Genetic polymorphisms of cytochrome P450 enzymes have also been linked to autism, specifically CYP27B1 that is essential for proper vitamin D metabolism
  • There are several environmental factors in concert with genetic susceptibilities that are contributing to this rise. Impaired methylation and mutations of mecp2 have been associated with autistic spectrum disorders, and related Rett syndrome.
  • ...1 more annotation...
  • Other factors that have been considered include: maternally derived antibodies, maternal infection, heavy metal exposure, folic acid supplementation, epigenetics, measles, mumps, rubella vaccination, and even electromagnetic radiation.
  • Nathan Goodyear on 05 Jul 11
     
    Autism has many potential causes.  At the heart is poor detoxification
Nathan Goodyear

Abnormal transmethylation/transsulfuration metabolism and DNA hypomethylation among par... - 0 views

www.ncbi.nlm.nih.gov/...PMC2584168

autism spectrum disorders children detoxifcation methylation sulfation glutathione

shared by Nathan Goodyear on 05 Jul 11 - No Cached
  • Nathan Goodyear on 05 Jul 11
     
    abnormal detoxification at heart of autism
Nathan Goodyear

Vitamin-Dependent Methionine Metabolism and Alcoholic Liver Disease - 0 views

advances.nutrition.org/...421.full

methionine metabolism Alcoholic liver disease vitamin B12 Folate B6 transmethylation methylation pathway

shared by Nathan Goodyear on 28 Oct 11 - No Cached
  • Nathan Goodyear on 28 Oct 11
     
    nice article discussing disrupted methionine metabolism and development of Alcoholic Liver Disease
Nathan Goodyear

Caloric restriction delays age-related methylation drift | Nature Communications - 0 views

www.nature.com/...s41467-017-00607-3

calorie restriction epigenetics

shared by Nathan Goodyear on 27 Feb 18 - No Cached
  • Nathan Goodyear on 27 Feb 18
     
    How does calorie restriction work? Epigenetics.
Nathan Goodyear

Curcumin-Mediated Reversal of p15 Gene Promoter Methylation: Implication in Anti-Neopla... - 0 views

www.ncbi.nlm.nih.gov/...26333125

curcumin cancer leukemia AML

shared by Nathan Goodyear on 12 May 18 - No Cached
  • Nathan Goodyear on 12 May 18
     
    curcumin induces apoptosis and genomic instability in AML cell cells.
Nathan Goodyear

Mulberry fruit ameliorates Parkinson's-disease-related pathology by reducing ... - 0 views

www.jnutbio.com/...fulltext

mulberry mulberry fruit extract Parkinson's disease

shared by Nathan Goodyear on 23 May 17 - No Cached
  • Nathan Goodyear on 23 May 17
     
    full study of animal model that found neuroprotective effects of mulberry fruit extract in Parkinson's disease.
Nathan Goodyear

Mulberry fruit ameliorates Parkinson's-disease-related pathology by reducing ... - 0 views

www.ncbi.nlm.nih.gov/...27741433

mulberry mulberry fruit extract Parkinson's disease

shared by Nathan Goodyear on 23 May 17 - No Cached
  • Nathan Goodyear on 23 May 17
     
    mulberry fruit extract found to treatment option to prevent dopaminergic damage and prevention of Parkinson's disease in animal model.
Nathan Goodyear

Cross-kingdom inhibition of breast cancer growth by plant miR159 - 0 views

www.ncbi.nlm.nih.gov/...PMC4746606

cancer epigenetics nutrigenomics nutrition diet

shared by Nathan Goodyear on 11 Dec 17 - No Cached
  • MicroRNAs (miRNAs), a major family of small RNAs, are ∼23 nt-long single strands of RNA that bind to mRNA transcripts to inhibit their translation
  • A recent study by Zhang et al. reported that plant-derived miRNAs can be found in human serum.
  • The group demonstrates that the plant miRNA miR168 may be taken up through dietary intake to inhibit the expression of its target low-density lipoprotein receptor 1 in the liver21, providing the first evidence that miRNA in food may influence gene expression in mammalian organs.
  • ...6 more annotations...
  • A more recent finding by the same group shows that a plant miRNA from honeysuckle is able to inhibit Influenza A replication22, indicating that plant miRNAs may be useful for treating human diseases.
  • We found that plant miR159 could be detected in human sera and its levels were inversely correlated with BC incidence and progression.
  • We further identified TCF7 as a mammalian target for miR159 and showed the anti-proliferative function of miR159 in BC cells using in vitro and in vivo models, demonstrating for the first time that a plant miRNA is able to influence BC cell growth.
  • certain dietary miRNAs from plants and other species may serve as highly affordable and powerful means of treatment with minimal inconvenience to patients.
  • miR159 which (using a synthetic mimic) targets TCF7 to inhibit the proliferation of cells whose growth is dependent on TCF7 such as the BC cells MDA-MB-231
  • our study using a BC model clearly indicates the anti-tumor effect of orally administered synthetic miR159 in its naturally existing form with the plant-specific 2'-O-methylation, suggesting the feasibility of using synthetic forms of plant miRNAs as dietary supplements in the treatment of human cancers, including those outside of the GI track
  • Nathan Goodyear on 11 Dec 17
     
    Plant microRNA found to exist in human serum from gut absorption to then alter genetic expression in in-vitro and in vivo studies.
Nathan Goodyear

https://www.researchgate.net/profile/Osama_Arafat/publication/234135338_METHYLCOBALAMIN... - 0 views

www.researchgate.net/...C-HYPOPHYSEAL-ADRENAL-AXIS.pdf

methylcobalamin methyl-B12 B12 hypertension norepinephrine adrenal medulla adrenal

shared by Nathan Goodyear on 18 Dec 17 - No Cached
  • Nathan Goodyear on 18 Dec 17
     
    Animal study points to methylB12 as the cause of an increase in adrenal medulla norepinephrine production.  This has significant implications in individuals with hypertension.
Nathan Goodyear

The acute effect of high-dose intravenous vitamin C and other nutrients on blood pressu... - 0 views

www.ncbi.nlm.nih.gov/...PMC4864764

vitamin C IV vitamin C hypertension vitamin B12 blood pressure cardiovascular disease CVD

shared by Nathan Goodyear on 14 Aug 17 - No Cached
  • the reduction in BP within the first 10–20 min may be primarily attributed to a direct vasodilatory physiological effect, described as venodilation
  • BP reduction observed after 70–90 min is likely attributable to pharmacokinetically plausible vitamin C absorption and vasodilation because of nitric oxide release
  • Pharmacokinetic studies of IVC administration observed peak plasma levels within the first 90 min, with plasma levels reaching 13350 μmol/l for 50 g of IVC
  • ...6 more annotations...
  • Essential hypertension, associated with endothelial dysfunction because of an impaired nitric oxide/l-arginine pathway and impaired vasodilation can be restored by vitamin C
  • marked increase in BP response when IVB12 is administered
  • The mean BP increased significantly up to 12–16 mmHg systolic and diastolic independent of the dosage of vitamin B12
  • The production of norepinephrine, which can stimulate angiotensin-II production, which in turn influences BP, has been suggested as a possible mechanism for the increase in BP with IVB12
  • excess norephinephrine levels stimulate the sympathetic nervous system, leading to increased cortisol production, which has also been linked to increases in BP
  • Animal studies have found higher serum levels of norepinephrine (noradrenaline) in the adrenal medulla of rats receiving methylcobalamin (methyl-vitamin B12)
  • Nathan Goodyear on 14 Aug 17
     
    IV vitamin C in mostly normotensive patients (> 30 grams) reduced blood pressure.  Some of the patients were pre-hypertensive. Vitamin B12 increase the blood pressure.
Nathan Goodyear

Curcumin induces re-expression of BRCA1 and suppression of γ synuclein by mod... - 0 views

www.ncbi.nlm.nih.gov/...PMC7041105

BRCA curcumin

shared by Nathan Goodyear on 18 Jan 21 - No Cached
  • Nathan Goodyear on 18 Jan 21
     
    Curcumin induces BRCA re-expression in cell line study
Nathan Goodyear

Repurposing Drugs in Oncology (ReDO)-chloroquine and hydroxychloroquine as anti-cancer ... - 0 views

www.ncbi.nlm.nih.gov/...PMC5718030

chloroquine hydroxychloroquine cancer repurposed drugs

shared by Nathan Goodyear on 03 May 21 - No Cached
  • HCQ, doses for long-term use range between 200 and 400 mg per day.
  • Short-term administration of CQ or HCQ rarely causes severe side effects
  • Short-term administration of CQ or HCQ rarely causes severe side effects
  • ...24 more annotations...
  • bone marrow suppression
  • cardiomyopathy
  • irreversible retinal toxicity
  • hypoglycaemia
  • daily doses up to 400 mg of HCQ or 250 mg CQ for several years are considered to carry an acceptable risk for CQ-induced retinopathies, with the exception of individuals of short stature
  • chronic CQ or HCQ therapy be monitored through regular ophthalmic examinations (3–6 month intervals), full blood counts and blood glucose level checks
  • long-term HCQ exposure, skeletal muscle function and tendon reflexes should be monitored for weakness
  • both CQ and HCQ, specific caution is advised in patients suffering from impaired hepatic function (especially when associated with cirrhosis), porphyria, renal disease, epilepsy, psoriasis, glucose-6-phosphate dehydrogenase deficiency and known hypersensitivity to 4-aminoquinoline compounds
  • CQ and HCQ can effectively increase the efficacy of various anti-cancer drugs
  • CQ can prevent the entrapment of protonated chemotherapeutic drugs by buffering the extracellular tumour environment and intracellular acidic spaces
  • This study recommends an adjuvant HCQ dose of 600 mg, twice daily.
  • HCQ addition was shown to produce metabolic stress in the tumours
  • HCQ (400 mg/day)
  • important effects of CQ and HCQ on the tumour microenvironment
  • The main and most studied anti-cancer effect of CQ and HCQ is the inhibition of autophagy
  • the expression levels of TLR9 are higher in hepatocellular carcinoma, oesophageal, lung, breast, gastric and prostate cancer cells as compared with adjacent noncancerous cells, and high expression is often linked with poor prognosis
  • TLR9-mediated activation of the NF-κB signalling pathway and the associated enhanced expression of matrix metalloproteinase-2 (MMP-2), MMP-7 and cyclo-oxygenase 2 mRNA
  • HCQ can activate caspase-3 and modulate the Bcl-2/Bax ratio inducing apoptosis in CLL, B-cell CLL and glioblastoma cells
  • In triple-negative breast cancer, CQ was shown to eliminate cancer stem cells through reduction of the expression of Janus-activated kinase 2 and DNA methyl transferase 1 [106] or through induction of mitochondrial dysfunction, subsequently causing oxidative DNA damage and impaired repair of double-stranded DNA breaks
  • CQ or HCQ would be considered for use in combination with immunomodulation anti-cancer therapies
  • Therapies used in combination with CQ or HCQ include chemotherapeutic drugs, tyrosine kinase inhibitors, various monoclonal antibodies, hormone therapies and radiotherapy
  • Most studies hypothesise that CQ and HCQ could increase the efficacy of other anti-cancer drugs by blocking pro-survival autophagy.
  • daily doses between 400 and 1200 mg for HCQ are safe and well tolerated, but two studies identified 600-mg HCQ daily as the MTD
  • HCQ is often administered twice daily to limit plasma fluctuations and toxicity
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