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Nathan Goodyear

Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer ... - 0 views

clincancerres.aacrjournals.org/...2580.abstract

sulforaphane breast cancer broccoli

shared by Nathan Goodyear on 18 Mar 11 - No Cached
  • sulforaphane, a natural compound derived from broccoli/broccoli sprouts
  • Sulforaphane inhibits breast CSCs
  • These findings support the use of sulforaphane for the chemoprevention of breast cancer stem cells
  • Nathan Goodyear on 18 Mar 11
     
    Sulforaphane, naturally found in broccoli  inhibits breast CSCs
Nathan Goodyear

The dietary phase 2 protein inducer sulforaph... [Am J Hypertens. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22052072

methylation sulforphane broccoli nutrition diet

shared by Nathan Goodyear on 09 Sep 13 - No Cached
  • Nathan Goodyear on 09 Sep 13
     
    Granted, an animal study, sulforphane from broccoli reduces blood pressure through methylation.
Nathan Goodyear

Drug Screening Identifies Niclosamide as an Inhibitor of Breast Cancer Stem-Like Cells - 0 views

journals.plos.org/...article

Niclosamide cancer cancer stem cells breast cancer

shared by Nathan Goodyear on 21 Mar 18 - No Cached
  • cancer stem cells may also contribute to tumor formation, metastasis, and treatment resistance
  • Studies have shown that some agents (such as metformin) can selectively target cancer stem cells and that dietary polyphenols, curcumin, peperine, and sulforaphane, which are derived from broccoli/broccoli sprouts, are able to target breast cancer stem cells via inhibition of the Wnt signaling, which affects mammosphere size and colony formation
  • niclosamide inhibits tumor growth and reduces tumor weight
  • ...8 more annotations...
  • Niclosamide treatment inhibited the expression of cyclin D1, Hes1, and PTCH by 33%, 57%, and 79%, respectively
  • The mechanism via which niclosamide, a protonophoric anthelmintic drug, induces stem-like-cell-specific toxicity in breast cancer is interesting. It is an old drug that has been used to treat tapeworms in animals
  • Niclosamide is known to uncouple mitochondrial oxidative phosphorylation during tapeworm killing
  • A screening of autophagy modulators revealed that niclosamide is a novel inhibitor of mTORC1 signaling
  • A recent work also demonstrated that niclosamide induces the apoptosis of myelogenous leukemic cells via the inactivation of NF-kappaB and reactive oxygen species generation
  • Niclosamide was also reported to inhibit Wnt signaling [31]–[33] in colon cancer cells
  • Our recent work demonstrated that niclosamide disrupts multiple metabolic pathways in ovarian-cancer-initiating cells
  • The present study showed that niclosamide treatment resulted in the downregulation of target genes involved in the self-renewal of cancer stem-like cells and inhibited breast SPS
  • Nathan Goodyear on 21 Mar 18
     
    Old ant-parasitic, niclosamide, found to down-regulate cancer stem cell activity.
Nathan Goodyear

Steam cooking significantly improves in vitro bile acid binding of collard greens, kale... - 0 views

www.nrjournal.com/...abstract

bile acid gallbladder diet nutrition

shared by Nathan Goodyear on 26 Mar 17 - No Cached
  • Nathan Goodyear on 26 Mar 17
     
    steamed veggies aid acid function.
Nathan Goodyear

Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi - 0 views

www.ncbi.nlm.nih.gov/...PMC5374554

epigenetics nutrition Genome nutrigenomics

shared by Nathan Goodyear on 11 Dec 17 - No Cached
  • Plant miRNA miR168a was found to present in the sera of mammals including human and regulate human gene LDLRAP1
  • plant miRNAs can present within human circulating system through dietary intake and regulate human gene expression emerged. Broccoli sourced miR159 was found in human sera and proved to inhibit breast cancer growth through targeting the gene TCF7
  • This miRNA, with same 6mer and 7mer-A1 target seed sequence as hsa-miR-4259 and hsa-miR-4715-5p, was predicted to target human JAK-STAT signaling pathway gene SPRY4 and transcription regulation genes through miRTar
  • ...1 more annotation...
  • plant miRNAs present in human circulating system were proven to be able to target human genes
  • Nathan Goodyear on 11 Dec 17
     
    Plant microRNA found in human serum.  Previous studies have shown that these plant microRNA's can interact with the human genome.
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