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Nathan Goodyear

Weight gain after primary surgery fo... [Breast Cancer Res Treat. 1992] - PubMed - NCBI - 0 views

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    The increased weight with tamoxifen is seen premenopausal women, but less with postmenopausal women.
Nathan Goodyear

CYP1A1 and CYP1B1 polymorphisms and their association with estradiol and estrogen metab... - 0 views

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    estrogen metabolites and associated risk.
Nathan Goodyear

Comparison of physical and emotional side effects ... [Menopause. 2002 Jul-Aug] - PubMe... - 0 views

  • MPA users reported more vaginal bleeding and breast tenderness than progesterone users.
  • he lesser side effects of the micronized progesterone-containing regimen suggest that some women may prefer it to an MPA-containing regimen.
Nathan Goodyear

Effects of ethyl-eicosapentaenoic acid omega-3 fat... [Menopause. 2009 Mar-Apr] - PubMe... - 0 views

  • Effects of ethyl-eicosapentaenoic acid omega-3 fatty acid supplementation on hot flashes and quality of life among middle-aged women: a double-blind, placebo-controlled, randomized clinical trial.
  • Supplementation with E-EPA omega-3 fatty acid reduced HF frequency and improved the HF score relative to placebo
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    omega-3 aids in hot flash relief
Nathan Goodyear

The Prevalence of Hypoactive Sexual Desire Disorder in Surgically Menopausal Women: An ... - 0 views

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    Low Hormones, post-ovary removal, linked to low libido
Nathan Goodyear

Menopause: a review on the role of oxygen stress a... [Arch Gerontol Geriatr. 2006 May-... - 0 views

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    antioxidants beneficial in postmenopausal women
Nathan Goodyear

Cardiovascular effects of testosterone: implications of the "male menopause"? - 0 views

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    low Testosterone increases cardiovascular disease risk
Nathan Goodyear

Effects of myo-inositol supplementation in postmen... [Menopause. 2011] - PubMed result - 0 views

  • Myo-inositol plus diet improved systolic and diastolic blood pressure, HOMA index, cholesterol, and triglyceride serum levels with highly significant differences,
  • Supplementation with myo-inositol may be considered a reliable option in the treatment of metabolic syndrome in postmenopausal women
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    myo-inositol proven to be a good treatment for those postmenopausal women with metabolic syndrome
Nathan Goodyear

Do urinary oestrogen metabolites predict breast ca... [Br J Cancer. 1998] - PubMed result - 0 views

  • post-menopausal (but not premenopausal) women at baseline who went on to develop breast cancer showed about a 15% lower 2:16alpha-OHE1 ratio than matched control subjects
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    can the pathway of estrogen metabolism help to predict postmenopausal breast cancer?  according to this study, yes.
Nathan Goodyear

Effect of valerian on sleep quality in postmenopau... [Menopause. 2011] - PubMed result - 0 views

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    Valerian root improves sleep in postmenopausal women suffering with insomnia
Nathan Goodyear

Comparison of regimens containing oral micronized ... [J Womens Health Gend Based Med. ... - 0 views

  • Approximately 80% of women reported overall satisfaction with the micronized progesterone-containing regimen. A micronized progesterone-containing HRT regimen offers the potential for improved QOL as measured by improvement of menopause-associated symptoms.
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    watch out!  bioidentical progesterone provides improved symptom control versus synthetic progestin MPA
Nathan Goodyear

Dietary glycemic index, glycemic load, and the risk of breast cancer in an Italian pros... - 0 views

  • GI is a measure of carbohydrate quality in relation to glucose availability and is independent of quantity, whereas GL is a measure of the total glycemic effect and hence is anindicator of the insulin demand of the diet. High-glycemic diets are in fact generally associated with greater insulin secretion
  • the consumption of large quantities of high-GI foods rather than the consumption of high quantities of carbohydrates is linked to the development of breast cancer.
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    High glycemic load and glycemic index associated with increased breast cancer risk in premenopausal women.
Nathan Goodyear

Activation of estrogen re... [J Steroid Biochem Mol Biol. 2007 Nov-Dec] - PubMed - NCBI - 0 views

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    It is always important to work out the biochemical mechanism of action.  Study finds Siberian Rhubarbs mechanism of action is through activation ER-beta receptors.  No activity/affinity for ER-alpha found in this study.  This is important as the ER-beta provides an anti-inflammatory, antigrowth signal.
Nathan Goodyear

Subtype-specific activation of estrogen recept... [Phytomedicine. 2007] - PubMed - NCBI - 0 views

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    Study finds that Err 731, extract of Siberian Rhubarb, strong affinity for ER-beta and weak activity for ER-alpha in bone, though none found present in endometrial cells.  This is the second study to provide evidence of molecular mechanism of action through ER-beta receptors.
Nathan Goodyear

Associations between sex hormone binding globulin and metabolic syndrome parameters in ... - 0 views

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    Low SHGB associated with increased association with metabolic syndrome components.  Low SHBG particuraliy associated with increased obesity (visceral) and glucose dysmetabolism. This study looked at premenopausal women.
Nathan Goodyear

ENDOGENOUS SEX HORMONES, BLOOD PRESSURE CHANGE, AND RISK OF HYPERTENSION IN POSTMENOPAU... - 0 views

  • Among postmenopausal women, serum T was elevated in hypertensive participants [9, 11, 12], and total T, free T, and DHEA were positively correlated with SBP
  • T and DHEA were attenuated by adjustment for BMI, reflecting either a confounding or a mediating effect of obesity
  • SHBG concentration was inversely associated with risk of hypertension and longitudinal rise of BP over time
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  • SHBG has been postulated as a marker for insulin resistance
  • In vitro studies showed that insulin inhibits SHBG production from hepatoma cells
  • In intervention studies, successful weight loss and weight maintenance increased SHBG in men with obesity
  • E2 may also induce insulin resistance and thereafter tend to raise BP.
  • strong association between E2 and measures of insulin resistance in postmenopausal women, independent of adiposity
  • In postmenopausal women that received hormone replacement therapy, estrogen therapy increased mononuclear cell secretion of tumor necrosis factor alpha (TNF-α)
  • estrone levels were positively associated with inflammatory markers in postmenopausal women
  • higher baseline concentrations of endogenous E2, total and bioavailable T, and DHEA and lower concentration of SHBG were associated with a higher incidence of hypertension and a greater increase in BP during follow-up
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    Data from MESA study finds that increasing endogenous Estradiol, Total and free Testosterone, DHEA, and lower SHBG were associated with hypertension in postmenopausal women.
Nathan Goodyear

Red alert for women's heart: the urgent need for more research and knowledge on cardiov... - 0 views

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    Vasomotor symptoms (hot flashes and night sweats) is associated with increased cardiovascular risk in women.
Nathan Goodyear

Correlation between Hormonal Statuses and Metabolic Syndrome in Postmenopausal Women - 0 views

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    Study of 110 women finds metabolic syndrome prevalence at 39%.  The women with metabolic syndrome had statistically higher Testosterone levels and statistically lower SHBG.  This stands in start contrast to metabolic syndrome in men.
Nathan Goodyear

Effects of testosterone administration on cognitive function in hys... - PubMed - NCBI - 0 views

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    Testosterone therapy in women post-hysterectomy, with low total and low free Testosterone, provides no benefit in cognitive function.
Nathan Goodyear

Covariation of change in bioavailable testosterone and adiposity in... - PubMed - NCBI - 0 views

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    Bioavailable Testosterone is positively associated with Visceral adipose tissue and to a lesser degree subcutaneous fat in women.  
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