Effects of ethyl-eicosapentaenoic acid omega-3 fatty acid supplementation on hot flashes and quality of life among middle-aged women: a double-blind, placebo-controlled, randomized clinical trial.
Supplementation with E-EPA omega-3 fatty acid reduced HF frequency and improved the HF score relative to placebo
Myo-inositol plus diet improved systolic and diastolic blood pressure, HOMA index, cholesterol, and triglyceride serum levels with highly significant differences,
Supplementation with myo-inositol may be considered a reliable option in the treatment of metabolic syndrome in postmenopausal women
post-menopausal (but not premenopausal) women at baseline who went on to develop breast cancer showed about a 15% lower 2:16alpha-OHE1 ratio than matched control subjects
Approximately 80% of women reported overall satisfaction with the micronized progesterone-containing regimen. A micronized progesterone-containing HRT regimen offers the potential for improved QOL as measured by improvement of menopause-associated symptoms.
GI is a measure of carbohydrate quality in relation
to glucose availability and is independent of quantity, whereas GL is a measure of the total glycemic effect and hence is
anindicator of the insulin demand of the diet. High-glycemic diets are in fact generally associated with greater insulin secretion
the consumption of large quantities of high-GI foods rather than the consumption of high quantities of carbohydrates
is linked to the development of breast cancer.
It is always important to work out the biochemical mechanism of action. Study finds Siberian Rhubarbs mechanism of action is through activation ER-beta receptors. No activity/affinity for ER-alpha found in this study. This is important as the ER-beta provides an anti-inflammatory, antigrowth signal.
Study finds that Err 731, extract of Siberian Rhubarb, strong affinity for ER-beta and weak activity for ER-alpha in bone, though none found present in endometrial cells. This is the second study to provide evidence of molecular mechanism of action through ER-beta receptors.
Low SHGB associated with increased association with metabolic syndrome components. Low SHBG particuraliy associated with increased obesity (visceral) and glucose dysmetabolism. This study looked at premenopausal women.
Among postmenopausal women, serum T was elevated in hypertensive participants [9, 11, 12], and total T, free T, and DHEA were positively correlated with SBP
T and DHEA were attenuated by adjustment for BMI, reflecting either a confounding or a mediating effect of obesity
SHBG concentration was inversely associated with risk of hypertension and longitudinal rise of BP over time
SHBG has been postulated as a marker for insulin resistance
In vitro studies showed that insulin inhibits SHBG production from hepatoma cells
In intervention studies, successful weight loss and weight maintenance increased SHBG in men with obesity
E2 may also induce insulin resistance and thereafter tend to raise BP.
strong association between E2 and measures of insulin resistance in postmenopausal women, independent of adiposity
In postmenopausal women that received hormone replacement therapy, estrogen therapy increased mononuclear cell secretion of tumor necrosis factor alpha (TNF-α)
estrone levels were positively associated with inflammatory markers in postmenopausal women
higher baseline concentrations of endogenous E2, total and bioavailable T, and DHEA and lower concentration of SHBG were associated with a higher incidence of hypertension and a greater increase in BP during follow-up
Data from MESA study finds that increasing endogenous Estradiol, Total and free Testosterone, DHEA, and lower SHBG were associated with hypertension in postmenopausal women.
Study of 110 women finds metabolic syndrome prevalence at 39%. The women with metabolic syndrome had statistically higher Testosterone levels and statistically lower SHBG. This stands in start contrast to metabolic syndrome in men.