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Nathan Goodyear

Effects of physiologic testosterone therapy on qua... [Menopause. 2014] - PubMed - NCBI - 1 views

www.ncbi.nlm.nih.gov/...24473536

testosterone therapy menopause premature ovarian failure women

shared by Nathan Goodyear on 03 Feb 14 - No Cached
  • Nathan Goodyear on 03 Feb 14
     
    12 months of Testosterone in women with premature ovarian failure found no benefit in quality of life measures.  Testosterone is being marketed and touted as a means to help women through menopause.  This study, though no side effects found, no benefit found.
Nathan Goodyear

Efficacy and safety of testosterone in the managem... [J Sex Med. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22304681

CVD Testosterone women menopause post-menopause libido therapy female hormone hormones

shared by Nathan Goodyear on 20 Mar 14 - No Cached
  • Nathan Goodyear on 20 Mar 14
     
    review of the literature finds that Testosterone therapy in women with low libido improves sexual activity without CVD and breast cancer risk in postmenopausal women.  Post menopause is a time associated with an increased risk of CVD in women.
Nathan Goodyear

Menopause and Ovariectomy Cause a Low Grade of Systemic Inflammation that May Be Preven... - 0 views

www.jimmunol.org/...1393.abstract

Menopause inflammation estrogen hormone hormones

shared by Nathan Goodyear on 15 Jul 13 - No Cached
  • Nathan Goodyear on 15 Jul 13
     
    Menopausal rats and rats that had ovaries removed have increased low grade inflammatory signaling.  This study treated the rats in question with either Estradiol and Losartan and both decreased inflammatory signaling.
Nathan Goodyear

Is Timing Everything? New Insights into Why the Effect of Estrogen Therapy on Memory Mi... - 0 views

endo.endojournals.org/...2570.full

estrogen therapy memory hormone therapy HRT BHRT Estradiol neurology brain women hormone hormones

shared by Nathan Goodyear on 06 Aug 13 - No Cached
  • Women who have an oophorectomy before the normal age at menopause show an increased risk for cognitive impairment or dementia later in life unless they are treated with estrogen until the normal age at menopause
  • SIRT1 has been implicated in the disruption of mitochondrial bioenergenetics in Alzheimer's disease and mild cognitive impairment
  • the increase in dementia observed with CEE/MPA rather than CEE alone suggests potential deleterious effects of MPA on brain function in older women
  • ...1 more annotation...
  • SIRT 1 as a potential mediator of the impact of E2
  • Nathan Goodyear on 06 Aug 13
     
    Early estrogen therapy in perimenopause and early menopause, with Estradiol, provides more health benefits than later therapy.  This article looked at Estrogen's effects on a woman's brain.  This likely has its origins in the change in estrogen receptors. The signal is not changing, but the reception of that signal is.  How else can one explain a different response to the same hormone dosage?
Nathan Goodyear

ARS | Publication request: Sex hormone modulation of proinflammatory cytokine and CRP e... - 0 views

www.ars.usda.gov/...publications.htm

hormone hormones inflammation Testosterone estrogen women LDL

shared by Nathan Goodyear on 17 Nov 13 - No Cached
  • Nathan Goodyear on 17 Nov 13
     
    Study finds that Testosterone provided a small anti-inflammatory effect in post-menopausal women and men, whereas Estrogen increased macrophage cytokine production in post-menopausal women with elevated LDL.  Now, this study did not differentiate PCOS versus non-PCOS, nor did it look at the effects of adiposity in these hormonal effects in women.  Both of which, will effect the outcome.
Nathan Goodyear

Menopause and the Metabolic Syndrome - 0 views

www.ncbi.nlm.nih.gov/...PMC2894539

metabolic syndrome menopause testosterone women hormone hormones MetS

shared by Nathan Goodyear on 30 Aug 13 - No Cached
  • Nathan Goodyear on 30 Aug 13
     
    Menopause transition is associated with increasing Testosterone levels in women.  This is associated with an increase in MetS.
Nathan Goodyear

Study Finds Estrogen Therapy Improves Depression and Anxiety in Recently Menopausal Wom... - 0 views

www.prnewswire.com/...gnitive-effects-172536101.html

estrogen therapy HT BHRT HRT depression anxiety

shared by Nathan Goodyear on 29 Oct 13 - No Cached
  • Nathan Goodyear on 29 Oct 13
     
    Estrogen therapy in women recently postmenopausal, found to improve symptoms of depression and anxiety.  The mean age of women in this study was 52.7.  Average age of menopause is 51, so apprx 1 year postmenopausal in this study.  Both premarin and bioidentical estradiol was used in different arms of the study.  Bioidentical progesterone was used in all 3 arms.
Nathan Goodyear

Systemic lupus erythematosus and hormone repla... [Menopause Int. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17540136

SLE Lupus hormone hormones progesterone HRT BHRT menopause

shared by Nathan Goodyear on 30 Oct 13 - No Cached
  • Nathan Goodyear on 30 Oct 13
     
    Women with SLE enter menopause earlier.  This study comments on the need for hormone testing in women with SLE and appropriate therapy as indicated.  This study recommended against estrogen therapy due to studies revealing increased flares.  The problem with those studies is that they looked at OCPs and synthetic HRT.
Nathan Goodyear

The special extract ERr 731 of the roots o... [Menopause. 2007 Mar-Apr] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17213754

anxiety ERr 731 siberian Rhubarb menopause women health

shared by Nathan Goodyear on 01 Jul 14 - No Cached
  • Nathan Goodyear on 01 Jul 14
     
    ERr 731 extract from Siberian Rhubarb found to be effective against anxiety related to menopause.
Nathan Goodyear

Effects of Alcohol Consumption on Plasma and Urinary Hormone Concentrations in Premenop... - 0 views

jnci.oxfordjournals.org/...722.short

alcohol cancer estrogen pre-menopause

shared by Nathan Goodyear on 10 Feb 11 - No Cached
  • This study has shown increases in total estrogen levels and amount of bioavailable estrogens in association with alcohol consumption in pre-menopausal women.
  • Nathan Goodyear on 10 Feb 11
     
    alcohol increases estrogen production in pre-menopausal women;  implications that alcohol intake increases risk of estrogen sensitive cancers
Nathan Goodyear

Homeopathy service in a National Health Service community menopause clinic: audit of cl... - 0 views

mi.rsmjournals.com/...72.abstract

homeopathy health menopause

shared by Nathan Goodyear on 21 Sep 11 - No Cached
  • Nathan Goodyear on 21 Sep 11
     
    study shows that homeopathy improves 81.4% of menopause symptoms
Nathan Goodyear

Biologic and Pharmacologic Principles of ET for Menopause: Estrogen Steroidogenesis and... - 0 views

www.medscape.com/...523196_3

estrogen biochemistry action synthesis menopause

shared by Nathan Goodyear on 17 Jul 11 - No Cached
  • Nathan Goodyear on 17 Jul 11
     
    biologic and pharmacologic principles of ET for Menopause: Estrogen synthesis and action
Nathan Goodyear

Program Planner | Presentation - 0 views

www.abstractsonline.com/pp8

CAD cardiovascular disease women hormone hormones Estradiol progesterone BHRT bio-identical hormones female

shared by Nathan Goodyear on 16 Dec 14 - No Cached
  • Nathan Goodyear on 16 Dec 14
     
    Just an abstract from the Presentation at the 2014 Scientific Session. The abstract points to a 40% reduction in CAD with the onset of BHRT (Estradiol and progesterone topical) within 6 years of menopause compared to women 10 years post-menopause.  This points to timing as a critical component of BHRT in women and CAD.
Nathan Goodyear

Inclusion of Endogenous Hormone Levels in Risk ... [J Clin Oncol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25135988

post-menopause post menopause women female hormones hormone estradiol estrone testosterone DHEA prolactin SHBG dehydroepiandrosterone breast cancer

shared by Nathan Goodyear on 21 Aug 14 - No Cached
  • Nathan Goodyear on 21 Aug 14
     
    study finds hormone evaluations in post menopause women aids in breast cancer risk assessment.
Nathan Goodyear

Menopause and the Metabolic Syndrome - 0 views

www.ncbi.nlm.nih.gov/...PMC2894539

metabolic syndrome CVD cardiovascular disease Testosterone Menopause women female hormone hormones

shared by Nathan Goodyear on 04 Mar 15 - No Cached
  • Nathan Goodyear on 04 Mar 15
     
    Menopause transition can become a Testosterone dominant phase associated with increased CVD and increased metabolic syndrome.
Nathan Goodyear

PLOS ONE: Persistent Organic Pollutants and Early Menopause in U.S. Women - 0 views

journals.plos.org/...article

EDC endocrine disrupting chemicals women hormone hormones female xenoestrogens endocrine disruptors menopause

shared by Nathan Goodyear on 30 Jan 15 - No Cached
  • Nathan Goodyear on 30 Jan 15
     
    study identifies 15 Endocrine Disrupting Chemicals that lead to earlier Menopause.  Maybe we should change it to Chemopause.
Nathan Goodyear

Circulating 2-hydroxy and 16-α hydroxy estrone levels and risk of breast canc... - 1 views

www.ncbi.nlm.nih.gov/...PMC2562592

estrogen metabolism menopause post-menopause post menopause estrogen metabolite 2-OH-estrone 16-alpha-OH-estrone 2:16alpha-OH estrone breast cancer risk hormone hormones

shared by Nathan Goodyear on 21 Aug 14 - No Cached
  • 2-OH estrogens bind to the estrogen receptor (ER) with affinity equivalent to or greater than estradiol
  • previous prospective studies have not observed any significant associations with either 2-OH or 16α-OH estrone or the ratio of the two metabolites and breast cancer risk overall.
    • Nathan Goodyear
      Nathan Goodyear on 08 Oct 15
       
      whether that risk is increased or decreased
  • it has been hypothesized that metabolism favoring the 2-OH over the 16α-OH pathway may be inversely associated with breast cancer risk (28).
  • ...24 more annotations...
  • they may act as only weak mitogens (14, 15), or as inhibitors of proliferation
  • No significant associations have been observed between 2-OH estrone and breast cancer risk
  • While 16α-OH estrone binds to the ER with lower affinity than estradiol, it binds covalently (18-20) and once bound, fails to down-regulate the receptor (21). Thus, 16α-OH estrone stimulates cell proliferation in a manner comparable to estradiol in ER+ breast cancer cell lines
  • In this large prospective study of 2-OH and 16α-OH estrone metabolites and breast cancer risk, we did not observe any significant associations overall with either individual metabolite or with the ratio of the two metabolites
  • we observed positive associations with 2-OH estrone and the 2:16α-OH estrone ratio among women with lower BMI and women with ER-/PR-tumors,
  • To date, several epidemiologic studies have examined the association between the 2-OH and 16α-OH estrogen metabolites and breast cancer risk with inconclusive results.
  • circulating estrogen levels have been associated more strongly with ER+/PR+ tumors than with ER-/PR- tumors
  • our results do not support the hypothesis that metabolism favoring the 2-OH estrone pathway is more beneficial to breast cancer risk than that favoring the 16α-OH estrone pathway
  • we observed significant positive associations of both 2-OH estrone and the 2:16α-OH estrone ratio with ER-/PR-tumors
  • Three (30, 32, 33) of four (30-33) studies observed RRs above 1 for the association between 16α-OH estrone and breast cancer risk (range of RRs=1.23-2.47); none of the point estimates was statistically significant though one trend was suggestive
  • based on animal studies, 2-OH estrone and the 2:16α-OH estrone ratio have been hypothesized to be inversely associated with breast cancer risk
  • No significant associations have been observed between 2-OH estrone, 16α-OH estrone, or the 2:16α-OH estrone ratio and breast cancer risk and the direction of the estimates is not consistent across studies.
    • Nathan Goodyear
      Nathan Goodyear on 08 Oct 15
       
      better worded is no consistent, significant associations.   There are some studies that point to the 16 catecholestrogen and increased cancer risk; limited studies show negative effects of 2 catecholestrogens on cancer risk and prospective studies available pretty much dispel the idea that the 2:16 ratio has an risk predictability.
  • we observed a suggestive inverse association with 16α-OH estrone and a significant positive association with the 2:16α-OH estrone ratio among lean women, suggesting possible associations in a low estrogen environment.
  • 16α-OH estrone increases unscheduled DNA synthesis in mouse mammary cells (27) and hence also may be genotoxic
  • Although 2-OH estrogens are capable of redox cycling, the semiquinones and quinones (i.e., the oxidized forms) form stable DNA adducts that are reversible without DNA destruction
  • In our population of PMH nonusers, we observed no associations with ER+/PR+ tumors, but significant positive associations with 2-OH estrone and the 2:16α-OH estrone ratio among women with ER-/PR- tumors
    • Nathan Goodyear
      Nathan Goodyear on 08 Oct 15
       
      one of the few studies to find this association between 2 catecholestrogens and the 2:16 ratio and ER-/PR-tumors
  • Animal and in vitro studies have shown that hydroxy estrogens can induce DNA damage either directly, through the formation of quinones and DNA adducts, or indirectly, through redox cycling and the generation of reactive oxygen species
    • Nathan Goodyear
      Nathan Goodyear on 08 Oct 15
       
      genotoxic via directe DNA adducts and indirectly via ROS; this is in addition to the proliferative effect
  • we observed a significant positive association between the 2:16α-OH estrone ratio and breast cancer risk among lean women
  • No significant associations have been observed with the 2:16α-OH estrone ratio
  • In the Danish study, no associations were observed with either ER+ or ER- tumors among PMH nonusers
  • significant positive associations with 2-OH estrone and the 2:16α-OH estrone ratio were observed among PMH users with ER+, but not ER-, tumors
  • it is possible that the genotoxicity of 2-OH estrone plays a role in hormone receptor negative tumors
  • 4-OH estrogens have a greater estrogenic potential than 2-OH estrogens, given the lower dissociation rate from estrogen receptors compared with estradiol (61), and are potentially more genotoxic since the quinones form unstable adducts, leading to depurination and mutation in vitro and in vivo
  • the balance between the catechol (i.e., 2-OH and 4-OH) and methoxy (i.e., 2-Me and 4-Me) estrogens may impact risk
  • Nathan Goodyear on 21 Aug 14
     
    The risks of estrogen metabolism are not clear cut.  Likely never will be due to the complexity of individual metabolism.  This study found no correlation between 2OH-Estrone and 2OH:16alpha-Estrone and breast cancer risk in ER+/PR+ breast cancer.  Translated: no benefit in breast cancer risk in 2OH-Estrone metabolism or increased 2OH:16alpha estrone metabolism.  There was a positive association between 2OH-Estrone and 2:16alpha-Estrone in women with ER-/PR- tumors and low BMI.
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Nathan Goodyear

Changes in the immune system during menopause and aging. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20515802

menopause disease NK cells natural killer cells CD4 aging

shared by Nathan Goodyear on 05 Oct 16 - No Cached
  • Nathan Goodyear on 05 Oct 16
     
    Menopause is associated with a decline in CD4 T and B cells and well as a decrease in NK cells.  This is a set up for disease, particularly cancer.
Nathan Goodyear

A cross-sectional study of different patterns of oral contraceptive use among premenopa... - 0 views

www.ncbi.nlm.nih.gov/...PMC3123282

birth control pills OCP contraception IGF-1 HGH pre-menopausal women human growth hormone

shared by Nathan Goodyear on 20 Feb 13 - No Cached
  • Nathan Goodyear on 20 Feb 13
     
    Birth control pills were found to reduce IGF-1 levels in the short term and long term.  Those that had used birth control pills had lower IGF-1 levels compared to those that had never used birth control pills.  This fits with the current knowledge that oral estrogen reduces HGH and IGF-1.  Those were in post-menopausal women, but this is in pre-menopaus women.  This has implications on health, weight, disease...
Nathan Goodyear

Accelerated Accumulation of Multimorbidity After Bilateral Oophorectomy: A Population-B... - 0 views

www.mayoclinicproceedings.org/...abstract

oophorectomy menopause chronic disease of aging women hormones

shared by Nathan Goodyear on 04 Oct 16 - No Cached
  • Nathan Goodyear on 04 Oct 16
     
    For most women, the practice of pre-menopausal, preventative removal of ovaries should be no more.  Evidence does not support a reduction in ovarian cancer; but, it does support an increased risk of depression, hyper lipidemia, cardiac arrhythmia, CAD, arthritis, asthma, COPD, and asthma.
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