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Nathan Goodyear

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and L... - 0 views

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    Rat study found that High fat and high branch chain amino acid intake long-term leads to insulin resistance.  This occurred through phosphorylation of insulin signaling downstream and differed between lean versus obese individuals.  
Nathan Goodyear

Frontiers | Prevalence of Non-responders for Glucose Control Markers after 10 Weeks of ... - 0 views

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    Exercise is key to healthy lifestyle: High Intensity Interval Training for Insulin resistance found to improve waist circumference, systolic bp, and HOMA-IR; Increased non-responders for insulin and glucose in those with mild IR versus severe IR.
Nathan Goodyear

Insulin Resistance Induced by Hyperinsulinemia Coincides with a Persistent Alteration a... - 0 views

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    Hyperinsulinemia causes insulin resistance through an attempt to downregulates over signaling.
Nathan Goodyear

Effect of Dehydroepiandrosterone Replacement on Insulin Sensitivity and Lipids in Hypoa... - 0 views

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    Study finds 50 mg of DHEA improves insulin sensitivity in Hypoadrenal women.  The authors also found and increase in DHEAS, bioavailable T, androstenedione, and a reduced SHBG, insulin, and glucagon.
Nathan Goodyear

Diabetologia, Volume 46, Number 5 - SpringerLink - 0 views

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    This study finds obesity associated with inflammation, but insulin resistance not.  But insulin resistance contributes to obesity...
Nathan Goodyear

Testosterone Concentrations in Women and Men With NIDDM - 1 views

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    insulin resistance has different effects in men versus women.  In men, insulin resistance is associated with low T in men, but in elevate T in women.
Nathan Goodyear

Higher Serum Testosterone Concentration in Older Women is Associated with Insulin Resis... - 0 views

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    This study found that increasing Testosterone, as determined by serum, is associated with increased CVD, insulin resistance, and metabolic syndrome in postmenopausal women.  I believe that this massive Testosterone doping campaign that we are seeing in men and women is following the same patter seen with premarin and provera. 
Nathan Goodyear

Bacterial Endotoxin Activity in Human Serum Is Associated With Dyslipidemia, Insulin Re... - 0 views

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    LPS linked to dsylipidemia, insulin resistance, obesity, and chronic inflammation.
Nathan Goodyear

JNK Expression by Macrophages Promotes Obesity-induced Insulin Resistance and Inflammation - 0 views

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    JNK pathway plays important role in inflammation signaling.  In this article, JNK activation plays role in insulin resistance, obesity, and metabolic dysfunction.
Nathan Goodyear

Type 1 diabetes associated with acquired generaliz... [J Clin Endocrinol Metab. 2008] -... - 0 views

  • Acquired generalized lipodystrophy (AGL) is marked by severe insulin resistance and hypertriglyceridemia. Rarely, AGL and type 1 diabetes (T1D) coexist.
  • Long-term recombinant leptin therapy is effective in treating the insulin resistance of patients with the unusual combination of T1D and AGL.
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    leptin useful in severe insulin resistance, hypertriglyceridemia and type 1 Diabetes
Nathan Goodyear

Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with D... - 0 views

  • Low testosterone levels were independently associated with insulin resistance in men with type 1 diabetes as well as type 2 diabetes
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    low Testosterone associated with insulin resistance
Nathan Goodyear

-Absence of Melatonin and Insulin Resistance - 0 views

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    insulin resistance associated with absence of melatonin
Nathan Goodyear

ScienceDirect - Journal of Diabetes and its Complications : Starvation diet and very-lo... - 0 views

  • The metabolic situation in extremely low-calorie diets may be comparable to that in starvation
  • increased insulin resistance in states of starvation and anorexia nervosa, with a concomitant role in stress hormones.
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    very-low-calorie diets, like found in the HCG diet, results in insulin resistance in many individuals, results in muscle mass loss, and results in many negative effects, including weight gain.
Nathan Goodyear

Impact of Metabolic Syndrome on Benign Prostatic Hy... [Urol Int. 2014] - PubMed - NCBI - 0 views

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    Metabolic syndrome associated with increased risk of prostate enlargement in elderly Chinese men.  The study highlighted insulin resistance as a key risk.  Insulin resistance is known to increase aromatase activity and thus estrogen production which will increase prostate growth.
Nathan Goodyear

Insulin resistance is another factor that increase... [Endocrine. 2014] - PubMed - NCBI - 0 views

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    Interesting that insulin resistance appears to be associated with treatment failure and recurrent disease in papillary thyroid cancer.
Nathan Goodyear

The relation of proinsulin, insulin, and proinsulin... [Diabetes. 1997] - PubMed - NCBI - 0 views

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    insulin resistance promotes increased processing of proinsulin to insulin
Nathan Goodyear

Uncoupling between insulin and rele... [Metab Syndr Relat Disord. 2010] - PubMed - NCBI - 0 views

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    Obese women with PCOS found to have uncoupled insulin and d-chiro-inositol secretion thus worsening insulin resistance
Nathan Goodyear

Insulin increases CSF Abeta42 levels in normal old... [Neurology. 2003] - PubMed - NCBI - 0 views

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    elevated insulin, found in insulin resistance, associated with disordered Beta-amyloid metabolism.
Nathan Goodyear

Metabolic influences on neuroendocrine regulation of reproduction - 0 views

  • Energy storage occurs mainly at the level of white adipose tissue, where adipocytes secrete the anorexigenic adipokine leptin
  • humans and laboratory animals with leptin or insulin deficiency or resistance and/or increased ghrelin levels exhibit delayed or absent puberty and frequently display hypogonadotropic hypogonadism, which prevents fertility
  • Ghrelin suppresses pulsatile gonadotropin-releasing hormone (GnRH) release [14,15], thus serving as a signal to suppress reproduction in times of famine
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  • GnRH neurons have been shown to express insulin receptor mRNA and protein [27] and are activated by insulin
  • AgRP and NPY have the opposite (orexigenic) effect, inducing food intake.
  • Neuropeptides derived from POMC/CART neurons exert a potent anorectic action, thus decreasing food intake and body weight
  • Kisspeptins (encoded by KISS1) have been identified in the last decade as the most potent secretagogues of GnRH release.
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    Good, although brief, discussion of the interaction between metabolism and hormones.  Kisspeptin is a GNRH secreatagogue "upstream".   Insulin, Leptin, and Gherlin can inhibit GNRH through resistance and low levels.  Probably a U shaped graph of optimal activity.
Nathan Goodyear

Evidence for an Inhibitory Effect of Physiological Levels of Insulin on the Growth Horm... - 0 views

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    Insulin inhibits HGH production.  Key component of weight gain in our society today, with insulin resistance at an all time high.
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