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Nathan Goodyear

Oxidative Stress and Its Relationship With Adenosine Deaminase Activity in Various Stag... - 0 views

www.ncbi.nlm.nih.gov/...PMC3547448

Adenosine Deaminase ADA cancer breast cancer superoxide disumutase glutathione peroxidase oxidative stress inflammation

shared by Nathan Goodyear on 10 Nov 14 - No Cached
  • Reduced SOD activity might be responsible for excessive accumulation of superoxide anions leading to increased free radical mediated injury. Increased free radical production has been shown to be responsible for chromosomal damage leading to mutagenecity, cell proliferation and carcinogenesis. SOD activity showed marked improvement after mastectomy indicating the lowering of oxidative stress.
  • The increased production of reactive oxygen species causes oxidative stress leading to cell proliferation and hence increased inflammatory conditions
  • Superoxide dismutase is an important antioxidant enzyme which decomposes the harmful superoxide anions into hydrogen peroxide thus protects the body from the action of free radicals
  • ...20 more annotations...
  • Females suffering from breast cancer had significantly decreased Superoxide dismutase (SOD) and reduced glutathione (GSH) levels in comparison to normal females
  • ADA seems to be a promising marker of inflammation in breast cancer thereby suggesting that it can be used as a diagnostic tool to detect the stage of breast cancer along with cytopathological studies
  • In conclusion, our study confirmed the role of oxidative stress in the pathogenesis of breast cancer.
  • Another potent antioxidant molecule is reduced glutathione. It acts as reductant which converts hydrogen peroxide into water and reduces lipid peroxidation products into their corresponding alcohols and thus mediates protective action.
  • In the present study, significantly low SOD activity has been observed in female patients suffering from carcinoma breast both pre as well as post operative in comparison to healthy females.
  • We observed significantly decreased SOD activity and GSH levels in patients belonging to clinical stage 4 as compared to those having stages 1, 2 or 3 of breast cancer.
  • Increased ADA activity in breast cancer patients has also been reported
  • The compromised antioxidant defence system produces the oxidative stress which in turn creates the inflammatory response shown by concomitant increased adenosine deaminase (ADA) activity in female patients.
  • Experimental and epidemiological evidences implicate the involvement of oxygen derived free radical in the pathogenesis of breast cancer.
  • Antioxidant status was highly depressed in advanced stages of breast cancer as compared to initial stage.
  • In the present study, significantly low GSH levels were observed in female patients of carcinoma breast as compared to normal females
  • Walia et al. (1995) reported increased ADA activity in breast cancer patients as compared to age matched normal subjects.
  • These free radicals are able to cause damage to membrane, mitochondria and macromolecules including proteins, lipids and DNA and actively take part in cell proliferation. This cascade in turn generates the inflammatory response and causes the progression of the disease.
  • increased oxidative stress gives rise to inflammation which could further aggravates the disease
  • Breast carcinoma involves a cascade of events that are highly inflammatory.
  • Marked oxidative stress in stage 4 of breast cancer indicated advancement of the disease, hence checking oxidative stress at initial stage could be helpful for controlling the progression of the disease.
  • They concluded that ADA is a better probable parameter for detection of breast cancer
  • Adenosine deaminase enzyme (ADA) catalyzes the conversion of adenosine to inosine which finally gets converted to uric acid
  • serum ADA activity tends to increase with advancing age,
  • Prevalence of oxidative stress gives rise to inflammation.
  • Nathan Goodyear on 10 Nov 14
     
    Study finds a reduction in SuperOxide Dismutase and Glutathione Perioxidase in advancing breast cancer.  Cancer is a high oxidative stress disease that results in inflammation, mitochondrial dysfunction and proliferation.  Adenosine Deaminase (ADA) is proposed to be another biomarker to assess tumor stage.  
Nathan Goodyear

Sex differences in the gut microbiome drive hormone-dependent regul... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23328391

Testosterone gut flora gut microbiota gut bacteria hormone hormones flora microbiota

shared by Nathan Goodyear on 01 Mar 15 - No Cached
  • Nathan Goodyear on 01 Mar 15
     
    mouse study finds but flora effects Testosterone levels.  This study, available only in abstract form, found that commensal transplant from male to female mice resulted in an increase in Testosterone levels in the female mice.
Nathan Goodyear

ftp://www.bf.lu.lv/grozs/MolekularasBiologijas/Imunol%20II/Publik%C4%81cijas%20semin%C4... - 0 views

www.bf.lu.lv/...ent%20regulation%20of%20AI.pdf

gut flora gut microbiome gut microbiota gut Testosterone hormone hormones autoimmune disease

shared by Nathan Goodyear on 30 Apr 15 - No Cached
  • Nathan Goodyear on 30 Apr 15
     
    full article to previous abstract:  fecal transplant from male mice to female mice resulted in an increase in Testosterone production in the female mice revealing a link between the gut microbial population, diversity and Testosterone production.
Nathan Goodyear

Sex differences in the adult HPA axis and affectiv... [Brain Res. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24857958

bisphenol A Bisphenol-A BPA xenoestrogen HPA hypothalamic-pituitary-adrenal EDR endocrine disrupter brain hormone hormones

shared by Nathan Goodyear on 27 May 14 - No Cached
  • Nathan Goodyear on 27 May 14
     
    Animal study finds that Bisphenol A exposure in utero has profound different effects in male offspring versus female offspring.  In the male offspring there appears to be an up regulation of the HPA axis.  The opposite appears true in the female off spring.  Additionally, the receptors are effected differently as well.
Nathan Goodyear

The implication of neuroactive steroids in Tourette syndrome pathogenesis: a ... - 0 views

www.ncbi.nlm.nih.gov/...PMC3849218

tourette's syndrome hormones 5-alpha reductase

shared by Nathan Goodyear on 08 Dec 15 - No Cached
  • The typical onset of TS occurs at 6–7 years of age and is characterized by the appearance of simple, recurrent motor tics, followed by the manifestation of phonic tics after several months [12]. In most children, TS symptoms undergo a progressive exacerbation, which reaches its zenith at the beginning of puberty (11–12 years of age), and is then followed by a gradual remission in the majority of patients
  • 30–40% of TS-affected children retain their symptoms in adulthood
  • Multiple neurotransmitters have been implicated in TS, including dopamine (DA), serotonin, norepinephrine, acetylcholine, glutamate and γ-amino-butyric acid (GABA)
  • ...11 more annotations...
  • female gender may predict greater tic severity in adulthood
  • male gender is a major risk factor for TS (with a male:female prevalence ratio estimated at ~4:1)
  • the typical age of onset coincides with adrenarche (6–7 years old); symptoms increase in severity until the beginning of puberty (12 years old) and then undergo a spontaneous amelioration, which becomes apparent with the end of puberty (at 18–19 years of age)
  • TS is diagnosed later in females than males
  • ample evidence supports the involvement of DAergic dysfunctions in TS
  • a number of clinical observations showed that tics in TS patients could be exacerbated by anabolic androgens
  • steroidogenic enzymes and androgen receptors may serve as putative therapeutic targets for this disorder
  • Unlike males, tic severity is typically increased after puberty in females
  • 26% of females were found to experience exacerbation of tics in the estrogenic phase of the menstrual cycle, and this phenomenon was found to be correlated with increased tic severity at menarche
  • biochemical hallmark of adrenarche is the acquisition of 17,20 lyase activity by cytochrome P450 C17 (CYP17A1)
  • increased synthesis of dehydroepiandrosterone (DHEA) and androstenedione, which leads to the growth of axillary and pubic hair as well as enhancement in the oiliness of the skin
  • Nathan Goodyear on 08 Dec 15
     
    interesting read on hormones and tourette's.. Proposed that 5 alpha reductase activity is involved in worsening of tics.  This makes sense as Testosterone in men with low T is known to increase dopamine and dopaminergic dysfunction is known to play a role in tourette's;  the clinical presentation of girls vs boys is very different.  The authors of this article propose that 5 alpha reductase activity controls a back door method where by progesterone is converted to androgens.
anonymous

Warda - Arab Female Escorts In Dubai Al Nahda +971523202298 - 0 views

www.escortsinburdubai.com/...b-female-escorts-in-dubai.html

Female Escorts In Dubai

shared by anonymous on 06 May 17 - No Cached
  • anonymous on 06 May 17
     
    Hi, I'm Warda from Uae Escorts. I'm work at Arab Female Escorts In Dubai Al Nahda.
Nathan Goodyear

urn:nbn:se:umu:diva-124842 : Training and hormones in physically active women : with an... - 0 views

umu.diva-portal.org/...record.jsf

resistance training exercise women hormones training female

shared by Nathan Goodyear on 27 Sep 16 - No Cached
  • Nathan Goodyear on 27 Sep 16
     
    Only abstract available: resistance training in first half of female cycle found to increase muscle mass and strength beyond that of the last 2 weeks.  No difference was found in the use of OCPs.
Nathan Goodyear

Testosterone: More Than Having the Guts to Win the Tour de France - 0 views

www.sciencedirect.com/...S1074761313003439

Testosterone gut flora gut microbiome gut microbiota autoimmune disease diabetes

shared by Nathan Goodyear on 30 Apr 15 - No Cached
  • female adult mice have microbiomes similar to those of prepubescent mice of both sexes;
  • the commensal microbial community in adult male mice significantly deviates from this shared initial pool.
  • the microbiome in castrated adult males clearly shifts away from that of normal adult males and is closer to the microbiome of females
  • ...10 more annotations...
  • The incidence of T1D in these mice is positively correlated with the “femaleness” of the microbiota
  • These results support the hypothesis that the host androgen level is influential in determining the composition of the microbiota, which in turn affects T1D initiation and progression
  • a high testosterone level enriches the microbiota for specific organisms such as segmented filamentous bacteria (SFB) and Escherichia coli or Shigella–like (SECS) strains.
  • A minimum level of testosterone and specific male-enriched microbes working together upregulate M2 macrophage and IFN-γ producing T cells in pancreatic lymph nodes. Microarray data show that both the IFN-γ and IL-1β pathways are also stimulated.
  • These microbes also upregulate host testosterone
  • In four independent experiments, the authors found no universal unique “male microbiome”
  • they did find that four distinct combinations of microbial groupings (with an interesting lack of overlap at the individual family level in the four experiments) were enhanced by androgen
  • one species consists of the segmented filamentous bacteria (SFB) and belongs to the Firmicutes, whereas the other is an Escherichia coli or Shigella–like (SECS) strain belonging to the Proteobacteria
  • colonization with protective microbiomes—e.g., SPF microbiota, SFB, and SECS—is positively correlated with high blood testosterone levels in male mice
  • A direct implication of this study is that probiotic administration or fecal transplantation is a theoretically possible approach to protection against T1D
  • Nathan Goodyear on 30 Apr 15
     
    nice summary of article on the relationship between Testosteorne and gut microbiome in autoimmune disease.
Nathan Goodyear

Calcium and vitamin d supplementation decreases incidence of stress fractures in female... - 0 views

www.ncbi.nlm.nih.gov/...18433305

vitamin d stress fractures bones calcium

shared by Nathan Goodyear on 24 Aug 15 - No Cached
  • Nathan Goodyear on 24 Aug 15
     
    low dose vitamin D plus higher dose of calcium reduced stress fractures in female military recruits.
Nathan Goodyear

Association of testosterone with estrogen abolishes the beneficial effects of estrogen ... - 0 views

ajpheart.physiology.org/...ajpheart.00681.2014

Testosterone Estrogen CVD cardiovascular health disease heart hormone hormones women female

shared by Nathan Goodyear on 02 Feb 15 - No Cached
  • Nathan Goodyear on 02 Feb 15
     
    Testosterone reduced the vascular benefits of Estrogen (conjugated equine Estrogen) in female rat model.  Testosterone is seeing widespread use in women with very little positive data.  In fact, the majority of data points to poor metabolic effects and poor outcomes.
Nathan Goodyear

Female pattern hair loss may be triggered by low oestrogen to androgen ratio. - PubMed ... - 0 views

www.ncbi.nlm.nih.gov/...18333699

hair loss hair hormones estrogen androgens Testosterone DHEA

shared by Nathan Goodyear on 27 Oct 15 - No Cached
  • Nathan Goodyear on 27 Oct 15
     
    Only abstract available here: low estrogen:androgen ratio implicated in female hair loss.
anonymous

Sexy Female Escort In Dubai - 0 views

www.eindiangirlsindubai.com/...xy-female-escort-in-dubai.html

Top Model Escort Student Escorts Indian Bollywood Vip in Massage dubai low price call girls Cheap Service hot sexy night uae Pakistani

shared by anonymous on 28 Oct 15 - No Cached
  • anonymous on 28 Oct 15
     
    Hey I'm Naveen from Dubai Abu Dhabi Sharjah (UAE) Escorts. I'm work at Sexy Female Escort In Dubai.
Nathan Goodyear

The Human Vaginal Bacterial Biota and Bacterial Vaginosis - 0 views

www.hindawi.com/...750479

vaginal flora flora microbiome female lactobacillus

shared by Nathan Goodyear on 29 Feb 16 - No Cached
  • Nathan Goodyear on 29 Feb 16
     
    review of female vaginal microbiome.
Nathan Goodyear

http://pediatrics.aappublications.org/content/pediatrics/138/2/e20160922.full.pdf - 0 views

pediatrics.aappublications.org/...e20160922.full.pdf

athlete training female

shared by Nathan Goodyear on 15 Sep 17 - No Cached
  • Nathan Goodyear on 15 Sep 17
     
    Interesting clinical report on what is termed the "female athlete triad": menstrual dysfunction i.e. loss of menses is not normal and is the result of reduced "energy availability"; sounds like overtraining syndrome.
Nathan Goodyear

Effect of testosterone treatment on v... [J Cardiovasc Pharmacol. 1995] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...7769819

testosterone treatment therapy

shared by Nathan Goodyear on 01 Jun 13 - No Cached
  • Nathan Goodyear on 01 Jun 13
     
    Granted a porcine model, but testosterone shown to have different effects in male versus female.
Nathan Goodyear

Neuroestradiol in the Hypothalamus Contributes to the Regulation of Gonadotropin Releas... - 0 views

www.jneurosci.org/...19051.full

estrogen hormones brain neurotransmitter.

shared by Nathan Goodyear on 30 Sep 16 - No Cached
  • Nathan Goodyear on 30 Sep 16
     
    Estrogen appears to play a role as a neurotransmitter in the female brain.  The authors call it neuroestradiol.
Nathan Goodyear

Chronic antioxidant treatment improves arterial renovascular hypertension and oxidative... - 0 views

www.ncbi.nlm.nih.gov/...20186128

blood pressure hypertension vitamin C oxidative stress

shared by Nathan Goodyear on 16 Jan 17 - No Cached
  • Nathan Goodyear on 16 Jan 17
     
    animal study finds vitamin C improves hypertension via renovascular source and oxidative stress.  The dosage was 150 mg/kg/day.  This would be equivalent to 10,800 grams daily for a 72 human.  But what about a 200 lb male or female?  That would be 13,650 grams of vitamin C daily.
Nathan Goodyear

Progesterone-Based Therapy Protects Against Influenza by Promoting Lung Repair and Reco... - 0 views

journals.plos.org/...article

progesterone hormones flu influenza female hormones

shared by Nathan Goodyear on 15 Feb 17 - No Cached
  • Nathan Goodyear on 15 Feb 17
     
    new study suggests progesterone protects against the flu in women. This was an animal study.
Nathan Goodyear

Effect of low-fat diet on female sex hormone levels. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...3480374

nutrition diet low fat diet hormones female hormones estrogen Testosterone

shared by Nathan Goodyear on 15 Feb 17 - No Cached
  • Nathan Goodyear on 15 Feb 17
     
    low fat diet drops estrogen levels precipitously in women.  It also dropped Testosterone levels.
Nathan Goodyear

Estradiol Enhances Recovery After Myocardial Infarction by Augmenting Incorporation of ... - 0 views

circ.ahajournals.org/...1605.long

estradiol estrogen EPCs MI CVD endothelial progenitor cells hormone hormones

shared by Nathan Goodyear on 11 Jul 12 - No Cached
  • Nathan Goodyear on 11 Jul 12
     
    Estradiol shown to increase EPC activity post MI in female MI rat model
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