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Nathan Goodyear

Oxidative Stress and Its Relationship With Adenosine Deaminase Activity in Various Stag... - 0 views

www.ncbi.nlm.nih.gov/...PMC3547448

Adenosine Deaminase ADA cancer breast cancer superoxide disumutase glutathione peroxidase oxidative stress inflammation

shared by Nathan Goodyear on 10 Nov 14 - No Cached
  • Reduced SOD activity might be responsible for excessive accumulation of superoxide anions leading to increased free radical mediated injury. Increased free radical production has been shown to be responsible for chromosomal damage leading to mutagenecity, cell proliferation and carcinogenesis. SOD activity showed marked improvement after mastectomy indicating the lowering of oxidative stress.
  • The increased production of reactive oxygen species causes oxidative stress leading to cell proliferation and hence increased inflammatory conditions
  • Superoxide dismutase is an important antioxidant enzyme which decomposes the harmful superoxide anions into hydrogen peroxide thus protects the body from the action of free radicals
  • ...20 more annotations...
  • Females suffering from breast cancer had significantly decreased Superoxide dismutase (SOD) and reduced glutathione (GSH) levels in comparison to normal females
  • ADA seems to be a promising marker of inflammation in breast cancer thereby suggesting that it can be used as a diagnostic tool to detect the stage of breast cancer along with cytopathological studies
  • In conclusion, our study confirmed the role of oxidative stress in the pathogenesis of breast cancer.
  • Another potent antioxidant molecule is reduced glutathione. It acts as reductant which converts hydrogen peroxide into water and reduces lipid peroxidation products into their corresponding alcohols and thus mediates protective action.
  • In the present study, significantly low SOD activity has been observed in female patients suffering from carcinoma breast both pre as well as post operative in comparison to healthy females.
  • We observed significantly decreased SOD activity and GSH levels in patients belonging to clinical stage 4 as compared to those having stages 1, 2 or 3 of breast cancer.
  • Increased ADA activity in breast cancer patients has also been reported
  • The compromised antioxidant defence system produces the oxidative stress which in turn creates the inflammatory response shown by concomitant increased adenosine deaminase (ADA) activity in female patients.
  • Experimental and epidemiological evidences implicate the involvement of oxygen derived free radical in the pathogenesis of breast cancer.
  • Antioxidant status was highly depressed in advanced stages of breast cancer as compared to initial stage.
  • In the present study, significantly low GSH levels were observed in female patients of carcinoma breast as compared to normal females
  • Walia et al. (1995) reported increased ADA activity in breast cancer patients as compared to age matched normal subjects.
  • These free radicals are able to cause damage to membrane, mitochondria and macromolecules including proteins, lipids and DNA and actively take part in cell proliferation. This cascade in turn generates the inflammatory response and causes the progression of the disease.
  • increased oxidative stress gives rise to inflammation which could further aggravates the disease
  • Breast carcinoma involves a cascade of events that are highly inflammatory.
  • Marked oxidative stress in stage 4 of breast cancer indicated advancement of the disease, hence checking oxidative stress at initial stage could be helpful for controlling the progression of the disease.
  • They concluded that ADA is a better probable parameter for detection of breast cancer
  • Adenosine deaminase enzyme (ADA) catalyzes the conversion of adenosine to inosine which finally gets converted to uric acid
  • serum ADA activity tends to increase with advancing age,
  • Prevalence of oxidative stress gives rise to inflammation.
  • Nathan Goodyear on 10 Nov 14
     
    Study finds a reduction in SuperOxide Dismutase and Glutathione Perioxidase in advancing breast cancer.  Cancer is a high oxidative stress disease that results in inflammation, mitochondrial dysfunction and proliferation.  Adenosine Deaminase (ADA) is proposed to be another biomarker to assess tumor stage.  
Nathan Goodyear

Associations between fluorosis of permanent inciso... [J Am Dent Assoc. 2010] - PubMed ... - 0 views

www.ncbi.nlm.nih.gov/...20884921

fluorosis flouride

shared by Nathan Goodyear on 11 Mar 11 - No Cached
  • Nathan Goodyear on 11 Mar 11
     
    ADA warns against flouride use
Sooth Dental

Dentist near me for my child's dental care - Floss Mcallen - 0 views

www.flossmcallen.com/eep-their-childs-teeth-healthy

dentist near me kid's dentist dental care

shared by Sooth Dental on 15 Mar 19 - No Cached
  • Sooth Dental on 15 Mar 19
     
    According to the American Dental Association (ADA), if any sort of misalignment or gaps in the teeth is noticed or there exists any with the occlusion of your child's dental outlay, orthodontic treatment may be applied to that kid as soon as he or she attains the age of 7!
gensehat

Impotensi - Penyebab Dan Pengobatannya. - gensehat - 0 views

gensehat.id/nsi-penyebab-dan-pengobatannya

sex Diigo impotent

shared by gensehat on 14 Sep 22 - No Cached
  • gensehat on 14 Sep 22
     
    Impotensi kerap terjadi khususnya oleh pria yang sudah berumur 40 tahun ke atas dan ada beberapa faktor yang melatarbelakanginya baik karena faktor kesehatan maupun psikologis.
gensehat

Gejala dan Pengobatan Penyakit Sifilis - gensehat - 0 views

gensehat.id/an-pengobatan-penyakit-sifilis

syphilis sex

shared by gensehat on 16 Sep 22 - No Cached
  • gensehat on 16 Sep 22
     
    Penyakit sifilis adalah penyakit menular seksual yang terjadi karena bakteri Treponema pallidum (T.pallidum). Ada tiga tahap atau stadium penyakit sifilis yaitu: stadium primer, sekunder, dan tersier. Lantas, obat sipilis apa yang bisa Anda gunakan?
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