Effect of Testosterone Replacement Therapy on Cognitive Performance and Depression in M... - 0 views
www.ncbi.nlm.nih.gov/...PMC5209560
low T Low testosterone Testosterone male hormones Testosterone therapy depression brain cognition ED erectile dysfunction
shared by Nathan Goodyear on 09 Jan 17
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Azad et al [15] used single photon emission computed tomography and showed that, after 3~5 weeks of TRT, cerebral perfusion was increased in the midbrain and the superior frontal gyrus in seven men with hypogonadism
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After 12~14 weeks, increased perfusion was still observed in the midbrain as well as in the midcingulate gyrus
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TDS patients who received TRT showed significant improvement in cognitive function only if mild cognitive impairment was present at baseline
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Cherrier et al [17] evaluated a sample of 32 subjects, which included 17 men with mild cognitive impairment and 15 with Alzheimer's disease. At the 6-week follow-up, patients who received TRT showed significantly better scores regarding spatial memory, constructional abilities, and verbal memory compared to those noted in the placebo group. Taken together, these results suggest that TRT has a beneficial effect on cognitive function
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The study by Pope et al [20] involved men with depression refractory to standard anti-depressants, and found that TRT lowered the Hamilton Depression score,
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depression tends to increase as testosterone levels decrease [21], it is highly likely that TRT improved symptoms of depression by increasing testosterone levels.