Understand: surgery is surgery. The death rate from weight loss surgeries is higher than reported as this large study shows. Another thought: what are the long-term health implications. I can tell you from the clients that I see, it is not good
Study reviews the studies of IV vitamin C and cancer. The authors discuss the mechanism of action of the high dose vitamin C. The authors are correct in their conclusion that a large body of evidence is lacking and that the majority are case study. However, to even discount these in the face of the safety and the reduction in side effects associated with chemotherapy by IV vitamin C would be unacceptable. To delay recommendation due to a full lack of understanding would be unacceptable as well. No deaths have been reported due to IV vitamin C. Contrast this with chemotherapy. However, case studies have pointed to IV vitamin C as a positive tool to attach cancer.
Alzheimer's model finds that amyloid-beta supresses vitamin D receptor. This study found that vitamin D therapy protected neurons by up regulating vitamin D receptors. This prevented cytotoxicity and cell death.
overall mortality and CV mortality were inversely associated with serum T concentrations.
men with low serum T, defined as < 8.7 nmol l−1 (250 ng dl−1 ), demonstrated significantly greater all-cause mortality than men with higher serum T (hazard ratio [HR]: 2.24; 95% CI: 1.41-3.57), as well as greater CV mortality
lower T levels were significantly associated with the presence of any CV disease
more than 30 years of studies suggesting that low levels of T represent an increased risk for CV and overall mortality,
lower serum T concentrations also are associated with CV disease, including incident coronary artery disease [17],[18],[19] and atherosclerosis,
the actual rate of adverse events was only half as great in the T group (123 events in 1223 men at risk = 10.1%) as in the untreated group (1587 events in 7486 men = 21.2%)
The study by Vigen et al. [7] has already undergone two published corrections,
29 medical societies have called for retraction of the article, asserting "gross data mismanagement and contamination," that rendered the study "no longer credible
Mortality in T-treated men was reduced by approximately half in treated men compared with untreated men, at 10.3% versus 20.7%, respectively
The mortality rate for men who received TTh was 3.4 deaths per 100 person-years, and 5.7 deaths per 100 person-years in untreated men
HR of 0.61 (95%CI: 0.42-0.88; P = 0.008), indicating a significant reduction in mortality with TTh
men in the highest prognostic MI risk quartile, treatment with TTh was associated with reduced risk
tripling in T prescriptions in the US over the last decade
a majority of observational studies have found that low endogenous serum T levels are associated with increased mortality.
Men who received TTh were able to exercise significantly longer without ischemia compared with men who received placebo
In men with congestive heart failure, those who received T demonstrated greater walking distance and other functional endpoints compared with those who received placebo
TTh has been shown uniformly and repeatedly to improve several known CV risk factors, including reduced fat mass, body fat percent, and waist circumference, and increased lean mass
improved glycemic control
reductions in insulin resistance.
the evidence strongly points to improved CV status with normal serum T or treatment with TTh in men with TD
analysis of health insurance claims data that reported a 36% increased rate of nonfatal MI in the 90d following receipt of a T prescription compared with the 12 prior months.
Comparison with men who received a prescription for a phosphodiesterase type 5 inhibitor (PDE5i) revealed no increased rate of MI following the prescription
Great review by Morgentaler of Testosterone and CVD. He highlights the significant flaws in the JAMA and the NEJM articles of Testosterone therapy risks. Morgentaler highlights the significant evidence that points to low T and increased risk of CVD.
On contention I have, is Morgantaler seems to flip aside the massive uptick of Testosterone use in the US as compared to other countries. The evidence definitely points to Testosterone therapy as being safe in those with low T, but there is definitely a problem of significant Testosterone doping that is taking place as well.
Selenium (Se) deficiency is associated with increased oxidative stress. Selenium is a cofactor necessary for glutathione perioxidase. Selenium reduced 8-OHdG, promoted cell growth inhibition and cell death pointing to significant Cancer implications.
Calorie restriction and protein restriction inhibit IGF-1, insulin, AkT, PI3K, and mTOR. In addition, those with protein intake >20%, compared to 10%, was associated with a 4 fold increase in cancer death risk and a 75% increase in overall mortality. Protein restriction inhibits tumor growth, associated with a 30-70% reduction in IGF-1, reduced the accumulation of oxidized proteins. The restriction of tryptophan alone reduced inflammation.
Ferritin is increased as a byproduct of the inflammation, which studies suggest, are the result of TAMs. Some ferritin is also likely the result of release from cell death. L-ferritin is the most prevalent in cancer. Elevated ferritin is associated with a poor prognosis in many cancers. It also correlates with CRP, WBC in this study. 1 mg/ml of serum ferritin correlates to 8mg of stored Fe.
Only abstract available here, but EDTA chelation found to reduce risk of death, reinfarction, stroke, hospitalization, angina in individuals with diabetes and prior MI from 38% to 25%.
IV vitamin C and K3 induces cancer cell death through production of H2O2 in catalase deficient cancer cells. Pretreament shown to potentiate traditional chemotherapy.
A cancer registry is the cancer cases which are registered in a population or specific country. In whole world mortality rate due to cancer is 20%. In USA cancer is the second largest disease of causing death after heart disease. Recently in 2016 estimated that 595,690 people die from this disease according to cancer statistics of National Cancer Institute USA.