Group items tagged

inflammation leads to cognitive impairment

Testosterone found to provide small improvement in depression in men > 60 and starting serum Testosterone levels < 300.  Small improvement in cognition also noted.  

Testosterone therapy in women post-hysterectomy, with low total and low free Testosterone, provides no benefit in cognitive function.

combination of l-Theanine and EGCT improve cognition.

interesting cohort study: plasma vitamin C levels correlate with metabolic health i.e. insulin, HgbA1c and cognition.

review finds Mediterranean diet may slow cognitive decline and decrease risk of Alzheimer's disease.

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short term use of anti-cholinergics linked to cognitive decline.

Chemo brain.  Does it exist?  Large study finds significant cognitive decline in follow up at 6 months in breast cancer patients treated with chemo compared to control group.

Those with Alzheimer's disease have associated dysfunction of glucose metabolism in the brain, particularly in the hippocampus. It has been reported that a ketogenic diet can improve cognitive function in these individuals. In this study, the ketone bodies were initiated through a diet high in medium chain fatty acids. The ketone bodies served as an alternative fuel source for the brain.

omega-3 supplementation shown to slow cognitive decline in study of elderly Chinese women and men

diabetes associated with increased advanced glycation end products (AGE) in elderly population.  This increase in AGE associated with cognitive decline as evaluated by MMSE.

oxidative damage found to be present in early Alzheimer's disease.  This early mild cognitive impairment is the time for treatment to delay disease progression.  As this study points out, most studies up to this point have been done on individuals with late Alzheimer's disease.  This show that oxidative damage plays a prominent role in disease development.  This study found oxidative damage through several markers: lipid peroxides,isoprostanes, 8-hydroxy-2-deoxyguanosine...

diets with high high-fructose corn syrup and low omega-3 shown to slow cognitive processing in rat model.  This is basically, metabolic syndrome of the brain, as it is the result of hyperinsulinemia.

Estrogen with progestin worsens cognitive decline in women >65.  Little can be taken from this study other than, medroxyprogesterone acetate is a bad drug and should not be given to women for any purpose, especially in those >65.  One wonders if bioidentical, physiologic hormone replacement would have the same effect?  I doubt it.  The likely negative impact of hormones on the brain in women >65 is due to the negative effects of MPA, the change in inflammatory cytokines, and the change in receptors.

Rat model induced inflammatory reaction in brain via LPS injection.  The result was impaired memory.  RG3 from panax ginseng was shown to reduce inflammation, TNF-alpha, IL-1beta, cox-2, thus improving memory and cognitive function.

After school fitness/exercise improved focus, attention, and cognition of children.

Higher T4 and T3 results in improved cognitive function.  Higher with the normal reference range that is.  Thyroid levels cannot be taken purely in reference to "normal".

T3 plays a significant role in astrocyte maturation.  This has significant cognitive and disease impact.

curcumin shown to improve cognitive function through a decrease in lipid peroxidation in the brain of rats.