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Nathan Goodyear

Subclinical Thyroid Dysfunction: A Joint Statement on Management from the American Asso... - 0 views

  • the potential benefits of early detection and treatment of subclinical thyroid dysfunction significantly outweigh the potential side-effects that could result from early diagnosis and therapy
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    Joint statement on early treatment of thyroid disease and subclinical thyroid dysfunction from The american association of clinical endocrinologists, the American Thyroid Association, and the Endocrine Society
Nathan Goodyear

JAMA Network | JAMA | Trends in Obesity Among Adults in the United States, 2005 to 2014 - 0 views

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    Obesity trends continue in the wrong direction.  According to most recent stats, 40% of American women are obese and 35% of men are obese.  Severe obesity sits at 10% for American women.
Nathan Goodyear

America's State of Mind: New Report Finds Americans Increasingly Turn to Medications to... - 0 views

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    Our current health care paradigm is failing us!  20% of women are on anti-depressants and 1 in 4 American women are on some psychiatric medicine.  And we wonder why we are unhealthy?
Nathan Goodyear

Obesity - Will All Americans Become Overweight or Obese? Estimating the Progression and... - 0 views

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    86% of Americans projected to be obese or overweight by the year 2030.
Nathan Goodyear

Fructose, weight gain, and the insulin resistance syndrome - 0 views

  • he combined effects of lowered circulating leptin and insulin in individuals who consume diets that are high in dietary fructose could therefore increase the likelihood of weight gain and its associated metabolic sequelae
  • fructose, compared with glucose, is preferentially metabolized to lipid in the liver
  • Fructose consumption induces insulin resistance, impaired glucose tolerance, hyperinsulinemia, hypertriacylglycerolemia, and hypertension in animal models
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    Fructose increase in American diets parallels obesity rise in Americans;  Physiologic mechanism of fructose contribution to obesity discussed
brandnew12

Home Remedies: Longevity Tips - Kindle edition by John Okeniyi. Health, Fitness & D... - 0 views

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    Are you struggling with the fact that you really don't know anything about how to get into shape? If you're busy living in yesterday's errors, many of your decisions will be founded on guilt and shame instead of what you really want (and need) to accomplish to achieve your goals. Real change comes from day-to-day choices and becoming mindful and basing your choices on what you need now (rather than what you did or didn't do yesterday) will make your exercise life much more passable. What if I can offer you a solution that will help you to attain greatness, to become a success and learn about the best ways to get in shape? In this book, you will learn about: - Navigate the Astral Plane - MIRROR MADNESS - The Health Zen - Vitamin Vitality - Native American Healing - Boost your Health with Gua Sha - Beautiful Body Essential - Secret of Food Combination - Lose Weight Fasting - Child Diet - many other useful things!
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    Are you struggling with the fact that you really don't know anything about how to get into shape? If you're busy living in yesterday's errors, many of your decisions will be founded on guilt and shame instead of what you really want (and need) to accomplish to achieve your goals. Real change comes from day-to-day choices and becoming mindful and basing your choices on what you need now (rather than what you did or didn't do yesterday) will make your exercise life much more passable. What if I can offer you a solution that will help you to attain greatness, to become a success and learn about the best ways to get in shape? In this book, you will learn about: - Navigate the Astral Plane - MIRROR MADNESS - The Health Zen - Vitamin Vitality - Native American Healing - Boost your Health with Gua Sha - Beautiful Body Essential - Secret of Food Combination - Lose Weight Fasting - Child Diet - many other useful things!
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    Are you struggling with the fact that you really don't know anything about how to get into shape? If you're busy living in yesterday's errors, many of your decisions will be founded on guilt and shame instead of what you really want (and need) to accomplish to achieve your goals. Real change comes from day-to-day choices and becoming mindful and basing your choices on what you need now (rather than what you did or didn't do yesterday) will make your exercise life much more passable. What if I can offer you a solution that will help you to attain greatness, to become a success and learn about the best ways to get in shape? In this book, you will learn about: - Navigate the Astral Plane - MIRROR MADNESS - The Health Zen - Vitamin Vitality - Native American Healing - Boost your Health with Gua Sha - Beautiful Body Essential - Secret of Food Combination - Lose Weight Fasting - Child Diet - many other useful things!
Nathan Goodyear

Inflammation and Native American medicine: the role of botanicals - 0 views

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    review of medicinal botanicals used by native Americans.
Mysmart Spine

Dr. Eduardo Anguizola - Pain Management Specialist in California - 0 views

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    Dr Eduardo Anguizola, MD. a Member of American Medical Association and best Pain Management Specialist in California; offers full pain management services including conservative care to international treatment.
Nathan Goodyear

Age and Sex Patterns of Drug Prescribing in a Defined American Population - 0 views

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    Startling statistics on the heavy use of prescription drugs by Americans.
Nathan Goodyear

Validation of a cortisol enzyme immunoassay and characterization of salivary cortisol c... - 0 views

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    granted, this comes from the American Journal of Primatology; but their conclusion says it all: "we recommend that saliva collection may be the moste effective method of measuring stress reactivity and as the potential to complement behavioral, cognitive, physiologic, and welfare studies".
Nathan Goodyear

Oxidative Stress, Testosterone, and Cognition among Caucasian and Mexican-American Men ... - 0 views

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    Interesting study. This study points out the differences between individuals and groups i.e. Mexian-Americans and Caucasians in this study.  Men with low oxidative stress, Testosterone was associated with no cognitive dysfunction.  In contrast, with high oxidative stress, Testosterone therapy was associated with cognitive impairment in caucasians only.
Nathan Goodyear

Testosterone therapy affects Mexican American men differently - UNT Health Science Cent... - 0 views

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    This is the public announcement of a article yet to be published.  The study, yet unread, points to increase damage to brain health in those caucasian men with oxidative stress.  This was not found in mexican-Americans.  Until I read this study, that is all I will say here.  
Nathan Goodyear

Management of Helicobacter pylori Infection | American College of Gastroenterology - 0 views

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    American college of Gastroenterology review on H.pylori.  The treatment regimens are significant issues as tetracycline is no longer available.
Nathan Goodyear

Clinical controversies in screening women for thyr... [J Midwifery Womens Health. 2006 ... - 0 views

  • In November 2002, the American Association of Clinical Endocrinologists (AACE) released new guidelines for clinical practice for the diagnosis and treatment of hyperthyroidism and hypothyroidism, which includes a new thyroid-stimulating hormone (TSH) reference range of 0.3 to 3.0 mIU/
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    TSH "screening" needs to be between 0.3 and 3 according to American Association of Clinical Endocrinologists
Nathan Goodyear

A Population-Level Decline in Serum Testosterone Levels in American Men - 0 views

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    15% decline in Testosterone found in American men from 1987 to 2004
Nathan Goodyear

Obese Americans now outweigh the merely overweight | Reuters - 0 views

  • Numbers posted by the National Center for Health Statistics show that more than 34 percent of Americans are obese, compared to 32.7 percent who are overweight. It said just under 6 percent are "extremely" obese.
  • More than one-third of adults, or over 72 million people, were obese in 2005-2006, the NCHS said in its report
  • In May, the CDC reported that 32 percent of U.S. children fit the definition of being overweight, 16 percent were obese and 11 percent were extremely obese.
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    obesity in America
Nathan Goodyear

Concussions' Lingering Effects Linked to Hormone Deficiency - Scientific American - 0 views

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    Scientific American article from 2013 highlights the link between head trauma and pituitary dysfunction.  
Nathan Goodyear

Association between circulating specific leukocyte types and blood pressure: the Athero... - 0 views

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    Blood pressure is a s symptom of inflammation.  In this study it was found that elevated neutrophils and decreased lymphocytes was associated with hypertension in the African American population
obat sehat

Diabetes - 0 views

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    Insulin is a hormone produced by the pancreas to control blood sugar. Diabetes can be caused by too little insulin, resistance to insulin, or both. To understand diabetes, it is important to first understand the normal process by which food is broken down and used by the body for energy. Several things happen when food is digested: A sugar called glucose enters the bloodstream. Glucose is a source of fuel for the body. An organ called the pancreas makes insulin. The role of insulin is to move glucose from the bloodstream into muscle, fat, and liver cells, where it can be used as fuel. People with diabetes have high blood sugar because their body cannot move sugar into fat, liver, and muscle cells to be stored for energy. This is because either: Their pancreas does not make enough insulin Their cells do not respond to insulin normally Both of the above There are two major types of diabetes. The causes and risk factors are different for each type: Type 1 diabetes can occur at any age, but it is most often diagnosed in children, teens, or young adults. In this disease, the body makes little or no insulin. Daily injections of insulin are needed. The exact cause is unknown. Type 2 diabetes makes up most diabetes cases. It most often occurs in adulthood. However, because of high obesity rates, teens and young adults are now being diagnosed with it. Many people with type 2 diabetes do not know they have it. Gestational diabetes is high blood sugar that develops at any time during pregnancy in a woman who does not have diabetes. Diabetes affects more than 20 million Americans. Over 40 million Americans have pre-diabetes (which often comes before type 2 diabetes).
Nathan Goodyear

American College of Cardiology Foundation | Journal of the American College of Cardiolo... - 0 views

  • Although currently no drugs that specifically target mitochondrial biogenesis in HF are available, acceleration of this process through adenosine monophosphate–activated kinase (AMPK), endothelial nitric oxide synthase (eNOS), and other pathways may represent a promising therapeutic approach
  • Mitochondrial biogenesis can be enhanced therapeutically with the use of adenosine monophosphate kinase (AMPK) agonists, stimulants of nitric oxide/cyclic guanosine monophosphate (NO/cGMP) pathway (including phosphodiesteraes type 5 inhibitors), or resveratrol
  • metformin, a commonly used antidiabetic drug that activates AMPK signaling
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  • Recent evidence suggests that the eNOS/NO/cGMP pathway is an important activator of mitochondrial biogenesis
  • BH4 (tetrahydrobiopterin) supplementation can prevent eNOS uncoupling and was found to reduce left ventricular hypertrophy
  • folic acid is known to replenish reduced BH4 and has been shown to protect the heart through increased eNOS activity
  • Both folate deficiency and inhibition of BH4 synthesis were associated with reduced mitochondrial number and function
  • Resveratrol, a polyphenol compound responsible for the cardioprotective properties of red wine, was recently identified as a potent stimulator of mitochondrial biogenesis
  • epidemiological studies reveal a reduced risk of cardiovascular disease in premenopausal, but not post-menopausal, women compared with men
  • post-menopausal women
    • Nathan Goodyear
       
      I would hypothesis that a change in the predominance of ER expression is one of ER beta to ER alpha: creating a more pro-inflammatory signal.
  • The majority of ROS in the heart appear to come from uncoupling of mitochondrial electron transport chain at the level of complexes I and III
  • Because the majority of ROS in HF comes from mitochondria, these organelles are the primary target of oxidative damage.
  • cardioprotective therapies such as angiotensin-converting enzyme inhibitors and ATII receptor blockers were shown to possess antioxidant properties, although it is not known whether they target mitochondrial ROS directly or indirectly
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    great review of mitochondrial biogenesis, oxidative stress and heart failure.  
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