Skip to main content

Home/ Dr. Goodyear/ Group items tagged prescriptions

Rss Feed Group items tagged

Nathan Goodyear

PLOS ONE: Increased Risk of Non-Fatal Myocardial Infarction Following Testosterone Ther... - 0 views

  • For all TT prescription subjects combined, the post/pre prescription rate ratio for MI (RR)was 1.36
  • In men aged 65 years and older the RR was 2.19 (1.27, 3.77), while in men under age 65 years the RR was 1.17
  • increasing RR with increasing age.
  • ...20 more annotations...
  • The RRs were 0.95 (0.54, 1.67) under 55 years
  • 1.35 (0.77, 2.38) at 55–59
  • 1.29 (0.71, 2.35) at 60–64,
  • 1.35 (0.44, 4.18) at 65–69, 1.62
  • 3.43 (1.54, 7.66) at 75 years and older
  • The adjusted post/pre RR for PDE5I across all ages was 1.08
  • For TT prescription, in men under age 65 years, the RR was 2.90 (1.49, 5.62) for those with a history of heart disease and 0.90 (0.61, 1.34) for those without
  • In men aged 65 year and older, the RR was 2.16 (0.92, 5.10) for those with a history of heart disease and 2.21 (1.09, 4.45) for those without.
  • Among men aged 65 years and older, we observed a two-fold increase in the risk of MI in the 90 days after filling an initial TT prescription
  • Among younger men with a history of heart disease, we observed a two to three-fold increased risk of MI in the 90 days following an initial TT prescription and no excess risk in younger men without such a history
  • Among older men, the two-fold increased risk was associated with TT prescription regardless of cardiovascular disease history
  • our own findings appear consistent with a higher frequency of thrombotic events following TT prescription among men with more extensive coronary vascular disease.
  • Our findings are consistent with a recent meta-analysis of placebo-controlled randomized trials of testosterone therapy lasting 12 or more weeks among mainly older men, which reported that testosterone therapy increased the risk of adverse cardiovascular-related events (OR = 1.54, 95%CI:1.09, 2.18), as well as serious adverse cardiovascular-related events (OR = 1.61, 95%CI:1.01, 2.56) which included myocardial infarction along with other conditions
  • This association appeared unrelated to average baseline testosterone level (p = 0.70) but varied by source of funding (p = 0.03), with a stronger summary effect in a meta-analysis of studies not funded by the pharmaceutical industry (OR = 2.06, 95%CI:1.34, 3.17) compared with studies funded by the pharmaceutical industry
    • Nathan Goodyear
       
      This supports prior analysis that studies done by pharmaceutical corps will be more favorable to their product(s) than those independently funded.  This is called bias.
  • the evidence supports an association between testosterone therapy and risk of serious, adverse cardiovascular-related events–including non-fatal myocardial infarction–in men
  • there is some evidence that low endogenous testosterone levels may also be positively associated with cardiovascular events
  • effects of endogenous and exogenous testosterone may differ. Exogenous testosterone (TT) is associated with physiologic changes that predispose to clotting and thrombotic disorders including increased blood pressure [18], polycythemia [19], reductions in HDL cholesterol [18], [20], and hyperviscosity of the blood and platelet aggregation. [20]–[23]; TT also increases circulating estrogens [24], [25] which may play a role in the observed excess of adverse cardiovascular-related events, given that estrogen therapy has been associated with this excess in both men and women
  • did not include information on the serologic or diagnostic indications for treatment.
  • no association between PDE5I prescriptions and the risk of MI
  • Recently TT has been increasing extraordinarily rapidly, including among younger men and among those without hormone measurement
  •  
    New cohort study finds increased risk of Testosterone in men > 65 and those : these are based in marketing-based medicine not evidence based medicine.
Nathan Goodyear

Concomitant Dietary Supplement and Prescription Medication Use Is Prevalent among US Ad... - 0 views

  •  
    Study worries over the risks of supplements and prescription drugs.  The author should worry more over the lack of knowledge by physicians of the health benefits of supplements.  Instead of focusing on the prescriptions themselves, how about focusing on the supplements to reduce the need for the prescriptions.  This authors focus is all wrong.   Obviously, the patient needs to be forthcoming with his/her physician about all supplements that they are on.  
Nathan Goodyear

Age and Sex Patterns of Drug Prescribing in a Defined American Population - 0 views

  •  
    Startling statistics on the heavy use of prescription drugs by Americans.
Nathan Goodyear

Emergency Department visits for Adverse Events related to dietary supplements - 0 views

  •  
    new study finds increase AE and ER with supplements at 22,000 annually; in contrast, 700,000 ER visits due to prescription drugs annually according to CDC--with 120,000 hospitalized.
Nathan Goodyear

Hospitalizations for Poisoning by Prescription Opioids, Sedatives, and Tranquilizers - 0 views

  •  
    Prescription medications are one of the leading causes of death today.
Nathan Goodyear

Testosterone deficiency and cardiovascular mortality Morgentaler A, - Asian J Androl - 0 views

  • overall mortality and CV mortality were inversely associated with serum T concentrations.
  • men with low serum T, defined as < 8.7 nmol l−1 (250 ng dl−1 ), demonstrated significantly greater all-cause mortality than men with higher serum T (hazard ratio [HR]: 2.24; 95% CI: 1.41-3.57), as well as greater CV mortality
  • lower T levels were significantly associated with the presence of any CV disease
  • ...19 more annotations...
  • more than 30 years of studies suggesting that low levels of T represent an increased risk for CV and overall mortality,
  • lower serum T concentrations also are associated with CV disease, including incident coronary artery disease [17],[18],[19] and atherosclerosis,
  • the actual rate of adverse events was only half as great in the T group (123 events in 1223 men at risk = 10.1%) as in the untreated group (1587 events in 7486 men = 21.2%)
  • The study by Vigen et al. [7] has already undergone two published corrections,
  • 29 medical societies have called for retraction of the article, asserting "gross data mismanagement and contamination," that rendered the study "no longer credible
  • Mortality in T-treated men was reduced by approximately half in treated men compared with untreated men, at 10.3% versus 20.7%, respectively
  • The mortality rate for men who received TTh was 3.4 deaths per 100 person-years, and 5.7 deaths per 100 person-years in untreated men
  • HR of 0.61 (95%CI: 0.42-0.88; P = 0.008), indicating a significant reduction in mortality with TTh
  • men in the highest prognostic MI risk quartile, treatment with TTh was associated with reduced risk
  • tripling in T prescriptions in the US over the last decade
  • a majority of observational studies have found that low endogenous serum T levels are associated with increased mortality.
  • Men who received TTh were able to exercise significantly longer without ischemia compared with men who received placebo
  • In men with congestive heart failure, those who received T demonstrated greater walking distance and other functional endpoints compared with those who received placebo
  • TTh has been shown uniformly and repeatedly to improve several known CV risk factors, including reduced fat mass, body fat percent, and waist circumference, and increased lean mass
  • improved glycemic control
  • reductions in insulin resistance.
  • the evidence strongly points to improved CV status with normal serum T or treatment with TTh in men with TD
  • analysis of health insurance claims data that reported a 36% increased rate of nonfatal MI in the 90d following receipt of a T prescription compared with the 12 prior months.
  • Comparison with men who received a prescription for a phosphodiesterase type 5 inhibitor (PDE5i) revealed no increased rate of MI following the prescription
  •  
    Great review by Morgentaler of Testosterone and CVD.  He highlights the significant flaws in the JAMA and the NEJM articles of Testosterone therapy risks.  Morgentaler highlights the significant evidence that points to low T and increased risk of CVD. On contention I have, is Morgantaler seems to flip aside the massive uptick of Testosterone use in the US as compared to other countries.  The evidence definitely points to Testosterone therapy as being safe in those with low T, but there is definitely a problem of significant Testosterone doping that is taking place as well.
Nathan Goodyear

Prescription drug abuse surged 400 percent in past decade - CSMonitor.com - 0 views

  •  
    The current drug abuse problem to day has the hands of the medical community involved.
Nathan Goodyear

Frontiers | Performance enhancement at the cost of potential brain plasticity: neural r... - 0 views

  •  
    Great article on the detriment of prescription stimulants for cognitive enhancement.  The authors describe an inverted "U" efficacy curve.
tramadolorder

Buy Tramadol 100 mg Online | Order Tramadol Without Prescription - 0 views

  •  
    Buy Cheap Tramadol Online for sale with Cash on Delivery from the reputed pharmacy. Tramadol for sale, no prescription for buy Tramadol online with overnight shipping. Buy Tramadol Online now Contact Info Address: New York, NY Ph: (+1) 3473055444 Email : onlinecarehelpline@gmail.com website - https://www.youronlinerx.com
pharmacybiz

DHSC adds Dexcom One transmitter to March 2023 Drug Tariff - 0 views

  •  
    Department of Health of Social Care (DHSC) has confirmed that the Dexcom One Transmitter will be added to Part IXA of the March 2023 Drug Tariff. "Previously, patients were advised to obtain the free-of-charge Dexcom One transmitters directly from the pharmacies, without a prescription, as the original Drug Tariff application for the transmitter was unsuccessful," said the Pharmaceutical Services Negotiating Committee (PSNC) It has raised concerns with DHSC and Dexcom that these distribution arrangements for transmitters are unacceptable because they result in extra unfunded activity for community pharmacies. Both, DHSC and Dexcom acted upon these concerns by agreeing to add the Dexcom One transmitter to the Drug Tariff from March 2023. At the same time, Dexcom One CGM System (containing 1 sensor, 1 sensor applicator, 1 transmitter) will also be added to the March Drug Tariff.
medicines 2u

Best treatment and cure for the problem of Haemorrhoids - 0 views

  •  
    Medicines2U brings a complete new range of online prescription pharmacy for people suffering from Haemorrhoids and associated symptoms.
Nathan Goodyear

Hypnotics' association with mortality or cancer: a matched cohort study -- Kripke et al... - 0 views

  •  
    prescription sleep aids and hypnotics associated with 3 fold increase in death.  Scary thought considering how many use sleep aids today.  First do no harm is suppose to be a physician's moto.
Nathan Goodyear

Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Re... - 0 views

  • Long-term DPs play a large role in determining the selective environment that the gut microbiota faces, ultimately influencing the composition and diversity of taxa maintained within the gut microbial community
  • Americans consuming unrestricted diets maintained less diverse fecal microbiota than those of individuals adhering to a plant-rich diet with restricted caloric intake
  • Experiments in mice have shown that multigenerational exposure to a Western diet poor in “microbiota-accessible carbohydrates” can lead to extirpation of specific bacterial lineages
  •  
    Diet is the key to gut microbe diversity.  Gut microbes are key to maintaining optimal cellular metabolism.  Nutrition can be a prescription for improving and reprogramming gut bacteria.
Nathan Goodyear

Obesity - The Obesity Pandemic: Where Have We Been and Where Are We Going? - 0 views

  •  
    nice study on contributors to the obesity epidemic.  Particularly inflammation.  This article touches on the idea that fat acts as a hormone producing organ.  Minus some of the treatment strategies, surgery and prescription drugs, this is a good article.   This article also touches on the implications of the obesity Pandemic as they state.
Nathan Goodyear

Reported Paediatric Adverse Drug Reactions in the UK 2000-2009 - Hawcutt - British Jour... - 0 views

  •  
    study that shows that 66% of adverse drug reports in UK were due to childhood vaccinations.  That is 66% of all drug adverse reactions reported in the UK.  If we had a prescription or OTC therapy that provided this kind of negative reaction, would it still be on the market?
Nathan Goodyear

Systemic sclerosis: environmental factors. [J Rheumatol. 2009] - PubMed - NCBI - 0 views

  •  
    Environmental toxins such as slice and organic solvents have been associated with the development of scleroderma.  Other exposures include bacterial, viral, pesticides, prescription drugs...
Nathan Goodyear

Metformin and breast cancer risk: a ... [Breast Cancer Res Treat. 2012] - PubMed - NCBI - 0 views

  •  
    Studies like this surprise me. This study lauds the benefit of metformin as a breast cancer protective in postmenopuasal womb.  Their focus is on the bandaid--the prescription drug.  They completely ignore the cause--glucose.  The Warburg effect in cancer is well known.  Limit simple sugar intake and support oxidative phosphorylation will do the same.  That is treating the cause.
Nathan Goodyear

Neonatal abstinence syndrome and associated health care... [JAMA. 2012] - PubMed - NCBI - 0 views

  •  
    Very disturbing trend.  Study finds that opioid addicted infants are on a dramatic risk in the US.  This study looked at Neionatal abstinence syndrome from 2000 to 2009.  This follows the significant increase in maternal opioid prescription use.  We physicians must do better.  Patients must demand better.  This study just focused on hospital costs directly associated with the Neonatal period.  No cost estimates are evaluated for long-term care.
Nathan Goodyear

Dietary supplement adverse events: Report of a one-year poison center surveillance project - 0 views

  •  
    Context, context, context.   In the year 2006, there were 1.5 million adverse events reported directly related to prescription drugs at a cost of 3.5$ billion.  One often hears of the dangers of supplements.  This analysis from 2008 found 275 adverse events reported.  Contrast 1.5 million versus 275 and it really puts into context where the dangers lie.
Nathan Goodyear

A rare case of amiodarone-induced hypothyroidis... [Int J Angiol. 2011] - PubMed - NCBI - 0 views

  •  
    Very interesting case study of amiodarone induced hypothyroidism that resulted in pericardial effusion and cardiac tamponade.
1 - 20 of 44 Next › Last »
Showing 20 items per page