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North America the leading Gluten Free Products Market - 0 views

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    The global Gluten Free Products Market is projected to reach $6,206.2 million at a CAGR of 10.2% by 2018. North America is the largest market for gluten-free products that held a volume share of 57% in 2012,
market reports

North America Injectable Drug Delivery Market - 0 views

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    North American injectable drug delivery technologies market was valued at $9.3 billion in 2012 and is estimated to grow at a CAGR of 12.3% from 2012 to 2017 to reach $16.6 billion by 2017
market reports

What is Driving the Gluten-Free Products Market - 0 views

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    The global Gluten-Free Products Market is projected to reach $6,206.2 million at a CAGR of 10.2% by 2018. North America is the largest market for gluten-free products that held a volume share of 57% in 2012
Nathan Goodyear

Divergent trends in obesity and fat intake patterns... [Am J Med. 1997] - PubMed - NCBI - 0 views

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    Fat intake is inversely associated with the obesity trend.  During, the 80's, a low fat diet was all the craze.  However, the obesity trend increased with the incorporation of the the low fat diet in America.
Nathan Goodyear

CDC - Autism Spectrum Disorder (ASDs) - NCBDDD - 0 views

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    new CDC study finds Autism in America continues to increase.  Now 1 in 88.  Previously, was 1 in 110.  That is a 23% increase
Nathan Goodyear

Obesity and Overweight for Professionals: Data and Statistics: U.S. Obesity Trends | DN... - 0 views

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    US obesity Trends.  Just watch short animated map to see the unprecedented problem facing America.
Nathan Goodyear

http://chrisbeatcancer.com/wp-content/uploads/2011/12/contribution-of-chemotherapy-to-5... - 0 views

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    This study from 2004 reveals the marketing-based medicine era that we live in.  This meta-analysis of studies conducted for 5 year survival benefit found the contribution of chemotherapy was 2.3% in Australia and 2.1% in America.  The authors conclusion: "it is clear that cytotoxic chemotherapy only makes a minor contribution to cancer survival".  Compare this to the chemotherapy harm and the balance of benefit versus harm reveals a complete lack of evidence with regards to how therapy is practiced in Cancer
Nathan Goodyear

Obesity levels off, but extreme cases tipping the scales - 0 views

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    I don't normally post press articles, but this one is important as a reference to the expanding severe obesity rates in America.
Nathan Goodyear

Prevalence and Correlates of Late-Onset Hypogonadism Among Korean Men Aged 40 Years or ... - 0 views

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    Study of Korean men finds late onset of hypogonadism to be 16.8% in their study of 1,235 men older than 40.  This is a higher rate than other studies, but lower than others (38.7% in American men).  The test definition of low T was set at 3.2 ng/ml.  Abdominal obesity, metabolic syndrome, diabetes, and increasing age were associated with low T. Low T is clearly not a problem unique to America.  It definitely appears that a decreasing Testosterone level is a marker of poor health in men.  
Nathan Goodyear

Epidemiology of non-alcoholic fatty liver disease. [Dig Dis. 2010] - PubMed result - 0 views

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    non-alcoholic fatty liver disease the result of Metabolic syndrome.  New epidemic associated with obesity. Scary statistics about the children of America.
Nathan Goodyear

Obese Americans now outweigh the merely overweight | Reuters - 0 views

  • Numbers posted by the National Center for Health Statistics show that more than 34 percent of Americans are obese, compared to 32.7 percent who are overweight. It said just under 6 percent are "extremely" obese.
  • More than one-third of adults, or over 72 million people, were obese in 2005-2006, the NCHS said in its report
  • In May, the CDC reported that 32 percent of U.S. children fit the definition of being overweight, 16 percent were obese and 11 percent were extremely obese.
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    obesity in America
Nathan Goodyear

Nutrition & Metabolism | Full text | Over-stimulation of insulin/IGF-1 signaling by Wes... - 0 views

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    Elevated insulin and IGF-1 as a result of the typical western diet results in increased risk of many of the chronic diseases of aging that we see in America--cancer.
Nathan Goodyear

Evidence of estrogenic endocrine disruption in smallmouth and largemouth bass inhabitin... - 0 views

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    Is our effect on the environment and the environments, in turn, effect on us politics or science?  It is science that is manipulated by politicians for political gain/power.  In this study of male small/large mouth bass in NE America are found to have significant female characteristics  i.e. eggs where testes should exist...where none should exist.  The numbers were as high as 85% in the small mouth base compared to 27% for the large mouth bass.  Is there any wonder we have a low T epidemic in men?  The most likely cause are endocrine disruptors.  It is a concern that the authors did not look for endocrine disruptors in the water at the time of this study of the fish.
Nathan Goodyear

https://academic.oup.com/DocumentLibrary/humupd/PR/dmx022_final.pdf - 0 views

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    The problem of male infertility continues to grow. New study finds that from 1973 to 2011, sperm count among men in North America, Europe, Australia, and New Zealand drop by 50-60%.
Nathan Goodyear

America's State of Mind: New Report Finds Americans Increasingly Turn to Medications to... - 0 views

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    Our current health care paradigm is failing us!  20% of women are on anti-depressants and 1 in 4 American women are on some psychiatric medicine.  And we wonder why we are unhealthy?
Nathan Goodyear

The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic ... - 0 views

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    CDC recommendations on lyme treatment
Nathan Goodyear

JSTOR: Proceedings of the National Academy of Sciences of the United States of America,... - 0 views

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    D-chiro-inositol in diabetes
Nathan Goodyear

Health and economic burden of the projected obesity trends in the USA and the UK : The ... - 0 views

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    1 in 2 adult Americans projected to be obese by 2030.  This study estimates an additional $66 billion /year to the medical costs in USA....unsustainable.
Nathan Goodyear

Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Post-Tr... - 0 views

  • In this study, we have demonstrated microscopic pathology ranging from minimal to moderate in multiple different tissues previously reported to be involved with LD, including the nervous system (central and peripheral), heart, skeletal muscle, joint-associated tissues, and urinary bladder 12 to 13 months following tick-inoculation of rhesus macaques by Bb strain B31
  • Based on histomorphology, inflammation consisted predominantly of lymphocytes and plasma cells, with rare scattered histiocytes
  • in rare instances, morphologically intact spirochetes were observed in inflamed brain and heart tissue sections from doxycycline-treated animals
  • ...41 more annotations...
  • colocalization of the Bb 23S rRNA probe was not observed in any of the sections of experimental inoculated animals shown to harbor rare persistent spirochetes (Supplemental Figure S1). Previous in vitro work has shown large decreases in Bb rRNA levels when in a stationary phase of growth despite the majority of spirochetes remaining viable
  • The possibility that the spirochetes were intact but dead also exists, though this may be unlikely given the precedence for viable but non-cultivable B. burgdorferi post-treatment
  • The doxycycline dose utilized in this study (5mg/kg) was based on a previous pharmacokinetic analysis of oral doxycycline in rhesus macaques proven to be comparable to levels achieved in humans and was meant to mimic treatment of disseminated LD
  • In addition to the brain of two treated animals, rare morphologically intact spirochetes immunoreactive to OspA were observed in the heart of one treated animal
  • Although we did not measure the doxycycline levels in the cerebrospinal fluid, they have been found to be 12% to 15% of the amount measured in serum
  • We and others have demonstrated the development of a drug-tolerant persister population when B. burgdorferi are treated with antibiotics in vitro
  • The adoption of a dormant or slow-growing phenotype likely allows the spirochetes to survive and re-grow following removal of antibiotic
  • The basic premise that antibiotic tolerance may be an adaptation of the sophisticated stringent response required for the enzootic cycle by the spirochetes is described in a recent review as well
  • Although current IDSA guidelines recommend intravenous ceftriaxone (2g daily for 30 days) over oral doxycycline for treatment of neuroborreliosis, a randomized clinical trial failed to show any enhanced efficacy of I.V. penicillin G to oral doxycycline for treatment of Lyme neuroborreliosis (no treatment failures were reported in this study of 54 patients).
  • we can speculate that the minimal to moderate inflammation that was observed, especially within the CNS and PNS can, in part, explain the breadth of symptoms experienced by late stage Lyme disease patients, such as cognitive impairment and neuralgia.
  • Erythema migrans, the clinical hallmark of early localized Lyme disease, was observed in one of the rhesus macaques from this study.
  • In 2014, a trailblazing study in mice demonstrated a dramatic decline in B. burgdorferi DNA in the tissues for up to eight months after antibiotic treatment followed by the resurgence of B. burgdorferi growth 12 months after treatment
  • This study provides evidence that the slow-growing spirochetes which persist after treatment, but are not cultivable in standard growth media may remain viable.
  • The first well-documented indication of Lyme disease (LD) in the United States occurred in the early 1970s
  • Lyme, Connecticut.
  • Lyme disease is now known to be caused by multiple closely related genospecies classified within the Bb sensu lato complex, representing the most common tick-borne human disease in the Northern Hemisphere
  • approximately 30,000 physician-reported cases occur annually in the United States, the annual incidence has been estimated to be 10-fold higher by the Centers for Disease Control and Prevention.6
  • Current antibiotic therapy guidelines outlined by the Infectious Disease Society of America (IDSA) are successful in the treatment of LD for the majority of LD patients, especially when administered early in disease immediately following identification of erythema migrans (EM)
  • ‘post-treatment Lyme disease syndrome’ (PTLDS)
  • host-adapted spirochetes that persist in the tissues, probably in small numbers, inaccessible or impervious to antibiotic
  • inflammatory responses to residual antigens from dead organisms
  • residual tissue damage following pathogen clearance;
  • autoimmune responses, possibly elicited by antigenic mimicry
  • Experimental studies on immunocompetent mice, dogs, and rhesus macaques have provided evidence for the persistence of Bb spirochetes subsequent to antibiotic treatment in the form of residual spirochetes detected within tissue by IFA and PCR, and recovered by xenodiagnoses
  • Ten male rhesus macaques
  • half (five) of the NHP received antibiotic treatment, consisting of 5 mg/kg oral doxycycline twice per day.
  • Minimal and focal lymphoplasmacytic inflammation
  • inflammation was observed in the leptomeninges overlying a section of temporal cerebral cortex
  • Minimal localized lymphoplasmacytic choroiditis
  • Peripheral nerves contained minimal to moderate lymphoplasmacytic inflammation with a predilection for collagen-rich epineurium and perivascular spaces
  • Inflammation was observed in 56% (5/9) of the NHPs irrespective of treatment group
  • For all animals, inflammation was reserved to perineural tissue
  • The treatment lasted 28 days
  • Minimal to mild lymphoplasmacytic inflammation of either the myocardial interstitium (Figure 2Figure 2A), pericardium (Figure 2Figure 2B), or combination therein was observed in 60% of NHPs
  • A single morphologically intact spirochete, as indicated by positive red immunofluorescence (Figure 2Figure 2C), was observed in the myocardium of one treated animal
  • mild, multifocal lymphoplasmacytic inflammation was observed in one doxycycline-treated animal
  • three animals exhibited minimal to mild lymphoplasmacytic inflammation affecting joint-associated structures
  • 10% to -20% of human patients treated
  • Multiple randomized placebo-controlled studies which evaluated sustained antimicrobial therapy concluded that there is no benefit in alleviating patients’ symptoms and indicated that long-term antibiotic therapy may even be detrimental to patients due to potential associated complications (ie, catheter infection and/or clostridial colitis)
  • and the rapid clearance of dead spirochetes in a murine model
  • higher doses may be needed to combat neuroborreliosis
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    persistent borrelia burgdorferia were found in the brain (2) and the heart (1) up to 13 months post standard antibiotic treatment suggesting borrelia burdorferia, the cause of Lyme, can persist in a chronic, persistant state poste acute treatment.
Nathan Goodyear

Statins use and coronary artery plaque composition: Results from the International Mult... - 0 views

  • Statin use is associated with an increased prevalence and extent of coronary plaques possessing calcium
  • As compared with individuals not taking statins, those taking statins possessed a significantly higher prevalence of obstructive CAD, as well as higher numbers of vessels with obstructive CAD
  • non-calcified plaques (NCP)
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  • non-calcified (NCP), mixed (MP), or calcified (CP) plaque
  • statin use was each associated with a significantly higher prevalence of NCP, MP and CP
  • statin use was associated with increased presence of MP [odds ratio (OR) 1.46, 95% confidence interval (CI) 1.27–1.68, p < 0.001] and CP (OR 1.54, 95% CI 1.36–1.74, p < 0.001], but not NCP
  • statin use was associated with increasing numbers of coronary segments possessing MP and CP but not associated with increasing numbers of coronary segments possessing NCP
  • North America, Europe and Asia
  • A total of 6673 individuals (2413 on statin therapy and 4260 not on statin therapy) comprised the study population
  • we identified a strong association of statin use to coronary artery plaque features
  • statin use was associated with a differentially increased prevalence and extent of MP and CP
  • one potential unifying hypothesis is that rather than regression of coronary plaque, statins may contribute to the conversion of coronary plaque constituents, perhaps by conversion of NCP to plaque possessing calcium
  • Coronary computed tomographic angiography (CCTA)
  • Statin use was associated with a higher frequency of severe coronary artery stenoses as well as numbers of coronary vessels with obstructive CAD
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    Study finds statin therapy associated with increased coronary plaque with calcium.
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