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Nathan Goodyear

Breast cancer mortality trends in England and the assessment of the effectiveness of ma... - 0 views

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    40 year study out of England finds no mortality benefit from mammograms screening.
Nathan Goodyear

Effect of Screening on Ovarian Cancer Mortality, June 8, 2011, Buys et al. 305 (22): 22... - 0 views

  • Among women in the general US population, simultaneous screening with CA-125 and transvaginal ultrasound compared with usual care did not reduce ovarian cancer mortality
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    Ovarian Cancer screening provides no benefit
Nathan Goodyear

Twenty five year follow-up for breast cancer incidence and mortality of the Canadian Na... - 0 views

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    Study that followed breast screening for 25 years with mammograms finds that no decrease in mortality from regular mammograms.
Nathan Goodyear

Validation of salivary testosterone as a screening... [Aging Male. 2006] - PubMed result - 0 views

  • hese studies support the use of salivary testosterone as an acceptable assay for screening for hypogonadism.
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    Validation of salivary testosterone as a screening test for male hypogonadism.
Nathan Goodyear

Clinical controversies in screening women for thyr... [J Midwifery Womens Health. 2006 ... - 0 views

  • In November 2002, the American Association of Clinical Endocrinologists (AACE) released new guidelines for clinical practice for the diagnosis and treatment of hyperthyroidism and hypothyroidism, which includes a new thyroid-stimulating hormone (TSH) reference range of 0.3 to 3.0 mIU/
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    TSH "screening" needs to be between 0.3 and 3 according to American Association of Clinical Endocrinologists
Nathan Goodyear

Salivary IgA antigliadin antibody as a marker for coeliac disease. - 0 views

  • Measurement of salivary IgA AGA provided excellent discrimination between those children with coeliac disease and the control groups, and our study suggests that it may provide a rapid, non-invasive method of screening for this disease before intestinal biopsy
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    salivary IgA antigliadin antibodies shown to be highly effective as screening tool for celiac disease
Nathan Goodyear

MRI for breast cancer screening, diagnosis, and treatment : The Lancet - 0 views

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    new study sheds serious doubt on the benefit of breast MRI for breast cancer screening.  NO correlation to improved survival can be drawn.  Conclusion: "...to date do not show clear benefit for MRI."  
Nathan Goodyear

Testosterone deficiency syndrome and cardiovascular health: An assessment of beliefs, k... - 0 views

  • The vast majority (88%) did not screen cardiac patients for TDS.
  • Testosterone deficiency has a prevalence of 7% in the general population, rising to 20% in elderly males
  • Males with CAD have lower testosterone levels than those with normal coronary angiograms of the same age,5 suggesting that the prevalence of testosterone deficiency is much higher in the CAD population
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  • Men with hypertension, another established risk factor for CAD, have lower testosterone compared to normotensive men
  • Recent meta-analyses showed that testosterone levels are generally lower among patients with metabolic syndrome, regardless of the various definitions of metabolic syndrome that are used
  • Testosterone (total and bioavailable) and sex-hormone binding globulin (SHBG) are inversely associated with the prevalence of metabolic syndrome in men between the ages of 40 and 80, and this association persists across racial and ethnic backgrounds
  • ower levels of testosterone and SHBG predict a higher incidence of metabolic syndrome.
  • Low testosterone levels have been related to increased insulin resistance and cardiovascular mortality,12 even in the absence of overt type 2 diabetes mellitus.
  • testosterone levels (total and bioavailable) in middle-aged men are inversely correlated with insulin resistance
  • The Massachusetts Male Aging Study (MMAS) demonstrated that low levels of testosterone and SHBG are independent risk factors for the development of type 2 diabetes,
  • Andropausal men (age 58 ± 7 years) have a higher maximal carotid artery intima-media thickness
  • There is an inverse linear correlation between body mass index (BMI) and wait-to-hip ratio with testosterone and insulin-like growth factor-1 levels.
  • Testosterone supplementation for 1 year in hypogonadal men has been shown to cause a significant improvement in body weight, BMI, waist size, lipid profile, and C-reactive protein levels
  • TRT for 3 months in hypogonadal men with type 2 diabetes significantly improved fasting insulin sensitivity, fasting blood glucose and glycated hemoglobin.
  • Testosterone replacement can improve angina symptoms and delay the onset of cardiac ischemia, likely through a coronary vasodilator mechanism
  • ADT is associated with an increased risk of cardiovascular events, including myocardial infarction and cardiovascular mortality.
  • ADT significantly increases fat mass, decreases lean body mass,29,30 increases fasting plasma insulin and decreases insulin sensitivity31 and increases serum cholesterol and triglyceride levels
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    Startling study on the knowledge of Testosterone and cardiovascular disease in general practitioners and cardiologists in Canada.  Eight-eight percent did not screen patients with cardiovascular disease for low Testosterone.  A whopping 67% of physicians did not know that low T was a risk factor for cardiovascular disease, yet 62% believed Testosterone would increase exercise tolerance. The lack of knowledge displayed by physicians today is staggering and is an indictment of the governing bodies.  This was a survey conducted in Canada so there are obvious limitations to the strength/conclusion of this study.
Nathan Goodyear

Early Detection of Head and Neck Cancer: Development of a Novel Screening Tool Using Mu... - 0 views

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    Article looks at proposed 25 biomarkers to screen for Head and Neck squamous cancer.  Most of these could be used for all cancers as they are inflammatory cytokines.
Nathan Goodyear

Salivary cortisol for screening of Cushing's syndr... [Clin Endocrinol (Oxf). 1999] - P... - 0 views

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    Salivary cortisol for screening of Cushing's syndrome in children.
Nathan Goodyear

Overnight dexamethasone suppression test: comparis... [Eur J Endocrinol. 1996] - PubMed... - 0 views

  • In conclusion we recommend the overnight dexamethasone suppression test with measurement of salivary cortisol as a screening test for Cushing's syndrome.
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    saliva testing of cortisol preferred for screening for Cushing's syndrome
Nathan Goodyear

Serum and salivary antigliadin antibodies and ... [Acta Paediatr. 1996] - PubMed - NCBI - 0 views

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    salivary antigliadin antibodies shown to be highly effective in screening for celiac disease
Nathan Goodyear

Evaluation of plasma, salivary, and urinary cortis... [Endocr J. 2010] - PubMed result - 0 views

  • Late-night salivary cortisol measurement is therefore a primary method of choice in the screening of patients suspected of having Cushing's syndrome.
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    "cortisol measurement is therefore a primary method of choice in the screening of patients suspected of having Cushing's syndrome".  This study compared plasma, salivary, and urinary tests.  salivary testing of cortisol is settled. Safe, reliable, and preferred method of evaluation.
Nathan Goodyear

Efficacy and effectiveness of influenza va... [Lancet Infect Dis. 2012] - PubMed - NCBI - 0 views

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    interesting screening of 5707 articles on flu vaccine finds that evidence for flu vaccine in those > 65 is "lacking".
Nathan Goodyear

Prevalence of Autism Spectrum Disorders - Autism and Developmental Disabilities Monitor... - 0 views

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    23% increase in autism in white children. That is now 1 in 88.  The news is worse for black children (91% increase) and even worse for hispanics (110% increase).  And no, this is not due to an increase in screening as some would propose.
Nathan Goodyear

Salivary testosterone for the diagnosis of androgen deficiency in end-stage renal disease - 0 views

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    salivary testosterone shown to effective in screening for androgen deficiency in men with ESRD.
Nathan Goodyear

ScienceDirect - Clinical Biochemistry : Advantage of salivary cortisol measurements in ... - 1 views

  • nighttime salivary cortisol is more adequate than serum in the screening of Cushing's syndrome
  • Morning salivary cortisol is as good as serum as screening test for patients with Addison's disease
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    salivary cortisol is shown to be reliable for both Addison's and Cushing's Syndrome
Nathan Goodyear

Role of salivary cortisol determinations in the diagnosis of... : Current Opinion in En... - 0 views

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    salivary cortisol testing said to be "screening test of choice".  Salivary cortisol testing validated.
Nathan Goodyear

Hormone Replacement Therapy in the Geriatric Patient: Current State of the Evidence and... - 0 views

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    TSH is not a reliable reproducible reflection of tissue T3 levels. In fact, in many ways TSH is merely just a screening tool. Research has shown that inflammation decreases TSH levels.
Nathan Goodyear

How a charity oversells mammography | BMJ - 1 views

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    This article reveals how data is massaged to promote a viewpoint. In this case mammograms.  Don't let your passions get the best of you, objectively review the data.  Scientists are not doing that these days. Mammograms do help and are needed in the screening, however, mammograms do cause harm and help to promote the same disease it seeks to detect early.  This is in some cases. Also, remember, mammograms are early detection, not prevention.
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