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Nathan Goodyear

Concomitant Dietary Supplement and Prescription Medication Use Is Prevalent among US Ad... - 0 views

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    Study worries over the risks of supplements and prescription drugs.  The author should worry more over the lack of knowledge by physicians of the health benefits of supplements.  Instead of focusing on the prescriptions themselves, how about focusing on the supplements to reduce the need for the prescriptions.  This authors focus is all wrong.   Obviously, the patient needs to be forthcoming with his/her physician about all supplements that they are on.  
Nathan Goodyear

Age and Sex Patterns of Drug Prescribing in a Defined American Population - 0 views

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    Startling statistics on the heavy use of prescription drugs by Americans.
Nathan Goodyear

Hospitalizations for Poisoning by Prescription Opioids, Sedatives, and Tranquilizers - 0 views

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    Prescription medications are one of the leading causes of death today.
Nathan Goodyear

Emergency Department visits for Adverse Events related to dietary supplements - 0 views

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    new study finds increase AE and ER with supplements at 22,000 annually; in contrast, 700,000 ER visits due to prescription drugs annually according to CDC--with 120,000 hospitalized.
Nathan Goodyear

Testosterone deficiency and cardiovascular mortality Morgentaler A, - Asian J Androl - 0 views

  • overall mortality and CV mortality were inversely associated with serum T concentrations.
  • men with low serum T, defined as < 8.7 nmol l−1 (250 ng dl−1 ), demonstrated significantly greater all-cause mortality than men with higher serum T (hazard ratio [HR]: 2.24; 95% CI: 1.41-3.57), as well as greater CV mortality
  • lower T levels were significantly associated with the presence of any CV disease
  • ...19 more annotations...
  • more than 30 years of studies suggesting that low levels of T represent an increased risk for CV and overall mortality,
  • lower serum T concentrations also are associated with CV disease, including incident coronary artery disease [17],[18],[19] and atherosclerosis,
  • the actual rate of adverse events was only half as great in the T group (123 events in 1223 men at risk = 10.1%) as in the untreated group (1587 events in 7486 men = 21.2%)
  • The study by Vigen et al. [7] has already undergone two published corrections,
  • 29 medical societies have called for retraction of the article, asserting "gross data mismanagement and contamination," that rendered the study "no longer credible
  • Mortality in T-treated men was reduced by approximately half in treated men compared with untreated men, at 10.3% versus 20.7%, respectively
  • The mortality rate for men who received TTh was 3.4 deaths per 100 person-years, and 5.7 deaths per 100 person-years in untreated men
  • HR of 0.61 (95%CI: 0.42-0.88; P = 0.008), indicating a significant reduction in mortality with TTh
  • men in the highest prognostic MI risk quartile, treatment with TTh was associated with reduced risk
  • tripling in T prescriptions in the US over the last decade
  • a majority of observational studies have found that low endogenous serum T levels are associated with increased mortality.
  • Men who received TTh were able to exercise significantly longer without ischemia compared with men who received placebo
  • In men with congestive heart failure, those who received T demonstrated greater walking distance and other functional endpoints compared with those who received placebo
  • TTh has been shown uniformly and repeatedly to improve several known CV risk factors, including reduced fat mass, body fat percent, and waist circumference, and increased lean mass
  • improved glycemic control
  • reductions in insulin resistance.
  • the evidence strongly points to improved CV status with normal serum T or treatment with TTh in men with TD
  • analysis of health insurance claims data that reported a 36% increased rate of nonfatal MI in the 90d following receipt of a T prescription compared with the 12 prior months.
  • Comparison with men who received a prescription for a phosphodiesterase type 5 inhibitor (PDE5i) revealed no increased rate of MI following the prescription
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    Great review by Morgentaler of Testosterone and CVD.  He highlights the significant flaws in the JAMA and the NEJM articles of Testosterone therapy risks.  Morgentaler highlights the significant evidence that points to low T and increased risk of CVD. On contention I have, is Morgantaler seems to flip aside the massive uptick of Testosterone use in the US as compared to other countries.  The evidence definitely points to Testosterone therapy as being safe in those with low T, but there is definitely a problem of significant Testosterone doping that is taking place as well.
ashleyobama

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Nathan Goodyear

Prescription drug abuse surged 400 percent in past decade - CSMonitor.com - 0 views

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    The current drug abuse problem to day has the hands of the medical community involved.
Nathan Goodyear

Study finds impotence risk higher in men taking several drugs: MedlinePlus - 0 views

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    Study reveals that the more medications a man takes, the more symptoms of ED he has.  This was found to be independent from variables such as hypertension, diabetes...  ED symptoms started at 1 medication
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Nathan Goodyear

A rare case of amiodarone-induced hypothyroidis... [Int J Angiol. 2011] - PubMed - NCBI - 0 views

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    Very interesting case study of amiodarone induced hypothyroidism that resulted in pericardial effusion and cardiac tamponade.
Nathan Goodyear

Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system - 0 views

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    Great read on the use of CBD, THC in nausea/vomiting. Data in humans is lacking and most of the data is related to prescription drugs.
Nathan Goodyear

How Medications Impact Libido - 0 views

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    This is a reference to a blog, but a well referenced blog on low libido and meds, particularly antidepressants and psychotropics.
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https://dblendstore.com/which-antidepressant-is-right-for-you/ - 0 views

Finding the right antidepressant medication can feel like a "hit or miss" proposition. While it may appear that doctors choose which antidepressant to prescribe for you at random, there is some log...

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