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Nathan Goodyear

JAMA Network | JAMA Neurology | Beneficial Effects of Testosterone Replacement for the ... - 0 views

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    Testosterone shown to provide benefit for non motor Parkinson symptoms.
Nathan Goodyear

Nicotine from edible Solanaceae and risk of Parkinson disease - Nielsen - 2013 - Annals... - 0 views

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    Nicotine from plants like peppers found to be associated with reduced incidence of Parkinsons disease.
Nathan Goodyear

Pictorial Review of Glutamate Excitotoxicity: Fundamental Concepts for Neuroimaging - 0 views

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    excellent article on the imaging of excitotoxicity.  Glutamate excitotoxicity is a key component in neurodegenerative diseases: Alzheimers, Parkinsons, ALS, MS...
Nathan Goodyear

Molecular Neurodegeneration | Full text | alpha-Synuclein and neuronal cell death - 0 views

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    alpha synuclein and Parkinsons disease
Nathan Goodyear

HE3286 as Treatment for Parkinson's Disease | The Michael J. Fox Foundation - 0 views

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    Synthetic analogue of DHEA metabolite, HE3286, analyzed as treatment in Parkinson.s disease.
Nathan Goodyear

High doses of vitamin E in the treatment of disorders of the central nervous system in ... - 0 views

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    High dose vitamin E, in doses up to 2,000 IU, in patients with Parkinson, Alzheimers and tar dive dyskinesia found to be safe and somewhat effective in these disease states in older individuals.  The length of the studies reviewed were up to 2 years.
Nathan Goodyear

The development of mitochondrial medicine - 0 views

  • n addition to being a primary cause of disease, mitochondrial DNA mutations and impaired oxidation have now been found to occur as secondary phenomena in aging as well as in age-related degenerative diseases such as Parkinson, Alzheimer, and Huntington diseases, amyotrophic lateral sclerosis and cardiomyopathies, atherosclerosis, and diabetes mellitus.
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    good discussion on primary and secondary mitochondrial diseases.  Aging and age-related disease are the result of secondary mitochondrial dysfunction
Nathan Goodyear

JAMA Network | JAMA Neurology | Refractory Nonmotor Symptoms in Male Patients With Park... - 0 views

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    Testosterone therapy aids symptoms of Parkinson's disease.  Whether low T is an associated finding or plays a role has yet to be determined.  However, we do know that androgens play an anti-inflammatory role in men and we know that inflammation plays a role in the neurodegenerative disease that is Parkinson's disease.
Nathan Goodyear

Exposure to pesticides or solvents and risk of Parkinson disease - 0 views

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    meta-analysis finds that exposure to pesticide and solvents increase Parkinson's disease by 80%.  One potentially problematic pesticide was paraquat.
Nathan Goodyear

LRRK2 G2019S Impairs Chaperone-Mediated Autophagy in Neurons (S13.003) -- Kuo et al. 80... - 0 views

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    impaired auto destruction process leads to the Lewy bodies found in Parkinson's disease.
Nathan Goodyear

Exposure to pesticides or solvents and risk of Parkinson disease - 0 views

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    Meta-analysis finds link between insecticides and Parkinson's disease.  This is not a political issue.  This is science.
Nathan Goodyear

PLOS ONE: N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Prelim... - 0 views

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    pilot study finds that NAC protects the dopaminergic neurons in the brains in cell line stud.  Clinical found increased dopamine binding in the brain compared to placebo in individuals with Parkinson's disease.
Nathan Goodyear

Annals of Internal Medicine | Gene-Diet Interactions in Brain Aging and Neurodegenerati... - 0 views

  • it appears that dietary restriction promotes neuronal survival, plasticity, and even neurogenesis by inducing a mild cellular stress response that involves activation of genes that encode proteins designed to promote neuronal growth and surviva
  • Studies of animal models of Alzheimer disease and Parkinson disease have shown that, by decreasing homocysteine levels, dietary folic acid can be neuroprotective
  • The current average daily calorie intake of Americans is approximately 2700 for women and more than 3000 for men
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    what you eat and how many calories you eat effects you brain and your risk of neurodegenerative diseases, such as Parkinson's and Alzheimer's disease.
Nathan Goodyear

Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study - 0 views

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    Hyperketogenic diet shown to provide many therapeutic benefits in other disease states. This study, though very small, showed that symptoms did improve with a hyperketonemic diet. This was a feasibility study.
Nathan Goodyear

Glutathione and Parkinson's Disease - ACAM Integrative Medicine (IM) Blog - 0 views

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    IV glutathione therapy as adjuvant in people with Parkinson's disease
Nathan Goodyear

Astrocytes and therapeutics for Parkinson'... [Neurotherapeutics. 2010] - PubMed - NCBI - 0 views

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    astrocytes play role in neurodegenerative disorders.
Nathan Goodyear

Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity - Gash - 2007... - 0 views

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    TCE shown to mitochondrial toxic and risk factor for Parkinson's disease
Nathan Goodyear

Risk of Parkinson Disease Onset in Patients With Diabetes - 0 views

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    Diabetes associated with an increased risk of Parkinson's disease in young men, middle aged women, and the elderly.
Nathan Goodyear

Unrecognized vitamin D3 deficiency is common in Parkinson disease - 0 views

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    low Vitamin D associated with Parkinson's disease
Nathan Goodyear

Oxidative stress, mitochondrial dysfunction and ce... [J Neurol Sci. 2005] - PubMed result - 0 views

  • There is significant evidence that the pathogenesis of several neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, Friedreich's ataxia (FRDA), multiple sclerosis and amyotrophic lateral sclerosis, may involve the generation of reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) associated with mitochondrial dysfunction
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    Mitochondrial dysfunction at heart of diseases such as Parkinson's, Alzheimers, MS, ALS..
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