Group items tagged Neurology - Dr. Goodyear

Ketoacids? Good medicine? - 0 views

www.ncbi.nlm.nih.gov/...tacca00002-0213.pdf

Beta-hydroxybutyrate brain neurology neuroplasticity neurogenesis inflammation calorie restriction ketosis ketoacids

shared by Nathan Goodyear on 25 Jun 12 - No Cached

Nathan Goodyear on 25 Jun 12

Great, great read on how biochemistry effects brain function. Beta-hydroxybutyrate is an alternative fuel source for the brain in times of calorie restriction. This promotes neuroplasticity and neurogenesis without the inflammatory effects of glucose and insulin.

<div class="cArrow"> </div><div class="cContentInner">Great, great read on how biochemistry effects brain function. Beta-hydroxybutyrate is an alternative fuel source for the brain in times of calorie restriction. This promotes neuroplasticity and neurogenesis without the inflammatory effects of glucose and insulin.</div>

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VITAMINS AND ENTACAPONE IN LEVODOPA-INDUCED HYPERHOMOCYSTEINEMIA: A RANDOMIZED CONTROLL... - 0 views

www.neurology.org/...1440.extract

Levodopa parkinson's disease Parkinson's homocysteine neurodegenerative disease vitamins

shared by Nathan Goodyear on 26 Jun 12 - No Cached

Nathan Goodyear on 26 Jun 12

It appears that Levodopa administration in those with Parkinson's disease will deplete methylation (SAMe), and thus increase homocysteine, which is a neurotoxin. Additionally, depletion of methylation is associated with depression, commonly seen in Parkinson's disease

<div class="cArrow"> </div><div class="cContentInner">It appears that Levodopa administration in those with Parkinson's disease will deplete methylation (SAMe), and thus increase homocysteine, which is a neurotoxin. Additionally, depletion of methylation is associated with depression, commonly seen in Parkinson's disease</div>

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Neuroendocrine disorders after... [J Neurol Neurosurg Psychiatry. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18559460

PTHP traumatic brain injury TBI neuroendocrine post-traumatic hypopituitarism brain injury neurology hormone hormones pituitary hypothalamus psychiatry

shared by Nathan Goodyear on 09 Jul 12 - No Cached

Nathan Goodyear on 09 Jul 12

The majority of people with PTHP after TBI remain undiagnosed. The current thought, is that 25% of those with TBI have at least one pituitary hormone deficiency. It does not have to be total pituitary failure. Deficiencies can be isolated.

<div class="cArrow"> </div><div class="cContentInner">The majority of people with PTHP after TBI remain undiagnosed. The current thought, is that 25% of those with TBI have at least one pituitary hormone deficiency. It does not have to be total pituitary failure. Deficiencies can be isolated.</div>

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Hypopituitarism after traumatic brain injury - 0 views

www.eje-online.org/...679.full

post-traumatic hypopituitarism PTHP TBI traumatic brain injury brain trauma neurology pituitary hypothalamus hormone hormones injury

shared by Nathan Goodyear on 09 Jul 12 - No Cached

PTHP is observed in about 40% of patients with a history of TBI
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Nathan Goodyear on 09 Jul 12

post-traumatic hypopituitarism is found in 40% of those with TBI. The severity does correlate with the increased likelihood of developing PTHP. Isolated deficiencies have been found in PTHP.

<div class="cArrow"> </div><div class="cContentInner">post-traumatic hypopituitarism is found in 40% of those with TBI. The severity does correlate with the increased likelihood of developing PTHP. Isolated deficiencies have been found in PTHP.</div>

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Progesterone and allopregnanolone reduce inflamma... [Exp Neurol. 2004] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15380490

progesterone allopregnanolone inflammatory cytokines IL-1Beta TNF-alpha brain neurology TBI traumatic brain injury

shared by Nathan Goodyear on 09 Jul 12 - No Cached

Nathan Goodyear on 09 Jul 12

progesterone and allopregnanolone shown to reduce IL-1beta and TNF-alpha in TBI rat model.

<div class="cArrow"> </div><div class="cContentInner">progesterone and allopregnanolone shown to reduce IL-1beta and TNF-alpha in TBI rat model.</div>

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Progesterone treatment inhibits the inflammatory a... [Brain Res. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15932748

progesterone treatment brain inflammation neurology NF-kapppB cytokines inflammatory TBI traumatic brain injury

shared by Nathan Goodyear on 09 Jul 12 - No Cached

Nathan Goodyear on 09 Jul 12

progesterone shown to decrease NF-KappaB and other inflammatory signaling after TBI in rat model. Part of the role of progesterone is as an anti-inflammatory.

<div class="cArrow"> </div><div class="cContentInner">progesterone shown to decrease NF-KappaB and other inflammatory signaling after TBI in rat model. Part of the role of progesterone is as an anti-inflammatory.</div>

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The Neurosteroid Allopregnanolone Promotes Proliferation of Rodent and Human Neural Pro... - 0 views

www.jneurosci.org/...4706.short

allopregnanolone brain neurology inflammation TBI traumatic brain injury human neural stem cells stem cells NPCs neuroprogenitor cells

shared by Nathan Goodyear on 09 Jul 12 - No Cached

Nathan Goodyear on 09 Jul 12

allopregnanolone increases human neural stem cells. Not only does allopregnanolone reduce inflammation, it plays a role in neurogenesis and thus recovery.

<div class="cArrow"> </div><div class="cContentInner">allopregnanolone increases human neural stem cells. Not only does allopregnanolone reduce inflammation, it plays a role in neurogenesis and thus recovery.</div>

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IOS Press - Journal Article - 0 views

iospress.metapress.com/...c828m5t46j6850x5

progesterone hormone hormones neuroprotection brain neurology

shared by Nathan Goodyear on 10 Jul 12 - No Cached

Nathan Goodyear on 10 Jul 12

progesterone shown to have neuroprotective effects in brain ischemic rat model.

<div class="cArrow"> </div><div class="cContentInner">progesterone shown to have neuroprotective effects in brain ischemic rat model.</div>

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Effects of progesterone administration on infarct volume and functional deficits follow... - 0 views

www.ncbi.nlm.nih.gov/...PMC2656912

progesterone hormone hormones brain neurology

shared by Nathan Goodyear on 10 Jul 12 - No Cached

Nathan Goodyear on 10 Jul 12

progesterone shown to provide substantial reduction in volume of infarct in rat stroke model. This is very promising, and with with other studies revealing the same benefit in the human brain, progesterone should become a part of initial treatment in those with acute brain injuries and should be evaluated for those with aging diseases of the brain.

<div class="cArrow"> </div><div class="cContentInner">progesterone shown to provide substantial reduction in volume of infarct in rat stroke model. This is very promising, and with with other studies revealing the same benefit in the human brain, progesterone should become a part of initial treatment in those with acute brain injuries and should be evaluated for those with aging diseases of the brain.</div>

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Allopregnanolone, a progesterone metabolite, i... [Ann Emerg Med. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16546625

progesterone allopregnanolone hormone hormones brain neurology stroke

shared by Nathan Goodyear on 10 Jul 12 - No Cached

Nathan Goodyear on 10 Jul 12

again an animal model; but progesterone and allopregnanolone shown to reduce brain damage. Allopregnanolone was more effective in this animal model.

<div class="cArrow"> </div><div class="cContentInner">again an animal model; but progesterone and allopregnanolone shown to reduce brain damage. Allopregnanolone was more effective in this animal model.</div>

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Neuroprotection of Sex Steroids - 0 views

www.ncbi.nlm.nih.gov/...PMC3036837

hormones estrogen progesterone testosterone sex hormones brain neurology neuroprotection neuroprotective hormones hormone

shared by Nathan Goodyear on 10 Jul 12 - No Cached

Nathan Goodyear on 10 Jul 12

great article on sex hormones and neuroprotection. This article summarizes the research on estrogen, progesterone, and aromatase activity in in vitro and in vivo studies. Additionally, the study reviews the androgenic neuroprotection in men. Who has said that hormones are not needed post menopausal again? Maybe, that is the sign that they need the neuroprotective effect of hormones.

<div class="cArrow"> </div><div class="cContentInner">great article on sex hormones and neuroprotection. This article summarizes the research on estrogen, progesterone, and aromatase activity in in vitro and in vivo studies. Additionally, the study reviews the androgenic neuroprotection in men. Who has said that hormones are not needed post menopausal again? Maybe, that is the sign that they need the neuroprotective effect of hormones.</div>

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JAMA Network | Archives of Neurology | Effects of Growth Hormone-Releasing Hormone on C... - 0 views

archneur.jamanetwork.com/article.aspx

GHRH cognitive function executive aging hormone hormones

shared by Nathan Goodyear on 07 Sep 12 - No Cached

Nathan Goodyear on 07 Sep 12

GHRH, for 20 weeks shown to subjectively and objectively improve cognitive function in adults.

<div class="cArrow"> </div><div class="cContentInner">GHRH, for 20 weeks shown to subjectively and objectively improve cognitive function in adults. </div>

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IOS Press - Journal Article - 0 views

iospress.metapress.com/...6q583tlvm0kxd197

allopregnanolone progesterone bio-identical bioidentical hormone hormones brain injury neurology TBI

shared by Nathan Goodyear on 29 Jan 12 - No Cached

Nathan Goodyear on 29 Jan 12

Allopregnanolone, a produce of progesterone metabolism, shown to reduce brain injury post TBI.

<div class="cArrow"> </div><div class="cContentInner">Allopregnanolone, a produce of progesterone metabolism, shown to reduce brain injury post TBI.</div>

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short-term benefit from oral vancomycin treatment of regressive-onset autism - 0 views

www.ncbi.nlm.nih.gov/pubmed

autism ASD dysbiosis inflammation gut GI gastrointestinal children

shared by Nathan Goodyear on 30 Jan 12 - No Cached

Nathan Goodyear on 30 Jan 12

disruption of gut bacteria balance, dysbiosis, proposed to play role in regression autism. This study treated these children with vancomycin. Short interval improvement was found. The take home from this study is the gut-brain connection in children with regression autism

<div class="cArrow"> </div><div class="cContentInner">disruption of gut bacteria balance, dysbiosis, proposed to play role in regression autism. This study treated these children with vancomycin. Short interval improvement was found. The take home from this study is the gut-brain connection in children with regression autism</div>

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Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity - Gash - 2007... - 0 views

onlinelibrary.wiley.com/...abstract

TCE environmental toxins mitochondria Parkinson's Disease PD

shared by Nathan Goodyear on 14 Nov 11 - No Cached

Nathan Goodyear on 14 Nov 11

TCE shown to mitochondrial toxic and risk factor for Parkinson's disease

<div class="cArrow"> </div><div class="cContentInner">TCE shown to mitochondrial toxic and risk factor for Parkinson's disease</div>

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Study Suggests Coenzyme Q10 Slows Functional Decline in Parkinson's Disease: National I... - 0 views

www.ninds.nih.gov/...kinsons_coenzymeq10_101402.htm

CoQ10 Parkinson's disease Huntington's ecitotoxic neurotoxic

shared by Nathan Goodyear on 07 Nov 11 - Cached

Nathan Goodyear on 07 Nov 11

high dose CoQ10 shown to slow disease progression in Parkinson's disease. A similar study had shown the same finding in Huntington's disease. Both are excitotoxic diseases

<div class="cArrow"> </div><div class="cContentInner">high dose CoQ10 shown to slow disease progression in Parkinson's disease. A similar study had shown the same finding in Huntington's disease. Both are excitotoxic diseases</div>

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Use of Zinc as a Treatment for Tr... [Neurorehabil Neural Repair. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22331212

TBI Zn zinc traumatic brain injury brain neurology

shared by Nathan Goodyear on 31 Jul 12 - No Cached

Nathan Goodyear on 31 Jul 12

Another study showing benefit of Zn in TBI

<div class="cArrow"> </div><div class="cContentInner">Another study showing benefit of Zn in TBI</div>

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Improving treatments and outcomes: an emerging role... [Nutr Rev. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22747843

TBI Zn zinc traumatic brain injury brain neurology

shared by Nathan Goodyear on 31 Jul 12 - No Cached

Nathan Goodyear on 31 Jul 12

Zinc emerging as a tool in the treatment/recovery of TBI

<div class="cArrow"> </div><div class="cContentInner">Zinc emerging as a tool in the treatment/recovery of TBI</div>

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Glucose tolerance status and risk of dementia in the community - 0 views

neurology.org/...1126.abstract

dementia Alzheimer's Alzheimer's disease OGTT post prandial glucose tolerance test glucose tolerance

shared by Nathan Goodyear on 11 Jun 12 - No Cached

Nathan Goodyear on 11 Jun 12

elevated 2 hour post prandial OGTT associated with all-cause dementia, including Alzheimer's disease. Interestingly, the association was not found with fasting glucose levels.

<div class="cArrow"> </div><div class="cContentInner">elevated 2 hour post prandial OGTT associated with all-cause dementia, including Alzheimer's disease. Interestingly, the association was not found with fasting glucose levels.</div>

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Alzheimer's disease--synergistic effects of ... [J Neural Transm. 1998] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9720973

AD AGE advanced glycation end products Alzheimer's disease neurofibrillary tangles Beta-amyloid protein microglia brain neurology oxidative stress alzheimer

shared by Nathan Goodyear on 11 Jun 12 - No Cached

AGEs are protein modifications that contribute to the formation of the histopathological and biochemical hallmarks of AD: amyloid plaques, neurofibrillary tangles and activated microglia
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Nathan Goodyear on 11 Jun 12

good review of understanding of how poor glucose control, oxidative stress result in AGE and Alzheimer's disease.

<div class="cArrow"> </div><div class="cContentInner">good review of understanding of how poor glucose control, oxidative stress result in AGE and Alzheimer's disease.</div>

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Group items tagged

Ketoacids? Good medicine? - 0 views

VITAMINS AND ENTACAPONE IN LEVODOPA-INDUCED HYPERHOMOCYSTEINEMIA: A RANDOMIZED CONTROLL... - 0 views

Neuroendocrine disorders after... [J Neurol Neurosurg Psychiatry. 2008] - PubMed - NCBI - 0 views

Hypopituitarism after traumatic brain injury - 0 views

Progesterone and allopregnanolone reduce inflamma... [Exp Neurol. 2004] - PubMed - NCBI - 0 views

Progesterone treatment inhibits the inflammatory a... [Brain Res. 2005] - PubMed - NCBI - 0 views

The Neurosteroid Allopregnanolone Promotes Proliferation of Rodent and Human Neural Pro... - 0 views

IOS Press - Journal Article - 0 views

Effects of progesterone administration on infarct volume and functional deficits follow... - 0 views

Allopregnanolone, a progesterone metabolite, i... [Ann Emerg Med. 2006] - PubMed - NCBI - 0 views

Neuroprotection of Sex Steroids - 0 views

JAMA Network | Archives of Neurology | Effects of Growth Hormone-Releasing Hormone on C... - 0 views

IOS Press - Journal Article - 0 views

short-term benefit from oral vancomycin treatment of regressive-onset autism - 0 views

Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity - Gash - 2007... - 0 views

Study Suggests Coenzyme Q10 Slows Functional Decline in Parkinson's Disease: National I... - 0 views

Use of Zinc as a Treatment for Tr... [Neurorehabil Neural Repair. 2012] - PubMed - NCBI - 0 views

Improving treatments and outcomes: an emerging role... [Nutr Rev. 2012] - PubMed - NCBI - 0 views

Glucose tolerance status and risk of dementia in the community - 0 views

Alzheimer's disease--synergistic effects of ... [J Neural Transm. 1998] - PubMed - NCBI - 0 views

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