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Nathan Goodyear

PLOS ONE: N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Prelim... - 0 views

journals.plos.org/...article

Parkinsons Parkinson's disease NAC N-acetylcysteine brain

shared by Nathan Goodyear on 17 Jun 16 - No Cached
  • Nathan Goodyear on 17 Jun 16
     
    pilot study finds that NAC protects the dopaminergic neurons in the brains in cell line stud.  Clinical found increased dopamine binding in the brain compared to placebo in individuals with Parkinson's disease.
Nathan Goodyear

'Metabolic syndrome' in the brain: deficiency in omega-3 fatty acid exacerbates dysfunc... - 0 views

jp.physoc.org/...2485.abstract

metabolic syndrome brain insulin fructose resistance omega 3 n-3

shared by Nathan Goodyear on 03 Sep 12 - No Cached
  • n-3 deficient diet and fructose interventions disrupted insulin receptor signalling in hippocampus as evidenced by a decrease in phosphorylation of the insulin receptor and its downstream effector Akt
  • Nathan Goodyear on 03 Sep 12
     
    rats fed high fructose diet and omega-3 diet found to have memory decline.  The purpose of this study was to look at the effects of Metabolic syndrome on the brain.
Nathan Goodyear

Effects of supplementation with fish oil-derived n−3 fatty acids and γ-linole... - 0 views

www.ajcn.org/37.full

Omega-3 n-3 GLA fish oil cholesterol LDL fatty acids fish oil

shared by Nathan Goodyear on 23 Jul 12 - No Cached
  • Nathan Goodyear on 23 Jul 12
     
    mixture of omega-3 and GLA shown to statistically lower LDL.  The mixture that was statistically significant was 4:2.
Nathan Goodyear

N-Acetylcysteine: Multiple Clinical Applications - August 1, 2009 - American Family Phy... - 0 views

www.aafp.org/...p265.html

NAC N-acetylcysteine detoxification

shared by Nathan Goodyear on 02 Mar 12 - No Cached
  • Nathan Goodyear on 02 Mar 12
     
    use of NAC provides many health benefits above and beyond tylenol overdose.
Nathan Goodyear

Adiponectin is involved in the protective effect of... [Steroids. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18534650

DHEA adiponectin overweight obesity omega-6 omega-3 n-6 n-3

shared by Nathan Goodyear on 01 Mar 12 - No Cached
  • Nathan Goodyear on 01 Mar 12
     
    DHEA increased adiponectin, improved omega 6/omega 3 ratios, and improved body fat content.
Nathan Goodyear

n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases - 0 views

ajcn.nutrition.org/...S1505.full

inflammation n-3 omega 3 EFA essential fatty acids disease

shared by Nathan Goodyear on 05 Sep 13 - No Cached
  • Nathan Goodyear on 05 Sep 13
     
    Omega 3 and inflammation.  Good review of the biochemistry of inflammation and the interaction of omega-3 as a disruptor of inflammation.
Nathan Goodyear

PLOS ONE: Effect of Marine-Derived n-3 Polyunsaturated Fatty Acids on C-React... - 0 views

www.plosone.org/...10.1371%2Fjournal.pone.0088103

inflammation omega 3 omega-3 n-3 CRP IL-6 TNF-alpha

shared by Nathan Goodyear on 14 Feb 14 - No Cached
  • Nathan Goodyear on 14 Feb 14
     
    meta-analysis finds that omega-3 fatty acids decrease CRP, IL-6, and TNF-alpha.
Nathan Goodyear

A Randomized Controlled Pilot Trial of Oral N-Acetylcysteine in Children with Autism - 0 views

www.biologicalpsychiatryjournal.com/...fulltext

autism ASD glutathione NAC N-acetylcysteine children

shared by Nathan Goodyear on 04 Mar 14 - No Cached
  • Nathan Goodyear on 04 Mar 14
     
    900 mg of NAC over short 4 week course provided significant improvement in behavior of children with autism.  No pre treatment evaluation was performed.  One wonders if therapeutic therapy was actually undertaken if the results would have been better.  NAC is a precursor to Glutathione production and detoxification compromise is common place in autism.
Nathan Goodyear

Palmitoleic acid (n-7) increases white adipocyte lipolysis and lipase content... - 0 views

ajpendo.physiology.org/...E1093

omega-7 n-7 palmitoleic acid PPAR-alpha PPAR

shared by Nathan Goodyear on 14 Nov 13 - No Cached
  • Nathan Goodyear on 14 Nov 13
     
    Palmitoleic acid, an omega-7, is associated with increased lipolysis through PPARalpha.
Nathan Goodyear

Review of health risks of low testosterone and testosterone administration - 0 views

www.ncbi.nlm.nih.gov/...PMC4391003

low Testosterone low T Testosterone men male hormone hormones health

shared by Nathan Goodyear on 28 Apr 15 - No Cached
  • Hypogonadism may be defined either as serum concentration of T (either total T, bioavailable T or free T) or as low T plus symptoms of hypogonadism
  • The Baltimore Longitudinal Study on Aging reported the incidence of total serum T < 325 ng/dL to be 20% for men in their 60s, 30% for men in their 70s and 50% for men over 80
  • The Massachusetts Aging Male Study reported that 12.3% of men aged 40 to 70 had a total serum T of < 200 ng/dL with 3 or more symptoms of hypogonadism
  • ...19 more annotations...
  • The Boston Area Community Health Study reported that 5.6% of men aged 30 to 70 were hypogonadal, as defined by total serum T < 300 ng/dL; or, free serum T < 5 ng/dL plus 3 or more symptoms of hypogonadism
  • In a health screening project among 819 men in Taiwan, the prevalence of hypogonadism (total serum T < 300 ng/dL) ranged from 16.5% for men in their 40s, 23.0% for men in their 50s, 28.9% for men in their 60s, and 37.2% for men older than 70 years of age
  • The prevalence of hypogonadism among men in Taiwan is higher than the prevalence reported in the Massachusetts Male Aging Study
  • CAG repeat sequence, within the androgen receptor (AR). Rajender et al[12] reviewed over 30 studies on the AR trinucleotide repeat and infertility
  • suggestion that CAG repeat length may determine androgen responsiveness, this issue is not clearly settled
  • reported prevalence of low T in older men range from 5.6% to 50%
  • Those in the hypogonadal group (n = 4269) had direct health care costs, that exceeded the eugonadal group (n = 4269) by an average of $7100 over the course of the observation window
  • higher economic burden and presence of co-morbidities for hypogonadism
  • minor to moderate improvements in lean mass and muscle strength
  • increased bone mineral density
  • modest enhancement in sexual function
  • reduced adiposity
  • lessening of depressive symptoms
  • Meta-analyses of clinical TRT trials as of 2010 have identified three major adverse events resulting from TRT: (1) polycythemia; (2) an increase in prostate-related events; and (3) and a slight reduction in serum high-density lipoprotein (HDL) cholesterol
  • polycythemia (> 3.5-fold increase in risk
  • TRT produced a 40% prostate enlargement in older hypogonadal male Veterans over 12 mo
  • no published analysis has reported measurable increases in prostate cancer risk or Gleason score in men undergoing TRT, or in hypogonadal men with a history of prostate cancer undergoing TRT
  • the prostate which highly expresses the type II 5α-reductase enzyme. Inhibition of this enzyme via finasteride (a type II 5α-reductase inhibitor) or dutasteride (a dual type I and II 5α-reductase inhibitor) reduces circulating DHT 50%-75% and > 90%, respectively[47], and reduces prostate mass[48] and prostate cancer risk
  • Normally estradiol partially regulates testosterone levels, at the hypothalamus, blunting LH and FSH release from the pituitary. As a selective estrogen receptor modulator, CC interrupts this pathway, and consequently there is a greater stimulation for the production of testosterone in Leydig cells
    • Nathan Goodyear
      Nathan Goodyear on 28 Apr 15
       
      this would only apply if E1 and/or E2 levels were elevated, which the authors make no mention of.
  • Nathan Goodyear on 28 Apr 15
     
    to be read
Nathan Goodyear

Exercise and the brain: something to chew on - 0 views

www.ncbi.nlm.nih.gov/...PMC2680508

exercise brain neurogenesis neurplasticity

shared by Nathan Goodyear on 03 Nov 13 - No Cached
  • Nathan Goodyear on 03 Nov 13
     
    The absolute best way to promote neurogenesis is through exercise.  This is through an increase in BDNF.  There are ways to augment this: curcumin, n-3, nutrition...  The concept that the brain doesn't heal is out the window.
Nathan Goodyear

ω-3 Fatty Acid Supplementation as a Potential Therapeutic Aid for the Recover... - 0 views

advances.nutrition.org/...268.full

omega 3 DHA EPA fish oil TBI traumatic brain injury concussions concussion brain injury

shared by Nathan Goodyear on 30 Aug 15 - No Cached
  • There is a growing body of preclinical literature suggesting that ω-3 FAs, and DHA in particular, may play a therapeutic role in mTBI
  • the potential for ameliorating or possibly even preventing the complications associated with concussions
  • DHA is the predominant ω-3 FA present in the brain, and, consistent with this finding, DHA, and not EPA, has been demonstrated to be critical for brain development and cognitive function throughout life
  • ...7 more annotations...
  • the concentration of EPA in the brain is negligible (77–80), suggesting that EPA plays a limited role in mediating the beneficial effects of LCPUFA supplementation on mTBI pathology
  • the current state of the science regarding LCPUFA supplementation for the treatment of concussion is based primarily on animal models
  • there is evidence that the amount of DHA in brain tissue is decreased after mTBI (65, 66), suggesting an elevated need for DHA in mTBI recovery.
  • the well-established role of DHA in supporting the structure and function of the brain throughout the lifespan (26, 27, 46, 47, 53) provides encouragement that LCPUFAs may also prove beneficial in the context of concussion recovery.
  • no therapies are currently available to aid the recovery from this injury
  • Previously discussed reports outlining the use of ω-3 FAs in the recovery from severe TBIs (reviewed in Ref. 92) described the use of very-high doses of LCPUFAs (16.2 g/d EPA plus DHA) in the recovery of these patients
  • Within the context of mTBIs/concussions, translating a DHA intake used in several rat studies of mTBI recovery (40 mg ⋅ kg−1 ⋅ d−1 DHA) (57, 63, 64) using body surface area conversion methods (93) amounts to an estimated human intake of 387 mg/d DHA
  • Nathan Goodyear on 30 Aug 15
     
    nice review of the evidence of n-3, particularily DHA, in concussions and concussion recovery.
Nathan Goodyear

The frequency of salivary progesterone sampling an... [Gynecol Endocrinol. 1992] - PubM... - 0 views

www.ncbi.nlm.nih.gov/...1502930

saliva salivary testing progesterone

shared by Nathan Goodyear on 22 Nov 10 - No Cached
  • A single mid-luteal salivary progesterone estimation or the mid-luteal Lenton progesterone index (n = 4) satisfactorily reflected the normal luteal phase, but a frequency of one sample every 3 days over the luteal phase (n = 5-6) was necessary to allow recognition of a short luteal phase or poor progesterone surge.
  • Nathan Goodyear on 22 Nov 10
     
    The frequency of salivary progesterone sampling and the diagnosis of luteal phase insufficiency.
Nathan Goodyear

Serial salivary estriol to detect an increased ris... [Obstet Gynecol. 2000] - PubMed r... - 0 views

www.ncbi.nlm.nih.gov/...11004346

salivary estriol saliva bioidentical testing

shared by Nathan Goodyear on 24 Nov 10 - No Cached
  • CONCLUSION: Elevated salivary E3 is associated with increased risk of preterm birth in asymptomatic women and symptomatic women who present for evaluation of preterm labor.
  • Nathan Goodyear on 24 Nov 10
     
    salivary estriol, again, validated n PTL risk assessment
Nathan Goodyear

Effects of thyroxine as compared with thyroxine pl... [N Engl J Med. 1999] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...9971866

T3 T4 hypothyroidism armour thyroid USP

shared by Nathan Goodyear on 19 Nov 10 - No Cached
  • n patients with hypothyroidism, partial substitution of triiodothyronine for thyroxine may improve mood and neuropsychological function;
  • Nathan Goodyear on 19 Nov 10
     
    Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism.
Nathan Goodyear

(n-3) Fatty Acids and Cancer Therapy - J. Nutr. - 0 views

jn.nutrition.org/...3427S.abstract

Omega-3 cancer

shared by Nathan Goodyear on 11 Feb 11 - No Cached
  • Used alone, an (n-3) supplement may be a useful alternative therapy for patients who are not candidates for standard toxic cancer therapies.
  • Nathan Goodyear on 11 Feb 11
     
    Omega-3 reduce inflammation, inhibit tumor growth, inhibit angiogenesis, induce cancer cell death, and inhibit estrogen signaling
Nathan Goodyear

(n-3) Fatty Acids: Clinical Trials in People with Type 2 Diabetes - 0 views

advances.nutrition.org/...3.short

omega-3 trigylcerides hypertriglyceridemia

shared by Nathan Goodyear on 28 Apr 11 - No Cached
  • had varying effects on serum cholesterol, LDL cholesterol, and HDL cholesterol
  • (n-3) Fatty acids generally decreased serum triglycerides
  • Nathan Goodyear on 28 Apr 11
     
    Omega 3 review lowers triglycerides
Nathan Goodyear

An unusual cause of adult onset cerebellar ataxia with hypogonadism Menon RN, Sanghani ... - 0 views

www.annalsofian.org/article.asp

celiac disease celiac disease hypogonadism hypogonadotropic hypogonadism low T Testosterone men male hormone hormones

shared by Nathan Goodyear on 28 Jul 14 - No Cached
  • Nathan Goodyear on 28 Jul 14
     
    Case study of man with celiac disease that presented with hypogonadotropic hypogonadism.  Though the evidence for a link is present in the literature, the number of studies is limited.
Nathan Goodyear

N-Acetylcysteine for Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis o... - 0 views

www.ncbi.nlm.nih.gov/...PMC4306416

NAC N-acetylcysteine PCOS infertility women women's health female hormone hormones

shared by Nathan Goodyear on 23 Feb 15 - No Cached
  • compared effects of NAC with placebo or metformin in women with PCOS
  • NAC significantly improved rates of live births and spontaneous ovulation compared to placebo in women with PCOS
  • we found no evidence of effects of NAC on improving menstrual regularity, acne, hirsutism, BMI, fasting insulin, fasting glucose, or HOMA-IR
  • ...3 more annotations...
  • NAC was not associated with greater benefits to metformin for improving pregnancy rate, spontaneous ovulations, and menstrual regularity
  • Metformin also improved the BMI, total testosterone, insulin level, and lipid levels compared to NAC
  • All the studies were of short duration (three months)
  • Nathan Goodyear on 23 Feb 15
     
    Data review finds NAC improves pregnancy rates and ovulation rates in women with PCOS against placebo.  Meta-analysis revealed limited studies on the topic.  When compared to metformin, there was no difference found.  Though, one wonders if attacking insulin resistance through proper diet and additional neutraceutical approach would negate that.  The reason?  NAC and metformin are working in different biochemical pathways.  The authors here seem to not realize this. It appears that they think NAC and metormin are both working in the same manner, but they don't.  The fact that there is still benefit found compared to placebo, despited the authors lack of understanding of what NAC is and does is a positive.
Nathan Goodyear

http://n.ethz.ch/~aguayod/download/The%20Influence%20of%20Frequency,Intensity,%20Volume... - 0 views

n.ethz.ch/...ionaAl%20rea%20in%20Humans.pdf

resistance training weight training weight lifting muscle exercise

shared by Nathan Goodyear on 20 Mar 15 - No Cached
  • Nathan Goodyear on 20 Mar 15
     
    Thorough review on resistance training and the effects on muscle.
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