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Nathan Goodyear

PLOS ONE: Depletion of Brain Docosahexaenoic Acid Impairs Recovery from Traumatic Brain... - 0 views

journals.plos.org/...article

DHA TBI traumatic brain injury omega 3 brain injury brain omega-3

shared by Nathan Goodyear on 31 Aug 15 - No Cached
  • The polyunsaturated fatty acids linoleic (LA, 18:2n-6) and linolenic acid (LNA, 18:3n-3) are essential fatty acids that cannot be synthesized by the body.
  • LNA serves as the precursor for long chain omega-3 fatty acids such as docosahexaenoic acid (DHA) while LA is converted into long chain omega-6 fatty acids such as arachidonic acid (AA)
  • DHA and AA are abundantly found in the brain, where these are stored mainly in membrane phospholipids
  • ...10 more annotations...
  • DHA has been shown to increase neurite outgrowth and synaptogenesis, and promotes glutamatergic neurotransmission through increase in glutamate receptor subunit expression
  • DHA has been shown to be converted to anti-inflammatory, proresolving and neuroprotective mediators, such as resolvins [7] and protectins
  • AA is converted by cyclooxygenases into 2-series prostaglandins and 4-series leukotrienes, most of which exert pro-inflammatory effects
  • Supplementation of DHA exerts neuroprotective effects and has been reported to afford protection from diffuse axonal injury [11] and mixed brain injury [12] as well
  • severe depletion of membrane DHA in the brain renders mice significantly more susceptible to TBI and impairs recovery following the injury
  • Omega-3 fatty acids may serve as nutraceutical agents and precondition the brain to make it more resilient to injury
  • it can be suggested that enriching DHA in the brain may be prophylactic and protective against brain injury
  • severe DHA deficiency in the brain impairs functional recovery from TBI in terms of vestibulo-motor and cognitive deficits
  • DHA deficiency further elevates TBI-induced production of SBDPs
  • less neurons were found around the injury site of DHA deficient brain after TBI compared to the omega-3 fatty acid adequate group
  • Nathan Goodyear on 31 Aug 15
     
    mouse study finds prolonged recovery in DHA deficient mice compared to controls.
Nathan Goodyear

Palmitoleic acid (n-7) increases white adipocyte lipolysis and lipase content... - 0 views

ajpendo.physiology.org/...E1093

omega-7 n-7 palmitoleic acid PPAR-alpha PPAR

shared by Nathan Goodyear on 14 Nov 13 - No Cached
  • Nathan Goodyear on 14 Nov 13
     
    Palmitoleic acid, an omega-7, is associated with increased lipolysis through PPARalpha.
Nathan Goodyear

Arch Intern Med -- Abstract: Effect of Different Antilipidemic Agents and Diets on Mort... - 0 views

archinte.ama-assn.org/...725

Omega-3 fish oil lipids cholesterol

shared by Nathan Goodyear on 15 Feb 11 - No Cached
  • Statins and n-3 fatty acids are the most favorable lipid-lowering interventions with reduced risks of overall and cardiac mortality.
  • Nathan Goodyear on 15 Feb 11
     
    Omega-3 most favorable lipid lowering agent
Nathan Goodyear

Web of Knowledge [v.5.3] - Web of Science - 0 views

cel.webofknowledge.com/full_record.do

DHEA DHEA-S adipose tissue obesity overweight fat

shared by Nathan Goodyear on 20 Mar 12 - No Cached
  • Nathan Goodyear on 20 Mar 12
     
    human study: revealed a decrease in saturated fatty acids, omega-6 in those supplemented with DHEA-S.  DHEA-S was found to improve the metabolic profile of adipose tissue
Nathan Goodyear

Results of the MIDAS trial: Effects of docosahexaenoic acid on physiological and safety... - 0 views

www.alzheimersanddementia.com/...abstract

omega 3 n-3 omega-3 cognition brain

shared by Nathan Goodyear on 04 Nov 13 - No Cached
  • Nathan Goodyear on 04 Nov 13
     
    no abstract available, however this study found DHA slowed age related cognitive decline at 900 mg daily.
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