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Nathan Goodyear

Making the Right Fish Choices: Fatty Acid Contents of 33 Different Fish Species. Plus: ... - 0 views

suppversity.blogspot.com/...t-fish-choices-fatty-acid.html

omega 3 omega-3 omega-6 fish nutrition diet

shared by Nathan Goodyear on 14 Sep 17 - No Cached
  • Nathan Goodyear on 14 Sep 17
     
    I don't normally post blog posts, however, this post has merits for the purpose of figure 1 and figure 2.   Figure 1 highlights the different omega 3:omega 6 of different fish and figure 2 highlights the different omega3;6 in wild versus farm raised fish.
Nathan Goodyear

Survey of n-3 and n-6 polyunsaturated fatty acids in fish and fish products - 0 views

www.ncbi.nlm.nih.gov/...PMC3543232

omega 3 omega-6 omega-3 fish EPA DHA ALA diet nutrition

shared by Nathan Goodyear on 14 Sep 17 - No Cached
  • Nathan Goodyear on 14 Sep 17
     
    Good read on the omega 3 versus omega 6 content of different fish.
Nathan Goodyear

Epigenetic changes in blood leukocytes following an omega-3 fatty acid supplementation - 0 views

www.ncbi.nlm.nih.gov/...PMC5405524

epigenetics nutrigenomics omega 3 omega-3 diet nutrition methylation fats EPA DHA

shared by Nathan Goodyear on 15 Sep 17 - No Cached
  • Nathan Goodyear on 15 Sep 17
     
    Epigenetic and really nutrigenomics: 6 week study of 3 gram omega 3 intake induced methylation changes.  Get that?  Only 6 weeks of omega 3 intake induces a change in genetic expression.
Nathan Goodyear

Altered Preconception Fatty Acid Intake Is Associated with Improved Pregnancy Rates in ... - 0 views

www.ncbi.nlm.nih.gov/...PMC4728624

obesity overweight infertility IVF nutrition pregnancy omega-6 omega-3 omega 3 omg

shared by Nathan Goodyear on 17 Oct 16 - No Cached
  • Nathan Goodyear on 17 Oct 16
     
    Health fat intake associated with improved fertility in overweight and obese women undergoing IVF.  Higher intake of polyunsaturated fats were associated with improved fertile rates: specifically omega 6 and Linoleum acid.  Only a trend was seen with omega 3's.
Nathan Goodyear

Omega 3/6 fatty acids for reading in children: a randomized, double-blind, placebo-cont... - 0 views

onlinelibrary.wiley.com/...abstract

omega 3 omega-3 omega-6 brain children reading

shared by Nathan Goodyear on 19 Sep 16 - No Cached
  • Nathan Goodyear on 19 Sep 16
     
    Omega 3/6 supplementation in a 1:1 ration in children improved reading skills in 3 months.
Nathan Goodyear

Adiponectin is involved in the protective effect of... [Steroids. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18534650

DHEA adiponectin overweight obesity omega-6 omega-3 n-6 n-3

shared by Nathan Goodyear on 01 Mar 12 - No Cached
  • Nathan Goodyear on 01 Mar 12
     
    DHEA increased adiponectin, improved omega 6/omega 3 ratios, and improved body fat content.
Nathan Goodyear

PLOS ONE: Depletion of Brain Docosahexaenoic Acid Impairs Recovery from Traumatic Brain... - 0 views

journals.plos.org/...article

DHA TBI traumatic brain injury omega 3 brain injury brain omega-3

shared by Nathan Goodyear on 31 Aug 15 - No Cached
  • The polyunsaturated fatty acids linoleic (LA, 18:2n-6) and linolenic acid (LNA, 18:3n-3) are essential fatty acids that cannot be synthesized by the body.
  • LNA serves as the precursor for long chain omega-3 fatty acids such as docosahexaenoic acid (DHA) while LA is converted into long chain omega-6 fatty acids such as arachidonic acid (AA)
  • DHA and AA are abundantly found in the brain, where these are stored mainly in membrane phospholipids
  • ...10 more annotations...
  • DHA has been shown to increase neurite outgrowth and synaptogenesis, and promotes glutamatergic neurotransmission through increase in glutamate receptor subunit expression
  • DHA has been shown to be converted to anti-inflammatory, proresolving and neuroprotective mediators, such as resolvins [7] and protectins
  • AA is converted by cyclooxygenases into 2-series prostaglandins and 4-series leukotrienes, most of which exert pro-inflammatory effects
  • Supplementation of DHA exerts neuroprotective effects and has been reported to afford protection from diffuse axonal injury [11] and mixed brain injury [12] as well
  • severe depletion of membrane DHA in the brain renders mice significantly more susceptible to TBI and impairs recovery following the injury
  • Omega-3 fatty acids may serve as nutraceutical agents and precondition the brain to make it more resilient to injury
  • it can be suggested that enriching DHA in the brain may be prophylactic and protective against brain injury
  • severe DHA deficiency in the brain impairs functional recovery from TBI in terms of vestibulo-motor and cognitive deficits
  • DHA deficiency further elevates TBI-induced production of SBDPs
  • less neurons were found around the injury site of DHA deficient brain after TBI compared to the omega-3 fatty acid adequate group
  • Nathan Goodyear on 31 Aug 15
     
    mouse study finds prolonged recovery in DHA deficient mice compared to controls.
Nathan Goodyear

Omega-3 Fatty Acids and Inflammatory Processes - 0 views

www.ncbi.nlm.nih.gov/...PMC3257651

fats nutrition diet omega 3 inflammation NF-kappaB TNF-alpha omega-3 fish oil DHA EPA docosahexaenoic acid eicosapentaenoic acid

shared by Nathan Goodyear on 15 Sep 17 - No Cached
  • marine n-3 PUFAs have also been shown to alter the production of inflammatory proteins including chemokines, cytokines, growth factors and matrix proteases
  • Two transcription factors that are likely to play a role in inflammation are nuclear factor κ B (NFκB) and PPAR-γ
  • NFκB is the principal transcription factor involved in upregulation of inflammatory cytokine, adhesion molecule and cyclooxygenase-2 genes
  • ...3 more annotations...
  • PPAR-γ, is believed to act in an anti-inflammatory manner
  • PPAR-γ directly regulates inflammatory gene expression, it also interferes with the activation of NFκB creating an intriguing interaction between these two transcription factors
  • Both NFκB and PPAR-γ may be regulated by n-3 PUFAs.
  • Nathan Goodyear on 15 Sep 17
     
    great review of the anti-inflammatory effects of omega 3 DHA and EPA.  EPA inhibits COX and 5-LOX and their downstream prostaglandin and leukotrienes.  EPA/DHA inhibited endotoxin-stimulated IL-6, IL-8,TNF-alpha, and NFkappaB.
Nathan Goodyear

European Journal of Clinical Nutrition - Effect of maternal n-3 long-chain polyunsatura... - 0 views

www.nature.com/...ejcn2014158a.html

nutrition n-3 omega 3 omega-3 fish oil pregnancy childhood obesity

shared by Nathan Goodyear on 22 Dec 14 - No Cached
  • It is estimated that approximately 30% of children and adolescents in the United States and about 15–30% of those in Europe can be classified as overweight or obese
  • An increasing body of evidence now suggests that the nutritional environment encountered in utero and the early postnatal life may elicit permanent alterations in adipose tissue structure or function and, thereby, programme the individual’s propensity to later obesity
  • The composition of fatty acids in the Western diets has shifted toward an increasing dominance of n-6 relative to n-3 LCPUFAs over the past decades.9,10 This shift is also reflected in the fatty acid composition of breast milk
  • ...8 more annotations...
  • Evidence from animal studies suggests that the n-6 LCPUFA arachidonic acid promotes adipose tissue deposition, whereas the n-3 LCPUFAs eicosapentaenoic acid and docosahexaenoic acid seem to exert an opposite effect
  • Overall, no effect of supplementation was found on BMI in preschool (<5 years) and school-aged (6–12 years) children
  • increased adiposity, once established in childhood, tends to track into adulthood
  • Many studies have shown that even children <2 years with a high BMI are at increased risk of developing obesity later in life
  • The acquisition of fat cells early in life appears to be an irreversible process
  • Evidence from cell culture and animal studies suggests that early exposure to n-3 LCPUFAs has the potential to limit adipose tissue deposition mainly by attenuating the production of the arachidonic acid metabolite prostacyclin, which has been shown to enhance adipogenesis
  • In conclusion, there is currently no evidence to support that maternal n-3 LCPUFA supplementation during pregnancy and/or lactation exerts a favourable programming effect on adiposity status in childhood
  • our systematic review highlights that most of the trials reviewed were prone to methodological limitations
  • Nathan Goodyear on 22 Dec 14
     
    Literature review finds limited data (9 studies, only 6 RCTs) of omega-3 during pregnancy.  No data was found that supported reduced obesity in children by mothers taking n-3 during pregnancy.  No harm was found either.  Data was sparse.   Take home: not enough data, no harm to pregnancy, children, thus if indications are present for mother, then recommend n-3.  At this point not studies have pointed to reduced obesity in children.
Nathan Goodyear

n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases - 0 views

ajcn.nutrition.org/...S1505.full

inflammation n-3 omega 3 EFA essential fatty acids disease

shared by Nathan Goodyear on 05 Sep 13 - No Cached
  • Nathan Goodyear on 05 Sep 13
     
    Omega 3 and inflammation.  Good review of the biochemistry of inflammation and the interaction of omega-3 as a disruptor of inflammation.
Nathan Goodyear

PLOS ONE: Effect of Marine-Derived n-3 Polyunsaturated Fatty Acids on C-React... - 0 views

www.plosone.org/...10.1371%2Fjournal.pone.0088103

inflammation omega 3 omega-3 n-3 CRP IL-6 TNF-alpha

shared by Nathan Goodyear on 14 Feb 14 - No Cached
  • Nathan Goodyear on 14 Feb 14
     
    meta-analysis finds that omega-3 fatty acids decrease CRP, IL-6, and TNF-alpha.
Nathan Goodyear

The omega-3 index as a risk factor for coronary heart disease - 0 views

www.ajcn.org/...1997S.full

n-3 omega 3 coronary heart disease sudden cardiac death CVD cardiovascular disease heart cardiology heart disease

shared by Nathan Goodyear on 14 Jul 12 - No Cached
  • Nathan Goodyear on 14 Jul 12
     
    Omega-3 fatty acids can be used to predict risk for coronary heart disease death, especially sudden cardiac death.
Nathan Goodyear

Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases - 0 views

www.jacn.org/...495.full

Omega-3 fatty acids inflammation autoimmune diseases

shared by Nathan Goodyear on 13 Sep 11 - No Cached
  • Nathan Goodyear on 13 Sep 11
     
    Omega-3 reduces inflammation in patients with autoimmune disease
Nathan Goodyear

Dietary factors and growth and metabolism in experimental tumors - 0 views

www.jnutbio.com/...abstract

omega-6 inflammation tumor cancer dietary

shared by Nathan Goodyear on 10 Feb 11 - No Cached
  • Linoleic acid (LA), an essential n-6 polyunsaturated fatty acid (PUFA), was identified as an agent in dietary fat that is responsible for an up-regulation of tumor growth in vivo
  • Nathan Goodyear on 10 Feb 11
     
    High omega-6 intake in diet increases tumor growth
Nathan Goodyear

Waist circumference, waist:hip ratio, and risk of ... [Am J Epidemiol. 1999] - PubMed r... - 0 views

www.ncbi.nlm.nih.gov/...10604774

breast cancer weight obesity omega-6

shared by Nathan Goodyear on 24 Nov 10 - No Cached
  • Nathan Goodyear on 24 Nov 10
     
    overweight women and those with high omega-6 diets have lower survival with breast cancer
Nathan Goodyear

Modulation of dietary fat-enhanced colorectal carc... [Nutr Cancer. 1997] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...9383790

dietary fat omega-6 cancer

shared by Nathan Goodyear on 10 Feb 11 - No Cached
  • Nathan Goodyear on 10 Feb 11
     
    Diet high in OMega-6 increases risk of colorectal cancer; increased vegetables reduced risk
Nathan Goodyear

Host and tumor growth and energy substrates in blo... [Am J Clin Nutr. 1988] - PubMed r... - 0 views

www.ncbi.nlm.nih.gov/...3133941

Omega-6 inflammation diet insulin cancer

shared by Nathan Goodyear on 10 Feb 11 - No Cached
  • Nathan Goodyear on 10 Feb 11
     
    Inflammatory Omega-6 diet increase insulin production, which likely will stimulate cancer growth
Nathan Goodyear

Acute local inflammation potentiates tumor growth ... [Cancer Lett. 2000] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...10695986

inflammation Omega-6 cancer

shared by Nathan Goodyear on 10 Feb 11 - No Cached
  • Chronic inflammation in humans has been implicated in the pathogenesis of several types of cancer.
  • These data demonstrate for the first time that an acute, local inflammatory stimuli can induce accelerated tumor growth at the affected site
  • Nathan Goodyear on 10 Feb 11
     
    inflammatory diets, typical American diet high in Omega-6, promote cancer cell growth
Nathan Goodyear

Controversial issues of dietary fat and experiment... [Prev Med. 1993] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...8234213

omega-6 inflammation breast cancer

shared by Nathan Goodyear on 10 Feb 11 - No Cached
  • A voluminous amount of information is also available in the literature linking increased fat consumption, particularly polyunsaturated fat, and stimulation of mammary tumorigenesis
  • Nathan Goodyear on 10 Feb 11
     
    diet high omega-6 increases breast cancer metastasis
Nathan Goodyear

Dietary fat and mammary cancer. I. Promoting effec... [J Natl Cancer Inst. 1986] - PubM... - 0 views

www.ncbi.nlm.nih.gov/...3459924

dietary fat cancer omega-6

shared by Nathan Goodyear on 10 Feb 11 - No Cached
  • Nathan Goodyear on 10 Feb 11
     
    review of 97 animal studies reveal connection between high omega-6 dietary intake and cancer growth
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