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No surprise here as genetics and environment play in a role in all disease.  Here it is hormones.  

In cases of CRPC, there is endogenous androgen synthesis from weaker adrenal androgens.  Also, the authors point to a unregulated AR sensitivity in the lower androgen environment created by ADT.

knowledge of progesterone and its metabolites are important in the use of hormones.  As the authors concluded here: "natural steroids should not be disparaged...an update on endocrinological knowledge and experience is rather mandatory for gynecologists".  There in lies the problem.  The IOM has shown that the average physician practices at a level of 17 years behind the current scientific knowledge and the environment created by medical governing bodies discourages questions, so as to protect the system.

Prospective study finds that elevated total and free Estradiol levels in the follicular phase and elevated total and free Testosterone levels in both the follicular and luteal phase are associated with increased breast cancer in women.  The risk is for pre menopause in this study.  This and several other studies point to serious questions about the massive dosing of Testosterone via pellets, injections, and topicals for libido.  We appear to be following the same patter as seen with premarin, provera, now Testosterone in men and this may be the next ball to drop.  Is the Testosterone therapy merely producing an environment that feeds breast cancer?

Breast cancer incidence varies Asian American women living in Asia versus US.  The great variable here is the environment.  A change in phenotypic expression.

The environment is playing a role in reduced testicular function in men.

increased ADMA is associated with a proatherogenic environment in men.  Testosterone therapy was found to be associated with a reduction in ADMA in men.  This is one mechanism of Testosterone therapy and reduced CVD.

study finds prolonged exposure to estrogen associated with increased colorectal cancer risk in postmenopausal women. So many unanswered questions. What was the ER status of these patients? What was the weight of these patients? One cannot simply compare estrogen exposure to colorectal cancer risk and say aha! What is the environment of the individual(s)?!

It is important to understand that hormones in serum do not reflect the hormonal environment in the prostate.  Additionally, the diseased prostate does not respond the same as a healthy prostate.  That is high advanced Prostate cancer will respond to estrogen therapy and early prostate disease will increase with increased aromatase Testosterone to Estradiol conversion.

Only abstract available.  The autoimmune disease that can accompany adjuvants in vaccines is a interaction between genetic susceptibility and environment.  For example, if a person genetically does not detox well and then they are overloaded with adjuvants in an ever increasing vaccine regimen then they are a set up for ASIA.  

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Nice read on how loss environment and immune dysfunction help lead to LUpus

We are products of our genetics and our environment

deep read on the environment and endocrine disruptors

How you respond to stress is a reflection of your genetics and environment.  The bodies ability to express genes, such as the glial cell

How you respond to stress is a reflection of your genetics and environment.  The bodies ability to express genes, such as the glial cell-derived neurotrophic factor, impacts an individual's expression in the face of stress.  You have a genetic predisposition, but with poor methylation you end up with more depression in the presence of stress

saliva testing used to evaluate melatonin and cortisol in simulated space station environment

Amazing study that displays how the environment in the gut can effect the immune system in the lung.

Generation X more obese than baby boomers.  There was no difference in physical activity levels.  This points only to environment i.e. diet, environmental toxins...

environmental toxins that have estrogenic activity, i.e. BPA alter the prostate stem cells.  These and other xenoestrogens, as they are collectively called, increase the sensitivity of the prostate to estrogen.  This increases the risk of prostate Ca.  This just sets the pattern of signal interpretation and sensitivity.  Add in the continued estrogenic environment, add in the excess weight, the increased aromatase activity and resultant estrogen production and one has all the ingredients for prostate cancer.