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Nice review of Testosterone levels and some of the evidence linking Diabetes with low T.  However, the conclusion by the authors regarding what is causing the low T in men with Diabetes is baffling.  The literature does not point to one cause, it is clearly multifactorial--obesity, inflammation, high aromatase activity...I would suggest the authors continue their readings in the manner.

Testosterone levels vary amongst men by geography.  Testosterone levels are higher, 20% higher, in Asian men living in Hong Kong and Japan versus those that live in the US.  This is very similar to some of the date around breast cancer in Asian women.  Both suggesting diet and environment as the variable.

Breast cancer incidence varies Asian American women living in Asia versus US.  The great variable here is the environment.  A change in phenotypic expression.

study of adjuvant chemotherapy in Asian women found no weight gain post treatment; this is in contrast to American and European women in other studies.

men with UGT2B17 found to be poor metabolizers of endogenous Testosterone.  Normally, epi-Testosterone and Testosterone exist in a relative 1:1 ratio,  However, in these individuals with this SNP, they will have slightly elevated Testosterone levels due to disrupted phase II testosterone metabolism (glucuronidation).  This is found in 60% of Asian men, 50% of black men, and 1% in white men.

Asian study finds Testosterone is inversely associated with increased central obesity, increased dyslipidemia, and metabolic syndrome in me with new diagnosis of type II diabetes and hypertension.  Men with metabolic syndrome, type II diabetes, and CVD must have appropriate hormone evaluation.

Curcumin consumption associated with increased cognition in elderly Asians.

Low cardiac surgery cost in India and high ranges of expertise have made India a leading location for heart treatment for people from West Asian and African nations.

This article, abstract only, looks at the cause of low Testosterone.  It is well known that low T increases CAD in men.  But what causes the low T?  Is the "normal" decline in testosterone actually normal or a product of accumulative dysfunction.

vitamin D deficiency associated with increased type II DM.  This was found to be associated independently from other variables.

This study shows that DHT is a good alternative androgen to Testosterone.  It was shown to have no positive/negative effect on the prostate.  The negative of this study was found to be bone loss from supra physiologic DHT.  The point there is to keep hormone replacement physiologic, as one should with all BHRT.

fresh, young coconut water shown to be equal to sports drinks in rehydration from heavy exercise.

Mouse model shows that intratumor conversion of DHEA to DHT stimulates tumor growth in prostate cancer model.

Low Testosterone is a very significant problem in men with type II Diabetes.  Estimated to reach 40%, likely much higher.  They based these estimates only on T levels and sexual symptoms. Testosterone improves glycemic control primarily through Increased transcription and transloction of GLUT4 insulin receptors to the cell surface.  Inflammation reduction is also a mechanism.  Testosteorne lowers Triglycerides in the traditional lipid profile.  Studies are mixed on the other aspects of  lipids.  

Nice review of all the sex hormones and their relationship to CVD in men.  

Nice review of the mixed data on Testosterone and Prostate disease. It is clear that Testosterone does not precipitate prostate cancer.  The intraprostatic hormone milieu likely is different than that present in the serum.  No surprise there.  5alpha reductase decreases prostate volume, PSA, and low-grade prostate cancer, but actually increases aggressive prostate cancer. Supraphysiologic doping in young men associated with no increase in prostate disease. PSA no longer to be followed in men < 55.  Mortality rate not changed.  PSA change of 1.4 ng/ml is appropriate for additional prostate evaluation.  Testosterone therapy on average increased 0.5 ng/ml. Still, no mention of aromatase activity in this article.  Why is it that hormone sensitive disease in men is only with regards to androgens and women estrogen.

to be read

To be read

Low Testosterone found to disrupt restful sleep in men.  However, in contrast, Testosterone doping leads to sleep disruption as well.  I love how the authors describe it: ...in supra therapeutic doses, or in the context abuse."

Review of xenoestrogens and techniques for evaluation.  Brief discussion of the different EDCs is included, but the majority of the study is to evaluate the different testing techniques.